Arthropodicidal carboxanilides

ABSTRACT

Arthropodicidal carboxanilides of Formula I or II:ed from the group    &lt;IMAGE&gt;  Q-1   &lt;IMAGE&gt;  Q-2   R4, R5, R6 and n are as defined in the text, arthropodicidal compositions containing said compounds and a method for using the compounds to control arthropods.

This is a division of Ser. No. 08/075,534, filed Jun. 18, 1993, now U.S. Pat. No. 5,462,938, issued Oct. 31, 1995, which is the national filing of PCT/U.S. Ser. No. 91/09,164, filed Dec. 17, 1991, which is a continuation-in-part of Ser. No. 07/714,401, filed Jun. 11, 1991, now abandoned, which is a continuation-in-part of Ser. No. 07/632,438, filed Dec. 21, 1990, now abandoned.

BACKGROUND OF THE INVENTION

Arthropodicidal carboxanilides, compositions containing them, and use of the carboxanilides to control arthropods. Relevant to this invention are WO 88/07,994 and EPA 330,678 which disclose insecticidal pyrazolines and WO 90/07495 which discloses insecticidal semicarbazone arthropodicides.

SUMMARY OF THE INVENTION

The invention pertains to compounds of Formula I and II, including all geometric and stereoisomers, agriculturally suitable salts thereof, agricultural compositions containing them and their use for the control of arthropods in both agronomic and non-agronomic uses. The term "compounds" will be understood to include all such isomers and salts thereof. The compounds are: ##STR3## wherein: Q is selected from the group ##STR4## A is H; E is selected from the group H and C₁ -C₃ alkyl; or

A and E can be taken together to form --CH₂ --, --CH₂ CH₂ --, --O--, --S--, --S(O)--, --S(O)₂ --, --NR⁷ --, --OCH₂ --, --SCH₂ --, --N(R⁷)CH₂ --, substituted --CH₂ --, and substituted --CH₂ CH₂ -- the substituents independently selected from 1-2 halogen and 1-2 methyl;

G is selected from the group ##STR5## X is selected from the group O, S and N--X² ; X¹ is selected from the group Cl, Br, OR⁸, SR⁸ and NR⁸ R⁹ ;

X² is selected from the group R⁸, OH, OR⁸, CN, SO₂ R⁸, SO₂ Ph, OC(O)NR⁹ R¹⁰, OC(O)OR⁸, NR⁹ R¹⁰ and phenyl optionally substituted with R¹¹ ;

Y is selected from the group H; C₁ -C₆ alkyl, benzyl; C₂ -C₆ alkoxyalkyl; C₂ -C₆ alkenyl; C₂ -C₆ alkynyl; C₁ -C₆ alkyl optionally substituted by halogen, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, CN, NO₂, S(O)_(r) R³², COR³², CO₂ R³², phenyl optionally substituted by halogen, CN, C₁ -C₂ haloalkyl and C₁ -C₂ haloalkoxy; C₃ -C₆ cycloalkyl; C₃ -C₆ cyclohaloalkyl; C₃ -C₆ cycloalkylalkyl; CHO; C₂ -C₆ alkylcarbonyl; C₂ -C₆ alkoxycarbonyl; C₂ -C₆ haloalkylcarbonyl; COR³⁶ ; CO₂ R³⁶ ; C₁ -C₆ alkylthio; C₁ -C₆ haloalkylthio; phenylthio; R¹² OC(O)N(R¹³)S-- and R¹⁴ (R¹⁵)NS--;

A¹ is H;

A¹ and Y can be taken together to form --(CH₂)_(t) --;

Z is C or N;

Z¹ is O, S or NR³¹ ;

R¹ and R² are independently selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, N₃, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, NR¹⁸ C(O)R¹⁷, OC(O)NHR¹⁷, NR¹⁸ C (O)NHR¹⁷, NR¹⁸ SO₂ R¹⁷, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; or when m or n is 2, (R¹)₂ can be taken together, or (R²)₂ can be taken together as --OCH₂ O--, --OCF₂ O--, --OCH₂ CH₂ O--, --CH₂ C(CH₃)₂ O--, --CF₂ CF₂ O or --OCF₂ CF₂ O-- to form a cyclic bridge; provided that when R¹ or R² is S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷ or OS(O)₂ R¹⁷ then R¹⁷ is other than H;

R³ is selected from the group H, J, N₃, NO₂, halogen, N(R²²)R²³, C(R³⁴)═N--O--R³⁵, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₂ -C₆ alkoxylalkyl, C₃ -C₈ alkoxycarbonylalkyl, CO₂ R¹⁷, OR¹⁹, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, C(S)NR¹⁷ R¹⁸, C(S)R¹⁷, C(S)SR¹⁷, CN, Si(R²⁸)(R²⁹)R²⁷, SR²⁷, S(O)R²⁷, SO₂ R²⁷, --P(O)(OR²⁷)₂, phenyl, phenyl substituted with (R¹⁶)_(p), benzyl and benzyl substituted with 1 to 3 substituents independently selected from W; or R³ is C₂ -C₆ epoxyalkyl optionally substituted with a group selected from C₁ -C₃ alkyl, CN, C(O)R²⁴, CO₂ R²⁴ and phenyl optionally substituted with W; or R³ is C₁ -C₆ alkyl substituted with a group selected from C(O)N(R²⁵)R²⁶, C(O)R²⁵, SR²⁷, S(O)R²⁷, SO₂ R²⁷, SCN, CN, C₁ -C₂ haloalkoxy, Si(R²⁸)(R²⁹)R³⁰, N(R²²)R²³, NO₂, OC(O)R²⁵, --P(O)(OR²⁷)₂ and J;

J is selected from the group saturated, partially unsaturated or aromatic 5- or 6-membered heterocyclic ring, bonded through carbon or nitrogen, containing 1-4 heteroatoms independently selected from the group consisting of 0-2 oxygen, 0-2 sulfur and 0-4 nitrogen, this substituent optionally containing one carbonyl and optionally substituted with one or more members selected from W;

R⁴ and R⁵ are independently selected from the group H, C₁ -C₄ alkyl, COR²⁰ and C₂ -C₄ alkoxycarbonyl; or

R⁴ and R⁵ can be taken together to form ═O or ═S;

R⁶ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkylcarbonyl, C₂ -C₄ haloalkoxycarbonyl, C₂ -C₄ alkoxycarbonyl C₂ -C₄ haloalkoxycarbonyl, COR³⁶, CO₂ R³⁶, C₂ -C₅ alkylaminocarbonyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, C₄ -C₇ alkylcycloalkyl, C₄ -C₇ haloalkylcycloalkyl, C₁ -C₄ alkylsulfonyl, C₁ -C₄ haloalkylsulfonyl and SO₂ Ph optionally substituted with Cl, Br or CH₃ ;

R⁷ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkenyl, C₂ -C₄ haloalkenyl, SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, C(O)R¹⁷, CO₂ R¹⁷, C(O)NR¹⁷ R²¹, C(S)NR¹⁷ R²¹, C(S)R¹⁷, C(S)OR¹⁷, --P(O) (OR¹⁷)₂, --P(S) (OR¹⁷)₂, P(O) (R¹⁷)OR¹⁷, P(O) (R¹⁷)SR²¹, and optionally substituted phenyl and benzyl wherein the substituent(s) are selected from F, Cl, Br, CH₃, CF₃ or OCF₃ ; provided that when R⁷ is other than C(O)R¹⁷, C(O)NR¹⁷ R²¹ or C(S)NR¹⁷ R²¹ then R¹⁷ is other than H;

R⁸ is selected from the group C₁ -C₃ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, C₁ -C₃ haloalkyl, C₂ -C₄ haloalkenyl, C₃ -C₆ cycloalkyl; C₁ -C₃ alkyl substituted with OCH₃, OCH₂ CH₃, NO₂, CN, CO₂ CH₃, CO₂ CH₂ CH₃, SCH₃ or SCH₂ CH₃ and benzyl optionally substituted with R¹¹ ;

R⁹ is selected from the group H, C₁ -C₄ alkyl C₁ -C₄ haloalkyl, C₂ -C₄ alkoxycarbonyl, and optionally substituted phenyl and pyridine wherein the substituent(s) are selected from R¹⁵ ; or

R⁸ and R⁹ can be taken together to form --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ -- each of which is optionally and independently substituted with 1 or 2 CH₃ groups;

R¹⁰ is selected from the group H and C₁ -C₄ alkyl; or

R⁹ and R¹⁰ can be taken together to form --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ -- each of which is optionally and independently substituted with 1 or 2 CH₃ groups;

R¹¹ is selected from halogen, CN, C₁ -C₃ haloalkyl and C₁ -C₃ haloalkoxy;

R¹² is C₁ -C₆ alkyl;

R¹³ is C₁ -C₄ alkyl;

R¹⁴ and R¹⁵ are independently C₁ -C₄ alkyl; or

R¹⁴ and R¹⁵ can be taken together as --CH₂ CH₂ CH₂ CH₂ CH₂ -- or --CH₂ CH₂ OCH₂ CH₂ --;

R¹⁶ is selected from the group C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, N₃, SCN NO₂, OR¹⁷, SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, NR¹⁸ C(O)R¹⁷, OC(O)NHR¹⁷, NR¹⁸ C(O)NHR¹⁷, NR¹⁸ SO₂ R¹⁷, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; or when p is 2, (R¹⁶)₂ can be taken together as --OCH₂ O--, --OCF₂ O--, --OCH₂ CH₂ O--, --CH₂ C(CH₃)₂ O--, --CF₂ CF₂ O or --OCF₂ CF₂ O-- to form a cyclic bridge; provided that when R¹⁶ is S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷ or OS(O)₂ R¹⁷ then R¹⁷ is other than H;

R¹⁷ is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, and optionally substituted phenyl and benzyl wherein the substituents are 1 to 3 substituents independently selected from W;

R¹⁸ is selected from the group H and C₁ -C₄ alkyl; or

R¹⁷ and R¹⁸, when attached to the same atom, can be taken together as --(CH₂)₄ --, --(CH₂)₅ --, or --CH₂ CH₂ OCH₂ CH₂ --;

R¹⁹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, C₂ -C₄ alkylcarbonyl, C₂ -C₄ alkoxycarbonyl and C₁ -C₄ alkylsulfonyl;

R²⁰ is C₁ -C₃ alkyl;

R²¹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl and C₂ -C₄ alkynyl;

R²² is selected from the group H, C₂ -C₇ alkylcarbonyl, C₂ -C₇ alkoxycarbonyl, optionally substituted C₁ -C₄ alkyl, optionally substituted C₂ -C₄ alkenyl, and optionally substituted C₂ -C₄ alkynyl, the substituents selected from C₁ -C₂ alkoxy, CN, C(O)R³⁰ and C(O)₂ R²⁷ ;

R²³ is selected from the group H, C₁ -C₃ alkyl, phenyl, phenyl substituted with W, benzyl and benzyl substituted with W;

R²⁴ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl and C₂ -C₄ alkynyl;

R²⁵ and R²⁶ are independently selected from the group H and C₁ -C₂ alkyl;

R²⁷ is selected from the group C₁ -C₃ alkyl, phenyl and phenyl substituted with W;

R²⁸ is C₁ -C₃ alkyl;

R²⁹ is C₁ -C₃ alkyl;

R³⁰ is selected from the group H, C₁ -C₃ alkyl, phenyl and phenyl substituted by W;

R³¹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkylcarbonyl or C₂ -C₄ alkoxycarbonyl;

R³² is selected from the group C₁ -C₃ alkyl;

R³⁴ is selected from the group H, Cl, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₂ thioalkyl and CN;

R³⁵ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₃ alkylcarbonyl and C₂ -C₃ alkoxycarbonyl;

R³⁶ is selected from the group phenyl and phenyl substituted with W;

W is selected from the group halogen, CN, NO₂, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy, C₁ -C₂ alkylthio, C₁ -C₂ haloalkylthio, C₁ -C₂ alkylsulfonyl and C₁ -C₂ haloalkylsulfonyl;

m is 1 to 3;

n is 1 to 3;

p is 1 to 3;

r is 0, 1 or 2;

t is 2 or 3; and

u is 1 or 2.

Exemplary values of J include: ##STR6##

Preferred Compounds A are those of Formulae I and II wherein:

R¹ is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, SO₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; with one R¹ substituent in the 4-position, or when m is 2 then (R¹)₂ can be taken together as --CH₂ C(CH₃)₂ O--, --OCH₂ CH₂ O--, --OCF₂ CF₂ O--, or --CF₂ CF₂ O-- to form a 5- or 6-membered fused ring;

R² is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W;

R³ is selected from the group H, C₁ -C₄ alkyl, C₃ -C₄ alkoxycarbonylalkyl, CO₂ R¹⁷, C(O)R¹⁷, phenyl and phenyl substituted by (R¹⁶)_(p) ;

R¹⁶ is selected from the group C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W;

R¹⁷ is selected from the group C₁ -C₄ alkyl, C₁ -C₂ haloalkyl, C₃ -C₄ alkenyl and propargyl;

R¹⁸ is selected from the group H and CH₃ ;

X¹ is selected from the group Cl, OR⁸, SR⁸ and N(CH₃)₂ ;

X² is selected from the group R⁸, OR⁸ and N(CH₃)₂ ;

m is 1 or 2;

n is 1 or 2; and

p is 1 or 2.

Preferred Compounds B are those of Preferred A wherein G is selected from the group G-2, G-3, G-7 and G-9. Preferred Compounds C are those of Preferred B wherein J is selected from the group J-1, J-2, J-8, J-9 and J-16. Preferred Compounds D are those of Preferred C wherein A and E are taken together to form --O--, --CH₂ --, --CH₂ CH₂ --, --OCH₂ --, --S--, --SCH₂ -- or NR⁷ ; R⁷ is selected from the group H, Me, SO₂ R¹⁷, CO₂ R¹⁷ and CON(R¹⁷)R²¹. Preferred Compounds E are Compounds D of Formula I wherein Z¹ is O. Preferred Compounds F are Compounds D of Formula I wherein Z¹ is S. Preferred Compounds G are Compounds D of Formula I wherein Z¹ is NR³¹. Preferred Compounds H are those of Preferred E wherein Q is Q-1. Preferred Compounds I are those of Preferred E wherein Q is Q-2. Preferred Compounds J are those of Preferred E wherein Y is C₁ -C₆ alkyl. Preferred Compounds K are those of Preferred J wherein Y is CH₃.

Specifically preferred are compounds:

(L) methyl 7-chloro-2,3-dihydro-2- 4-trifluoromethoxy)phenylamino!carbonyl!indeno 1,2-e! 1,3,4!oxadiazine-4a(5H)-carboxylate;

(M) methyl 7-chloro-2,5-dihydro-2- N-methyl-N- 4-(trifluoromethoxy)phenyl!aminocarbonyl!indeno 1,2-e! 1,3,4!oxadiazine-4a(3H)-carboxylate;

(N) methyl 7-chloro-2,5-dihydro-2- N-methyl-N- 4-trifluoromethyl)phenyl!amino!carbonyl!indeno 1,2-e! 1,3,4!oxadiazine-4a(3H)-carboxylate;

(O) 7-fluoro-4a-(4-fluorophenyl)-4a,5-dihydro-N- 4-(trifluoromethoxy)phenyl!indeno 1,2-e! 1,3,4!oxadiazine-2(3H)-carboxamide; and

(P) 7-chloro-4a,5-dihydro-4a-methyl-N- 4-(trifluoromethoxy)phenyl!indeno 1,2-e! 1,3,4!oxadiazine-2(3H)-carboxamide.

In the above definitions, the term "alkyl", used either alone or in compounds words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, such as methyl, ethyl, n-propyl, isopropyl or the different butyl, pentyl, hexyl isomers. Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and the different butoxy or pentoxy isomers. Alkenyl denotes straight chain or branched alkenes, such as vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl, pentenyl and hexenyl isomers. Alkynyl denotes straight chain or branched alkynes, such as ethynyl, 1-propynyl, 3-propynyl and the different butynyl, pentynyl and hexynyl isomers. Alkylthio denotes methylthio, ethylthio and the different propylthio, butylthio, pentylthio and hexylthio isomers. Alkylsulfinyl, alkylsulfonyl, alkylamino, and the like are defined analogously to the above examples. Cycloalkyl denotes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl" said alkyl may be partially or fully substituted with halogen atoms, which may be the same or different. Examples of haloalkyl include CH₂ CH₂ F, CF₂ CF₂ and CH₂ CHFCl. The terms "halocycloalkyl", "haloalkenyl" and "haloalkynyl" are defined analogously to the term "haloalkyl".

The total number of carbon atoms in a substituent group is indicated by the "C_(i) -C_(j) " prefix where i and j are numbers from 1 to 8. For example, C₁ -C₃ alkylsulfonyl designates methylsulfonyl through propylsulfonyl; C₂ alkoxyalkoxy designates OCH₂ OCH₃ ; C₄ alkoxyalkoxy designates the various isomers of an alkoxy group substituted with a second alkoxy group containing a total of 4 carbon atoms, examples including OCH₂ OCH₂ CH₂ CH₃ and OCH₂ CH₂ OCH₂ CH₃ ; C₂ cyanoalkyl designates CH₂ CN and C₃ cyanoalkyl designates CH₂ CH₂ CN and CH(CN)CH₃ ; C₂ alkylcarbonyl designates C(O)CH₃ and C₄ alkylcarbonyl includes C(O)CH₂ CH₂ CH₃ and C(O)CH(CH₃)₂ ; C₂ alkoxycarbonyl designates C(O)OCH₃ and C₄ alkoxycarbonyl designates C(O)OCH₂ CH₂ CH₃ and C(O)OCH(CH₃)₂ ; and as a final example, C₃ alkoxycarbonylalkyl designates CH₂ CO₂ CH₃ and C₄ alkoxycarbonylalkyl includes CH₂ CH₂ CO₂ CH₃, CH₂ CO₂ CH₂ CH₃ and CH(CH₃)CO₂ CH₃.

DETAILS OF THE INVENTION

Compounds of Formulae I and II are prepared as described in Schemes 1 through 30 with substituents as previously defined, unless otherwise noted. The substituents R⁴ and R⁵ have been depicted as hydrogen for the purposes of clarity but also included are the values of these substituents as previously defined.

Compounds of Formula II (Q-1) can be prepared by the reaction of imidoylhalides of Formula II (Q-1) with sulfur, oxygen and nitrogen nucleophiles of Formula III as illustrated in Scheme 1. Typical reactions involve the combination of equimolar amounts of II (Q-1) and III in the presence of a base such as an alkali metal, tertiary amine, metal hydride and the like in conventional organic solvents, including ether, tetrahydrofuran, 1,2-dimethoxyethane, methylene chloride, chloroform, N,N-dimethylformamide and dimethylsulfoxide. The reaction can be conducted at temperatures ranging from -20° C. to 100° C. with temperatures in the range of -10° C. to 30° C. generally being preferred. One skilled in the art will recognize that reactions of this general type can be extended to other nucleophilic reagents. ##STR7##

The imidoylhalides of Formula II (Q-1) can be prepared by the reaction of Formula I (Q-1) compounds with an appropriate halogenating agent such as phosphorous trichloride, phosphorous pentachloride, phosphorous tribromide, phosphorous pentabromide, thionyl chloride, sulfuryl chloride, triphenyl phosphine and carbon tetrachloride (Wolkoff, Can. J. Chem., 1975, 53, 1333) and the like (see Fieser and Fieser, Reagents for Organic Synthesis, Vol. I, 1967) as illustrated in Scheme 2. Typical reactions involve the combination of Formula I (Q-1) compounds with an excess of the halogenating agent ranging from 1.1 to 10 equivalents, with 2 to 4 equivalents being preferred. The reaction can be conducted in the absence of a solvent or in the presence of a conventional organic solvent such as benzene, toluene, xylene, chloroform, methylene chloride, hexane and the like. The reaction temperature can range from -10° C. to 200° C. with 35° C. to 100° C. being preferred. The reaction is generally complete after 24 hours. ##STR8##

Alternatively, compounds of Formula II (Q-1), when X¹ is equal to R⁸ -S, can be prepared by the reaction of compounds of the Formula I (Q-1) where X is equal to S with an electrophile of the Formula IV in the presence of a suitable base, as illustrated in Scheme 3. Typical reactions involve the combination of equimolar amounts of Formula I (Q-1) compounds and the appropriate electrophile of Formula IV. A base such as an alkali metal, tertiary amine or metal hydride can be used. ##STR9##

Compounds of Formula I (Q-1) where X is S or O can be prepared by the reaction of Formula V compounds with isocyanates of Formula VI. Typical reactions involve the combination of equimolar amounts of V and VI in a conventional organic solvent such as but not limited to ethyl acetate, methylene chloride, chloroform, benzene or toluene. A base such as an alkali metal, tertiary amine, alkali metal alkoxide or metal hydride can be used. Scheme 4 illustrates this transformation. ##STR10##

Alternatively, compounds of Formula I (Q-1), where A and E are taken together to form a 1- or 2-atom bridge, as previously described, can be prepared by the reaction of semicarbazones of Formula VII with compounds of Formula VIII. Typical reactions involve the combination of an excess in molar amounts of a Formula VIII compound (1.1 equivalents to 40 equivalents) with 1 equivalent of a Formula VII compound in the presence of less than one molar equivalent of an acid catalyst (0 equivalents to 0.9 equivalents). Typical acid catalysts include alkyl or aryl sulfonic acids (such as methyl, camphor or p-toluene sulfonic) and mineral acids (such as hydrochloric or sulfuric). Conventional, polar organic solvents such as acetonitrile, dimethylformamide, tetrahydrofuran, methanol or ethanol can be used. The reaction temperature can vary from 0° C. to the reflux temperature of the particular solvent being used and the reaction is usually complete in less than 24 hours. Scheme 5 illustrates this transformation. ##STR11## wherein: R⁴ and R⁵ are not taken together to form ═O or ═S.

Alternatively, compounds of Formula I (Q-1), where A and E are taken together to form a 1- or 2-atom bridge, as previously described, can be prepared by the reaction of compounds of Formula VII with compounds of Formula IX (see Scheme 6). Typical reactions involve combination of an excess in molar amounts of a Formula IX compound (1.1 equivalents to 5.0 equivalents) with one equivalent of a Formula VII compound in the presence of a base such as a tertiary amine (such as triethylamine, pyridine or DBU), an alkali metal, an alkali metal hydride or an alkali metal alkoxide or hydroxide (such as sodium methoxide, potassium-t-butoxide, sodium hydroxide or potassium hydroxide). Conventional, polar organic solvents such as methanol, ethanol, propanol, dimethylformamide, THF, dichloromethane or acetonitrile can be used. The reaction temperatures can vary from 0° C. to the reflux temperature of the particular solvent being used and the reaction is usually complete in less than 24 hours.

Alternatively, when Z¹ =NR³¹, R⁴ and R⁵ =H and L¹ and L² are taken together as ═NMe₂.sup.⊕ I.sup.⊖ the reaction can be performed in the absence of base in aprotic solvents such as THF, dioxane and the like. Equimolar amounts of VII and IX are used and the reaction is usually complete in 72 hours. ##STR12## wherein: L¹, L² are Cl, Br, I, imidazole, or L¹ and L² may be taken together to equal ═O, ═S or ═N(CH₃)₂.sup.⊕ I.sup.⊖ (where Z¹ is NR³¹) provided that R⁴ and R⁵ are not taken together to form ═O.

Compounds of Formula V, where A and E are taken together to form a 1- or 2-atom bridge, as previously described, can be prepared by the reaction of Formula X compounds with either compounds of Formula VIII or compounds of Formula IX using methods analogous to those shown for the preparation of Formula I (Q-1) compounds in Schemes 5 and 6. The preparation of Formula V compounds is shown in Scheme 7. ##STR13##

Compounds of Formula VII where X is O or S can be prepared by the reaction of Formula X compounds with isocyanates of Formula VI as shown in Scheme 8. Typical reactions involve the combination of equimolar amounts of X and VI in the presence of 1 molar equivalent of water in a polar organic solvent such as tetrahydrofuran or dimethylformamide. The reaction is usually complete in less than 24 hours. ##STR14##

Alternatively, Formula VII compounds where X is O or S can be prepared by the reaction of compounds of Formula XI with semicarbazides of Formula XII. Conditions for this reaction optionally include an acid catalyst such as hydrochloric, sulfuric or p-toluene sulfonic acid. Reaction temperatures can range from 0° to 150° C. with the reflux temperature of the solvent used generally preferred. Suitable solvents include, but are not limited to, methanol, ethanol, isopropanol, tetrahydrofuran and dioxane. Scheme 9 illustrates this transformation. ##STR15##

The preparation of Formula X compounds can be accomplished by the reaction of Formula XI compounds with an excess of equivalents (1.1 to 10.0 equivalents) of hydrazine, hydrazine monohydrate, hydrazine acetate, hydrazine hydrochloride and the like. The reaction is conducted in an alcohol solvent such as methanol, ethanol, n-propanol, isopropanol, n-butanol and the like or acetic acid and the temperature is governed by the reflux temperature of the particular solvent. The reaction is generally complete in 24 hours. Scheme 10 illustrates this transformation. ##STR16##

Compounds of Formula XI where X³ is O can be prepared by the α-hydroxylation of ketones of Formula XIII using procedures that are well-known to one skilled in the art (e.g., J. Am. Chem. Soc., 1974, 96, 5944; Tetrahedron Lett., 1988, 29, 2835; J. Org. Chem., 1986, 51, 2402). Scheme 11 illustrates this transformation. ##STR17##

Numerous alternative procedures exist for the preparation of α-hydroxyketones of Formula XI (where X³ is O). Such procedures are well-known to one skilled in the art (March, Advanced Organic Chemistry, 3rd Edition, 1985, p. 1164). Compounds of Formula XI where X³ is O, R³ is aryl and E is H are benzoins whose preparations are well-known to one skilled in the art.

α-Keto sulfides of Formula XI where X³ is S can be prepared from ketones of Formula XIII using procedures known to the art (J. Am. Chem. Soc., 1985, 107, 4175; J. Org. Chem., 1988, 53, 3125).

α-Amino ketones of Formula XI where X³ is NR³¹ can be prepared from ketones of Formula XIII using procedures known in the art (J. Chem. Soc., 1959, 1479; Synthesis, 1972, 191).

Compounds XI where X³ is NHR³¹⊕ Cl.sup.⊖, can be prepared by the reaction of Formula XIII compounds with compounds of the type XIIIa using a procedure similar to those described in the art (Synthesis, 1991, 327). The conditions for this reaction are the combination of equimolar amounts of Formulae XIII and XIIIa derivatives in the presence of a base as a catalyst, such as, but not limited to, DABCO, DBU, sodium hydroxide and the like. Suitable solvents include, but are not limited to, toluene, dioxane and water. Scheme 11a illustrates this transformation. ##STR18##

The starting ketones of Formula XIII are known in the art or can be obtained by methods analogous to known procedures. Those skilled in the art will recognize the Formula XIII compounds to include indanones, tetralones, chromanones, thiochromanones, benzofuran-3-ones, isochromanones and others.

One skilled in the art will recognize that the transformation of Formula XIII compounds into Formula XI compounds may require the use of protecting groups to prevent unwanted side reactions of functionalities that may be sensitive to the reaction conditions (for example, an indoxyl nitrogen atom may require a protecting group to render it unreactive in an α-hydroxylation of the carbonyl group). Since numerous alternative synthetic methods for the preparations of Formula XI compounds exist, a further discussion of protecting-group chemistry will be omitted.

Semicarbazides of Formula XII where X is O or S and G is G-9 can be prepared using procedures well-known to those skilled in the art. Formula XII compounds where X is O or S and G is G-1 to G-8 can be prepared by using the procedure shown in Scheme 12. ##STR19## wherein: G is G-1 through G-8 and L¹ and L² are as already defined.

Typical reaction conditions involve the reaction of equimolar amounts of an amine of Formula XIV with a compound of Formula XV (usually, 1,1'-carbonyldiimidazole or thiophosgene are preferred) in a suitable solvent at a temperature between -20° C. and 50° C. Suitable solvents include, but are not limited to, methylene chloride, chloroform, tetrahydrofuran or dioxane. The reaction product, XVI, is used without purification and is treated with an excess of a molar amount of hydrazine or hydrazine hydrate in an alcohol solvent such as methanol, ethanol or isopropanol at a temperature from 0° to 110° C. with the preferred temperature being the boiling point of the solvent used. The formation of semicarbazide XII is usually complete within 72 hours.

Compounds of Formula I, where Q is Q-1 and G is equal to G-1 through G-8 can be prepared by treating intermediates of Formula V with triphosgene (O═C(OCCl₃)₂) or phosgene and NH₂ -G in the presence of a base such as pyridine as outlined in Scheme 13. ##STR20##

Compounds of Formula II (Q-2) can be prepared from Formula II (Q-2) imidoylhalide derivatives in an analogous fashion such as that described for the preparation of Formula II (Q-1) imidoylhalide compounds; see Scheme 14. ##STR21##

Formula II (Q-2) imidoylhalide compounds can be prepared from Formula I (Q-2) compounds in an analogous fashion as that described for Formula II (Q-1) compounds; see Scheme 15. ##STR22##

Compounds of Formula I (Q-2) can be prepared by the reaction of the acid chloride XVI with a substituted aniline of Formula XVII in equimolar proportions in the presence of an excess of an acid scavenger, such as tertiary alkylamines or pyridines, but not limited to these, in an aprotic organic solvent such as ether, tetrahydrofuran, chloroform, methylene chloride, benzene and/or toluene. Scheme 16 illustrates this transformation. ##STR23##

Compounds of the Formula XVI can be prepared from compounds of the Formula XVIII through conventional methodology generally used for the conversion of esters to their corresponding acid chlorides as illustrated in Scheme 17. ##STR24##

Formula XVIII derivatives (where A is equal to H) can be prepared by the reaction of Formula XIX compounds with an equimolar or greater amount of a Formula XX compound in the presence of an acid catalyst (with 0.05 to 0.2 molar equivalents preferred). The reaction can be carried out in a variety of polar organic solvents, including, but not limited to, tetrahydrofuran, acetonitrile, methanol or ethanol at a temperature of between 0° and 80° C. with the preferred temperature being the reflux temperature of the solvent. This reaction is illustrated by Scheme 18. ##STR25##

Compounds of Formula XIX where Z¹ is O can be prepared by treatment of Formula XXI compounds with a carboxylic acid such as formic, acetic or benzoic acid in the presence of 0 to 2.0 equivalents of a base including, but not limited to, potassium carbonate, sodium carbonate or sodium hydroxyde. Suitable solvents for the reaction include, but are not limited to, ethanol, tetrahydrofuran or dimethylformamide. The ester XXII formed in the initial reaction is subsequently hydrolyzed to the alcohol XIX (Z¹ is O) using a base such as sodium ethoxide in a solvent such as ethanol. Thiols of the Formula XIX (where Z¹ is S) can be prepared using analogous procedures starting with a thiocarboxylic acid (such as thiolacetic acid). The preparations of Formula XIX compounds (Z¹ is O or S) are illustrated by Scheme 19. ##STR26## wherein: Z¹ is O or S;

R³² is H, alkyl or aryl.

Compounds of Formula XIX where Z¹ is NR³¹ can be prepared using procedures analogous to those shown in Scheme 19 using either ammonia or a primary amine (R³¹ NH₂) in place of the carboxylic or thiocarboxylic acid.

Compounds of Formula XXI can be prepared from compounds of the Formula XXIII by the reaction with an equimolar amount of XXIV in conventional organic solvents such as, but not limited to, ether, tetrahydrofuran, methanol, ethanol, methylene chloride, benzene and toluene. Typical reaction temperatures can range from room temperature to the reflux temperature of the particular solvent utilized and the reaction is usually complete in 24 hours. Scheme 20 illustrates this reaction. ##STR27##

Formula XXIII compounds can be prepared from Formula XXV derivatives by a diazotization/reduction reaction well documented in the literature (see Organic Functional Group Preparation, 1983, pp. 452-453 and references cited therein). Scheme 21 illustrates this transformation. ##STR28##

Formula XXV compounds are known in the art or can be obtained by methods analogous to known procedures. Those skilled in the art will recognize Formula XXV compounds to be substituted anilines or aminopyridines.

Compounds of Formula I (Q-3) can be prepared by the reaction of tri- and tetravalent metal species such as titanium, silicon, tin and the like in combination with reducing agents such as sodium, lithium, or zinc borohydride, lithium aluminum hydride and the like with compounds of Formula I (Q-1) as illustrated in Scheme 22. Literature precedent for analogous reactions can be found in J. Org. Chem., 1987, 54, 3750, and Synthesis, 1980, 695. Typical reactions involve the addition of 1 equivalent of a compound of Formula I (Q-1) to a solution of 1.1 to 4.0 equivalents of titanium tetrachloride, with 1.5 to 2.5 equivalents being preferred, and 2.1 to 6.0 equivalents of sodium borohydride with 3.5 to 4.5 equivalents being preferred.

Conventional organic solvents such as ether, tetrahydrofuran, dimethoxyethane, methylene chloride and chloroform can be used with 1,2-dimethoxyethane being preferred. The reaction can be conducted at temperatures ranging from -70° C. to 50° C. with -10° C. to 30° C. being preferred. The reaction time can be 0.1 hour to 48 hours with 2 to 4 hours being preferred. ##STR29##

Formula I (Q-3) derivatives can be converted into Formula II (Q-3) compounds in an analogous fashion as described for the conversion of Formula I (Q-1) compounds into Formula II (Q-1) derivatives.

Formulae I (Q-4) and II (Q-4) compounds can be prepared in an analogous fashion as described for the preparation of Formulae I (Q-3) and II (Q-3) derivatives.

Additionally, compounds of Formula I, where Q is Q-1, A is H, Z is CH, E is H and R³ is H, alkyl or aryl, can be prepared as outlined in Scheme 23. This is generally accomplished by the reaction of equimolar amounts of a heterocycle such as XXVI with an aryl isocyanate or isothiocyanate of Formula VI in conventional organic solvents such as ether or tetrahydrofuran. The Formula I compounds of Scheme 23, where E is H, can be converted to the analogs where E is C₁ -C₃ alkyl by alkylation of the dianion with a C₁ -C₃ alkyl halide as shown. This is typically done by treatment of the compound where E is H with at least two equivalents of a strong base such as lithium diisopropylamide at low temperatures in the range of 0° to -78° C. in a solvent such as tetrahydrofuran. An alkyl halide (typically the iodide) is then added to the preformed dianion affording, after workup, compounds of Formula I where Q is Q-1, A is H and E is C₁ -C₃ alkyl. ##STR30##

Alkylation of the dianion of compounds such as XXVII is another useful method for the introduction of a variety of R³ groups, this method is outlined in Scheme 24. The R³ groups generally prepared by this method are derived from alkylating reagents R³ -L (where L is Cl, Br or I) and include, e.g., alkyl halides, substituted alkyl halides, acyl halides, alkylchloroformates, sulfenyl and sulfonyl halides, dialkylcarbamoyl halides and the like. Typical procedures are analogous to that described in Scheme 23 and include the use of strong base at low temperature. A second substituent E (where E is C₁ -C₃ alkyl) can also be introduced in a similar fashion. ##STR31##

Compounds of Formula I, where Q is Q-1 and R⁴ and R⁵ are taken together to form a carbonyl group (such as compound XXVIII) can be prepared by the reaction of an amide such as V, where R⁴ and R⁵ are taken together to form ═O, with an aryl isocyanate or isothiocyanate. This method is outlined in Scheme 25. This reaction can be run in a variety of conventional organic solvents such as ether, tetrahydrofuran or ethyl acetate and is preferably conducted at the reflux temperature of the solvent. It is also preferable, and in some cases necessary, to add a catalytic amount of an amine base such as triethylamine, pyridine or preferably N,N-dimethylaminopyridine. ##STR32##

Compounds of Formulae I (Q-5) and II (Q-5) can be prepared by the reaction of Formulae I (Q-1) and II (Q-1) derivatives where Z¹ is NH and R⁴ is H with an oxidizing agent, such as dichlorodicyanobenzoquinone (DDQ) (see Fieser and Fieser, Reagents for Organic Synthesis, 1967, Vol. I, pp. 215-219). The reaction involves the combination of an excess of molar equivalents of DDQ with one molar equivalent of Formula I (Q-1) or Formula II (Q-1) compounds where Z¹ is NH and R⁴ is H in a suitable solvent such as, but not limited to, methanol, ethanol, acetone and benzene. The reaction is conducted at room temperature to reflux temperature of the particular solvent utilized. The reaction is usually complete in 24 hours. Scheme 25a illustrates this reaction. ##STR33##

Compounds of Formulae I (Q-6) and II (Q-6) can be prepared in an analogous fashion as described in Scheme 25a for Formulae I (Q-5) and II (Q-5) derivatives.

Formulae I compounds where Y is other than H, can be prepared by standard alkylation, acylation or sulfenylation methods well documented in the literature.

Formula I compounds where Y and A¹ are taken together to form --(CH₂)_(t) -- can be prepared by coupling of a Formula V compound with an indoline (t is 2) or tetrahydroquinoline (t is 3) of Formula XXIX in the presence of phosgene or a phosgene equivalent. Typical reaction conditions involve combination of di- or triphosgene with the Formula V compound in a solvent such as tetrahydrofuran or chloroform followed by addition of the indoline or tetrahydroquinoline of Formula XXIX. This chemistry is depicted in Scheme 26. ##STR34##

The indoline (t is 2) and tetrahydroquinoline (t is 3) of Formula XXIX are well known in the art as well as procedures for their preparation.

Alternatively, compounds of Formula I where Y and A¹ are taken together to form (CH₂)_(t) -- can be prepared by the reactions semicarbazones of Formula XXX with compounds of Formula VIII, as depicted in Scheme 27. Procedures for this transformation are analogous to those described for Scheme 5. ##STR35##

Compounds of Formula XXX can be prepared by the reaction of Formula XI compounds with semicarbazides of Formula XXXI using procedures analogous to those described for Scheme 9. The formation of Formula XXX compounds is depicted in Scheme 28. ##STR36##

The formation of Formula XXXI semicarbazides can be achieved using procedures analogous to those described in Scheme 12 for Formula XII compounds.

Alternatively, compounds of Formula I can be prepared by the reaction of Formula XXXII compounds with anilines of Formula XVII as depicted in Scheme 29. ##STR37## wherein: L³ is an alkoxy or aryloxy leaving group and Z¹ is O or S.

Typical reaction conditions involve the reaction of XXXII with between 1 to 5 molar equivalents of XVII in a suitable solvent in the presence of 0 to 10 molar equivalents of a base such as pyridine, potassium carbonate or triethylamine. Suitable solvents include THF, DMF and acetonitrile.

Formula XXXII compounds can be prepared by the reaction of a Formula XXXIII compound with an alkyl or aryl chloroformate of Formula XXXIV, as depicted in Scheme 30. The reaction is generally carried out using an excess of one molar equivalent of XXXIV in a non-nucleophilic solvent such as benzene or xylenes. Alternatively, the reaction can be carried out in the absence of solvent. Reactions are generally run at temperatures between 20°-100° C. ##STR38## wherein: L³ is an alkoxy or aryloxy group and Z¹ is O or S.

Formula XXXIII compounds are oxadiazines and thiadiazines whose preparations are known to the literature (see, e.g., Synthesis, 1988, 208; Synthesis, 1990, 491).

The following Examples further illustrate the invention.

EXAMPLE 1

Step A: 3-Chloro-α-(4-chlorophenyl)benzenepropanoic acid

To a solution of 6.8 g (0.17 mol) of 60% sodium hydride in 150 ml of dimethylformamide under nitrogen was added 30.0 g (0.162 mol) of methyl 4-chlorophenylacetate dropwise such that hydrogen evolution was moderate and the temperature of the reaction was maintained at less than 50° C. Once hydrogen evolution had ceased, a solution of 33.2 g (0.162 m) of 3-chlorobenzylbromide in 30 ml of dimethylformamide was added very cautiously such that the reaction temperature was maintained at less than 60° C. The reaction was maintained at 50° to 60° C. with stirring overnight after which time it was partitioned between 5% aqueous NaHCO₃ and diethyl ether, the aqueous extracts were washed twice with ether and the combined organic extracts were then washed with water. The ether extracts were dried over MgSO₄, filtered and concentrated to afford 48.0 g of a brown oil.

The crude product was combined with 300 ml of methanol, 40 ml of water and 20 ml of 50% aqueous sodium bydroxide and refluxed overnight. After this time the reaction was concentrated and the crude residue partitioned between water and ether. The aqueous extracts were acidified with conc. hydrochloric acid and extracted several times with ether. The ether extracts were dried over MgSO₄, filtered and concentrated to 48.8 g of a yellow, oily solid.

¹ H NMR (CDCl₃) δ 3.0 (dd, 1H), 3.3 (m, 1H), 3.84 (t, 1H), 6.77 (d, 1H), 6.9-7.4 (m).

Step B: 5-Chloro-2-(4-chlorophenyl)-2,3-dihydro-1H-inden-1-one

The crude product from Step A was combined with 50 ml of thionyl chloride and then heated at reflux for 2 hours. Thionyl chloride was removed by concentration at reduced pressure and then the mixture was concentrated several times from carbon tetrachloride. The residue was combined with 200 ml of dichloroethane, cooled under nitrogen to 0° C., and 24.5 g of aluminum trichloride was then added. After stirring overnight the reaction was poured onto a mixture of ice in 1N hydrochloric acid, extracted three times with ether and chromatographed on silica gel (10% ethyl acetate/hexane) to afford 18.6 g of a yellow oily solid.

¹ H NMR (CDCl₃) δ 3.20 (dd, 1H), 3.68 (dd, 1H), 3.90 (dd, 1H), 6.9-7.6 (m, 6H), 7.75 (d, 1H).

Step C: 5-Chloro-2-(4-chlorophenyl)-2,3-dihydro-2-hydroxy-1H-inden-1-one

A solution of 2.4 g (0.009 moles) of the product obtained from Step B and 20 mL of toluene was added with stirring to a mixture of 1.8 g (0.010 moles) of triethylphosphite, 0.1 g (0.0004 moles) of benzyltriethyl ammonium chloride, 100 mL of toluene and 50 mL of 50% aqueous sodium hydroxide solution. A steady stream of air was introduced into the vigorously stirred reaction mixture at room temperature for 1 hour. The resulting mixture was partitioned between 100 mL of Et₂ O and 200 mL of water and the aqueous layer was extracted with two 100 mL portions of Et₂ O. The combined organic layers were washed twice with 100 mL of water, twice with saturated aqueous sodium bisulfite solution, dried over MgSO₄ and concentrated. The resulting crude product was chromatographed on silica gel using 2:1 hexanes-ethyl acetate to give 1.2 g of an oil that solidified on standing.

¹ H NMR (CDCl₃) δ 3.23 (broadened s, 1H), 3.54 (apparent s, 2H), 7.25 (abq, 4H), 7.44 (d, 1H), 7.53 (broadened s, 1H), 7.78 (d, 1H).

Step D: 2- 5-Chloro-2-(4-chlorophenyl)-2,3-dihydro-2-hydroxy-1H-inden-1-ylidene!-N- 4-(trifluoromethyl)phenyl!hydrazine-carboxamide

A solution of 1.0 g (0.003 moles) of the product obtained in Step C, 0.66 mL (0.014 moles) of hydrazine monohydrate and 17 mL of ethanol was heated at reflux for 3 hours. The resulting solution was partitioned between water and CH₂ Cl₂ and the aqueous layer was extracted with CH₂ Cl₂. The combined organic layers were washed twice with water, dried over MgSO₄ and concentrated. The residue was chromatographed on silica gel using 1:1 hexanes-ethyl acetate to give 0.53 g of a yellow solid.

A solution of 0.5 g of the above product, 0.24 mL (0.0016 moles) of α,α,α-trifluoro-p-tolyl isocyanate, 25 mL of tetrahydrofuran and 1 mL of water was stirred at room temperature for one hour and then concentrated. The residue was suspended in acetonitrile and concentrated to give 0.60 g of a white solid, melting point, 225° C. (decomposes).

¹ H NMR (d₆ -DMSO) δ 3.3 (d, 1H, partially obscured by H₂ O peak), 3.55 (d, 1H), 7.3-7.5 (m, 7H), 7.64 (d, 2H), 7.82 (d, 2H), 8.00 (d, 1H), 9.52 (broadened s, 1H).

Step E: 7-Chloro-4a-(4-chlorophenyl)-4a,5-dihydro-N- 4-(trifluoromethyl)phenyl!-indeno 1,2-e! 1,3,4!oxadiazine-2(3H)-carboxamide

A mixture of 0.30 g (0.0006 moles) of the product obtained in Step D, 0.36 g (0.012 moles) of paraformaldehyde, 50 mg of p-toluene sulfonic acid monohydrate and 30 mL of acetonitrile was refluxed for 1 hour. The resulting mixture was partitioned between CH₂ Cl₂ and saturated aqueous sodium bicarbonate and the aqueous layer was extracted twice with CH₂ Cl₂. The combined organic layers were dried over MgSO₄ and concentrated to give an oil that was chromatographed on silica gel using 4:1 hexanes-ethyl acetate to give 0.23 g of an oil that solidified on standing, melting point, 213°-214° C.

¹ H NMR (CDCl₃) δ 3.39 (d, 1H), 3.58 (d, 1H), 4.54 (d, 1H), 5.78 (d, 1H), 7.20-7.42 (m, 6H), 7.61 (abq, 4H), 7.72 (d, 1H), 8.58 (broadened s, 1H).

EXAMPLE 2

Step A: Methyl 5-chloro-2,3-dihydro-2-hydroxyl-1-oxo-1H-indene-2-carboxylate

Sodium hydride (24 g of 60% solution in oil, 0.6 moles) was washed with hexanes to remove the oil. The resulting washed NaH was suspended in 200 mL of DMF and then treated with a solution of 50 g (0.3 moles) of 5-chloro-1-indanone and 150 mL of DMF at such a rate that reaction temperature remained below 35° C. The resulting mixture was stirred for 30 min and then treated with 38 mL (0.45 moles) of dimethyl carbonate added over 15 min. The resulting mixture was stirred at room temperature for 1.5 h and then allowed to stand overnight. The reaction mixture was poured carefully into a mixture of 100 mL of concentrated HCl and about 1000 mL of ice. Then, 500 mL of ether was added and the aqueous layer was extracted twice with ether. The combined organic layers were washed with three portions of H₂ O, dried (MgSO₄) and concentrated to give 64.6 g of a brown oil.

A solution of 5.0 g (0.022 moles) of the above product and 70 mL of methylene chloride was treated with 10 g (ca. 0.032 moles) of 50-60% m-chloroperbenzoic acid (Aldrich) at room temperature. After 1 h, the reaction was cooled to 0° C. and quenched by careful addition of saturated aqueous sodium carbonate. The layer was washed twice with saturated aqeuous sodium carbonate, once with saturated sodium bisulfite, dried (MgSO₄) and concentrated to give 4.0 g of a yellow solid.

IR (CCl₄ solution) 3560, 1770, 1745 cm⁻¹.

¹ H NMR (CDCl₃, 200 mHz) δ 7.73 (d, 1H), 7.50 (br s, 1H), 7.42 (d, 1H), 4.04 (s, 1H, exchangeable with D₂ O), 3.75 (s, 3H), 3.69 (d, 1H), 3.24 (d, 1H).

Step B: Methyl 5-chloro-2,3-dihydro-2-hydroxy- 4-(trifluoromethoxy)phenyl!amino!carbonyl!hydrozono!-1H-indene-2-carboxylate

A solution of 1 g (0.004 moles) of the product from Step A and 10 mL of methanol was added to a solution of 0.61 mL (0.012 moles) of hydrazine monohydrate, 0.72 mL (0.012 moles) of glacial acetic acid and 20 mL of methanol at 0° C. The resulting mixture was refluxed for 2 h, cooled to room temperature and partitioned between 200 mL of methylene chloride and 200 mL of water. The aqueous layer was extracted with methylene chloride and the combined organic layers were washed twice with water, dried (K₂ CO₃) and concentrated to give 0.6 g of a yellow solid.

A solution of 0.5 g (0.002 moles) of the above product and 20 mL of THF was treated with a solution of 0.4 g (0.002 moles) 4-(trifluoromethoxy)phenyl isocyanate and 5 mL of THF. Two drops of water were added and the resulting solution was stirred at room temperature for 30 min. The reaction was then concentrated to give 0.90 g of slightly impure product that was used in the next step without further purification. An analytical sample was prepared by recrystallization from THF-hexanes, mp 233°-235° C.

¹ H NMR (200 MHz, d₆ -DMSO) δ 9.43 (s, 1H), 9.40 (s, 1H), 7.93 (d, 1H), 7.78 (d, 2H), 7.45 (apparent d, 3H), 7.33 (d, 2H), ca. 3.67 (d, 1H), 3.66 (s, 3H), 3.22 (d, 1H).

Step C: Methyl 7-chloro-2,5-dihydro-2- 4-trifluoromethoxy)phenyl!amino!carbonyl!indeno1,2-e!- 1,3,4!oxadiazine-4a(3H)-carboxylate

A mixture of 0.85 g (0.002 moles) of the product from Step B, 0.9 g of paraformaldehyde, 0.05 g of p-toluene sulfonic acid monohydrate and 50 mL of acetonitrile was heated at reflux for 1 h. The resulting mixture was cooled to room temperature and partitioned between CH₂ Cl₂ and saturated aqueous sodium bicarbonate. The aqueous layer was extracted with CH₂ Cl₂ and the combined organics were washed with saturated aqueous NaHCO₃, dried (MgSO₄) and concentrated. The residue was purified by flash chromatography on silica gel using 4:1 hexanes-EtOAc to give 0.50 g of a pale yellow solid, mp 99°-101° C. Trituration with hot hexanes gave a white solid melting at 126.5°-128.0° C.

¹ H NMR (200 MHz, CDCl₃) δ 8.37 (br s, 1H), 7.66-7.50 (m, 3H), 7.35 (d, 1H), 7.32 (s, 1H), 7.18 (d, 2H), 5.92 (d, 1H), 5.05 (d, 1H), 3.73 (s, 3H), 3.52 (d, 1H), 3.27 (d, 1H).

Step D: Methyl 7-chloro-2,5-dihydro-2- N-methyl-N- 4-(trifluoromethoxy)phenyl!amino!carboxnyl!indeno 1,2-e! 1,3,4!oxadiazine-4a(3H)-carboxylate

A solution of 1.0 g (0.002 moles) of the product from Step C and 10.5 mL of DMF was treated with 0.2 g (0.005 moles) of 60% NaH (in oil) at 0° C. After stirring for 10 min, 1.2 mL (0.02 moles) of iodomethane was added. The resulting mixture was stirred at room temperature for 2 h and then poured into ice-cold 1N HCl and extracted with three portions of ether. The combined organics were washed with water, dried (MgSO₄) and concentrated to give a crude yellow solid which was triturated with methanol to give 0.70 g of a yellow solid, mp 130°-131° C.

¹ H NMR (200 MHz, CDCl₃) δ 7.20 (apparent s, 1H), 7.16 (apparent s, 5H), 6.84 (d, 1H), 5.29 (abq, 2H), 3.67 (s, 3H), 3.38 (overlapping d, 1H and s, 3H), 3.13 (d, 1H).

EXAMPLE 3

Step A: Methyl 2-amino-5-chloro-2,3-dihydro-1-oxo-1H-indene-2-carboxylate hydrochloride

An ice cold solution of 11.4 g (100.8 mmol) of hydroxylamine-O-sulfonic acid in 102 mL of water and 50 mL of sodium hydroxide solution (2N) was added in one portion to 10 g (102 mmol) of cyclohexanone in 180 mL of toluene and 50 mL of sodium hydroxide solution (2N) at 0° C. The mixture was stirred for 10 minutes. The organic layer was removed and dried over magnesium sulphate. Then, 7 g (31.3 mmol) of methyl 5-chloro-2,3-dihydro-1-oxo-2-1H-indene-2-carboxylate was added to a 155 mL portion of the solution; and 0.1 g (0.89 mmol) DABCO was then added in one portion to the mixture which was stirred for 1 h at 5° C. The mixture was washed twice with 50 mL portions of hydrochloric acid (1N). The acid layer was evaporated under reduced pressure to give 4.37 g of a solid, m.p. 145° to 148° C. (dec).

¹ H NMR (free base) (200 MHz, CDCl₃) δ 7.73 (d, 1H), 7.48 (s, 1H), 7.41 (d, 1H), 3.69 (s, 3H), 3.68 (1/2 ABq, 1H), and 3.05 (1/2 ABq, 1H).

Step B: Methyl 2-amino-5-chloro-2-3-dihydro-1- -4-(trifluoromethoxy)phenyl!amino!carbonyl!hydrazono!-1H-indene-2-carboxylate

A mixture of 2 g (7.24 mmol) of the product from Step A and 1.83 g (7.78 mmol) of 4-(4-trifluoromethoxy)phenylsemicarbazide in 18 mL of ethanol was boiled for 2 h. The mixture was allowed to cool and was stirred at room temperature overnight. The mixture was poured into 200 mL of saturated sodium bicarbonate solution and then extracted with 3×100 mL of ethyl acetate. The combined extracts were dried and evaporated and the material washed with ether to give 1.0 g of an off-white solid, of which a small portion was further purified by chromatography on silica gel (ethyl acetate/ethanol 5:1), m.p. 156.5° to 158° C. (dec).

¹ H NMR (200 MHz, CDCl₃) δ 8.4 (s, 1H), 8.20 (s, 1H), 7.83 (d, 1H), 7.56 (d, 2H), 7.42-7.18 (m, 4H), 3.73-3.65 (m, 4H), 3.05 (1/2 ABq, 1H).

Step C: Methyl 2-amino-5-chloro-2,3-dihydro-1- -4-(trifluoromethoxy)phenyl!amino!carbonyl!hydrazono!-1H-indene-2-carboxylate

A slurry of 0.12 g (6.48 mmol) of Eschenmoser's salt in 3 mL of tetrahydrofuran was added to 0.3 g (6.57 mmol) of the product from Step B in 2 mL of tetrahydrofuran at room temperature. The mixture was stirred at room temperature for 65 h. The mixture was poured into 100 mL of saturated sodium bicarbonate solution and extracted with 3×50 mL of ethyl acetate. The combined extracts were dried and evaporated. Chromatography on silica gel (eluted with ethyl acetate/hexanes 1:1) gave 0.14 g of a white solid, m.p. 135° to 140° C. (dec).

IR (mineral oil): 3372, 3298, 1751, 1658, 1631, 1603, 1535, 1415, 1315, 1266, 1199, 1109, 1009, 967, 919, 889, and 826 cm⁻¹.

¹ H NMR (200 MHz, CDCl₃) δ 8.43 (s, 1H), 7.64-7.14 (m, 7H), 5.38 (1/2 ABq, 1H), 4.39 (1/2 ABq, 1H), 3.71 (s, 3H), 3.53 (1/2 ABq, 1H), 3.08 (1/2 ABq, 1H), 2.40 (bs, 1H).

By the general procedures described herein, or obvious modifications thereof, the compounds of Tables 1 through 72 can be prepared.

In Tables 1 through 72, the following notations have been used. ##STR39##

                                      TABLE 1                                      __________________________________________________________________________     R.sup.1                                                                             R.sup.3                                                                               Y      R.sup.1                                                                             R.sup.3                                                                               Y                                               __________________________________________________________________________     Cl   Me     H      OCF.sub.3                                                                           Me     COEt                                            Br   Me     H      Cl   Me     CO.sub.2 Me                                     CF.sub.3                                                                            Me     H      Br   Me     CO.sub.2 Me                                     OCF.sub.3                                                                           Me     H      CF.sub.3                                                                            Me     CO.sub.2 Me                                     Cl   Me     Me     OCF.sub.3                                                                           Me     CO.sub.2 Me                                     Br   Me     Me     Cl   Me     CO.sub.2 Et                                     CF.sub.3                                                                            Me     Me     Br   Me     CO.sub.2 Et                                     OCF.sub.3                                                                           Me     Me     CF.sub.3                                                                            Me     CO.sub.2 Et                                     Cl   Me     Et     OCF3 Me     CO.sub.2 Et                                     Br   Me     Et     Cl   Me     CH.sub.2 OMe                                    CF.sub.3                                                                            Me     Et     Br   Me     CH.sub.2 OMe                                    OCF.sub.3                                                                           Me     Et     CF.sub.3                                                                            Me     CH.sub.2 OMe                                    Cl   Me     n-Pr   OCF.sub.3                                                                           Me     CH.sub.2 OMe                                    Br   Me     n-Pr   Cl   Me     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Me     n-Pr   Br   Me     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Me     n-Pr   CF.sub.3                                                                            Me     CH.sub.2 CHCH.sub.2                             Cl   Me     COMe   OCF.sub.3                                                                           Me     CH.sub.2 CHCH.sub.2                             Br   Me     COMe   Cl   Me     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Me     COMe   Br   Me     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Me     COMe   CF.sub.3                                                                            Me     CH.sub.2 SCH.sub.3                              Cl   Me     COEt   OCF.sub.3                                                                           Me     CH.sub.2 SCH.sub.3                              Br   Me     COEt   OCF.sub.2 H                                                                         Me     H                                               CF.sub.3                                                                            Me     COEt   OCF.sub.2 H                                                                         Me     Me                                              Cl   Et     H      OCF.sub.3                                                                           Et     COEt                                            Br   Et     H      Cl   Et     CO.sub.2 Me                                     CF.sub.3                                                                            Et     H      Br   Et     CO.sub.2 Me                                     OCF.sub.3                                                                           Et     H      CF.sub.3                                                                            Et     CO.sub.2 Me                                     Cl   Et     Me     OCF.sub.3                                                                           Et     CO.sub.2 Me                                     Br   Et     Me     Cl   Et     CO.sub.2 Et                                     CF.sub.3                                                                            Et     Me     Br   Et     CO.sub.2 Et                                     OCF.sub.3                                                                           Et     Me     CF.sub.3                                                                            Et     CO.sub.2 Et                                     Cl   Et     Et     OCF.sub.3                                                                           Et     CO.sub.2 Et                                     Br   Et     Et     Cl   Et     CH.sub.2 OMe                                    CF.sub.3                                                                            Et     Et     Br   Et     CH.sub.2 OMe                                    OCF.sub.3                                                                           Et     Et     CF.sub.3                                                                            Et     CH.sub.2 OMe                                    Cl   Et     n-Pr   OCF.sub.3                                                                           Et     CH.sub.2 OMe                                    Br   Et     n-Pr   Cl   Et     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Et     n-Pr   Br   Et     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Et     n-Pr   CF.sub.3                                                                            Et     CH.sub.2 CHCH.sub.2                             Cl   Et     COMe   OCF.sub.3                                                                           Et     CH.sub.2 CHCH.sub.2                             Br   Et     COMe   Cl   Et     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Et     COMe   Br   Et     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Et     COMe   CF.sub.3                                                                            Et     CH.sub.2 SCH.sub.3                              Cl   Et     COEt   OCF.sub.3                                                                           Et     CH.sub.2 SCH.sub.3                              Br   Et     COEt   OCF.sub.2 H                                                                         Et     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Et     COEt   OCF.sub.2 H                                                                         Me     Et                                              OCF.sub.2 H                                                                         Et     H      OCF.sub.2 H                                                                         Me     n-Pr                                            OCF.sub.2 H                                                                         Et     Me     OCF.sub.2 H                                                                         Me     COMe                                            OCF.sub.2 H                                                                         Et     Et     OCF.sub.2 H                                                                         Me     COEt                                            OCF.sub.2 H                                                                         Et     n-Pr   OCF.sub.2 H                                                                         Me     CO.sub.2 Me                                     OCF.sub.2 H                                                                         Et     COMe   OCF.sub.2 H                                                                         Me     CO.sub.2 Et                                     OCF.sub.2 H                                                                         Et     COEt   OCF.sub.2 H                                                                         Me     CH.sub.2 OMe                                    OCF.sub.2 H                                                                         Et     CO.sub.2 Me                                                                           OCF.sub.2 H                                                                         Me     CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         Et     CO.sub.2 Et                                                                           OCF.sub.2 H                                                                         Me     CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         Et     CH.sub.2 OMe                                                       OCF.sub.2 H                                                                         Et     CH.sub.2 CHCH.sub.2                                                Cl   n-Pr   H      OCF.sub.3                                                                           n-Pr   COEt                                            Br   n-Pr   H      Cl   n-Pr   CO.sub.2 Me                                     CF.sub.3                                                                            n-Pr   H      Br   n-Pr   CO.sub.2 Me                                     OCF.sub.3                                                                           n-Pr   H      CF.sub.3                                                                            n-Pr   CO.sub.2 Me                                     Cl   n-Pr   Me     OCF.sub.3                                                                           n-Pr   CO.sub.2 Me                                     Br   n-Pr   Me     Cl   n-Pr   CO.sub.2 Et                                     CF.sub.3                                                                            n-Pr   Me     Br   n-Pr   CO.sub.2 Et                                     OCF.sub.3                                                                           n-Pr   Me     CF.sub.3                                                                            n-Pr   CO.sub.2 Et                                     Cl   n-Pr   Et     OCF.sub.3                                                                           n-Pr   CO.sub.2 Et                                     Br   n-Pr   Et     Cl   n-Pr   CH.sub.2 OMe                                    CF.sub.3                                                                            n-Pr   Et     Br   n-Pr   CH.sub.2 OMe                                    OCF.sub.3                                                                           n-Pr   Et     CF.sub.3                                                                            n-Pr   CH.sub.2 OMe                                    Cl   n-Pr   n-Pr   OCF.sub.3                                                                           n-Pr   CH.sub.2 OMe                                    Br   n-Pr   n-Pr   Cl   n-Pr   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            n-Pr   n-Pr   Br   n-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           n-Pr   n-Pr   CF.sub.3                                                                            n-Pr   CH.sub.2 CHCH.sub.2                             Cl   n-Pr   COMe   OCF.sub.3                                                                           n-Pr   CH.sub.2 CHCH.sub.2                             Br   n-Pr   COMe   Cl   n-Pr   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            n-Pr   COMe   Br   n-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           n-Pr   COMe   CF.sub.3                                                                            n-Pr   CH.sub.2 SCH.sub.3                              Cl   n-Pr   COEt   OCF.sub.3                                                                           n-Pr   CH.sub.2 SCH.sub.3                              Br   n-Pr   COEt   OCF.sub.2 H                                                                         n-Pr   COEt                                            CF.sub.3                                                                            n-Pr   COEt   OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Me                                     OCF.sub.2 H                                                                         n-Pr   H      OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Et                                     OCF.sub.2 H                                                                         n-Pr   Me     OCF.sub.2 H                                                                         n-Pr   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         n-Pr   Et     OCF.sub.2 H                                                                         n-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         n-Pr   n-Pr   OCF.sub.2 H                                                                         n-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         n-Pr   COMe                                                               Cl   i-Pr   H      OCF.sub.3                                                                           i-Pr   COEt                                            Br   i-Pr   H      Cl   i-Pr   CO.sub.2 Me                                     CF.sub.3                                                                            i-Pr   H      Br   i-Pr   CO.sub.2 Me                                     OCF.sub.3                                                                           i-Pr   H      CF.sub.3                                                                            i-Pr   CO.sub.2 Me                                     Cl   i-Pr   Me     OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                                     Br   i-Pr   Me     Cl   i-Pr   CO.sub.2 Et                                     CF.sub.3                                                                            i-Pr   Me     Br   i-Pr   CO.sub.2 Et                                     OCF.sub.3                                                                           i-Pr   Me     CF.sub.3                                                                            i-Pr   CO.sub.2 Et                                     Cl   i-Pr   Et     OCF.sub.3                                                                           i-Pr   CO.sub.2 Et                                     Br   i-Pr   Et     Cl   i-Pr   CH.sub.2 OMe                                    CF.sub.3                                                                            i-Pr   Et     Br   i-Pr   CH.sub.2 OMe                                    OCF.sub.3                                                                           i-Pr   Et     CF.sub.3                                                                            i-Pr   CH.sub.2 OMe                                    Cl   i-Pr   n-Pr   OCF.sub.3                                                                           i-Pr   CH.sub.2 OMe                                    Br   i-Pr   n-Pr   Cl   i-Pr   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            i-Pr   n-Pr   Br   i-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           i-Pr   n-Pr   CF.sub.3                                                                            i-Pr   CH.sub.2 CHCH.sub.2                             Cl   i-Pr   COMe   OCF.sub.3                                                                           i-Pr   CH.sub.2 CHCH.sub.2                             Br   i-Pr   COMe   Cl   i-Pr   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            i-Pr   COMe   Br   i-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           i-Pr   COMe   CF.sub.3                                                                            i-Pr   CH.sub.2 SCH.sub.3                              Cl   i-Pr   COEt   OCF.sub.3                                                                           i-Pr   CH.sub.2 SCH.sub.3                              Br   i-Pr   COEt   OCF.sub.2 H                                                                         i-Pr   COEt                                            CF.sub.3                                                                            i-Pr   COEt   OCF.sub.2 H                                                                         i-Pr   CO.sub.2 Me                                     OCF.sub.2 H                                                                         i-Pr   H      OCF.sub.2 H                                                                         i-Pr   CO.sub.2 Et                                     OCF.sub.2 H                                                                         i-Pr   Me     OCF.sub.2 H                                                                         i-Pr   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         i-Pr   Et     OCF.sub.2 H                                                                         i-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         i-Pr   n-Pr   OCF.sub.2 H                                                                         i-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         i-Pr   COMe                                                               Cl   i-Bu   H      OCF.sub.3                                                                           i-Bu   COEt                                            Br   i-Bu   H      Cl   i-Bu   CO.sub.2 Me                                     CF.sub.3                                                                            i-Bu   H      Br   i-Bu   CO.sub.2 Me                                     OCF.sub.3                                                                           i-Bu   H      CF.sub.3                                                                            i-Bu   CO.sub.2 Me                                     Cl   i-Bu   Me     OCF.sub.3                                                                           i-Bu   CO.sub.2 Me                                     Br   i-Bu   Me     Cl   i-Bu   CO.sub.2 Et                                     CF.sub.3                                                                            i-Bu   Me     Br   i-Bu   CO.sub.2 Et                                     OCF.sub.3                                                                           i-Bu   Me     CF.sub.3                                                                            i-Bu   CO.sub.2 Et                                     Cl   i-Bu   Et     OCF.sub.3                                                                           i-Bu   CO.sub.2 Et                                     Br   i-Bu   Et     Cl   i-Bu   CH.sub.2 OMe                                    CF.sub.3                                                                            i-Bu   Et     Br   i-Bu   CH.sub.2 OMe                                    OCF.sub.3                                                                           i-Bu   Et     CF.sub.3                                                                            i-Bu   CH.sub.2 OMe                                    Cl   i-Bu   n-Pr   OCF.sub.3                                                                           i-Bu   CH.sub.2 OMe                                    Br   i-Bu   n-Pr   Cl   i-Bu   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            i-Bu   n-Pr   Br   i-Bu   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           i-Bu   n-Pr   CF.sub.3                                                                            i-Bu   CH.sub.2 CHCH.sub.2                             Cl   i-Bu   COMe   OCF.sub.3                                                                           i-Bu   CH.sub.2 CHCH.sub.2                             Br   i-Bu   COMe   Cl   i-Bu   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            i-Bu   COMe   Br   i-Bu   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           i-Bu   COMe   CF.sub.3                                                                            i-Bu   CH.sub.2 SCH.sub.3                              Cl   i-Bu   COEt   OCF.sub.3                                                                           i-Bu   CH.sub.2 SCH.sub.3                              Br   i-Bu   COEt   OCF.sub.2 H                                                                         i-Bu   COEt                                            CF.sub.3                                                                            i-Bu   COEt   OCF.sub.2 H                                                                         i-Bu   CO.sub.2 Me                                     OCF.sub.2 H                                                                         i-Bu   H      OCF.sub.2 H                                                                         i-Bu   CO.sub.2 Et                                     OCF.sub.2 H                                                                         i-Bu   Me     OCF.sub.2 H                                                                         i-Bu   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         i-Bu   Et     OCF.sub.2 H                                                                         i-Bu   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         i-Bu   n-Pr   OCF.sub.2 H                                                                         i-Bu   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         i-Bu   CO.sub.2 Me                                                        Cl   CO.sub.2 Me                                                                           H      OCF.sub.3                                                                           CO.sub.2 Me                                                                           COEt                                            Br   CO.sub.2 Me                                                                           H      Cl   CO.sub.2 Me                                                                           CO.sub.2 Me                                     CF.sub.3                                                                            CO.sub.2 Me                                                                           H      Br   CO.sub.2 Me                                                                           CO.sub.2 Me                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                           H      CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                                     Cl   CO.sub.2 Me                                                                           Me     OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Me                                     Br   CO.sub.2 Me                                                                           Me     Cl   CO.sub.2 Me                                                                           CO.sub.2 Et                                     CF.sub.3                                                                            CO.sub.2 Me                                                                           Me     Br   CO.sub.2 Me                                                                           CO.sub.2 Et                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                           Me     CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                                     Cl   CO.sub.2 Me                                                                           Et     OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Et                                     Br   CO.sub.2 Me                                                                           Et     Cl   CO.sub.2 Me                                                                           CH.sub.2 OMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                           Et     Br   CO.sub.2 Me                                                                           CH.sub.2 OMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                           Et     CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 OMe                                    Cl   CO.sub.2 Me                                                                           n-Pr   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 OMe                                    Br   CO.sub.2 Me                                                                           n-Pr   Cl   CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr   Br   CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CO.sub.2 Me                                                                           n-Pr   CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             Cl   CO.sub.2 Me                                                                           COMe   CCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             Br   CO.sub.2 Me                                                                           COMe   Cl   CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CO.sub.2 Me                                                                           COMe   Br   CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CO.sub.2 Me                                                                           COMe   CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              Cl   CO.sub.2 Me                                                                           COEt   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              Br   CO.sub.2 Me                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           COEt                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 Me                                     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           H      OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 Et                                     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Me     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Et     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           n-Pr   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           COMe                                                               Cl   CO.sub.2 Et                                                                           H      OCF.sub.3                                                                           CO.sub.2 Et                                                                           COEt                                            Br   CO.sub.2 Et                                                                           H      Cl   CO.sub.2 Et                                                                           CO.sub.2 Me                                     CF.sub.3                                                                            CO.sub.2 Et                                                                           H      Br   CO.sub.2 Et                                                                           CO.sub.2 Me                                     OCF.sub.3                                                                           CO.sub.2 Et                                                                           H      CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 Me                                     Cl   CO.sub.2 Et                                                                           Me     OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 Me                                     Br   CO.sub.2 Et                                                                           Me     Cl   CO.sub.2 Et                                                                           CO.sub.2 Et                                     CF.sub.3                                                                            Co2Et  Me     Br   CO.sub.2 Et                                                                           CO.sub.2 Et                                     OCF.sub.3                                                                           CO.sub.2 Et                                                                           Me     CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 Et                                     Cl   CO.sub.2 Et                                                                           Et     OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 Et                                     Br   CO.sub.2 Et                                                                           Et     Cl   CO.sub.2 Et                                                                           CH.sub.2 OMe                                    CF.sub.3                                                                            CO.sub.2 Et                                                                           Et     Br   CO.sub.2 Et                                                                           CH.sub.2 OMe                                    OCF.sub.3                                                                           CO.sub.2 Et                                                                           Et     CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 OMe                                    Cl   CO.sub.2 Et                                                                           n-Pr   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 OMe                                    Br   CO.sub.2 Et                                                                           n-Pr   Cl   CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CO.sub.2 Et                                                                           n-Pr   Br   CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CO.sub.2 Et                                                                           n-Pr   CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             Cl   CO.sub.2 Et                                                                           COMe   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             Br   CO.sub.2 Et                                                                           COMe   Cl   CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CO.sub.2 Et                                                                           COMe   Br   CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           COMe   CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              Cl   CO.sub.2 Et                                                                           COEt   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              Br   CO.sub.2 Et                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           COEt                                            CF.sub.3                                                                            CO.sub.2 Et                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 Me                                     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           H      OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 Et                                     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           Me     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           Et     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           n-Pr   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           COMe                                                               Cl   Ph     H      OCF.sub.3                                                                           Ph     COEt                                            Br   Ph     H      Cl   Ph     CO.sub.2 Me                                     CF.sub.3                                                                            Ph     H      Br   Ph     CO.sub.2 Me                                     OCF.sub.3                                                                           Ph     H      CF.sub.3                                                                            Ph     CO.sub.2 Me                                     Cl   Ph     Me     OCF.sub.3                                                                           Ph     CO.sub.2 Me                                     Br   Ph     Me     Cl   Ph     CO.sub.2 Et                                     CF.sub.3                                                                            Ph     Me     Br   Ph     CO.sub.2 Et                                     OCF.sub.3                                                                           Ph     Me     CF.sub.3                                                                            Ph     CO.sub.2 Et                                     Cl   Ph     Et     OCF.sub.3                                                                           Ph     CO.sub.2 Et                                     Br   Ph     Et     Cl   Ph     CH.sub.2 OMe                                    CF.sub.3                                                                            Ph     Et     Br   Ph     CH.sub.2 OMe                                    OCF.sub.3                                                                           Ph     Et     CF.sub.3                                                                            Ph     CH.sub.2 OMe                                    Cl   Ph     n-Pr   OCF.sub.3                                                                           Ph     CH.sub.2 OMe                                    Br   Ph     n-Pr   Cl   Ph     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Ph     n-Pr   Br   Ph     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Ph     n-Pr   CF.sub.3                                                                            Ph     CH.sub.2 CHCH.sub.2                             Cl   Ph     COMe   OCF.sub.3                                                                           Ph     CH.sub.2 CHCH.sub.2                             Br   Ph     COMe   Cl   Ph     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Ph     COMe   Br   Ph     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Ph     COMe   CF.sub.3                                                                            Ph     CH.sub.2 SCH.sub.3                              Cl   Ph     COEt   OCF.sub.3                                                                           Ph     CH.sub.2 SCH.sub.3                              Br   Ph     COEt   OCF.sub.2 H                                                                         Ph     COEt                                            CF.sub.3                                                                            Ph     COEt   OCF.sub.2 H                                                                         Ph     CO.sub.2 Me                                     OCF.sub.2 H                                                                         Ph     H      OCF.sub.2 H                                                                         Ph     CO.sub.2 Et                                     OCF.sub.2 H                                                                         Ph     Me     OCF.sub.2 H                                                                         Ph     CH.sub.2 OMe                                    OCF.sub.2 H                                                                         Ph     Et     OCF.sub.2 H                                                                         Ph     CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         Ph     n-Pr   OCF.sub.2 H                                                                         Ph     CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         Ph     COMe                                                               Cl   4-Cl-Ph                                                                               H      OCF.sub.3                                                                           4-Cl-Ph                                                                               COEt                                            Br   4-Cl-Ph                                                                               H      Cl   4-Cl-Ph                                                                               CO.sub.2 Me                                     CF.sub.3                                                                            4-Cl-Ph                                                                               H      Br   4-C-Ph CO.sub.2 Me                                     OCF.sub.3                                                                           4-Cl-Ph                                                                               H      CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 Me                                     Cl   4-Cl-Ph                                                                               Me     OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 Me                                     Br   4-Cl-Ph                                                                               Me     Cl   4-Cl-Ph                                                                               CO.sub.2 Et                                     CF.sub.3                                                                            4-Cl-Ph                                                                               Me     Br   4-Cl-Ph                                                                               CO.sub.2 Et                                     OCF.sub.3                                                                           4-Cl-Ph                                                                               Me     CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 Et                                     Cl   4-Cl-Ph                                                                               Et     OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 Et                                     Br   4-Cl-Ph                                                                               Et     Cl   4-Cl-Ph                                                                               CH.sub.2 OMe                                    CF.sub.3                                                                            4-Cl-Ph                                                                               Et     Br   4-Cl-Ph                                                                               CH.sub.2 OMe                                    OCF.sub.3                                                                           4-Cl-Ph                                                                               Et     CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 OMe                                    Cl   4-Cl-Ph                                                                               n-Pr   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 OMe                                    Br   4-Cl-Ph                                                                               n-Pr   Cl   4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            4-Cl-Ph                                                                               n-Pr   Br   4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           4-Cl-Ph                                                                               n-Pr   CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             Cl   4-Cl-Ph                                                                               COMe   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             Br   4-Cl-Ph                                                                               COMe   Cl   4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            4-Cl-Ph                                                                               COMe   Br   4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           4-Cl-Ph                                                                               COMe   CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              Cl   4-Cl-Ph                                                                               COEt   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              Br   4-Cl-Ph                                                                               COEt   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               COEt                                            CF.sub.3                                                                            4-Cl-Ph                                                                               COEt   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 Me                                     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               H      OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 Et                                     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               Me     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 OMe                                    OCF.sub.2 H                                                                         4-Cl-Ph                                                                               Et     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         4-Cl-Ph                                                                               n-Pr   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         4-Cl-Ph                                                                               COMe                                                               Cl   4-F-Ph H      OCF.sub.3                                                                           4-F-Ph COEt                                            Br   4-F-Ph H      Cl   4-F-Ph CO.sub.2 Me                                     CF.sub.3                                                                            4-F-Ph H      Br   4-F-Ph CO.sub.2 Me                                     OCF.sub.3                                                                           4-F-Ph H      CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                                     Cl   4-F-Ph Me     OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                                     Br   4-F-Ph Me     Cl   4-F-Ph CO.sub.2 Et                                     CF.sub.3                                                                            4-F-Ph Me     Br   4-F-Ph CO.sub.2 Et                                     OCF.sub.3                                                                           4-F-Ph Me     CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                                     Cl   4-F-Ph Et     OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                                     Br   4-F-Ph Et     Cl   4-F-Ph CH.sub.2 OMe                                    CF.sub.3                                                                            4-F-Ph Et     Br   4-F-Ph CH.sub.2 OMe                                    OCF.sub.3                                                                           4-F-Ph Et     CF.sub.3                                                                            4-F-Ph CH.sub.2 OMe                                    Cl   4-F-Ph n-Pr   OCF.sub.3                                                                           4-F-Ph CH.sub.2 OMe                                    Br   4-F-Ph n-Pr   Cl   4-F-Ph CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            4-F-Ph n-Pr   Br   4-F-Ph CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           4-F-Ph n-Pr   CF.sub.3                                                                            4-F-Ph CH.sub.2 CHCH.sub.2                             Cl   4-F-Ph COMe   OCF.sub.3                                                                           4-F-Ph CH.sub.2 CHCH.sub.2                             Br   4-F-Ph COMe   Cl   4-F-Ph CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            4-F-Ph COMe   Br   4-F-Ph CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           4-F-Ph COMe   CF.sub.3                                                                            4-F-Ph CH.sub.2 SCH.sub.3                              Cl   4-F-Ph COEt   OCF.sub.3                                                                           4-F-Ph CH.sub.2 SCH.sub.3                              Br   4-F-Ph COEt   OCF.sub.2 H                                                                         4-F-Ph COEt                                            CF.sub.3                                                                            4-F-Ph COEt   OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 Me                                     OCF.sub.2 H                                                                         4-F-Ph H      OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 Et                                     OCF.sub.2 H                                                                         4-F-Ph Me     OCF2M                                                                               4-F-Ph CH.sub.2 OMe                                    OCF.sub.2 H                                                                         4-F-Ph Et     OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         4-F-Ph n-Pr   OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         4-F-Ph COMe                                                               Cl   CHCH.sub.2                                                                            H      OCF.sub.3                                                                           CHCH.sub.2                                                                            COEt                                            Br   CHCH.sub.2                                                                            H      Cl   CHCH.sub.2                                                                            CO.sub.2 Me                                     CF.sub.3                                                                            CHCH.sub.2                                                                            H      Br   CHCH.sub.2                                                                            CO.sub.2 Me                                     OCF.sub.3                                                                           CHCH.sub.2                                                                            H      CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Me                                     Cl   CHCH.sub.2                                                                            Me     OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Me                                     Br   CHCH.sub.2                                                                            Me     Cl   CHCH.sub.2                                                                            CO.sub.2 Et                                     CF.sub.3                                                                            CHCH.sub.2                                                                            Me     Br   CHCH.sub.2                                                                            CO.sub.2 Et                                     OCF.sub.3                                                                           CHCH.sub.2                                                                            Me     CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Et                                     Cl   CHCH.sub.2                                                                            Et     OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Et                                     Br   CHCH.sub.2                                                                            Et     Cl   CHCH.sub.2                                                                            CH.sub.2 OMe                                    CF.sub.3                                                                            CHCH.sub.2                                                                            Et     Br   CHCH.sub.2                                                                            CH.sub.2 OMe                                    OCF.sub.3                                                                           CHCH.sub.2                                                                            Et     CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 OMe                                    Cl   CHCH.sub.2                                                                            n-Pr   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 OMe                                    Br   CHCH.sub.2                                                                            n-Pr   Cl   CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CHCH.sub.2                                                                            n-Pr   Br   CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CHCH.sub.2                                                                            n-Pr   CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             Cl   CHCH.sub.2                                                                            COMe   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             Br   CHCH.sub.2                                                                            COMe   Cl   CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CHCH.sub.2                                                                            COMe   Br   CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CHCH.sub.2                                                                            COMe   CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              Cl   CHCH.sub.2                                                                            COEt   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              Br   CHCH.sub.2                                                                            COEt   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COEt                                            CF.sub.3                                                                            CHCH.sub.2                                                                            COEt   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Me                                     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            H      OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Et                                     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            Me     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CHCH.sub.2                                                                            Et     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CHCH.sub.2                                                                            n-Pr   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COMe                                                               Cl   C(CH.sub.3)CH.sub.2                                                                   H      OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COEt                                            Br   C(CH.sub.3)CH.sub.2                                                                   H      Cl   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   H      Br   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   H      CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     Cl   C(CH.sub.3)CH.sub.2                                                                   Me     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     Br   C(CH.sub.3)CH.sub.2                                                                   Me     Cl   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Me     Br   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Me     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     Cl   C(CH.sub.3)CH.sub.2                                                                   Et     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     Br   C(CH.sub.3)CH.sub.2                                                                   Et     Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Et     Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Et     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    Cl   C(CH.sub.3)CH.sub.2                                                                   n-Pr   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    Br   C(CH.sub.3)CH.sub.2                                                                   n-Pr   Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   n-Pr   Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   n-Pr   CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             Cl   C(CH.sub.3)CH.sub.2                                                                   COMe   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             Br   C(CH.sub.3)CH.sub.2                                                                   COMe   Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COMe   Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COMe   CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              Cl   C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              Br   C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COEt                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   H      OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Me     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Et     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   n-Pr   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COMe                                                               CF.sub.3                                                                            Me     CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            Me     CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            Me     CO(n-Pr)                                                                              CF.sub.3                                                                            n-Pr   CO(n-Pr)                                        CF.sub.3                                                                            Me     CO(i-Pr)                                                                              CF.sub.3                                                                            n-Pr   CO(i-Pr)                                        CF.sub.3                                                                            Me     CO(t-Bu)                                                                              CF.sub.3                                                                            n-Pr   CO(t-Bu)                                        CF.sub.3                                                                            Me     CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           Me     CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           Me     CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           Me     CO(n-Pr)                                                                              OCF.sub.3                                                                           n-Pr   CO(n-Pr)                                        OCF.sub.3                                                                           Me     CO(i-Pr)                                                                              OCF.sub.3                                                                           n-Pr   CO(i-Pr)                                        OCF.sub.3                                                                           Me     CO(t-Bu)                                                                              OCF.sub.3                                                                           n-Pr   CO(t-Bu)                                        OCF.sub.3                                                                           Me     CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            Et     CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            Et     CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            Et     CO(n-Pr)                                                                              CF.sub.3                                                                            i-Pr   CO(n-Pr)                                        CF.sub.3                                                                            Et     CO(i-Pr)                                                                              CF.sub.3                                                                            i-Pr   CO(i-Pr)                                        CF.sub.3                                                                            Et     CO(t-Bu)                                                                              CF.sub.3                                                                            i-Pr   CO(t-Bu)                                        CF.sub.3                                                                            Et     CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           Et     CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           Et     CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           Et     CO(n-Pr)                                                                              OCF.sub.3                                                                           i-Pr   CO(n-Pr)                                        OCF.sub.3                                                                           Et     CO(i-Pr)                                                                              OCF.sub.3                                                                           i-Pr   CO(i-Pr)                                        OCF.sub.3                                                                           Et     CO(t-Bu)                                                                              OCF.sub.3                                                                           i-Pr   CO(t-Bu)                                        OCF.sub.3                                                                           Et     CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         Me     CO(n-Pr)                                                                              OCF.sub.2 H                                                                         Et     CO(i-Pr)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         Et     CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         Me     CO(i-Pr)                                                                              OCF.sub.2 H                                                                         Et     CO(t-Bu)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         Et     CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         Me     CO(t-Bu)                                                                              OCF.sub.2 H                                                                         n-Pr   CO(n-Pr)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         Et     CO(n-Pr)                                                                              OCF.sub.2 H                                                                         n-Pr   CO(i-Pr)                                        OCF.sub.2 H                                                                         Et     CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            i-Bu   CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            i-Bu   CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            i-Bu   CO(n-Pr)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(n-Pr)                                        CF.sub.3                                                                            i-Bu   CO(i-Pr)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(i-Pr)                                        CF.sub.3                                                                            i-Bu   CO(t-Bu)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(t-Bu)                                        CF.sub.3                                                                            i-Bu   CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           i-Bu   CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           i-Bu   CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           i-Bu   CO(n-Pr)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(n-Pr)                                        OCF.sub.3                                                                           i-Bu   CO(i-Pr)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(i-Pr)                                        OCF.sub.3                                                                           i-Bu   CO(t-Bu)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(t-Bu)                                        OCF.sub.3                                                                           i-Bu   CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                                                              CF.sub.3                                                                            Ph     CO(n-Pr)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                                                              CF.sub.3                                                                            Ph     CO(i-Pr)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                                                              CF.sub.3                                                                            Ph     CO(t-Bu)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(n-Pr)                                                                              OCF.sub.3                                                                           Ph     CO(n-Pr)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(i-Pr)                                                                              OCF.sub.3                                                                           Ph     CO(i-Pr)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                                                                              OCF.sub.3                                                                           Ph     CO(t-Bu)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         n-Pr   CO(t-Bu)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(i-Pr)                                        OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (i-Pi)                                 OCF.sub.2 H                                                                         i-Pr   CO(i-Pr)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(t-Bu)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         i-Pr   CO(t-Bu)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(n-Pr)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         i-Pr   CO(n-Pr)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(n-Pr)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO(n-Pr)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(n-Pr)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO(i-Pr)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(i-Pr)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO(t-Bu)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(t-Bu)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(n-Pr)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(n-Pr)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(i-Pr)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(i-Pr)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(t-Bu)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(t-Bu)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            4-F-Ph CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-F-Ph CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                        CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                        CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                        CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           4-F-Ph CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           4-F-Ph CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                        OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                        OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                        OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(i-Pr)                                                                              OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(t-Bu)                                        OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(t-Bu)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(n-Pr)                                        OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(n-Pr)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(i-Pr)                                        OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(i-Pr)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(t-Bu)                                        OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (t-Bu)                                 __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________      ##STR40##                                                                     R.sup.1                                                                             R.sup.3                                                                               Y      R.sup.1                                                                             R.sup.3                                                                               Y                                               __________________________________________________________________________     Cl   Me     H      OCF.sub.3                                                                           Me     COEt                                            Br   Me     H      Cl   Me     CO.sub.2 Me                                     CF.sub.3                                                                            Me     H      Br   Me     CO.sub.2 Me                                     OCF.sub.3                                                                           Me     H      CF.sub.3                                                                            Me     CO.sub.2 Me                                     Cl   Me     Me     OCF.sub.3                                                                           Me     CO.sub.2 Me                                     Br   Me     Me     Cl   Me     CO.sub.2 Et                                     CF.sub.3                                                                            Me     Me     Br   Me     CO.sub.2 Et                                     OCF.sub.3                                                                           Me     Me     CF.sub.3                                                                            Me     CO.sub.2 Et                                     Cl   Me     Et     OCF.sub.3                                                                           Me     CO.sub.2 Et                                     Br   Me     Et     Cl   Me     CH.sub.2 OMe                                    CF.sub.3                                                                            Me     Et     Br   Me     CH.sub.2 OMe                                    OCF.sub.3                                                                           Me     Et     CF.sub.3                                                                            Me     CH.sub.2 OMe                                    Cl   Me     n-Pr   OCF.sub.3                                                                           Me     CH.sub.2 OMe                                    Br   Me     n-Pr   Cl   Me     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Me     n-Pr   Br   Me     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Me     n-Pr   CF.sub.3                                                                            Me     CH.sub.2 CHCH.sub.2                             Cl   Me     COMe   OCF.sub.3                                                                           Me     CH.sub.2 CHCH.sub.2                             Br   Me     COMe   Cl   Me     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Me     COMe   Br   Me     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Me     COMe   CF.sub.3                                                                            Me     CH.sub.2 SCH.sub.3                              Cl   Me     COEt   OCF.sub.3                                                                           Me     CH.sub.2 SCH.sub.3                              Br   Me     COEt   OCF.sub.2 H                                                                         Me     H                                               CF.sub.3                                                                            Me     COEt   OCF.sub.2 H                                                                         Me     Me                                              Cl   Et     H      OCF.sub.3                                                                           Et     COEt                                            Br   Et     H      Cl   Et     CO.sub.2 Me                                     CF.sub.3                                                                            Et     H      Br   Et     CO.sub.2 Me                                     OCF.sub.3                                                                           Et     H      CF.sub.3                                                                            Et     CO.sub.2 Me                                     Cl   Et     Me     OCF.sub.3                                                                           Et     CO.sub.2 Me                                     Br   Et     Me     Cl   Et     CO.sub.2 Et                                     CF.sub.3                                                                            Et     Me     Br   Et     CO.sub.2 Et                                     CCF.sub.3                                                                           Et     Me     CF.sub.3                                                                            Et     CO.sub.2 Et                                     Cl   Et     Et     OCF.sub.3                                                                           Et     CO.sub.2 Et                                     Br   Et     Et     Cl   Et     CH.sub.2 OMe                                    CF.sub.3                                                                            Et     Et     Br   Et     CH.sub.2 OMe                                    OCF.sub.3                                                                           Et     Et     CF.sub.3                                                                            Et     CH.sub.2 OMe                                    Cl   Et     n-Pr   OCF.sub.3                                                                           Et     CH.sub.2 OMe                                    Br   Et     n-Pr   Cl   Et     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Et     n-Pr   Br   Et     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Et     n-Pr   CF.sub.3                                                                            Et     CH.sub.2 CHCH.sub.2                             Cl   Et     COMe   OCF.sub.3                                                                           Et     CH.sub.2 CHCH.sub.2                             Br   Et     COMe   Cl   Et     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Et     COMe   Br   Et     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Et     COMe   CF.sub.3                                                                            Et     CH.sub.2 SCH.sub.3                              Cl   Et     COEt   OCF.sub.3                                                                           Et     CH.sub.2 SCH.sub.3                              Br   Et     COEt   OCF.sub.2 H                                                                         Et     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Et     COEt   OCF.sub.2 H                                                                         Me     Et                                              OCF.sub.2 H                                                                         Et     H      OCF.sub.2 H                                                                         Me     n-Pr                                            OCF.sub.2 H                                                                         Et     Me     OCF.sub.2 H                                                                         Me     COMe                                            OCF.sub.2 H                                                                         Et     Et     OCF.sub.2 H                                                                         Me     COEt                                            OCF.sub.2 H                                                                         Et     n-Pr   OCF.sub.2 H                                                                         Me     CO.sub.2 Me                                     OCF.sub.2 H                                                                         Et     COMe   OCF.sub.2 H                                                                         Me     CO.sub.2 Et                                     OCF.sub.2 H                                                                         Et     COEt   OCF.sub.2 H                                                                         Me     CH.sub.2 OMe                                    OCF.sub.2 H                                                                         Et     CO.sub.2 Me                                                                           OCF.sub.2 H                                                                         Me     CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         Et     CO.sub.2 Et                                                                           OCF.sub.2 H                                                                         Me     CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         Et     CH.sub.2 OMe                                                       OCF.sub.2 H                                                                         Et     CH.sub.2 CHCH.sub.2                                                Cl   n-Pr   H      OCF.sub.3                                                                           n-Pr   COEt                                            Br   n-Pr   H      Cl   n-Pr   CO.sub.2 Me                                     CF.sub.3                                                                            n-Pr   H      Br   n-Pr   CO.sub.2 Me                                     OCF.sub.3                                                                           n-Pr   H      CF.sub.3                                                                            n-Pr   CO.sub.2 Me                                     Cl   n-Pr   Me     OCF.sub.3                                                                           n-Pr   CO.sub.2 Me                                     Br   n-Pr   Me     Cl   n-Pr   CO.sub.2 Et                                     CF.sub.3                                                                            n-Pr   Me     Br   n-Pr   CO.sub.2 Et                                     OCF.sub.3                                                                           n-Pr   Me     CF.sub.3                                                                            n-Pr   CO.sub.2 Et                                     Cl   n-Pr   Et     OCF.sub.3                                                                           n-Pr   CO.sub.2 Et                                     Br   n-Pr   Et     Cl   n-Pr   CH.sub.2 OMe                                    CF.sub.3                                                                            n-Pr   Et     Br   n-Pr   CH.sub.2 OMe                                    OCF.sub.3                                                                           n-Pr   Et     CF.sub.3                                                                            n-Pr   CH.sub.2 OMe                                    Cl   n-Pr   n-Pr   OCF.sub.3                                                                           n-Pr   CH.sub.2 OMe                                    Br   n-Pr   n-Pr   Cl   n-Pr   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            n-Pr   n-Pr   Br   n-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           n-Pr   n-Pr   CF.sub.3                                                                            n-Pr   CH.sub.2 CHCH.sub.2                             Cl   n-Pr   COMe   OCF.sub.3                                                                           n-Pr   CH.sub.2 CHCH.sub.2                             Br   n-Pr   COMe   Cl   n-Pr   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            n-Pr   COMe   Br   n-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           n-Pr   COMe   CF.sub.3                                                                            n-Pr   CH.sub.2 SCH.sub.3                              Cl   n-Pr   COEt   OCF.sub.3                                                                           n-Pr   CH.sub.2 SCH.sub.3                              Br   n-Pr   COEt   OCF.sub.2 H                                                                         n-Pr   COEt                                            CF.sub.3                                                                            n-Pr   COEt   OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Me                                     OCF.sub.2 H                                                                         n-Pr   H      OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Et                                     OCF.sub.2 H                                                                         n-Pr   Me     OCF.sub.2 H                                                                         n-Pr   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         n-Pr   Et     OCF.sub.2 H                                                                         n-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         n-Pr   n-Pr   OCF.sub.2 H                                                                         n-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         n-Pr   COMe                                                               Cl   i-Pr   H      OCF.sub.3                                                                           i-Pr   COEt                                            Br   i-Pr   H      Cl   i-Pr   CO.sub.2 Me                                     CF.sub.3                                                                            i-Pr   H      Br   i-Pr   CO.sub.2 Me                                     OCF.sub.3                                                                           i-Pr   H      CF.sub.3                                                                            i-Pr   CO.sub.2 Me                                     Cl   i-Pr   Me     OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                                     Br   i-Pr   Me     Cl   i-Pr   CO.sub.2 Et                                     CF.sub.3                                                                            i-Pr   Me     Br   i-Pr   CO.sub.2 Et                                     OCF.sub.3                                                                           i-Pr   Me     CF.sub.3                                                                            i-Pr   CO.sub.2 Et                                     Cl   i-Pr   Et     OCF.sub.3                                                                           i-Pr   CO.sub.2 Et                                     Br   i-Pr   Et     Cl   i-Pr   CH.sub.2 OMe                                    CF.sub.3                                                                            i-Pr   Et     Br   i-Pr   CH.sub.2 OMe                                    OCF.sub.3                                                                           i-Pr   Et     CF.sub.3                                                                            i-Pr   CH.sub.2 OMe                                    Cl   i-Pr   n-Pr   OCF.sub.3                                                                           i-Pr   CH.sub.2 OMe                                    Br   i-Pr   n-Pr   Cl   i-Pr   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            i-Pr   n-Pr   Br   i-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           i-Pr   n-Pr   CF.sub.3                                                                            i-Pr   CH.sub.2 CHCH.sub.2                             Cl   i-Pr   COMe   OCF.sub.3                                                                           i-Pr   CH.sub.2 CHCH.sub.2                             Br   i-Pr   COMe   Cl   i-Pr   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            i-Pr   COMe   Br   i-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           i-Pr   COMe   CF.sub.3                                                                            i-Pr   CH.sub.2 SCH.sub.3                              Cl   i-Pr   COEt   OCF.sub.3                                                                           i-Pr   CH.sub.2 SCH.sub.3                              Br   i-Pr   COEt   OCF.sub.2 H                                                                         i-Pr   COEt                                            CF.sub.3                                                                            i-Pr   COEt   OCF.sub.2 H                                                                         i-Pr   CO.sub.2 Me                                     OCF.sub.2 H                                                                         i-Pr   H      OCF.sub.2 H                                                                         i-Pr   CO.sub.2 Et                                     OCF.sub.2 H                                                                         i-Pr   Me     OCF.sub.2 H                                                                         i-Pr   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         i-Pr   Et     OCF.sub.2 H                                                                         i-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         i-Pr   n-Pr   OCF.sub.2 H                                                                         i-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         i-Pr   COMe                                                               Cl   i-Bu   H      OCF.sub.3                                                                           i-Bu   COEt                                            Br   i-Bu   H      Cl   i-Bu   CO.sub.2 Me                                     CF.sub.3                                                                            i-Bu   H      Br   i-Bu   CO.sub.2 Me                                     OCF.sub.3                                                                           i-Bu   H      CF.sub.3                                                                            i-Bu   CO.sub.2 Me                                     Cl   i-Bu   Me     OCF.sub.3                                                                           i-Bu   CO.sub.2 Me                                     Br   i-Bu   Me     Cl   i-Bu   CO.sub.2 Et                                     CF.sub.3                                                                            i-Bu   Me     Br   i-Bu   CO.sub.2 Et                                     OCF.sub.3                                                                           i-Bu   Me     CF.sub.3                                                                            i-Bu   CO.sub.2 Et                                     Cl   i-3u   Et     OCF.sub.3                                                                           i-Bu   CO.sub.2 Et                                     Br   i-Bu   Et     Cl   i-Bu   CH.sub.2 OMe                                    CF.sub.3                                                                            i-Bu   Et     Br   i-Bu   CH.sub.2 OMe                                    OCF.sub.3                                                                           i-Bu   Et     CF.sub.3                                                                            i-Bu   CH.sub.2 OMe                                    Cl   i-Bu   n-Pr   OCF.sub.3                                                                           i-Bu   CH.sub.2 OMe                                    Br   i-Bu   n-Pr   Cl   i-Bu   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            i-Bu   n-Pr   Br   i-Bu   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           i-Bu   n-Pr   CF.sub.3                                                                            i-Bu   CH.sub.2 CHCH.sub.2                             Cl   i-Bu   COMe   OCF.sub.3                                                                           i-Bu   CH.sub.2 CHCH.sub.2                             Br   i-Bu   COMe   Cl   i-Bu   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            i-Bu   COMe   Br   i-Bu   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           i-Bu   COMe   CF.sub.3                                                                            i-Bu   CH.sub.2 SCH.sub.3                              Cl   i-Bu   COEt   OCF.sub.3                                                                           i-Bu   CH.sub.2 SCH.sub.3                              Br   i-Bu   COEt   OCF.sub.2 H                                                                         i-Bu   COEt                                            CF.sub.3                                                                            i-Bu   COEt   OCF.sub.2 H                                                                         i-Bu   CO.sub.2 Me                                     OCF.sub.2 H                                                                         i-Bu   H      OCF.sub.2 H                                                                         i-Bu   CO.sub.2 Et                                     OCF.sub.2 H                                                                         i-Bu   Me     OCF.sub.2 H                                                                         i-Bu   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         i-Bu   Et     OCF.sub.2 H                                                                         i-Bu   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         i-Bu   n-Pr   OCF.sub.2 H                                                                         i-Bu   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         i-Bu   COMe                                                               Cl   CO.sub.2 Me                                                                           H      OCF.sub.3                                                                           CO.sub.2 Me                                                                           COEt                                            Br   CO.sub.2 Me                                                                           H      Cl   CO.sub.2 Me                                                                           CO.sub.2 Me                                     CF.sub.3                                                                            CO.sub.2 Me                                                                           H      Br   CO.sub.2 Me                                                                           CO.sub.2 Me                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                           H      CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                                     Cl   CO.sub.2 Me                                                                           Me     OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Me                                     Br   CO.sub.2 Me                                                                           Me     Cl   CO.sub.2 Me                                                                           CO.sub.2 Et                                     CF.sub.3                                                                            CO.sub.2 Me                                                                           Me     Br   CO.sub.2 Me                                                                           CO.sub.2 Et                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                           Me     CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                                     Cl   CO.sub.2 Me                                                                           Et     OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Et                                     Br   CO.sub.2 Me                                                                           Et     Cl   CO.sub.2 Me                                                                           CH.sub.2 OMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                           Et     Br   CO.sub.2 Me                                                                           CH.sub.2 OMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                           Et     CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 OMe                                    Cl   CO.sub.2 Me                                                                           n-Pr   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 OMe                                    Br   CO.sub.2 Me                                                                           n-Pr   Cl   CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr   Br   CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CO.sub.2 Me                                                                           n-Pr   CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             Cl   CO.sub.2 Me                                                                           COMe   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             Br   CO.sub.2 Me                                                                           COMe   Cl   CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CO.sub.2 Me                                                                           COMe   Br   CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CO.sub.2 Me                                                                           COMe   CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              Cl   CO.sub.2 Me                                                                           COEt   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              Br   CO.sub.2 Me                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           COEt                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 Me                                     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           H      OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 Et                                     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Me     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Et     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           n-Pr   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           COMe                                                               Cl   CO.sub.2 Et                                                                           H      OCF.sub.3                                                                           CO.sub.2 Et                                                                           COEt                                            Br   CO.sub.2 Et                                                                           H      Cl   CO.sub.2 Et                                                                           CO.sub.2 Me                                     CF.sub.3                                                                            CO.sub.2 Et                                                                           H      Br   CO.sub.2 Et                                                                           CO.sub.2 Me                                     OCF.sub.3                                                                           CO.sub.2 Et                                                                           H      CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 Me                                     Cl   CO.sub.2 Et                                                                           Me     OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 Me                                     Br   CO.sub.2 Et                                                                           Me     Cl   CO.sub.2 Et                                                                           CO.sub.2 Et                                     CF.sub.3                                                                            CO.sub.2 Et                                                                           Me     Br   CO.sub.2 Et                                                                           CO.sub.2 Et                                     OCF.sub.3                                                                           CO.sub.2 Et                                                                           Me     CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 Et                                     Cl   CO.sub.2 Et                                                                           Et     OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 Et                                     Br   CO.sub.2 Et                                                                           Et     Cl   CO.sub.2 Et                                                                           CH.sub.2 OMe                                    CF.sub.3                                                                            CO.sub.2 Et                                                                           Et     Br   CO.sub.2 Et                                                                           CH.sub.2 OMe                                    OCF.sub.3                                                                           CO.sub.2 Et                                                                           Et     CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 OMe                                    Cl   CO.sub.2 Et                                                                           n-Pr   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 OMe                                    Br   CO.sub.2 Et                                                                           n-Pr   Cl   CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CO.sub.2 Et                                                                           n-Pr   Br   CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CO.sub.2 Et                                                                           n-Pr   CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             Cl   CO.sub.2 Et                                                                           COMe   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             Br   C02Et  COMe   Cl   CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CO.sub.2 Et                                                                           COMe   Br   CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           COMe   CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              Cl   CO.sub.2 Et                                                                           COEt   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              Br   CO.sub.2 Et                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           COEt                                            CF.sub.3                                                                            CO.sub.2 Et                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 Me                                     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           H      OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 Et                                     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           Me     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           Et     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           n-Pr   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           COMe                                                               Cl   Ph     H      OCF.sub.3                                                                           Ph     COEt                                            Br   Ph     H      Cl   Ph     CO.sub.2 Me                                     CF.sub.3                                                                            Ph     H      Br   Ph     CO.sub.2 Me                                     OCF.sub.3                                                                           Ph     H      CF.sub.3                                                                            Ph     CO.sub.2 Me                                     Cl   Ph     Me     OCF.sub.3                                                                           Ph     CO.sub.2 Me                                     Br   Ph     Me     Cl   Ph     CO.sub.2 Et                                     CF.sub.3                                                                            Ph     Me     Br   Ph     CO.sub.2 Et                                     OCF.sub.3                                                                           Ph     Me     CF.sub.3                                                                            Ph     CO.sub.2 Et                                     Cl   Ph     Et     OCF.sub.3                                                                           Ph     CO.sub.2 Et                                     Br   Ph     Et     Cl   Ph     CH.sub.2 OMe                                    CF.sub.3                                                                            Ph     Et     Br   Ph     CH.sub.2 OMe                                    OCF.sub.3                                                                           Ph     Et     CF.sub.3                                                                            Ph     CH.sub.2 OMe                                    Cl   Ph     n-Pr   OCF.sub.3                                                                           Ph     CH.sub.2 OMe                                    Br   Ph     n-Pr   Cl   Ph     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Ph     n-Pr   Br   Ph     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Ph     n-Pr   CF.sub.3                                                                            Ph     CH.sub.2 CHCH.sub.2                             Cl   Ph     COMe   OCF.sub.3                                                                           Ph     CH.sub.2 CHCH.sub.2                             Br   Ph     COMe   Cl   Ph     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Ph     COMe   Br   Ph     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Ph     COMe   CF.sub.3                                                                            Ph     CH.sub.2 SCH.sub.3                              Cl   Ph     COEt   OCF.sub.3                                                                           Ph     CH.sub.2 SCH.sub.3                              Br   Ph     COEt   OCF.sub.2 H                                                                         Ph     COEt                                            CF.sub.3                                                                            Ph     COEt   OCF.sub.2 H                                                                         Ph     CO.sub.2 Me                                     OCF.sub.2 H                                                                         Ph     H      OCF.sub.2 H                                                                         Ph     CO.sub.2 Et                                     OCF.sub.2 H                                                                         Ph     Me     OCF.sub.2 H                                                                         Ph     CH.sub.2 OMe                                    OCF.sub.2 H                                                                         Ph     Et     OCF.sub.2 H                                                                         Ph     CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         Ph     n-Pr   OCF.sub.2 H                                                                         Ph     CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         Ph     COMe                                                               Cl   4-Cl-Ph                                                                               H      OCF.sub.3                                                                           4-Cl-Ph                                                                               COEt                                            Br   4-Cl-Ph                                                                               H      Cl   4-Cl-Ph                                                                               CO.sub.2 Me                                     CF.sub.3                                                                            4-Cl-Ph                                                                               H      Br   4-Cl-Ph                                                                               CO.sub.2 Me                                     OCF.sub.3                                                                           4.-Cl-Ph                                                                              H      CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 Me                                     Cl   4-Cl-Ph                                                                               Me     OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 Me                                     Br   4-Cl-Ph                                                                               Me     Cl   4-Cl-Ph                                                                               CO.sub.2 Et                                     CF.sub.3                                                                            4-Cl-Ph                                                                               Me     Br   4-Cl-Ph                                                                               CO.sub.2 Et                                     OCF.sub.3                                                                           4-Cl-Ph                                                                               Me     CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 Et                                     Cl   4-Cl-Ph                                                                               Et     OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 Et                                     Br   4-Cl-Ph                                                                               Et     Cl   4-Cl-Ph                                                                               CH.sub.2 OMe                                    CF.sub.3                                                                            4-Cl-Ph                                                                               Et     Br   4-Cl-Ph                                                                               CH.sub.2 OMe                                    OCF.sub.3                                                                           4-Cl-Ph                                                                               Et     CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 OMe                                    Cl   4-Cl-Ph                                                                               n-Pr   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 OMe                                    Br   4-Cl-Ph                                                                               n-Pr   Cl   4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            4-Cl-Ph                                                                               n-Pr   Br   4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           4-Cl-Ph                                                                               n-Pr   CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             Cl   4-Cl-Ph                                                                               COMe   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             Br   4-Cl-Ph                                                                               COMe   Cl   4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            4-Cl-Ph                                                                               COMe   Br   4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           4-Cl-Ph                                                                               COMe   CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              Cl   4-Cl-Ph                                                                               COEt   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              Br   4-Cl-Ph                                                                               COEt   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               COEt                                            CF.sub.3                                                                            4-Cl-Ph                                                                               COEt   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 Me                                     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               H      OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 Et                                     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               Me     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 OMe                                    OCF.sub.2 H                                                                         4-Cl-Ph                                                                               Et     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         4-Cl-Ph                                                                               n-Pr   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         4-Cl-Ph                                                                               COMe                                                               Cl   4-F-Ph H      OCF.sub.3                                                                           4-F-Ph COEt                                            Br   4-F-Ph H      Cl   4-F-Ph CO.sub.2 Me                                     CF.sub.3                                                                            4-F-Ph H      Br   4-F-Ph CO.sub.2 Me                                     OCF.sub.3                                                                           4-F-Ph H      CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                                     Cl   4-F-Ph Me     OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                                     Br   4-F-Ph Me     Cl   4-F-Ph CO.sub.2 Et                                     CF.sub.3                                                                            4-F-Ph Me     Br   4-F-Ph CO.sub.2 Et                                     OCF.sub.3                                                                           4-F-Ph Me     CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                                     Cl   4-F-Ph Et     OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                                     Br   4-F-Ph Et     Cl   4-F-Ph CH.sub.2 OMe                                    CF.sub.3                                                                            4-F-Ph Et     Br   4-F-Ph CH.sub.2 OMe                                    OCF.sub.3                                                                           4-F-Ph Et     CF.sub.3                                                                            4-F-Ph CH.sub.2 OMe                                    Cl   4-F-Ph n-Pr   OCF.sub.3                                                                           4-F-Ph CH.sub.2 OMe                                    Br   4-F-Ph n-Pr   Cl   4-F-Ph CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            4-F-Ph n-Pr   Br   4-F-Ph CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           4-F-Ph n-Pr   CF.sub.3                                                                            4-F-Ph CH.sub.2 CHCH.sub.2                             Cl   4-F-Ph COMe   OCF.sub.3                                                                           4-F-Ph CH.sub.2 CHCH.sub.2                             Br   4-F-Ph COMe   Cl   4-F-Ph CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            4-F-Ph COMe   Br   4-F-Ph CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           4-F-Ph COMe   CF.sub.3                                                                            4-F-Ph CH.sub.2 SCH.sub.3                              Cl   4-F-Ph COEt   OCF.sub.3                                                                           4-F-Ph CH.sub.2 SCH.sub.3                              Br   4-F-Ph COEt   OCF.sub.2 H                                                                         4-F-Ph COEt                                            CF.sub.3                                                                            4-F-Ph COEt   OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 Me                                     OCF.sub.2 H                                                                         4-F-Ph H      OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 Et                                     OCF.sub.2 H                                                                         4-F-Ph Me     OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 OMe                                    OCF.sub.2 H                                                                         4-F-Ph Et     OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         4-F-Ph n-Pr   OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         4-F-Ph COMe                                                               Cl   CHCH.sub.2                                                                            H      OCF.sub.3                                                                           CHCH.sub.2                                                                            COEt                                            Br   CHCH.sub.2                                                                            H      Cl   CHCH.sub.2                                                                            CO.sub.2 Me                                     CF.sub.3                                                                            CHCH.sub.2                                                                            H      Br   CHCH.sub.2                                                                            CO.sub.2 Me                                     OCF.sub.3                                                                           CHCH.sub.2                                                                            H      CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Me                                     Cl   CHCH.sub.2                                                                            Me     OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Me                                     Br   CHCH.sub.2                                                                            Me     Cl   CHCH.sub.2                                                                            CO.sub.2 Et                                     CF.sub.3                                                                            CHCH.sub.2                                                                            Me     Br   CHCH.sub.2                                                                            CO.sub.2 Et                                     OCF.sub.3                                                                           CHCH.sub.2                                                                            Me     CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Et                                     Cl   CHCH.sub.2                                                                            Et     OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Et                                     Br   CHCH.sub.2                                                                            Et     Cl   CHCH.sub.2                                                                            CH.sub.2 OMe                                    CF.sub.3                                                                            CHCH.sub.2                                                                            Et     Br   CHCH.sub.2                                                                            CH.sub.2 OMe                                    OCF.sub.3                                                                           CHCH.sub.2                                                                            Et     CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 OMe                                    Cl   CHCH.sub.2                                                                            n-Pr   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 OMe                                    Br   CHCH.sub.2                                                                            n-Pr   Cl   CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CHCH.sub.2                                                                            n-Pr   Br   CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CHCH.sub.2                                                                            n-Pr   CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             Cl   CHCH.sub.2                                                                            COMe   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             Br   CHCH.sub.2                                                                            COMe   Cl   CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CHCH.sub.2                                                                            COMe   Br   CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CHCH.sub.2                                                                            COMe   CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              Cl   CHCH.sub.2                                                                            COEt   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              Br   CHCH.sub.2                                                                            COEt   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COEt                                            CF.sub.3                                                                            CHCH.sub.2                                                                            COEt   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Me                                     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            H      OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Et                                     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            Me     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CHCH.sub.2                                                                            Et     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CHCH.sub.2                                                                            n-Pr   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COMe                                                               Cl   C(CH.sub.3)CH.sub.2                                                                   H      OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COEt                                            Br   C(CH.sub.3)CH.sub.2                                                                   H      Cl   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   H      Br   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   H      CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     Cl   C(CH.sub.3)CH.sub.2                                                                   Me     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     Br   C(CH.sub.3)CH.sub.2                                                                   Me     Cl   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Me     Br   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Me     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     Cl   C(CH.sub.3)CH.sub.2                                                                   Et     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     Br   C(CH.sub.3)CH.sub.2                                                                   Et     Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Et     Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Et     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    Cl   C(CH.sub.3)CH.sub.2                                                                   n-Pr   OCF.sub.3                                                                           C;(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                    Br   C(CH.sub.3)CH.sub.2                                                                   n-Pr   Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   n-Pr   Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   n-Pr   CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             Cl   C(CH.sub.3)CH.sub.2                                                                   COMe   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             Br   C(CH.sub.3)CH.sub.2                                                                   COMe   Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            C(CH.sub.3)CH2,                                                                       COMe   Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COMe   CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              Cl   C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              Br   C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COEt                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   H      OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Me     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Et     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   n-Pr   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COMe                                                               CF.sub.3                                                                            Me     CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            Me     CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            Me     CO(n-Pr)                                                                              CF.sub.3                                                                            n-Pr   CO(n-Pr)                                        CF.sub.3                                                                            Me     CO(i-Pr)                                                                              CF.sub.3                                                                            n-Pr   CO(i-Pr)                                        CF.sub.3                                                                            Me     CO(t-Bu)                                                                              CF.sub.3                                                                            n-Pr   CO(t-Bu)                                        CF.sub.3                                                                            Me     CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           Me     CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           Me     CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           Me     CO(n-Pr)                                                                              OCF.sub.3                                                                           n-Pr   CO(n-Pr)                                        OCF.sub.3                                                                           Me     CO(i-Pr)                                                                              OCF.sub.3                                                                           n-Pr   CO(i-Pr)                                        OCF.sub.3                                                                           Me     CO(t-Bu)                                                                              OCF.sub.3                                                                           n-Pr   CO(t-Bu)                                        OCF.sub.3                                                                           Me     CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            Et     CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            Et     CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            Et     CO(n-Pr)                                                                              CF.sub.3                                                                            i-Pr   CO(n-Pr)                                        CF.sub.3                                                                            Et     CO(i-Pr)                                                                              CF.sub.3                                                                            i-Pr   CO(i-Pr)                                        CF.sub.3                                                                            Et     CO(t-Bu)                                                                              CF.sub.3                                                                            i-Pr   CO(t-Bu)                                        CF.sub.3                                                                            Et     CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           Et     CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           Et     CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           Et     CO(n-Pr)                                                                              OCF.sub.3                                                                           i-Pr   CO(n-Pr)                                        OCF.sub.3                                                                           Et     CO(i-Pr)                                                                              OCF.sub.3                                                                           i-Pr   CO(i-Pr)                                        OCF.sub.3                                                                           Et     CO(t-Bu)                                                                              OCF.sub.3                                                                           i-Pr   CO(t-Bu)                                        OCF.sub.3                                                                           Et     CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         Me     CO(n-Pr)                                                                              OCF.sub.2 H                                                                         Et     CO(i-Pr)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         Et     CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         Me     CO(i-Pr)                                                                              OCF.sub.2 H                                                                         Et     CO(t-Bu)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         Et     CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         Me     CO(t-Bu)                                                                              OCF.sub.2 H                                                                         n-Pr   CO(n-Pr)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         Et     CO(n-Pr)                                                                              OCF.sub.2 H                                                                         n-Pr   CO(i-Pr)                                        OCF.sub.2 H                                                                         Et     CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            i-Bu   CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            i-Bu   CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            i-Bu   CO(n-Pr)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(n-Pr)                                        CF.sub.3                                                                            i-Bu   CO(i-Pr)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(i-Pr)                                        CF.sub.3                                                                            i-Bu   CO(t-Bu)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(t-Bu)                                        CF.sub.3                                                                            i-Bu   CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           i-Bu   CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           i-Bu   CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           i-Bu   CO(n-Pr)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(n-Pr)                                        OCF.sub.3                                                                           i-Bu   CO(i-Pr)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(i-Pr)                                        OCF.sub.3                                                                           i-Bu   CO(t-Bu)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(t-Bu)                                        OCF.sub.3                                                                           i-Bu   CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                                                              CF.sub.3                                                                            Ph     CO(n-Pr)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                                                              CF.sub.3                                                                            Ph     CO(i-Pr)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                                                              CF.sub.3                                                                            Ph     CO(t-Bu)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(n-Pr)                                                                              OCF.sub.3                                                                           Ph     CO(n-Pr)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(i-Pr)                                                                              OCF.sub.3                                                                           Ph     CO(i-Pr)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                                                                              OCF.sub.3                                                                           Ph     CO(t-Bu)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         n-Pr   CO(t-Bu)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(i-Pr)                                        OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         i-Pr   CO(i-Pr)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(t-Bu)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         i-Pr   CO(t-Bu)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(n-Pr)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         i-Pr   CO(n-Pr)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(n-Pr)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO(n-Pr)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(n-Pr)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO(i-Pr)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(i-Pr)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO(t-Bu)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(t-Bu)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(n-Pr)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(n-Pr)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(i-Pr)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(i-Pr)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(t-Bu)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(t-Bu)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            4-F-Ph CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-F-Ph CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                        CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                        CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                        CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           4-F-Ph CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           4-F-Ph CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                        OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                        OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                        OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(i-Pr)                                                                              OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(t-Bu)                                        OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(t-Bu)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(n-Pr)                                        OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(n-Pr)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(i-Pr)                                        OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(i-Pr)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(t-Bu)                                        OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (t-Bu)                                 __________________________________________________________________________

                                      TABLE 3                                      __________________________________________________________________________      ##STR41##                                                                     R.sup.1                                                                             R.sup.3                                                                               Y      R.sup.1                                                                             R.sup.3                                                                               Y                                               __________________________________________________________________________     Cl   Me     H      OCF.sub.3                                                                           Me     COEt                                            Br   Me     H      Cl   Me     CO.sub.2 Me                                     CF.sub.3                                                                            Me     H      Br   Me     CO.sub.2 Me                                     OCF.sub.3                                                                           Me     H      CF.sub.3                                                                            Me     CO.sub.2 Me                                     Cl   Me     Me     OCF.sub.3                                                                           Me     CO.sub.2 Me                                     Br   Me     Me     Cl   Me     CO.sub.2 Et                                     CF.sub.3                                                                            Me     Me     Br   Me     CO.sub.2 Et                                     OCF.sub.3                                                                           Me     Me     CF.sub.3                                                                            Me     CO.sub.2 Et                                     Cl   Me     Et     OCF.sub.3                                                                           Me     CO.sub.2 Et                                     Br   Me     Et     Cl   Me     CH.sub.2 OMe                                    CF.sub.3                                                                            Me     Et     Br   Me     CH.sub.2 OMe                                    OCF.sub.3                                                                           Me     Et     CF.sub.3                                                                            Me     CH.sub.2 OMe                                    Cl   Me     n-Pr   OCF.sub.3                                                                           Me     CH.sub.2 OMe                                    Br   Me     n-Pr   Cl   Me     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Me     n-Pr   Br   Me     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Me     n-Pr   CF.sub.3                                                                            Me     CH.sub.2 CHCH.sub.2                             Cl   Me     COMe   OCF.sub.3                                                                           Me     CH.sub.2 CHCH.sub.2                             Br   Me     COMe   Cl   Me     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Me     COMe   Br   Me     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Me     COMe   CF.sub.3                                                                            Me     CH.sub.2 SCH.sub.3                              Cl   Me     COEt   OCF.sub.3                                                                           Me     CH.sub.2 SCH.sub.3                              Br   Me     COEt   OCF.sub.2 H                                                                         Me     H                                               CF.sub.3                                                                            Me     COEt   OCF.sub.2 H                                                                         Me     Me                                              Cl   Et     H      OCF.sub.3                                                                           Et     COEt                                            Br   Et     H      Cl   Et     CO.sub.2 Me                                     CF.sub.3                                                                            Et     H      Br   Et     CO.sub.2 Me                                     OCF.sub.3                                                                           Et     H      CF.sub.3                                                                            Et     CO.sub.2 Me                                     Cl   Et     Me     OCF.sub.3                                                                           Et     CO.sub.2 Me                                     Br   Et     Me     Cl   Et     CO.sub.2 Et                                     CF.sub.3                                                                            Et     Me     Br   Et     CO.sub.2 Et                                     OCF.sub.3                                                                           Et     Me     CF.sub.3                                                                            Et     CO.sub.2 Et                                     Cl   Et     Et     OCF.sub.3                                                                           Et     CO.sub.2 Et                                     Br   Et     Et     Cl   Et     CH.sub.2 OMe                                    CF.sub.3                                                                            Et     Et     Br   Et     CH.sub.2 OMe                                    OCF.sub.3                                                                           Et     Et     CF.sub.3                                                                            Et     CH.sub.2 OMe                                    Cl   Et     n-Pr   OCF.sub.3                                                                           Et     CH.sub.2 OMe                                    Br   Et     n-Pr   Cl   Et     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Et     n-Pr   Br   Et     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Et     n-Pr   CF.sub.3                                                                            Et     CH.sub.2 CHCH.sub.2                             Cl   Et     COMe   OCF.sub.3                                                                           Et     CH.sub.2 CHCH.sub.2                             Br   Et     COMe   Cl   Et     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Et     COMe   Br   Et     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Et     COMe   CF.sub.3                                                                            Et     CH.sub.2 SCH.sub.3                              Cl   Et     COEt   OCF.sub.3                                                                           Et     CH.sub.2 SCH.sub.3                              Br   Et     COEt   OCF.sub.2 H                                                                         Et     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Et     COEt   OCF.sub.2 H                                                                         Me     Et                                              OCF.sub.2 H                                                                         Et     H      OCF.sub.2 H                                                                         Me     n-Pr                                            OCF.sub.2 H                                                                         Et     Me     OCF.sub.2 H                                                                         Me     COMe                                            OCF.sub.2 H                                                                         Et     Et     OCF.sub.2 H                                                                         Me     COEt                                            OCF.sub.2 H                                                                         Et     n-Pr   OCF.sub.2 H                                                                         Me     CO.sub.2 Me                                     OCF.sub.2 H                                                                         Et     COMe   OCF.sub.2 H                                                                         Me     CO.sub.2 Et                                     OCF.sub.2 H                                                                         Et     COEt   OCF.sub.2 H                                                                         Me     CH.sub.2 OMe                                    OCF.sub.2 H                                                                         Et     CO.sub.2 Me                                                                           OCF.sub.2 H                                                                         Me     CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         Et     CO.sub.2 Et                                                                           OCF.sub.2 H                                                                         Me     CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         Et     CH.sub.2 OMe                                                       OCF.sub.2 H                                                                         Et     CH.sub.2 CHCH.sub.2                                                Cl   n-Pr   H      OCF.sub.3                                                                           n-Pr   COEt                                            Br   n-Pr   H      Cl   n-Pr   CO.sub.2 Me                                     CF.sub.3                                                                            n-Pr   H      Br   n-Pr   CO.sub.2 Me                                     OCF.sub.3                                                                           n-Pr   H      CF.sub.3                                                                            n-Pr   CO.sub.2 Me                                     Cl   n-Pr   Me     OCF.sub.3                                                                           n-Pr   CO.sub.2 Me                                     Br   n-Pr   Me     Cl   n-Pr   CO.sub.2 Et                                     CF.sub.3                                                                            n-Pr   Me     Br   n-Pr   CO.sub.2 Et                                     OCF.sub.3                                                                           n-Pr   Me     CF.sub.3                                                                            n-Pr   CO.sub.2 Et                                     Cl   n-Pr   Et     OCF.sub.3                                                                           n-Pr   CO.sub.2 Et                                     Br   n-Pr   Et     Cl   n-Pr   CH.sub.2 OMe                                    CF.sub.3                                                                            n-Pr   Et     Br   n-Pr   CH.sub.2 OMe                                    OCF.sub.3                                                                           n-Pr   Et     CF.sub.3                                                                            n-Pr   CH.sub.2 OMe                                    Cl   n-Pr   n-Pr   OCF.sub.3                                                                           n-Pr   CH.sub.2 OMe                                    Br   n-Pr   n-Pr   Cl   n-Pr   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            n-Pr   n-Pr   Br   n-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           n-Pr   n-Pr   CF.sub.3                                                                            n-Pr   CH.sub.2 CHCH.sub.2                             Cl   n-Pr   COMe   OCF.sub.3                                                                           n-Pr   CH.sub.2 CHCH.sub.2                             Br   n-Pr   COMe   Cl   n-Pr   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            n-Pr   COMe   Br   n-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           n-Pr   COMe   CF.sub.3                                                                            n-Pr   CH.sub.2 SCH.sub.3                              Cl   n-Pr   COEt   OCF.sub.3                                                                           n-Pr   CH.sub.2 SCH.sub.3                              Br   n-Pr   COEt   OCF.sub.2 H                                                                         n-Pr   COEt                                            CF.sub.3                                                                            n-Pr   COEt   OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Me                                     OCF.sub.2 H                                                                         n-Pr   H      OCF.sub.2 H                                                                         n-Pr   CO.sub.2 Et                                     OCF.sub.2 H                                                                         n-Pr   Me     OCF.sub.2 H                                                                         n-Pr   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         n-Pr   Et     OCF.sub.2 H                                                                         n-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         n-Pr   n-Pr   OCF.sub.2 H                                                                         n-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         n-Pr   COMe                                                               Cl   i-Pr   H      OCF.sub.3                                                                           i-Pr   COEt                                            Br   i-Pr   H      Cl   i-Pr   CO.sub.2 Me                                     CF.sub.3                                                                            i-Pr   H      Br   i-Pr   CO.sub.2 Me                                     OCF.sub.3                                                                           i-Pr   H      CF.sub.3                                                                            i-Pr   CO.sub.2 Me                                     Cl   i-Pr   Me     OCF.sub.3                                                                           i-Pr   CO.sub.2 Me                                     Br   i-Pr   Me     Cl   i-Pr   CO.sub.2 Et                                     CF.sub.3                                                                            i-Pr   Me     Br   i-Pr   CO.sub.2 Et                                     OCF.sub.3                                                                           i-Pr   Me     CF.sub.3                                                                            i-Pr   CO.sub.2 Et                                     Cl   i-Pr   Et     OCF.sub.3                                                                           i-Pr   CO.sub.2 Et                                     Br   i-Pr   Et     Cl   i-Pr   CH.sub.2 OMe                                    CF.sub.3                                                                            i-Pr   Et     Br   i-Pr   CH.sub.2 OMe                                    OCF.sub.3                                                                           i-Pr   Et     CF.sub.3                                                                            i-Pr   CH.sub.2 OMe                                    Cl   i-Pr   n-Pr   OCF.sub.3                                                                           i-Pr   CH.sub.2 OMe                                    Br   i-Pr   n-Pr   Cl   i-Pr   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            i-Pr   n-Pr   Br   i-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           i-Pr   n-Pr   CF.sub.3                                                                            i-Pr   CH.sub.2 CHCH.sub.2                             Cl   i-Pr   COMe   OCF.sub.3                                                                           i-Pr   CH.sub.2 CHCH.sub.2                             Br   i-Pr   COMe   Cl   i-Pr   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            i-Pr   COMe   Br   i-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           i-Pr   COMe   CF.sub.3                                                                            i-Pr   CH.sub.2 SCH.sub.3                              Cl   i-Pr   COEt   OCF.sub.3                                                                           i-Pr   CH.sub.2 SCH.sub.3                              Br   i-Pr   COEt   OCF.sub.2 H                                                                         i-Pr   COEt                                            CF.sub.3                                                                            i-Pr   COEt   OCF.sub.2 H                                                                         i-Pr   CO.sub.2 Me                                     OCF.sub.2 H                                                                         i-Pr   H      OCF.sub.2 H                                                                         i-Pr   CO.sub.2 Et                                     OCF.sub.2 H                                                                         i-Pr   Me     OCF.sub.2 H                                                                         i-Pr   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         i-Pr   Et     OCF.sub.2 H                                                                         i-Pr   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         i-Pr   n-Pr   OCF.sub.2 H                                                                         i-Pr   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         i-Pr   COMe                                                               Cl   i-Bu   H      OCF.sub.3                                                                           i-Bu   COEt                                            Br   i-Bu   H      Cl   i-Bu   CO.sub.2 Me                                     CF.sub.3                                                                            i-Bu   H      Br   i-Bu   CO.sub.2 Me                                     OCF.sub.3                                                                           i-Bu   H      CF.sub.3                                                                            i-Bu   CO.sub.2 Me                                     Cl   i-Bu   Me     OCF.sub.3                                                                           i-Bu   CO.sub.2 Me                                     Br   i-Bu   Me     Cl   i-Bu   CO.sub.2 Et                                     CF.sub.3                                                                            i-Bu   Me     Br   i-Bu   CO.sub.2 Et                                     OCF.sub.3                                                                           i-Bu   Me     CF.sub.3                                                                            i-Bu   CO.sub.2 Et                                     Cl   i-Bu   Et     OCF.sub.3                                                                           i-Bu   CO.sub.2 Et                                     Br   i-Bu   Et     Cl   i-Bu   CH.sub.2 OMe                                    CF.sub.3                                                                            i-Bu   Et     Br   i-Bu   CH.sub.2 OMe                                    OCF.sub.3                                                                           i-Bu   Et     CF.sub.3                                                                            i-Bu   CH.sub.2 OMe                                    Cl   i-Bu   n-Pr   OCF.sub.3                                                                           i-Bu   CH.sub.2 OMe                                    Br   i-Bu   n-Pr   Cl   i-Bu   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            i-Bu   n-Pr   Br   i-Bu   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           i-Bu   n-Pr   CF.sub.3                                                                            i-Bu   CH.sub.2 CHCH.sub.2                             Cl   i-Bu   COMe   OCF.sub.3                                                                           i-Bu   CH.sub.2 CHCH.sub.2                             Br   i-Bu   COMe   Cl   i-Bu   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            i-Bu   COMe   Br   i-Bu   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           i-Bu   COMe   CF.sub.3                                                                            i-Bu   CH.sub.2 SCH.sub.3                              Cl   i-Bu   COEt   OCF.sub.3                                                                           i-Bu   CH.sub.2 SCH.sub.3                              Br   i-Bu   COEt   OCF.sub.2 H                                                                         i-Bu   COEt                                            CF.sub.3                                                                            i-Bu   COEt   OCF.sub.2 H                                                                         i-Bu   CO.sub.2 Me                                     OCF.sub.2 H                                                                         i-Bu   H      OCF.sub.2 H                                                                         i-Bu   CO.sub.2 Et                                     OCF.sub.2 H                                                                         i-Bu   Me     OCF.sub.2 H                                                                         i-Bu   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         i-Bu   Et     OCF.sub.2 H                                                                         i-Bu   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         i-Bu   n-Pr   OCF.sub.2 H                                                                         i-Bu   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         i-Bu   COMe                                                               Cl   CO.sub.2 Me                                                                           H      OCF.sub.3                                                                           CO.sub.2 Me                                                                           COEt                                            Br   CO.sub.2 Me                                                                           H      Cl   CO.sub.2 Me                                                                           CO.sub.2 Me                                     CF.sub.3                                                                            CO.sub.2 Me                                                                           H      Br   CO.sub.2 Me                                                                           CO.sub.2 Me                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                           H      CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                                     Cl   CO.sub.2 Me                                                                           Me     OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Me                                     Br   CO.sub.2 Me                                                                           Me     Cl   CO.sub.2 Me                                                                           CO.sub.2 Et                                     CF.sub.3                                                                            CO.sub.2 Me                                                                           Me     Br   CO.sub.2 Me                                                                           CO.sub.2 Et                                     OCF.sub.3                                                                           CO.sub.2 Me                                                                           Me     CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                                     Cl   CO.sub.2 Me                                                                           Et     OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 Et                                     Br   CO.sub.2 Me                                                                           Et     Cl   CO.sub.2 Me                                                                           CH.sub.2 OMe                                    CF.sub.3                                                                            CO.sub.2 Me                                                                           Et     Br   CO.sub.2 Me                                                                           CH.sub.2 OMe                                    OCF.sub.3                                                                           CO.sub.2 Me                                                                           Et     CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 OMe                                    Cl   CO.sub.2 Me                                                                           n-Pr   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 OMe                                    Br   CO.sub.2 Me                                                                           n-Pr   Cl   CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr   Br   CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CO.sub.2 Me                                                                           n-Pr   CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             Cl   CO.sub.2 Me                                                                           COMe   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             Br   CO.sub.2 Me                                                                           COMe   Cl   CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CO.sub.2 Me                                                                           COMe   Br   CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CO.sub.2 Me                                                                           COMe   CF.sub.3                                                                            CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              Cl   CO.sub.2 Me                                                                           COEt   OCF.sub.3                                                                           CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              Br   CO.sub.2 Me                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           COEt                                            CF.sub.3                                                                            CO.sub.2 Me                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 Me                                     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           H      OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 Et                                     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Me     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           Et     OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           n-Pr   OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           COMe                                                               Cl   CO.sub.2 Et                                                                           H      OCF.sub.3                                                                           CO.sub.2 Et                                                                           COEt                                            Br   CO.sub.2 Et                                                                           H      Cl   CO.sub.2 Et                                                                           CO.sub.2 Me                                     CF.sub.3                                                                            CO.sub.2 Et                                                                           H      Br   CO.sub.2 Et                                                                           CO.sub.2 Me                                     OCF.sub.3                                                                           CO.sub.2 Et                                                                           H      CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 Me                                     Cl   CO.sub.2 Et                                                                           Me     OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 Me                                     Br   CO.sub.2 Et                                                                           Me     Cl   CO.sub.2 Et                                                                           CO.sub.2 Et                                     CF.sub.3                                                                            CO.sub.2 Et                                                                           Me     Br   CO.sub.2 Et                                                                           CO.sub.2 Et                                     OCF.sub.3                                                                           CO.sub.2 Et                                                                           Me     CF.sub.3                                                                            C02Et  CO.sub.2 Et                                     Cl   CO.sub.2 Et                                                                           Et     OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 Et                                     Br   CO.sub.2 Et                                                                           Et     Cl   CO.sub.2 Et                                                                           CH.sub.2 OMe                                    CF.sub.3                                                                            CO.sub.2 Et                                                                           Et     Br   CO.sub.2 Et                                                                           CH.sub.2 OMe                                    OCF.sub.3                                                                           CO.sub.2 Et                                                                           Et     CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 OMe                                    Cl   CO.sub.2 Et                                                                           n-Pr   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 OMe                                    Br   CO.sub.2 Et                                                                           n-Pr   Cl   CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CO.sub.2 Et                                                                           n-Pr   Br   CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CO.sub.2 Et                                                                           n-Pr   CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             Cl   CO.sub.2 Et                                                                           COMe   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             Br   CO.sub.2 Et                                                                           COMe   Cl   CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CO.sub.2 Et                                                                           COMe   Br   CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           COMe   CF.sub.3                                                                            CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              Cl   CO.sub.2 Et                                                                           COEt   OCF.sub.3                                                                           CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              Br   CO.sub.2 Et                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           COEt                                            CF.sub.3                                                                            CO.sub.2 Et                                                                           COEt   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 Me                                     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           H      OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 Et                                     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           Me     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           Et     OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           n-Pr   OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           COMe                                                               Cl   Ph     H      OCF.sub.3                                                                           Ph     COEt                                            Br   Ph     H      Cl   Ph     CO.sub.2 Me                                     CF.sub.3                                                                            Ph     H      Br   Ph     CO.sub.2 Me                                     OCF.sub.3                                                                           Ph     H      CF.sub.3                                                                            Ph     CO.sub.2 Me                                     Cl   Ph     Me     OCF.sub.3                                                                           Ph     CO.sub.2 Me                                     Br   Ph     Me     Cl   Ph     CO.sub.2 Et                                     CF.sub.3                                                                            Ph     Me     Br   Ph     CO.sub.2 Et                                     OCF.sub.3                                                                           Ph     Me     CF.sub.3                                                                            Ph     CO.sub.2 Et                                     Cl   Ph     Et     OCF.sub.3                                                                           Ph     CO.sub.2 Et                                     Br   Ph     Et     Cl   Ph     CH.sub.2 OMe                                    CF.sub.3                                                                            Ph     Et     Br   Ph     CH.sub.2 OMe                                    OCF.sub.3                                                                           Ph     Et     CF.sub.3                                                                            Ph     CH.sub.2 OMe                                    Cl   Ph     n-Pr   OCF.sub.3                                                                           Ph     CH.sub.2 OMe                                    Br   Ph     n-Pr   Cl   Ph     CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            Ph     n-Pr   Br   Ph     CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           Ph     n-Pr   CF.sub.3                                                                            Ph     CH.sub.2 CHCH.sub.2                             Cl   Ph     COMe   OCF.sub.3                                                                           Ph     CH.sub.2 CHCH.sub.2                             Br   Ph     COMe   Cl   Ph     CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            Ph     COMe   Br   Ph     CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           Ph     COMe   CF.sub.3                                                                            Ph     CH.sub.2 SCH.sub.3                              Cl   Ph     COEt   OCF.sub.3                                                                           Ph     CH.sub.2 SCH.sub.3                              Br   Ph     COEt   OCF.sub.2 H                                                                         Ph     COEt                                            CF.sub.3                                                                            Ph     COEt   OCF.sub.2 H                                                                         Ph     CO.sub.2 Me                                     OCF.sub.2 H                                                                         Ph     H      OCF.sub.2 H                                                                         Ph     CO.sub.2 Et                                     OCF.sub.2 H                                                                         Ph     Me     OCF.sub.2 H                                                                         Ph     CH.sub.2 OMe                                    OCF.sub.2 H                                                                         Ph     Et     OCF.sub.2 H                                                                         Ph     CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         Ph     n-Pr   OCF.sub.2 H                                                                         Ph     CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         Ph     COMe                                                               Cl   4-Cl-Ph                                                                               H      OCF.sub.3                                                                           4-Cl-Ph                                                                               COEt                                            Br   4-Cl-Ph                                                                               H      Cl   4-Cl-Ph                                                                               CO.sub.2 Me                                     CF.sub.3                                                                            4-Cl-Ph                                                                               H      Br   4-Cl-Ph                                                                               CO.sub.2 Me                                     OCF.sub.3                                                                           4-Cl-Ph                                                                               H      CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 Me                                     Cl   4-Cl-Ph                                                                               Me     OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 Me                                     Br   4-Cl-Ph                                                                               Me     Cl   4-Cl-Ph                                                                               CO.sub.2 Et                                     CF.sub.3                                                                            4-Cl-Ph                                                                               Me     Br   4-Cl-Ph                                                                               CO.sub.2 Et                                     OCF.sub.3                                                                           4-Cl-Ph                                                                               Me     CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 Et                                     Cl   4-Cl-Ph                                                                               Et     OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 Et                                     Br   4-Cl-Ph                                                                               Et     Cl   4-Cl-Ph                                                                               CH.sub.2 OMe                                    CF.sub.3                                                                            4-Cl-Ph                                                                               Et     Br   4-Cl-Ph                                                                               CH.sub.2 OMe                                    OCF.sub.3                                                                           4-Cl-Ph                                                                               Et     CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 OMe                                    Cl   4-Cl-Ph                                                                               n-Pr   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 OMe                                    Br   4-Cl-Ph                                                                               n-Pr   Cl   4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            4-Cl-Ph                                                                               n-Pr   Br   4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           4-Cl-Ph                                                                               n-Pr   CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             Cl   4-Cl-Ph                                                                               COMe   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             Br   4-Cl-Ph                                                                               COMe   Cl   4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            4-Cl-Ph                                                                               COMe   Br   4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           4-Cl-Ph                                                                               COMe   CF.sub.3                                                                            4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              Cl   4-Cl-Ph                                                                               COEt   OCF.sub.3                                                                           4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              Br   4-Cl-Ph                                                                               COEt   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               COEt                                            CF.sub.3                                                                            4-Cl-Ph                                                                               COEt   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 Me                                     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               H      OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 Et                                     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               Me     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 OMe                                    OCF.sub.2 H                                                                         4-Cl-Ph                                                                               Et     OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         4-Cl-Ph                                                                               n-Pr   OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         4-Cl-Ph                                                                               COMe                                                               Cl   4-F-Ph H      OCF.sub.3                                                                           4-F-Ph COEt                                            Br   4-F-Ph H      Cl   4-F-Ph CO.sub.2 Me                                     CF.sub.3                                                                            4-F-Ph H      Br   4-F-Ph CO.sub.2 Me                                     OCF.sub.3                                                                           4-F-Ph H      CF.sub.3                                                                            4-F-Ph CO.sub.2 Me                                     Cl   4-F-Ph Me     OCF.sub.3                                                                           4-F-Ph CO.sub.2 Me                                     Br   4-F-Ph Me     Cl   4-F-Ph CO.sub.2 Et                                     CF.sub.3                                                                            4-F-Ph Me     Br   4-F-Ph CO.sub.2 Et                                     OCF.sub.3                                                                           4-F-Ph Me     CF.sub.3                                                                            4-F-Ph CO.sub.2 Et                                     Cl   4-F-Ph Et     OCF.sub.3                                                                           4-F-Ph CO.sub.2 Et                                     Br   4-F-Ph Et     Cl   4-F-Ph CH.sub.2 OMe                                    CF.sub.3                                                                            4-F-Ph Et     Br   4-F-Ph CH.sub.2 OMe                                    OCF.sub.3                                                                           4-F-Ph Et     CF.sub.3                                                                            4-F-Ph CH.sub.2 OMe                                    Cl   4-F-Ph n-Pr   OCF.sub.3                                                                           4-F-Ph CH.sub.2 OMe                                    Br   4-F-Ph n-Pr   Cl   4-F-Ph CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            4-F-Ph n-Pr   Br   4-F-Ph CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           4-F-Ph n-Pr   CF.sub.3                                                                            4-F-Ph CH.sub.2 CHCH.sub.2                             Cl   4-F-Ph COMe   OCF.sub.3                                                                           4-F-Ph CH.sub.2 CHCH.sub.2                             Br   4-F-Ph COMe   Cl   4-F-Ph CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            4-F-Ph COMe   Br   4-F-Ph CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           4-F-Ph COMe   CF.sub.3                                                                            4-F-Ph CH.sub.2 SCH.sub.3                              Cl   4-F-Ph COEt   OCF.sub.3                                                                           4-F-Ph CH.sub.2 SCH.sub.3                              Br   4-F-Ph COEt   OCF.sub.2 H                                                                         4-F-Ph COEt                                            CF.sub.3                                                                            4-F-Ph COEt   OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 Me                                     OCF.sub.2 H                                                                         4-F-Ph H      OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 Et                                     OCF.sub.2 H                                                                         4-F-Ph Me     OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 OMe                                    OCF.sub.2 H                                                                         4-F-Ph Et     OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         4-F-Ph n-Pr   OCF.sub.2 H                                                                         4-F-Ph CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         4-F-Ph COMe                                                               Cl   CHCH.sub.2                                                                            H      OCF.sub.3                                                                           CHCH.sub.2                                                                            COEt                                            Br   CHCH.sub.2                                                                            H      Cl   CHCH.sub.2                                                                            CO.sub.2 Me                                     CF.sub.3                                                                            CHCH.sub.2                                                                            H      Br   CHCH.sub.2                                                                            CO.sub.2 Me                                     OCF.sub.3                                                                           CHCH.sub.2                                                                            H      CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Me                                     Cl   CHCH.sub.2                                                                            Me     OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Me                                     Br   CHCH.sub.2                                                                            Me     Cl   CHCH.sub.2                                                                            CO.sub.2 Et                                     CF.sub.3                                                                            CHCH.sub.2                                                                            Me     Br   CHCH.sub.2                                                                            CO.sub.2 Et                                     OCF.sub.3                                                                           CHCH.sub.2                                                                            Me     CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 Et                                     Cl   CHCH.sub.2                                                                            Et     OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 Et                                     Br   CHCH.sub.2                                                                            Et     Cl   CHCH.sub.2                                                                            CH.sub.2 OMe                                    CF.sub.3                                                                            CHCH.sub.2                                                                            Et     Br   CHCH.sub.2                                                                            CH.sub.2 OMe                                    OCF.sub.3                                                                           CHCH.sub.2                                                                            Et     CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 OMe                                    Cl   CHCH.sub.2                                                                            n-Pr   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 OMe                                    Br   CHCH.sub.2                                                                            n-Pr   Cl   CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            CHCH.sub.2                                                                            n-Pr   Br   CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           CHCH.sub.2                                                                            n-Pr   CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             Cl   CHCH.sub.2                                                                            COMe   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             Br   CHCH.sub.2                                                                            COMe   Cl   CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            CHCH.sub.2                                                                            COMe   Br   CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           CHCH.sub.2                                                                            COMe   CF.sub.3                                                                            CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              Cl   CHCH.sub.2                                                                            COEt   OCF.sub.3                                                                           CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              Br   CHCH.sub.2                                                                            COEt   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COEt                                            CF.sub.3                                                                            CHCH.sub.2                                                                            COEt   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Me                                     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            H      OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CO.sub.2 Et                                     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            Me     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 OMe                                    OCF.sub.2 H                                                                         CHCH.sub.2                                                                            Et     OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         CHCH.sub.2                                                                            n-Pr   OCF.sub.2 H                                                                         CHCH.sub.2                                                                            CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         CHCH.sub.2                                                                            COMe                                                               Cl   C(CH.sub.3)CH.sub.2                                                                   H      OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COEt                                            Br   C(CH.sub.3)CH.sub.2                                                                   H      Cl   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   H      Br   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   H      CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     Cl   C(CH.sub.3)CH.sub.2                                                                   Me     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     Br   C(CH.sub.3)CH.sub.2                                                                   Me     Cl   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Me     Br   C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Me     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     Cl   C(CH.sub.3)CH.sub.2                                                                   Et     OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     Br   C(CH.sub.3)CH.sub.2                                                                   Et     Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   Et     Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   Et     CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    Cl   C(CH.sub.3)CH.sub.2                                                                   n-Pr   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    Br   C(CH.sub.3)CH.sub.2                                                                   n-Pr   Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   n-Pr   Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   n-Pr   CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             Cl   C(CH.sub.3)CH.sub.2                                                                   COMe   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             Br   C(CH.sub.3)CH.sub.2                                                                   COMe   Cl   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   COMe   Br   C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   COMe   CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              Cl   C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              Br   C(CH.sub.3)CH.sub.2                                                                   COEt   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COEt                                            CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CoEt   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Me                                     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   H      OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 Et                                     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Me     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 OMe                                    OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   Et     OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   n-Pr   OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                         C(CH.sub.3)CH.sub.2                                                                   COMe                                                               CF.sub.3                                                                            Me     CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            Me     CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            Me     CO(n-Pr)                                                                              CF.sub.3                                                                            n-Pr   CO(n-Pr)                                        CF.sub.3                                                                            Me     CO(i-Pr)                                                                              CF.sub.3                                                                            n-Pr   CO(i-Pr)                                        CF.sub.3                                                                            Me     CO(t-Bu)                                                                              CF.sub.3                                                                            n-Pr   CO(t-Bu)                                        CF.sub.3                                                                            Me     CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            n-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           Me     CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           Me     CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           Me     CO(n-Pr)                                                                              OCF.sub.3                                                                           n-Pr   CO(n-Pr)                                        OCF.sub.3                                                                           Me     CO(i-Pr)                                                                              OCF.sub.3                                                                           n-Pr   CO(i-Pr)                                        OCF.sub.3                                                                           Me     CO(t-Bu)                                                                              OCF.sub.3                                                                           n-Pr   CO(t-Bu)                                        OCF.sub.3                                                                           Me     CO.sub.2 (t-BU)                                                                       OCF.sub.3                                                                           n-Pr   CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            Et     CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            Et     CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            Et     CO(n-Pr)                                                                              CF.sub.3                                                                            i-Pr   CO(n-Pr)                                        CF.sub.3                                                                            Et     CO(i-Pr)                                                                              CF.sub.3                                                                            i-Pr   CO(i-Pr)                                        CF.sub.3                                                                            Et     CO(t-Bu)                                                                              CF.sub.3                                                                            i-Pr   CO(t-Bu)                                        CF.sub.3                                                                            Et     CO.sub.2 (t-BU)                                                                       CF.sub.3                                                                            i-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           Et     CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           Et     CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           Et     CO(n-Pr)                                                                              OCF.sub.3                                                                           i-Pr   CO(n-Pr)                                        OCF.sub.3                                                                           Et     CO(i-Pr)                                                                              OCF.sub.3                                                                           i-Pr   CO(i-Pr)                                        OCF.sub.3                                                                           Et     CO(t-Bu)                                                                              OCF.sub.3                                                                           i-Pr   CO(t-Bu)                                        OCF.sub.3                                                                           Et     CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           i-Pr   CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         Me     CO(n-Pr)                                                                              OCF.sub.2 H                                                                         Et     CO(i-Pr)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (n-Pr)                                                                       OCF2H                                                                               Et     CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         Me     CO(i-Pr)                                                                              OCF.sub.2 H                                                                         Et     CO(t-Bu)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         Et     CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         Me     CO(t-Bu)                                                                              OCF.sub.2 H                                                                         n-Pr   CO(n-Pr)                                        OCF.sub.2 H                                                                         Me     CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         Et     CO(n-Pr)                                                                              OCF.sub.2 H                                                                         n-Pr   CO(i-Pr)                                        OCF.sub.2 H                                                                         Et     CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            i-Bu   CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            i-Bu   CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            i-Bu   CO(n-Pr)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(n-Pr)                                        CF.sub.3                                                                            i-Bu   CO(i-Pr)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(i-Pr)                                        CF.sub.3                                                                            i-Bu   CO(t-Bu)                                                                              CF.sub.3                                                                            CO.sub.2 Et                                                                           CO(t-Bu)                                        CF.sub.3                                                                            i-Bu   CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           i-Bu   CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           i-Bu   CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           i-Bu   CO(n-Pr)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(n-Pr)                                        OCF.sub.3                                                                           i-Bu   CO(i-Pr)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(i-Pr)                                        OCF.sub.3                                                                           i-Bu   CO(t-Bu)                                                                              OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO(t-Bu)                                        OCF.sub.3                                                                           i-Bu   CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           CO.sub.2 Et                                                                           CO.sub.2 (t-BU)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                                                              CF.sub.3                                                                            Ph     CO(n-Pr)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                                                              CF.sub.3                                                                            Ph     CO(i-Pr)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                                                              CF.sub.3                                                                            Ph     CO(t-Bu)                                        CF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            Ph     CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(n-Pr)                                                                              OCF.sub.3                                                                           Ph     CO(n-Pr)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(i-Pr)                                                                              OCF.sub.3                                                                           Ph     CO(i-Pr)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                                                                              OCF.sub.3                                                                           Ph     CO(t-Bu)                                        OCF.sub.3                                                                           CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           Ph     CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         n-Pr   CO(t-3u)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(i-Pr)                                        OCF.sub.2 H                                                                         n-Pr   CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         i-Pr   CO(i-Pr)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(t-Bu)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         i-Pr   CO(t-Bu)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO(n-Pr)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Me                                                                           CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         i-Pr   CO(n-Pr)                                                                              OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(n-Pr)                                        OCF.sub.2 H                                                                         i-Pr   CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            4-Cl-Ph                                                                               CO(n-Pr)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(n-Pr)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO(i-Pr)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(i-Pr)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO(t-Bu)                                                                              CF.sub.3                                                                            CHCH.sub.2                                                                            CO(t-Bu)                                        CF.sub.3                                                                            4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            CHCH.sub.2                                                                            CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(n-Pr)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(n-Pr)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(i-Pr)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(i-Pr)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO(t-Bu)                                                                              OCF.sub.3                                                                           CHCH.sub.2                                                                            CO(t-Bu)                                        OCF.sub.3                                                                           4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           CHCH.sub.2                                                                            CO.sub.2 (t-Bu)                                 CF.sub.3                                                                            4-F-Ph CO.sub.2 (n-Pr)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (n-Pr)                                 CF.sub.3                                                                            4-F-Ph CO.sub.2 (i-Pr)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (i-Pr)                                 CF.sub.3                                                                            4-F-Ph CO(n-Pr)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                        CF.sub.3                                                                            4-F-Ph CO(i-Pr)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                        CF.sub.3                                                                            4-F-Ph CO(t-Bu)                                                                              CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                        CF.sub.3                                                                            4-F-Ph CO.sub.2 (t-Bu)                                                                       CF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                           4-F-Ph CO.sub.2 (n-Pr)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                           4-F-Ph CO.sub.2 (i-Pr)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                           4-F-Ph CO(n-Pr)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(n-Pr)                                        OCF.sub.3                                                                           4-F-Ph CO(i-Pr)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(i-Pr)                                        OCF.sub.3                                                                           4-F-Ph CO(t-Bu)                                                                              OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO(t-Bu)                                        OCF.sub.3                                                                           4-F-Ph CO.sub.2 (t-Bu)                                                                       OCF.sub.3                                                                           C(CH.sub.3)CH.sub.2                                                                   CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(i-Pr)                                                                              OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(t-Bu)                                        OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO(t-Bu)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(n-Pr)                                        OCF.sub.2 H                                                                         CO.sub.2 Et                                                                           CO.sub.2 (t-Bu)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(n-Pr)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(i-Pr)                                        OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (n-Pr)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO(i-Pr)                                                                              OCF.sub.2 H                                                                         4-F-Ph CO(t-Bu)                                        OCF.sub.2 H                                                                         4-Cl-Ph                                                                               CO.sub.2 (i-Pr)                                                                       OCF.sub.2 H                                                                         4-F-Ph CO.sub.2 (t-Bu)                                 __________________________________________________________________________

                                      TABLE 4                                      __________________________________________________________________________      ##STR42##                                                                     R.sup.1                                                                              R.sup.3                                                                              Y     R.sup.1                                                                               R.sup.3                                                                              Y                                               __________________________________________________________________________     Cl    Me    H     OCF.sub.3                                                                             Me    COEt                                            Br    Me    H     Cl     Me    CO.sub.2 Me                                     CF.sub.3                                                                             Me    H     Br     Me    CO.sub.2 Me                                     OCF.sub.3                                                                            Me    H     CF.sub.3                                                                              Me    CO.sub.2 Me                                     Cl    Me    Me    OCF.sub.3                                                                             Me    CO.sub.2 Me                                     Br    Me    Me    Cl     Me    CO.sub.2 Et                                     CF.sub.3                                                                             Me    Me    Br     Me    CO.sub.2 Et                                     OCF.sub.3                                                                            Me    Me    CF.sub.3                                                                              Me    CO.sub.2 Et                                     Cl    Me    Et    OCF.sub.3                                                                             Me    CO.sub.2 Et                                     Br    Me    Et    Cl     Me    CH.sub.2 OMe                                    CF.sub.3                                                                             Me    Et    Br     Me    CH.sub.2 OMe                                    OCF.sub.3                                                                            Me    Et    CF.sub.3                                                                              Me    CH.sub.2 OMe                                    Cl    Me    n-Pr  OCF.sub.3                                                                             Me    CH.sub.2 OMe                                    Br    Me    n-Pr  Cl     Me    CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             Me    n-Pr  Br     Me    CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            Me    n-Pr  CF.sub.3                                                                              Me    CH.sub.2 CHCH.sub.2                             Cl    Me    COMe  OCF.sub.3                                                                             Me    CH.sub.2 CHCH.sub.2                             Br    Me    COMe  Cl     Me    CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             Me    COMe  Br     Me    CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            Me    COMe  CF.sub.3                                                                              Me    CH.sub.2 SCH.sub.3                              Cl    Me    COEt  OCF.sub.3                                                                             Me    CH.sub.2 SCH.sub.3                              Br    Me    COEt  OCF.sub.2 H                                                                           Me    H                                               CF.sub.3                                                                             Me    COEt  OCF.sub.2 H                                                                           Me    Me                                              Cl    Et    H     OCF.sub.3                                                                             Et    COEt                                            Br    Et    H     Cl     Et    CO.sub.2 Me                                     CF.sub.3                                                                             Et    H     Br     Et    CO.sub.2 Me                                     OCF.sub.3                                                                            Et    H     CF.sub.3                                                                              Et    CO.sub.2 Me                                     Cl    Et    Me    OCF.sub.3                                                                             Et    CO.sub.2 Me                                     Br    Et    Me    Cl     Et    CO.sub.2 Et                                     CF.sub.3                                                                             Et    Me    Br     Et    CO.sub.2 Et                                     OCF.sub.3                                                                            Et    Me    CF.sub.3                                                                              Et    CO.sub.2 Et                                     Cl    Et    Et    OCF.sub.3                                                                             Et    CO.sub.2 Et                                     Br    Et    Et    Cl     Et    CH.sub.2 OMe                                    CF.sub.3                                                                             Et    Et    Br     Et    CH.sub.2 OMe                                    OCF.sub.3                                                                            Et    Et    CF.sub.3                                                                              Et    CH.sub.2 OMe                                    Cl    Et    n-Pr  OCF.sub.3                                                                             Et    CH.sub.2 OMe                                    Br    Et    n-Pr  Cl     Et    CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             Et    n-Pr  Br     Et    CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            Et    n-Pr  CF.sub.3                                                                              Et    CH.sub.2 CHCH.sub.2                             Cl    Et    COMe  OCF.sub.3                                                                             Et    CH.sub.2 CHCH.sub.2                             Br    Et    COMe  Cl     Et    CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             Et    COMe  Br     Et    CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            Et    COMe  CF.sub.3                                                                              Et    CH.sub.2 SCH.sub.3                              Cl    Et    COEt  OCF.sub.3                                                                             Et    CH.sub.2 SCH.sub.3                              Br    Et    COEt  OCF.sub.2 H                                                                           Et    CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             Et    COEt  OCF.sub.2 H                                                                           Me    Et                                              OCF.sub.2 H                                                                          Et    H     OCF.sub.2 H                                                                           Me    n-Pr                                            OCF.sub.2 H                                                                          Et    Me    OCF.sub.2 H                                                                           Me    COMe                                            OCF.sub.2 H                                                                          Et    Et    OCF.sub.2 H                                                                           Me    COEt                                            OCF.sub.2 H                                                                          Et    n-Pr  OCF.sub.2 H                                                                           Me    CO.sub.2 Me                                     OCF.sub.2 H                                                                          Et    COMe  OCF.sub.2 H                                                                           Me    CO.sub.2 Et                                     OCF.sub.2 H                                                                          Et    COEt  OCF.sub.2 H                                                                           Me    CH.sub.2 OMe                                    OCF.sub.2 H                                                                          Et    CO.sub.2 Me                                                                          OCF.sub.2 H                                                                           Me    CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          Et    CO.sub.2 Et                                                                          OCF.sub.2 H                                                                           Me    CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          Et    CH.sub.2 OMe                                                       OCF.sub.2 H                                                                          Et    CH.sub.2 CHCH.sub.2                                                Cl    n-Pr  H     OCF.sub.3                                                                             n-Pr  COEt                                            Br    n-Pr  H     Cl     n-Pr  CO.sub.2 Me                                     CF.sub.3                                                                             n-Pr  H     Br     n-Pr  CO.sub.2 Me                                     OCF.sub.3                                                                            n-Pr  H     CF.sub.3                                                                              n-Pr  CO.sub.2 Me                                     Cl    n-Pr  Me    OCF.sub.3                                                                             n-Pr  CO.sub.2 Me                                     Br    n-Pr  Me    Cl     n-Pr  CO.sub.2 Et                                     CF.sub.3                                                                             n-Pr  Me    Br     n-Pr  CO.sub.2 Et                                     OCF.sub.3                                                                            n-Pr  Me    CF.sub.3                                                                              n-Pr  CO.sub.2 Et                                     Cl    n-Pr  Et    OCF.sub.3                                                                             n-Pr  CO.sub.2 Et                                     Br    n-Pr  Et    Cl     n-Pr  CH.sub.2 OMe                                    CF.sub.3                                                                             n-Pr  Et    Br     n-Pr  CH.sub.2 OMe                                    OCF.sub.3                                                                            n-Pr  Et    CF.sub.3                                                                              n-Pr  CH.sub.2 OMe                                    Cl    n-Pr  n-Pr  OCF.sub.3                                                                             n-Pr  CH.sub.2 OMe                                    Br    n-Pr  n-Pr  Cl     n-Pr  CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             n-Pr  n-Pr  Br     n-Pr  CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            n-Pr  n-Pr  CF.sub.3                                                                              n-Pr  CH.sub.2 CHCH.sub.2                             Cl    n-Pr  COMe  OCF.sub.3                                                                             n-Pr  CH.sub.2 CHCH.sub.2                             Br    n-Pr  COMe  Cl     n-Pr  CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             n-Pr  COMe  Br     n-Pr  CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            n-Pr  COMe  CF.sub.3                                                                              n-Pr  CH.sub.2 SCH.sub.3                              Cl    n-Pr  COEt  OCF.sub.3                                                                             n-Pr  CH.sub.2 SCH.sub.3                              Br    n-Pr  COEt  OCF.sub.2 H                                                                           n-Pr  COEt                                            CF.sub.3                                                                             n-Pr  COEt  OCF.sub.2 H                                                                           n-Pr  CO.sub.2 Me                                     OCF.sub.2 H                                                                          n-Pr  H     OCF.sub.2 H                                                                           n-Pr  CO.sub.2 Et                                     OCF.sub.2 H                                                                          n-Pr  Me    OCF.sub.2 H                                                                           n-Pr  CH.sub.2 OMe                                    OCF.sub.2 H                                                                          n-Pr  Et    OCF.sub.2 H                                                                           n-Pr  CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          n-Pr  n-Pr  OCF.sub.2 H                                                                           n-Pr  CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          n-Pr  COMe                                                               Cl    i-Pr  H     OCF.sub.3                                                                             i-Pr  COEt                                            Br    i-Pr  H     Cl     i-Pr  CO.sub.2 Me                                     CF.sub.3                                                                             i-Pr  H     Br     i-Pr  CO.sub.2 Me                                     OCF.sub.3                                                                            i-Pr  H     CF.sub.3                                                                              i-Pr  CO.sub.2 Me                                     Cl    i-Pr  Me    OCF.sub.3                                                                             i-Pr  CO.sub.2 Me                                     Br    i-Pr  Me    Cl     i-Pr  CO.sub.2 Et                                     CF.sub.3                                                                             i-Pr  Me    Br     i-Pr  CO.sub.2 Et                                     OCF.sub.3                                                                            i-Pr  Me    CF.sub.3                                                                              i-Pr  CO.sub.2 Et                                     Cl    i-Pr  Et    OCF.sub.3                                                                             i-Pr  CO.sub.2 Et                                     Br    i-Pr  Et    Cl     i-Pr  CH.sub.2 OMe                                    CF.sub.3                                                                             i-Pr  Et    Br     i-Pr  CH.sub.2 OMe                                    OCF.sub.3                                                                            i-Pr  Et    CF.sub.3                                                                              i-Pr  CH.sub.2 OMe                                    Cl    i-Pr  n-Pr  OCF.sub.3                                                                             i-Pr  CH.sub.2 OMe                                    Br    i-Pr  n-Pr  Cl     i-Pr  CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             i-Pr  n-Pr  Br     i-Pr  CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            i-Pr  n-Pr  CF.sub.3                                                                              i-Pr  CH.sub.2 CHCH.sub.2                             Cl    i-Pr  COMe  OCF.sub.3                                                                             i-Pr  CH.sub.2 CHCH.sub.2                             Br    i-Pr  COMe  Cl     i-Pr  CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             i-Pr  COMe  Br     i-Pr  CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            i-Pr  COMe  CF.sub.3                                                                              i-Pr  CH.sub.2 SCH.sub.3                              Cl    i-Pr  COEt  OCF.sub.3                                                                             i-Pr  CH.sub.2 SCH.sub.3                              Br    i-Pr  COEt  OCF.sub.2 H                                                                           i-Pr  COEt                                            CF.sub.3                                                                             i-Pr  COEt  OCF.sub.2 H                                                                           i-Pr  CO.sub.2 Me                                     OCF.sub.2 H                                                                          i-Pr  H     OCF.sub.2 H                                                                           i-Pr  CO.sub.2 Et                                     OCF.sub.2 H                                                                          i-Pr  Me    OCF.sub.2 H                                                                           i-Pr  CH.sub.2 OMe                                    OCF.sub.2 H                                                                          i-Pr  Et    OCF.sub.2 H                                                                           i-Pr  CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          i-Pr  n-Pr  OCF.sub.2 H                                                                           i-Pr  CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          i-Pr  COMe                                                               Cl    i-Bu  H     OCF.sub.3                                                                             i-Bu  COEt                                            Br    i-Bu  H     Cl     i-Bu  CO.sub.2 Me                                     CF.sub.3                                                                             i-Bu  H     Br     i-Bu  CO.sub.2 Me                                     OCF.sub.3                                                                            i-Bu  H     CF.sub.3                                                                              i-Bu  CO.sub.2 Me                                     Cl    i-Bu  Me    OCF.sub.3                                                                             i-Bu  CO.sub.2 Me                                     Br    i-Bu  Me    Cl     i-Bu  CO.sub.2 Et                                     CF.sub.3                                                                             i-Bu  Me    Br     i-Bu  CO.sub.2 Et                                     OCF.sub.3                                                                            i-Bu  Me    CF.sub.3                                                                              i-Bu  CO.sub.2 Et                                     Cl    i-Bu  Et    OCF.sub.3                                                                             i-Bu  CO.sub.2 Et                                     Br    i-Bu  Et    Cl     i-Bu  CH.sub.2 OMe                                    CF.sub.3                                                                             i-Bu  Et    Br     i-Bu  CH.sub.2 OMe                                    OCF.sub.3                                                                            i-Bu  Et    CF.sub.3                                                                              i-Bu  CH.sub.2 OMe                                    Cl    i-Bu  n-Pr  OCF.sub.3                                                                             i-Bu  CH.sub.2 OMe                                    Br    i-Bu  n-Pr  Cl     i-Bu  CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             i-Bu  n-Pr  Br     i-Bu  CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            i-Bu  n-Pr  CF.sub.3                                                                              i-Bu  CH.sub.2 CHCH.sub.2                             Cl    i-Bu  COMe  OCF.sub.3                                                                             i-Bu  CH.sub.2 CHCH.sub.2                             Br    i-Bu  COMe  Cl     i-Bu  CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             i-Bu  COMe  Br     i-Bu  CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            i-Bu  COMe  CF.sub.3                                                                              i-Bu  CH.sub.2 SCH.sub.3                              Cl    i-Bu  COEt  OCF.sub.3                                                                             i-Bu  CH.sub.2 SCH.sub.3                              Br    i-Bu  COEt  OCF.sub.2 H                                                                           i-Bu  COEt                                            CF.sub.3                                                                             i-Bu  COEt  OCF.sub.2 H                                                                           i-Bu  CO.sub.2 Me                                     OCF.sub.2 H                                                                          i-Bu  H     OCF.sub.2 H                                                                           i-Bu  CO.sub.2 Et                                     OCF.sub.2 H                                                                          i-Bu  Me    OCF.sub.2 H                                                                           i-Bu  CH.sub.2 OMe                                    OCF.sub.2 H                                                                          i-Bu  Et    OCF.sub.2 H                                                                           i-Bu  CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          i-Bu  n-Pr  OCF.sub.2 H                                                                           i-Bu  CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          i-Bu  COMe                                                               Cl    CO.sub.2 Me                                                                          H     OCF.sub.3                                                                             CO.sub.2 Me                                                                          COEt                                            Br    CO.sub.2 Me                                                                          H     Cl     CO.sub.2 Me                                                                          CO.sub.2 Me                                     CF.sub.3                                                                             CO.sub.2 Me                                                                          H     Br     CO.sub.2 Me                                                                          CO.sub.2 Me                                     OCF.sub.3                                                                            CO.sub.2 Me                                                                          H     CF.sub.3                                                                              CO.sub.2 Me                                                                          CO.sub.2 Me                                     Cl    CO.sub.2 Me                                                                          Me    OCF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Me                                     Br    CO.sub.2 Me                                                                          Me    Cl     CO.sub.2 Me                                                                          Cl.sub.2 Et                                     CF.sub.3                                                                             CO.sub.2 Me                                                                          Me    Br     CO.sub.2 Me                                                                          CO.sub.2 Et                                     OCF.sub.3                                                                            CO.sub.2 Me                                                                          Me    CF.sub.3                                                                              CO.sub.2 Me                                                                          CO.sub.2 Et                                     Cl    CO.sub.2 Me                                                                          Et    OCF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 Et                                     Br    CO.sub.2 Me                                                                          Et    Cl     CO.sub.2 Me                                                                          CH.sub.2 OMe                                    CF.sub.3                                                                             CO.sub.2 Me                                                                          Et    Br     CO.sub.2 Me                                                                          CH.sub.2 OMe                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                          Et    CF.sub.3                                                                              CO.sub.2 Me                                                                          CH.sub.2 OMe                                    Cl    CO.sub.2 Me                                                                          n-Pr  OCF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 OMe                                    Br    CO.sub.2 Me                                                                          n-Pr  Cl     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             CO.sub.2 Me                                                                          n-Pr  Br     CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            CO.sub.2 Me                                                                          n-Pr  CF.sub.3                                                                              CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                             Cl    CO.sub.2 Me                                                                          COMe  OCF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                             Br    CO.sub.2 Me                                                                          COMe  Cl     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             CO.sub.2 Me                                                                          COMe  Br     CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            CO.sub.2 Me                                                                          COMe  CF.sub.3                                                                              CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                              Cl    CO.sub.2 Me                                                                          COEt  OCF.sub.3                                                                             CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                              Br    CO.sub.2 Me                                                                          COEt  OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          COEt                                            CF.sub.3                                                                             CO.sub.2 Me                                                                          COEt  OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO.sub.2 Me                                     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          H     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO.sub.2 Et                                     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Me    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CH.sub.2 OMe                                    OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          Et    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          n-Pr  OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          CO.sub.2 Me                                                                          COMe                                                               Cl    CO.sub.2 Et                                                                          H     OCF.sub.3                                                                             CO.sub.2 Et                                                                          COEt                                            Br    CO.sub.2 Et                                                                          H     Cl     CO.sub.2 Et                                                                          CO.sub.2 Me                                     CF.sub.3                                                                             CO.sub.2 Et                                                                          H     Br     CO.sub.2 Et                                                                          CO.sub.2 Me                                     OCF.sub.3                                                                            CO.sub.2 Et                                                                          H     CF.sub.3                                                                              CO.sub.2 Et                                                                          CO.sub.2 Me                                     Cl    CO.sub.2 Et                                                                          Me    OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Me                                     Br    CO.sub.2 Et                                                                          Me    Cl     CO.sub.2 Et                                                                          CO.sub.2 Et                                     CF.sub.3                                                                             CO.sub.2 Et                                                                          Me    Br     CO.sub.2 Et                                                                          CO.sub.2 Et                                     OCF.sub.3                                                                            CO.sub.2 Et                                                                          Me    CF.sub.3                                                                              CO.sub.2 Et                                                                          CO.sub.2 Et                                     Cl    CO.sub.2 Et                                                                          Et    OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 Et                                     Br    CO.sub.2 Et                                                                          Et    Cl     CO.sub.2 Et                                                                          CH.sub.2 OMe                                    CF.sub.3                                                                             CO.sub.2 Et                                                                          Et    Br     CO.sub.2 Et                                                                          CH.sub.2 OMe                                    OCF.sub.3                                                                            CO.sub.2 Et                                                                          Et    CF.sub.3                                                                              CO.sub.2 Et                                                                          CH.sub.2 OMe                                    Cl    CO.sub.2 Et                                                                          n-Pr  OCF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 OMe                                    Br    CO.sub.2 Et                                                                          n-Pr  Cl     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             CO.sub.2 Et                                                                          n-Pr  Br     CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            CO.sub.2 Et                                                                          n-Pr  CF.sub.3                                                                              CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                             Cl    CO.sub.2 Et                                                                          COMe  OCF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                             Br    CO.sub.2 Et                                                                          COMe  Cl     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             CO.sub.2 Et                                                                          COMe  Br     CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            CO.sub.2 Et                                                                          COMe  CF.sub.3                                                                              CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                              Cl    CO.sub.2 Et                                                                          COEt  OCF.sub.3                                                                             CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                              Br    CO.sub.2 Et                                                                          COEt  OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          COEt                                            CF.sub.3                                                                             CO.sub.2 Et                                                                          COEt  OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          CO.sub.2 Me                                     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          H     OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          CO.sub.2 Et                                     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Me    OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          CH.sub.2 OMe                                    OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          Et    OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          n-Pr  OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          COMe                                                               Cl    Ph    H     OCF.sub.3                                                                             Ph    COEt                                            Br    Ph    H     Cl     Ph    CO.sub.2 Me                                     CF.sub.3                                                                             Ph    H     Br     Ph    CO.sub.2 Me                                     OCF.sub.3                                                                            Ph    H     CF.sub.3                                                                              Ph    CO.sub.2 Me                                     Cl    Ph    Me    OCF.sub.3                                                                             Ph    CO.sub.2 Me                                     Br    Ph    Me    Cl     Ph    CO.sub.2 Et                                     CF.sub.3                                                                             Ph    Me    Br     Ph    CO.sub.2 Et                                     OCF.sub.3                                                                            Ph    Me    CF.sub.3                                                                              Ph    CO.sub.2 Et                                     Cl    Ph    Et    OCF.sub.3                                                                             Ph    CO.sub.2 Et                                     Br    Ph    Et    Cl     Ph    CH.sub.2 OMe                                    CF.sub.3                                                                             Ph    Et    Br     Ph    CH.sub.2 OMe                                    OCF.sub.3                                                                            Ph    Et    CF.sub.3                                                                              Ph    CH.sub.2 OMe                                    Cl    Ph    n-Pr  OCF.sub.3                                                                             Ph    CH.sub.2 OMe                                    Br    Ph    n-Pr  Cl     Ph    CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             Ph    n-Pr  Br     Ph    CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            Ph    n-Pr  CF.sub.3                                                                              Ph    CH.sub.2 CHCH.sub.2                             Cl    Ph    COMe  OCF.sub.3                                                                             Ph    CH.sub.2 CHCH.sub.2                             Br    Ph    COMe  Cl     Ph    CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             Ph    COMe  Br     Ph    CH.sub.2 CH.sub.3                               OCF.sub.3                                                                            Ph    COMe  CF.sub.3                                                                              Ph    CH.sub.2 CH.sub.3                               Cl    Ph    COEt  OCF.sub.3                                                                             Ph    CH.sub.2 SCH.sub.3                              Br    Ph    COEt  OCF.sub.2 H                                                                           Ph    COEt                                            CF.sub.3                                                                             Ph    COEt  OCF.sub.2 H                                                                           Ph    CO.sub.2 Me                                     OCF.sub.2 H                                                                          Ph    H     OCF.sub.2 H                                                                           Ph    CO.sub.2 Et                                     OCF.sub.2 H                                                                          Ph    Me    OCF.sub.2 H                                                                           Ph    CH.sub.2 OMe                                    OCF.sub.2 H                                                                          Ph    Et    OCF.sub.2 H                                                                           Ph    CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          Ph    n-Pr  OCF.sub.2 H                                                                           Ph    CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          Ph    COMe                                                               Cl    4-ClPh                                                                               H     OCF.sub.3                                                                             4-ClPh                                                                               COEt                                            Br    4-ClPh                                                                               H     Cl     4-ClPh                                                                               CO.sub.2 Me                                     CF.sub.3                                                                             4-ClPh                                                                               H     Br     4-ClPh                                                                               CO.sub.2 Me                                     OCF.sub.3                                                                            4-ClPh                                                                               H     CF.sub.3                                                                              4-ClPh                                                                               CO.sub.2 Me                                     Cl    4-ClPh                                                                               Me    OCF.sub.3                                                                             4-ClPh                                                                               CO.sub.2 Me                                     Br    4-ClPh                                                                               Me    Cl     4-ClPh                                                                               CO.sub.2 Et                                     CF.sub.3                                                                             4-ClPh                                                                               Me    Br     4-ClPh                                                                               CO.sub.2 Et                                     CF.sub.3                                                                             4-ClPh                                                                               Me    CF.sub.3                                                                              4-ClPh                                                                               CO.sub.2 Et                                     Cl    4-ClPh                                                                               Et    OCF.sub.3                                                                             4-ClPh                                                                               CO.sub.2 Et                                     Br    4-ClPh                                                                               Et    Cl     4-ClPh                                                                               CH.sub.2 OMe                                    CF.sub.3                                                                             4-ClPh                                                                               Et    Br     4-ClPh                                                                               CH.sub.2 OMe                                    OCF.sub.3                                                                            4-ClPh                                                                               Et    CF.sub.3                                                                              4-ClPh                                                                               CH.sub.2 OMe                                    Cl    4-ClPh                                                                               n-Pr  OCF.sub.3                                                                             4-ClPh                                                                               CH.sub.2 OMe                                    Br    4-ClPh                                                                               n-Pr  Cl     4-ClPh                                                                               CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             4-ClPh                                                                               n-Pr  Br     4-ClPh                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            4-ClPh                                                                               n-Pr  CF.sub.3                                                                              4-ClPh                                                                               CH.sub.2 CHCH.sub.2                             Cl    4-ClPh                                                                               COMe  OCF.sub.3                                                                             4-ClPh                                                                               CH.sub.2 CHCH.sub.2                             Br    4-ClPh                                                                               COMe  Cl     4-ClPh                                                                               CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             4-ClPh                                                                               COMe  Br     4-ClPh                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            4-ClPh                                                                               COMe  CF.sub.3                                                                              4-ClPh                                                                               CH.sub.2 SCH.sub.3                              Cl    4-ClPh                                                                               COEt  OCF.sub.3                                                                             4-ClPh                                                                               CH.sub.2 SCH.sub.3                              Br    4-ClPh                                                                               COEt  OCF.sub.2 H                                                                           4-ClPh                                                                               COEt                                            CF.sub.3                                                                             4-ClPh                                                                               COEt  OCF.sub.2 H                                                                           4-ClPh                                                                               CO.sub.2 Me                                     OCF.sub.2 H                                                                          4-ClPh                                                                               H     OCF.sub.2 H                                                                           4-ClPh                                                                               CO.sub.2 Et                                     OCF.sub.2 H                                                                          4-ClPh                                                                               Me    OCF.sub.2 H                                                                           4-ClPh                                                                               CH.sub.2 OMe                                    OCF.sub.2 H                                                                          4-ClPh                                                                               Et    OCF.sub.2 H                                                                           4-ClPh                                                                               CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          4-ClPh                                                                               n-Pr  OCF.sub.2 H                                                                           4-ClPh                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          4-ClPh                                                                               COMe                                                               Cl    4-FPh H     OCF.sub.3                                                                             4-FPh COEt                                            Br    4-FPh H     Cl     4-FPh CO.sub.2 Me                                     CF.sub.3                                                                             4-FPh H     Br     4-FPh CO.sub.2 Me                                     OCF.sub.3                                                                            4-FPh H     CF.sub.3                                                                              4-FPh CO.sub.2 Me                                     Cl    4-FPh Me    OCF.sub.3                                                                             4-FPh CO.sub.2 Me                                     Br    4-FPh Me    Cl     4-FPh CO.sub.2 Et                                     CF.sub.3                                                                             4-FPh Me    Br     4-FPh CO.sub.2 Et                                     OCF.sub.3                                                                            4-FPh Me    CF.sub.3                                                                              4-FPh CO.sub.2 Et                                     Cl    4-FPh Et    OCF.sub.3                                                                             4-FPh CO.sub.2 Et                                     Br    4-FPh Et    Cl     4-FPh CH.sub.2 OMe                                    CF.sub.3                                                                             4-FPh Et    Br     4-FPh CH.sub.2 OMe                                    OCF.sub.3                                                                            4-FPh Et    CF.sub.3                                                                              4-FPh CH.sub.2 OMe                                    Cl    4-FPh n-Pr  OCF.sub.3                                                                             4-FPh CH.sub.2 OMe                                    Br    4-FPh n-Pr  Cl     4-FPh CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             4-FPh n-Pr  Br     4-FPh CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            4-FPh n-Pr  CF.sub.3                                                                              4-FPh CH.sub.2 CHCH.sub.2                             Cl    4-FPh COMe  OCF.sub.3                                                                             4-FPh CH.sub.2 CHCH.sub.2                             Br    4-FPh COMe  Cl     4-FPh CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             4-FPh COMe  Br     4-FPh CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            4-FPh COMe  CF.sub.3                                                                              4-FPh CH.sub.2 SCH.sub.3                              Cl    4-FPh COEt  OCF.sub.3                                                                             4-FPh CH.sub.2 SCH.sub.3                              Br    4-FPh COEt  OCF.sub.2 H                                                                           4-FPh COEt                                            CF.sub.3                                                                             4-FPh COEt  OCF.sub.2 H                                                                           4-FPh CO.sub.2 Me                                     OCF.sub.2 H                                                                          4-FPh H     OCF.sub.2 H                                                                           4-FPh CO.sub.2 Et                                     OCF.sub.2 H                                                                          4-FPh Me    OCF.sub.2 H                                                                           4-FPh CH.sub.2 OMe                                    OCF.sub.2 H                                                                          4-FPh Et    OCF.sub.2 H                                                                           4-FPh CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          4-FPh n-Pr  OCF.sub.2 H                                                                           4-F Ph                                                                               CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          4-FPh COMe                                                               Cl    CHCH.sub.2                                                                           H     OCF.sub.3                                                                             CHCH.sub.2                                                                           COEt                                            Br    CHCH.sub.2                                                                           H     Cl     CHCH.sub.2                                                                           CO.sub.2 Me                                     CF.sub.3                                                                             CHCH.sub.2                                                                           H     Er     CHCH.sub.2                                                                           CO.sub.2 Me                                     OCF.sub.3                                                                            CHCH.sub.2                                                                           H     CF.sub.3                                                                              CHCH.sub.2                                                                           CO.sub.2 Me                                     Cl    CHCH.sub.2                                                                           Me    OCF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Me                                     Br    CHCH.sub.2                                                                           Me    Cl     CHCH.sub.2                                                                           Co Et                                           CF.sub.3                                                                             CHCH.sub.2                                                                           Me    Br     CHCH.sub.2                                                                           CO.sub.2 Et                                     OCF.sub.3                                                                            CHCH.sub.2                                                                           Me    CF.sub.3                                                                              CHCH.sub.2                                                                           CO.sub.2 Et                                     Cl    CHCH.sub.2                                                                           Et    OCF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 Et                                     Br    CHCH.sub.2                                                                           Et    Cl     CHCH.sub.2                                                                           CH.sub.2 OMe                                    CF.sub.3                                                                             CHCH.sub.2                                                                           Et    Br     CHCH.sub.2                                                                           CH.sub.2 OMe                                    OCF.sub.3                                                                            CHCH.sub.2                                                                           Et    CF.sub.3                                                                              CHCH.sub.2                                                                           CH.sub.2 OMe                                    Cl    CHCH.sub.2                                                                           n-Pr  OCF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 OMe                                    Br    CHCH.sub.2                                                                           n-Pr  Cl     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             CHCH.sub.2                                                                           n-Pr  Br     CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            CHCH.sub.2                                                                           n-Pr  CF.sub.3                                                                              CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                             Cl    CHCH.sub.2                                                                           COMe  OCF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                             Br    CHCH.sub.2                                                                           COMe  Cl     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             CHCH.sub.2                                                                           COMe  Br     CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            CHCH.sub.2                                                                           COMe  CF.sub.3                                                                              CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                              Cl    CHCH.sub.2                                                                           COEt  OCF.sub.3                                                                             CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                              Br    CHCH.sub.2                                                                           COEt  OCF.sub.2 H                                                                           CHCH.sub.2                                                                           COEt                                            CF.sub.3                                                                             CHCH.sub.2                                                                           COEt  OCF.sub.2 H                                                                           CHCH.sub.2                                                                           CO.sub.2 Me                                     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           H     OCF.sub.2 H                                                                           CHCH.sub.2                                                                           CO.sub.2 Et                                     OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Me    OCF.sub.2 H                                                                           CHCH.sub.2                                                                           CH.sub.2 OMe                                    OCF.sub.2 H                                                                          CHCH.sub.2                                                                           Et    OCF.sub.2 H                                                                           CHCH.sub.2                                                                           CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                           n-Pr  OCF.sub.2 H                                                                           CHCH.sub.2                                                                           CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          CHCH.sub.2                                                                           COMe                                                               Cl    C(CH.sub.3)CH.sub.2                                                                  H     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COEt                                            Br    C(CH.sub.3)CH.sub.2                                                                  H     Cl     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  H     Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  H     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                     Cl    C(CH.sub.3)CH.sub.2                                                                  Me    OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                     Br    C(CH.sub.3)CH.sub.2                                                                  Me    Cl     C(CH.sub.3)CH.sub.2                                                                  Co Et                                           CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Me    Br     C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Me    CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                     Cl    C(CH.sub.3)CH.sub.2                                                                  Et    OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                     Br    C(CH.sub.3)CH.sub.2                                                                  Et    Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                    CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  Et    Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                    OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  Et    CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                    Cl    C(CH.sub.3)CH.sub.2                                                                  n-Pr  OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                    Br    C(CH.sub.3)CH.sub.2                                                                  n-Pr  Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  n-Pr  Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  n-Pr  CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                             Cl    C(CH.sub.3)CH.sub.2                                                                  COMe  OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                             Br    C(CH.sub.3)CH.sub.2                                                                  COMe  Cl     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                              CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COMe  Br     C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                              OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                  COMe  CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                              Cl    C(CH.sub.3)CH.sub.2                                                                  COEt  OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                              Br    C(CH.sub.3)CH.sub.2                                                                  COEt  OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                  COEt                                            CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  COEt  OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Me                                     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  H     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 Et                                     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Me    OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 OMe                                    OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  Et    OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 CHCH.sub.2                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  n-Pr  OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                  CH.sub.2 SCH.sub.3                              OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                  COMe                                                               CF.sub.3                                                                             Me    CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                              n-Pr  CO.sub.2 (n-Pr)                                 CF.sub.3                                                                             Me    CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                              n-Pr  CO.sub.2 (i-Pr)                                 CF.sub.3                                                                             Me    CO(n-Pr)                                                                             CF.sub.3                                                                              n-Pr  CO(n-Pr)                                        CF.sub.3                                                                             Me    CO(i-Pr)                                                                             CF.sub.3                                                                              n-Pr  CO(i-Pr)                                        CF.sub.3                                                                             Me    CO(t-Bu)                                                                             CF.sub.3                                                                              n-Pr  CO(t-Bu)                                        CF.sub.3                                                                             Me    CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                              n-Pr  CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                            Me    CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                             n-Pr  CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                            Me    CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                             n-Pr  CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                            Me    CO (n-Pr)                                                                            OCF.sub.3 .                                                                           n-Pr  CO (n-Pr)                                       OCF.sub.3                                                                            Me    CO(i-Pr)                                                                             OCF.sub.3                                                                             n-Pr  CO(i-Pr)                                        OCF.sub.3                                                                            Me    CO(t-Bu)                                                                             OCF.sub.3                                                                             n-Pr  CO(t-Bu)                                        OCF.sub.3                                                                            Me    CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                             n-Pr  CO.sub.2 (t-Bu)                                 CF.sub.3                                                                             Et    CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                              i-Pr  CO.sub.2 (n-Pr)                                 CF.sub.3                                                                             Et    CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                              i-Pr  CO.sub.2 (i-Pr)                                 CF.sub.3                                                                             Et    CO(n-Pr)                                                                             CF.sub.3                                                                              i-Pr  CO(n-Pr)                                        CF.sub.3                                                                             Et    CO(i-Pr)                                                                             CF.sub.3                                                                              i-Pr  CO(i-Pr)                                        CF.sub.3                                                                             Et    CO(t-Bu)                                                                             CF.sub.3                                                                              i-Pr  CO(t-Bu)                                        CF.sub.3                                                                             Et    CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                              i-Pr  CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                            Et    CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                             i-Pr  CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                            Et    CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                             i-Pr  CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                            Et    CO(n-Pr)                                                                             OCF.sub.3                                                                             i-Pr  CO(n-Pr)                                        OCF.sub.3                                                                            Et    CO(i-Pr)                                                                             OCF.sub.3                                                                             i-Pr  CO(i-Pr)                                        OCF.sub.3                                                                            Et    CO(t-Bu)                                                                             OCF.sub.3                                                                             i-Pr  CO(t-Bu)                                        OCF.sub.3                                                                            Et    CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                             i-Pr  CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                          Me    Co(n-Pr)                                                                             OCF.sub.2 H                                                                           Et    CO(i-Pr)                                        OCF.sub.2 H                                                                          Me    CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                           Et    CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                          Me    CO(i-Pr)                                                                             OCF.sub.2 H                                                                           Et    CO(t-Bu)                                        OCF.sub.2 H                                                                          Me    CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                           Et    CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                          Me    CO(t-Bu)                                                                             OCF.sub.2 H                                                                           n-Pr  CO(n-Pr)                                        OCF.sub.2 H                                                                          Me    CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                           n-Pr  CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                          Et    CO(n-Pr)                                                                             OCF.sub.2 H                                                                           n-Pr  CO(i-Pr)                                        OCF.sub.2 H                                                                          Et    CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                           n-Pr  CO.sub.2 (i-Pr)                                 CF.sub.3                                                                             i-Bu  CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                              CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                 CF.sub.3                                                                             i-Bu  CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                              CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                 CF.sub.3                                                                             i-Bu  CO(n-Pr)                                                                             CF.sub.3                                                                              CO.sub.2 Et                                                                          CO(n- Pr)                                       CF.sub.3                                                                             i-Bu  CO(i-Pr)                                                                             CF.sub.3                                                                              CO.sub.2 Et                                                                          CO(i-Pr)                                        CF.sub.3                                                                             i-Bu  CO(t-Bu)                                                                             CF.sub.3                                                                              CO.sub.2 Et                                                                          CO(t-Bu)                                        CF.sub.3                                                                             i-Bu  CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                              CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                            i-Bu  CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                            i-Bu  CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                            i-Bu  CO(n-Pr)                                                                             OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO(n-Pr)                                        OCF.sub.3                                                                            i-Bu  CO(i-Pr)                                                                             OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO(i-Pr)                                        OCF.sub.3                                                                            i-Bu  CO(t-Bu)                                                                             OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO(t-Bu)                                        OCF.sub.3                                                                            i-Bu  CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                             CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                 CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                              Ph    CO.sub.2 (n-Pr)                                 CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                              Ph    CO.sub.2 (i-Pr)                                 CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(n-Pr)                                                                             CF.sub.3                                                                              Ph    CO(n-Pr)                                        CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(i-Pr)                                                                             CF.sub.3                                                                              Ph    CO(i-Pr)                                        CF.sub.3                                                                             CO.sub.2 Me                                                                          CO(t-Bu)                                                                             CF.sub.3                                                                              Ph    CO(t-Bu)                                        CF.sub.3                                                                             CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                              Ph    CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                             Ph    CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                             Ph    CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(n-Pr)                                                                             OCF.sub.3                                                                             Ph    CO(n-Pr)                                        OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(i-Pr)                                                                             OCF.sub.3                                                                             Ph    CO(i- Pr)                                       OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO(t-Bu)                                                                             OCF.sub.3                                                                             Ph    CO(t-Bu)                                        OCF.sub.3                                                                            CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                             Ph    CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                          n-Pr  CO(t-Bu)                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO(i-Pr)                                        OCF.sub.2 H                                                                          n-Pr  CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO.sub.2 (i Pr)                                 OCF.sub.2 H                                                                          i-Pr  CO(i-Pr)                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO(t-Bu)                                        OCF.sub.2 H                                                                          i-Pr  CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                          i-Pr  CO(t-Bu)                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO(n-Pr)                                        OCF.sub.2 H                                                                          i-Pr  CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                           CO.sub.2 Me                                                                          CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                          i-Pr  CO(n-Pr)                                                                             OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          CO(n-Pr)                                        OCF.sub.2 H                                                                          i-Pr  CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                           CO.sub.2 Et                                                                          CO.sub.2 (n-Pr)                                 CF.sub.3                                                                             4-ClPh                                                                               CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                              CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                 CF.sub.3                                                                             4-ClPh                                                                               CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                              CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                 CF.sub.3                                                                             4-ClPh                                                                               CO(n-Pr)                                                                             CF.sub.3                                                                              CHCH  CO(n-Pr)                                        CF.sub.3                                                                             4-ClPh                                                                               CO(i-Pr)                                                                             CF.sub.3                                                                              CHCH.sub.2                                                                           CO(i-Pr)                                        CF.sub.3                                                                             4-ClPh                                                                               CO(t-Bu)                                                                             CF.sub.3                                                                              CHCH.sub.2                                                                           CO(t-Bu)                                        CF.sub.3                                                                             4-ClPh                                                                               CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                              CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                            4-ClPh                                                                               CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                            4-ClPh                                                                               CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                            4-ClPh                                                                               CO(n-Pr)                                                                             OCF.sub.3                                                                             CHCH.sub.2                                                                           CO(n-Pr)                                        OCF.sub.3                                                                            4-ClPh                                                                               CO(i-Pr)                                                                             OCF.sub.3                                                                             CHCH.sub.2                                                                           CO(i-Pr)                                        OCF.sub.3                                                                            4-ClPh                                                                               CO(t-Bu)                                                                             OCF.sub.3                                                                             CHCH.sub.2                                                                           CO(t-Bu)                                        OCF.sub.3                                                                            4-ClPh                                                                               CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                             CHCH.sub.2                                                                           CO.sub.2 (t-Bu)                                 CF.sub.3                                                                             4-FPh CO.sub.2 (n-Pr)                                                                      CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                 CF.sub.3                                                                             4-FPh CO.sub.2 (i-Pr)                                                                      CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                 CF.sub.3                                                                             4-FPh CO(n-Pr)                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                        CF.sub.3                                                                             4-FPh CO(i-Pr)                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                        CF.sub.3                                                                             4-FPh CO(t-Bu)                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                        CF.sub.3                                                                             4-FPh CO.sub.2 (t-Bu)                                                                      CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                 OCF.sub.3                                                                            4-FPh CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (n-Pr)                                 OCF.sub.3                                                                            4-FPh CO.sub.2 (i-Pr)                                                                      OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (i-Pr)                                 OCF.sub.3                                                                            4-FPh CO(n-Pr)                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(n-Pr)                                        OCF.sub.3                                                                            4-FPh CO(i-Pr)                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(i-Pr)                                        OCF.sub.3                                                                            4-FPh CO(t-Bu)                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO(t-Bu)                                        OCF.sub.3                                                                            4-FPh CO.sub.2 (t-Bu)                                                                      OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                  CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(i-Pr)                                                                             OCF.sub.2 H                                                                           4-ClPh                                                                               CO(t-Bu)                                        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                           4-ClPh                                                                               CO.sub.2 (t-Bu)                                 OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO(t-Bu)                                                                             OCF.sub.2 H                                                                           4-FPh CO(n-Pr)                                        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                          CO.sub.2 (t-Bu)                                                                      OCF.sub.2 H                                                                           4-FPh CO.sub.2 (n-Pr)                                 OCF.sub.2 H                                                                          4-ClPh                                                                               CO(n-Pr)                                                                             OCF.sub.2 H                                                                           4-FPh CO(i-Pr)                                        OCF.sub.2 H                                                                          4-ClPh                                                                               CO.sub.2 (n-Pr)                                                                      OCF.sub.2 H                                                                           4-FPh CO.sub.2 (i-Pr)                                 OCF.sub.2 H                                                                          4-ClPh                                                                               CO(i-Pr)                                                                             OCF.sub.2 H                                                                           4-FPh CO(t-Bu)                                        OCF.sub.2 H                                                                          4-ClPh                                                                               CO.sub.2 (i-Pr)                                                                      OCF.sub.2 H                                                                           4-FPh CO.sub.2 (t-Bu)                                 __________________________________________________________________________

                  TABLE 5                                                          ______________________________________                                          ##STR43##                                                                     R.sup.1                                                                              R.sup.3   Y        R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         Cl    Me        H        OCF.sub.3                                                                            Me      COEt                                    Br    Me        H        Cl    Me      CO.sub.2 Me                             CF.sub.3                                                                             Me        H        Br    Me      CO.sub.2 Me                             OCF.sub.3                                                                            Me        H        CF.sub.3                                                                             Me      CO.sub.2 Me                             Cl    Me        Me       OCF.sub.3                                                                            Me      CO.sub.2 Me                             Br    Me        Me       Cl    Me      CO.sub.2 Et                             CF.sub.3                                                                             Me        Me       Br    Me      CO.sub.2 Et                             OCF.sub.3                                                                            Me        Me       CF.sub.3                                                                             Me      CO.sub.2 Et                             Cl    Me        Et       OCF.sub.3                                                                            Me      CO.sub.2 Et                             Br    Me        Et       Cl    Me      CH.sub.2 OMe                            CF.sub.3                                                                             Me        Et       Br    Me      CH.sub.2 OMe                            OCF.sub.3                                                                            Me        Et       CF.sub.3                                                                             Me      CH.sub.2 OMe                            Cl    Me        n-Pr     OCF.sub.3                                                                            Me      CH.sub.2 OMe                            Br    Me        n-Pr     Cl    Me      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Me        n-Pr     Br    Me      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Me        n-Pr     CF.sub.3                                                                             Me      CH.sub.2 CHCH.sub.2                     Cl    Me        COMe     OCF.sub.3                                                                            Me      CH.sub.2 CHCH.sub.2                     Br    Me        COMe     Cl    Me      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Me        COMe     Br    Me      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Me        COMe     CF.sub.3                                                                             Me      CH.sub.2 SCH.sub.3                      Cl    Me        COEt     OCF.sub.3                                                                            Me      CH.sub.2 SCH.sub.3                      Br    Me        COEt     OCF.sub.2 H                                                                          Me      H                                       CF.sub.3                                                                             Me        COEt     OCF.sub.2 H                                                                          Me      Me                                      Cl    Et        H        OCF.sub.3                                                                            Et      COEt                                    Br    Et        H        Cl    Et      CO.sub.2 Me                             CF.sub.3                                                                             Et        H        Br    Et      CO.sub.2 Me                             OCF.sub.3                                                                            Et        H        CF.sub.3                                                                             Et      CO.sub.2 Me                             Cl    Et        Me       OCF.sub.3                                                                            Et      CO.sub.2 Me                             Br    Et        Me       Cl    Et      CO.sub.2 Et                             CF.sub.3                                                                             Et        Me       Br    Et      CO.sub.2 Et                             OCF.sub.3                                                                            Et        Me       CF.sub.3                                                                             Et      CO.sub.2 Et                             Cl    Et        Et       OCF.sub.3                                                                            Et      CO.sub.2 Et                             Br    Et        Et       Cl    Et      CH.sub.2 OMe                            CF.sub.3                                                                             Et        Et       Br    Et      CH.sub.2 OMe                            OCF.sub.3                                                                            Et        Et       CF.sub.3                                                                             Et      CH.sub.2 OMe                            Cl    Et        n-Pr     OCF.sub.3                                                                            Et      CH.sub.2 OMe                            Br    Et        n-Pr     Cl    Et      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Et        n-Pr     Br    Et      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Et        n-Pr     CF.sub.3                                                                             Et      CH.sub.2 CHCH.sub.2                     Cl    Et        COMe     OCF.sub.3                                                                            Et      CH.sub.2 CHCH.sub.2                     Br    Et        COMe     Cl    Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COMe     Br    Et      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Et        COMe     CF.sub.3                                                                             Et      CH.sub.2 SCH.sub.3                      Cl    Et        COEt     OCF.sub.3                                                                            Et      CH.sub.2 SCH.sub.3                      Br    Et        COEt     OCF.sub.2 H                                                                          Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COEt     OCF.sub.2 H                                                                          Me      Et                                      OCF.sub.2 H                                                                          Et        H        OCF.sub.2 H                                                                          Me      n-Pr                                    OCF.sub.2 H                                                                          Et        Me       OCF.sub.2 H                                                                          Me      COMe                                    OCF.sub.2 H                                                                          Et        Et       OCF.sub.2 H                                                                          Me      COEt                                    OCF.sub.2 H                                                                          Et        n-Pr     OCF.sub.2 H                                                                          Me      CO.sub.2 Me                             OCF.sub.2 H                                                                          Et        COMe     OCF.sub.2 H                                                                          Me      CO.sub.2 Et                             OCF.sub.2 H                                                                          Et        COEt     OCF.sub.2 H                                                                          Me      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Et        CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Et        CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Et        CH.sub.2 OMe                                                   OCF.sub.2 H                                                                          Et        CH.sub.2 CHCH.sub.2                                            Cl    n-Pr      H        OCF.sub.3                                                                            n-Pr    COEt                                    Br    n-Pr      H        Cl    n-Pr    CO.sub.2 Me                             CF.sub.3                                                                             n-Pr      H        Br    n-Pr    CO2Me                                   OCF.sub.3                                                                            n-Pr      H        CF.sub.3                                                                             n-Pr    CO.sub.2 Me                             Cl    n-Pr      Me       OCF.sub.3                                                                            n-Pr    CO.sub.2 Me                             Br    n-Pr      Me       Cl    n-Pr    CO.sub.2 Et                             CF.sub.3                                                                             n-Pr      Me       Br    n-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            n-Pr      Me       CF.sub.3                                                                             n-Pr    CO.sub.2 Et                             Cl    n-Pr      Et       OCF.sub.3                                                                            n-Pr    CO.sub.2 Et                             Br    n-Pr      Et       Cl    n-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             n-Pr      Et       Br    n-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            n-Pr      Et       CF.sub.3                                                                             n-Pr    CH.sub.2 OMe                            Cl    n-Pr      n-Pr     OCF.sub.3                                                                            n-Pr    CH.sub.2 OMe                            Br    n-Pr      n-Pr     Cl    n-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             n-Pr      n-Pr     Br    n-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            n-Pr      n-Pr     CF.sub.3                                                                             n-Pr    CH.sub.2 CHCH.sub.2                     Cl    n-Pr      COMe     OCF.sub.3                                                                            n-Pr    CH.sub.2 CHCH.sub.2                     Br    n-Pr      COMe     Cl    n-Pr    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             n-Pr      COMe     Br    n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            n-Pr      COMe     CF.sub.3                                                                             n-Pr    CH.sub.2 SCH.sub.3                      Cl    n-Pr      COEt     OCF.sub.3                                                                            n-Pr    CH.sub.2 SCH.sub.3                      Br    n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    COEt                                    CF.sub.3                                                                             n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Me                             OCF.sub.2 H                                                                          n-Pr      H        OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Et                             OCF.sub.2 H                                                                          n-Pr      Me       OCF.sub.2 H                                                                          n-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          n-Pr      Et       OCF.sub.2 H                                                                          n-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          n-Pr      n-Pr     OCF.sub.2 H                                                                          n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 M                                                                          n-Pr      COMe                                                           Cl    i-Pr      H        OCF.sub.3                                                                            i-Pr    COEt                                    Br    i-Pr      H        Cl    i-Pr    CO.sub.2 Me                             CF.sub.3                                                                             i-Pr      H        Br    i-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            i-Pr      H        CF.sub.3                                                                             i-Pr    CO.sub.2 Me                             Cl    i-Pr      Me       OCF.sub.3                                                                            i-Pr    CO.sub.2 Me                             Br    i-Pr      Me       Cl    i-Pr    CO.sub.2 Et                             CF.sub.3                                                                             i-Pr      Me       Br    i-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            i-Pr      Me       CF.sub.3                                                                             i-Pr    CO.sub.2 Et                             Cl    i-Pr      Et       OCF.sub.3                                                                            i-Pr    CO.sub.2 Et                             Br    i-Pr      Et       Cl    i-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             i-Pr      Et       Br    i-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Pr      Et       CF.sub.3                                                                             i-Pr    CH.sub.2 OMe                            Cl    i-Pr      n-Pr     OCF.sub.3                                                                            i-Pr    CH.sub.2 OMe                            Br    i-Pr      n-Pr     Cl    i-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Pr      n-Pr     Br    i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Pr      n-Pr     CF.sub.3                                                                             i-Pr    CH.sub.2 CHCH.sub.2                     Cl    i-Pr      COMe     OCF.sub.3                                                                            i-Pr    CH.sub.2 CHCH.sub.2                     Br    i-Pr      COMe     Cl    i-Pr    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             i-Pr      COMe     Br    i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Pr      COMe     CF.sub.3                                                                             i-Pr    CH.sub.2 SCH.sub.3                      Cl    i-Pr      COEt     OCF.sub.3                                                                            i-Pr    CH.sub.2 SCH.sub.3                      Br    i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    COEt                                    CF.sub.3                                                                             i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Pr      H        OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Pr      Me       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Pr      Et       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Pr      n-Pr     OCF.sub.2 H                                                                          i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Pr      COMe                                                           Cl    i-Bu      H        OCF.sub.3                                                                            i-Bu    COEt                                    Br    i-Bu      H        Cl    i-Bu    CO.sub.2 Me                             CF.sub.3                                                                             i-Bu      H        Br    i-Bu    CO.sub.2 Me                             OCF.sub.3                                                                            i-Bu      H        CF.sub.3                                                                             i-Bu    CO.sub.2 Me                             Cl    i-Bu      Me       OCF.sub.3                                                                            i-Bu    CO.sub.2 Me                             Br    i-Bu      Me       Cl    i-Bu    CO.sub.2 Et                             CF.sub.3                                                                             i-Bu      Me       Br    i-Bu    CO.sub.2 Et                             OCF.sub.3                                                                            i-Bu      Me       CF.sub.3                                                                             i-Bu    CO.sub.2 Et                             Cl    i-Bu      Et       OCF.sub.3                                                                            i-Bu    CO.sub.2 Et                             Br    i-Bu      Et       Cl    i-Bu    CH.sub.2 OMe                            CF.sub.3                                                                             i-Bu      Et       Br    i-Bu    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Bu      Et       CF.sub.3                                                                             i-Bu    CH.sub.2 OMe                            Cl    i-Bu      n-Pr     OCF.sub.3                                                                            i-Bu    CH.sub.2 OMe                            Br    i-Bu      n-Pr     Cl    i-Bu    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Bu      n-Pr     Br    i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Bu      n-Pr     CF.sub.3                                                                             i-Bu    CH.sub.2 CHCH.sub.2                     Cl    i-Bu      COMe     OCF.sub.3                                                                            i-Bu    CH.sub.2 CHCH.sub.2                     Br    i-Bu      COMe     Cl    i-Bu    CH2SCH.sub.3                            CF.sub.3                                                                             i-Bu      COMe     Br    i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Bu      COMe     CF.sub.3                                                                             i-Bu    CH.sub.2 SCH.sub.3                      Cl    i-Bu      COEt     OCF.sub.3                                                                            i-Bu    CH.sub.2 SCH.sub.3                      Br    i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    COEt                                    CF.sub.3                                                                             i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Bu      H        OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Bu      Me       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Bu      Et       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Bu      n-Pr     OCF.sub.2 H                                                                          i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Bu      COMe                                                           Cl    CO.sub.2 Me                                                                              H        OCF.sub.3                                                                            CO2Me   COEt                                    Br    CO.sub.2 Me                                                                              H        Cl    CO.sub.2 Me                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                              H        Br    CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              H        CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Me                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                             Br    CO.sub.2 Me                                                                              Me       Cl    CO.sub.2 Me                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                              Me       Br    CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              Me       CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Me                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                             Br    CO.sub.2 Me                                                                              Et       Cl    CO.sub.2 Me                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Me                                                                              Et       Br    CO.sub.2 Me                                                                            CH.sub.2 OMe                            OCF.sub.3                                                                            CO.sub.2 Me                                                                              Et       CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Me                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Me                                                                              n-Pr     Cl    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Me                                                                              n-Pr     Br    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Me                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Me                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Me                                                                              COMe     Cl    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Me                                                                              COMe     Br    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Me                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Me                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              COMe                                                           Cl    CO.sub.2 Et                                                                              H        OCF.sub.3                                                                            CO.sub.2 Et                                                                            COEt                                    Br    CO.sub.2 Et                                                                              H        Cl    CO.sub.2 Et                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Et                                                                              H        Br    CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              H        CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Et                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Me                             Br    CO.sub.2 Et                                                                              Me       Cl    CO.sub.2 Et                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Et                                                                              Me       Br    CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              Me       CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Et                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Et                             Br    CO.sub.2 Et                                                                              Et       Cl    CO.sub.2 Et                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Et                                                                              Et       Br    CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.3                                                                            CO.sub.2 Et                                                                              Et       CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Et                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Et                                                                              n-Pr     Cl    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Et                                                                              n-Pr     Br    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Et                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Et                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Et                                                                              COMe     Cl    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Et                                                                              COMe     Br    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Et                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Et                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              COMe                                                           Cl    Ph        H        OCF.sub.3                                                                            Ph      COEt                                    Br    Ph        H        Cl    Ph      CO.sub.2 Me                             CF.sub.3                                                                             Ph        H        Br    Ph      CO.sub.2 Me                             OCF.sub.3                                                                            Ph        H        CF.sub.3                                                                             Ph      CO.sub.2 Me                             Cl    Ph        Me       OCF.sub.3                                                                            Ph      CO.sub.2 Me                             Br    Ph        Me       Cl    Ph      CO.sub.2 Et                             CF.sub.3                                                                             Ph        Me       Br    Ph      CO.sub.2 Et                             OCF.sub.3                                                                            Ph        Me       CF.sub.3                                                                             Ph      CO.sub.2 Et                             Cl    Ph        Et       OCF.sub.3                                                                            Ph      CO.sub.2 Et                             Br    Ph        Et       Cl    Ph      CH.sub.2 OMe                            CF.sub.3                                                                             Ph        Et       Br    Ph      CH.sub.2 OMe                            OCF.sub.3                                                                            Ph        Et       CF.sub.3                                                                             Ph      CH.sub.2 OMe                            Cl    Ph        n-Pr     OCF.sub.3                                                                            Ph      CH.sub.2 OMe                            Br    Ph        n-Pr     Cl    Ph      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Ph        n-Pr     Br    Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Ph        n-Pr     CF.sub.3                                                                             Ph      CH.sub.2 CHCH.sub.2                     Cl    Ph        COMe     OCF.sub.3                                                                            Ph      CH.sub.2 CHCH.sub.2                     Br    Ph        COMe     Cl    Ph      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Ph        COMe     Br    Ph      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Ph        COMe     CF.sub.3                                                                             Ph      CH.sub.2 SCH.sub.3                      Cl    Ph        COEt     OCF.sub.3                                                                            Ph      CH.sub.2 SCH.sub.3                      Br    Ph        COEt     OCF.sub.2 H                                                                          Ph      COEt                                    CF.sub.3                                                                             Ph        COEt     OCF.sub.2 H                                                                          Ph      CO.sub.2 Me                             OCF.sub.2 H                                                                          Ph        H        OCF.sub.2 H                                                                          Ph      CO.sub.2 Et                             OCF.sub.2 H                                                                          Ph        Me       OCF.sub.2 H                                                                          Ph      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Ph        Et       OCF.sub.2 H                                                                          Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Ph        n-Pr     OCF.sub.2 H                                                                          Ph      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Ph        COMe                                                           Cl    4-ClPh    H        OCF.sub.3                                                                            4-ClPh  COEt                                    Br    4-ClPh    H        Cl    4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             4-ClPh    H        Br    4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            4-ClPh    H        CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             Cl    4-ClPh    Me       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             Br    4-ClPh    Me       Cl    4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             4-ClPh    Me       Br    4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            4-ClPh    Me       CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             Cl    4-ClPh    Et       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             Br    4-ClPh    Et       Cl    4-ClPh  CH.sub.2 OMe                            CF.sub.3                                                                             4-ClPh    Et       Br    4-ClPh  CH.sub.2 OMe                            OCF.sub.3                                                                            4-ClPh    Et       CF.sub.3                                                                             4-ClPh  CH.sub.2 OMe                            Cl    4-ClPh    n-Pr     OCF.sub.3                                                                            4-ClPh  CH.sub.2 OMe                            Br    4-ClPh    n-Pr     Cl    4-ClPh  CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-ClPh    n-Pr     Br    4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-ClPh    n-Pr     CF.sub.3                                                                             4-ClPh  CH.sub.2 CHCH.sub.2                     Cl    4-ClPh    COMe     OCF.sub.3                                                                            4-ClPh  CH.sub.2 CHCH.sub.2                     Br    4-ClPh    COMe     Cl    4-ClPh  CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-ClPh    COMe     Br    4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-ClPh    COMe     CF.sub.3                                                                             4-ClPh  CH.sub.2 SCH.sub.3                      Cl    4-ClPh    COEt     OCF.sub.3                                                                            4-ClPh  CH.sub.2 SCH.sub.3                      Br    4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  COEt                                    CF.sub.3                                                                             4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Me                             OCF.sub.2 H                                                                          4-ClPh    H        OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Et                             OCF.sub.2 H                                                                          4-ClPh    Me       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-ClPh    Et       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-ClPh    n-Pr     OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-ClPh    COMe                                                           Cl    4-FPh     H        OCF.sub.3                                                                            4-FPh   COEt                                    Br    4-FPh     H        Cl    4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             4-FPh     H        Br    4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            4-FPh     H        CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             Cl    4-FPh     Me       OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             Br    4-FPh     Me       Cl    4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             4-FPh     Me       Br    4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            4-FPh     Me       CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             Cl    4-FPh     Et       OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             Br    4-FPh     Et       Cl    4-FPh   CH.sub.2 OMe                            CF.sub.3                                                                             4-FPh     Et       Br    4-FPh   CH.sub.2 OMe                            OCF.sub.3                                                                            4-FPh     Et       CF.sub.3                                                                             4-FPh   CH.sub.2 OMe                            Cl    4-FPh     n-Pr     OCF.sub.3                                                                            4-FPh   CH.sub.2 OMe                            Br    4-FPh     n-Pr     Cl    4-FPh   CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-FPh     n-Pr     Br    4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-FPh     n-Pr     CF.sub.3                                                                             4-FPh   CH.sub.2 CHCH.sub.2                     Cl    4-FPh     COMe     OCF.sub.3                                                                            4-FPh   CH.sub.2 CHCH.sub.2                     Br    4-FPh     COMe     Cl    4-FPh   CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-FPh     COMe     Br    4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-FPh     COMe     CF.sub.3                                                                             4-FPh   CH.sub.2 SCH.sub.3                      Cl    4-FPh     COEt     OCF.sub.3                                                                            4-FPh   CH.sub.2 SCH.sub.3                      Br    4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   COEt                                    CF.sub.3                                                                             4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Me                             OCF.sub.2 H                                                                          4-FPh     H        OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Et                             OCF.sub.2 H                                                                          4-FPh     Me       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-FPh     Et       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-FPh     n-Pr     OCF.sub.2 H                                                                          4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-FPh     COMe                                                           Cl    CHCH.sub.2                                                                               H        OCF.sub.3                                                                            CHCH.sub.2                                                                             COEt                                    Br    CHCH.sub.2                                                                               H        Cl    CHCH.sub.2                                                                             CO.sub.2 Me                             CF.sub.3                                                                             CHCH.sub.2                                                                               H        Br    CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.3                                                                            CHCH.sub.2                                                                               H        CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                             Cl    CHCH.sub.2                                                                               Me       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Me                             Br    CHCH.sub.2                                                                               Me       Cl    CHCH.sub.2                                                                             CO.sub.2 Et                             CF.sub.3                                                                             CHCH.sub.2                                                                               Me       Br    CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.3                                                                            CHCH.sub.2                                                                               Me       CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Et                             Cl    CHCH.sub.2                                                                               Et       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Et                             Br    CHCH.sub.2                                                                               Et       Cl    CHCH.sub.2                                                                             CH.sub.2 OMe                            CF.sub.3                                                                             CHCH.sub.2                                                                               Et       Br    CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.3                                                                            CHCH.sub.2                                                                               Et       CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 OMe                            Cl    CHCH.sub.2                                                                               n-Pr     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 OMe                            Br    CHCH.sub.2                                                                               n-Pr     Cl    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CHCH.sub.2                                                                               n-Pr     Br    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CHCH.sub.2                                                                               n-Pr     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Cl    CHCH.sub.2                                                                               COMe     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Br    CHCH.sub.2                                                                               COMe     Cl    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CHCH.sub.2                                                                               COMe     Br    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CHCH.sub.2                                                                               COMe     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Cl    CHCH.sub.2                                                                               COEt     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Br    CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             COEt                                    CF.sub.3                                                                             CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               H        OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Me       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Et       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CHCH.sub.2                                                                               n-Pr     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CHCH.sub.2                                                                               COMe                                                           Cl    C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    COEt                                    Br    C(CH.sub.3)CH.sub.2                                                                      H        Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      H        Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      H        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Cl    C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Br    C(CH.sub.3)CH.sub.2                                                                      Me       Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Me       Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Me       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Cl    C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Br    C(CH.sub.3)CH.sub.2                                                                      Et       Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Et       Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Et       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Cl    C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Br    C(CH.sub.3)CH.sub.2                                                                      n-Pr     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      n-Pr     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      n-Pr     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Cl    C(CH.sub.3)CH.sub.2                                                                      COMe     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Br    C(CH.sub.3)CH.sub.2                                                                      COMe     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COMe     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      COMe     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Cl    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Br    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    COEt                                    CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      COMe                                                           CF.sub.3                                                                             Me        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Me        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Me        CO(n-Pr) CF.sub.3                                                                             n-Pr    CO(n-Pr)                                CF.sub.3                                                                             Me        CO(i-Pr) CF.sub.3                                                                             n-Pr    CO(i-Pr)                                CF.sub.3                                                                             Me        CO(t-Bu) CF.sub.3                                                                             n-Pr    CO(t-Bu)                                CF.sub.3                                                                             Me        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Me        CO(n-Pr) OCF.sub.3                                                                            n-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Me        CO(i-Pr) OCF.sub.3                                                                            n-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Me        CO(t-Bu) OCF.sub.3                                                                            n-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Et        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Et        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Et        CO(n-Pr) CF.sub.3                                                                             i-Pr    CO(n-Pr)                                CF.sub.3                                                                             Et        CO(i-Pr) CF.sub.3                                                                             i-Pr    CO(i-Pr)                                CF.sub.3                                                                             Et        CO(t-Bu) CF.sub.3                                                                             i-Pr    CO(t-Bu)                                CF.sub.3                                                                             Et        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Et        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Et        CO(n-Pr) OCF.sub.3                                                                            i-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Et        CO(n-Pr) OCF.sub.3                                                                            i-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Et        CO(t-Bu) OCF.sub.3                                                                            i-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Et        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(n-Pr) OCF.sub.2 H                                                                          Et      CO(i-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          Me        CO(i-Pr) OCF.sub.2 H                                                                          Et      CO(t-Bu)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(t-Bu) OCF.sub.2 H                                                                          n-Pr    CO(n-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          Et        CO(n-Pr) OCF.sub.2 H                                                                          n-Pr    CO(i-Pr)                                OCF.sub.2 H                                                                          Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO(n-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(n-Pr)                                CF.sub.3                                                                             i-Bu      CO(i-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(i-Pr)                                CF.sub.3                                                                             i-Bu      CO(t-Bu) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(t-Bu)                                CF.sub.3                                                                             i-Bu      CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            i-Bu      CO(n-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.3                                                                            i-Bu      CO(i-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(i-Pr)                                OCF.sub.3                                                                            i-Bu      CO(t-Bu) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(t-Bu)                                OCF.sub.3                                                                            i-Bu      CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (n-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (i-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(n-Pr) CF.sub.3                                                                             Ph      CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(i-Pr) CF.sub.3                                                                             Ph      CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(t-Bu) CF.sub.3                                                                             Ph      CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(n-Pr) OCF.sub.3                                                                            Ph      CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(i-Pr) OCF.sub.3                                                                            Ph      CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(t-Bu) OCF.sub.3                                                                            Ph      CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          n-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(i-Pr)                                OCF.sub.2 H                                                                          n-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(i-Pr) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(t-Bu)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          i-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(n-Pr) OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-ClPh    CO(n-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(n-Pr)                                CF.sub.3                                                                             4-ClPh    CO(i-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(i-Pr)                                CF.sub.3                                                                             4-ClPh    CO(t-Bu) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(t-Bu)                                CF.sub.3                                                                             4-ClPh    CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-ClPh    CO(n-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(n-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(i-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(i-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(t-Bu) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(t-Bu)                                OCF.sub.3                                                                            4-ClPh    CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-FPh     CO(n-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                CF.sub.3                                                                             4-FPh     CO(i-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                CF.sub.3                                                                             4-FPh     CO(t-Bu) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                CF.sub.3                                                                             4-FPh     CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-FPh     CO(n-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                OCF.sub.3                                                                            4-FPh     CO(i-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                OCF.sub.3                                                                            4-FPh     CO(t-Bu) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                OCF.sub.3                                                                            4-FPh     CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(i-Pr) OCF.sub.2 H                                                                          4-ClPh  CO(t-Bu)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(t-Bu) OCF.sub.2 H                                                                          4-FPh   CO(n-Pr)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(n-Pr) OCF.sub.2 H                                                                          4-FPh   CO(i-Pr)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(i-Pr) OCF.sub.2 H                                                                          4-FPh   CO(t-Bu)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (t-Bu)                         ______________________________________                                    

                  TABLE 6                                                          ______________________________________                                          ##STR44##                                                                     R.sup.1                                                                              R.sup.3   Y        R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         Cl    Me        H        OCF.sub.3                                                                            Me      COEt                                    Br    Me        H        Cl    Me      CO.sub.2 Me                             CF.sub.3                                                                             Me        H        Br    Me      CO.sub.2 Me                             OCF.sub.3                                                                            Me        H        CF.sub.3                                                                             Me      CO.sub.2 Me                             Cl    Me        Me       OCF.sub.3                                                                            Me      CO.sub.2 Me                             Br    Me        Me       Cl    Me      CO.sub.2 Et                             CF.sub.3                                                                             Me        Me       Br    Me      CO.sub.2 Et                             OCF.sub.3                                                                            Me        Me       CF.sub.3                                                                             Me      CO.sub.2 Et                             Cl    Me        Et       OCF.sub.3                                                                            Me      CO.sub.2 Et                             Br    Me        Et       Cl    Me      CH.sub.2 OMe                            CF.sub.3                                                                             Me        Et       Br    Me      CH.sub.2 OMe                            OCF.sub.3                                                                            Me        Et       CF.sub.3                                                                             Me      CH.sub.2 OMe                            Cl    Me        n-Pr     OCF.sub.3                                                                            Me      CH.sub.2 OMe                            Br    Me        n-Pr     Cl    Me      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Me        n-Pr     Br    Me      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Me        n-Pr     CF.sub.3                                                                             Me      CH.sub.2 CHCH.sub.2                     Cl    Me        COMe     OCF.sub.3                                                                            Me      CH.sub.2 CHCH.sub.2                     Br    Me        COMe     Cl    Me      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Me        COMe     Br    Me      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Me        COMe     CF.sub.3                                                                             Me      CH.sub.2 SCH.sub.3                      Cl    Me        COEt     OCF.sub.3                                                                            Me      CH.sub.2 SCH.sub.3                      Br    Me        COEt     OCF.sub.2 H                                                                          Me      H                                       CF.sub.3                                                                             Me        COEt     OCF.sub.2 H                                                                          Me      Me                                      Cl    Et        H        OCF.sub.3                                                                            Et      COEt                                    Br    Et        H        Cl    Et      CO.sub.2 Me                             CF.sub.3                                                                             Et        H        Br    Et      CO.sub.2 Me                             OCF.sub.3                                                                            Et        H        CF.sub.3                                                                             Et      CO.sub.2 Me                             Cl    Et        Me       OCF.sub.3                                                                            Et      CO.sub.2 Me                             Br    Et        Me       Cl    Et      CO.sub.2 Et                             CF.sub.3                                                                             Et        Me       Br    Et      CO.sub.2 Et                             OCF.sub.3                                                                            Et        Me       CF.sub.3                                                                             Et      CO.sub.2 Et                             Cl    Et        Et       OCF.sub.3                                                                            Et      CO.sub.2 Et                             Br    Et        Et       Cl    Et      CH.sub.2 OMe                            CF.sub.3                                                                             Et        Et       Br    Et      CH.sub.2 OMe                            OCF.sub.3                                                                            Et        Et       CF.sub.3                                                                             Et      CH.sub.2 OMe                            Cl    Et        n-Pr     OCF.sub.3                                                                            Et      CH.sub.2 OMe                            Br    Et        n-Pr     Cl    Et      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Et        n-Pr     Br    Et      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Et        n-Pr     CF.sub.3                                                                             Et      CH.sub.2 CHCH.sub.2                     Cl    Et        COMe     OCF.sub.3                                                                            Et      CH.sub.2 CHCH.sub.2                     Br    Et        COMe     Cl    Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COMe     Br    Et      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Et        COMe     CF.sub.3                                                                             Et      CH.sub.2 SCH.sub.3                      Cl    Et        COEt     OCF.sub.3                                                                            Et      CH.sub.2 SCH.sub.3                      Br    Et        COEt     OCF.sub.2 H                                                                          Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COEt     OCF.sub.2 H                                                                          Me      Et                                      OCF.sub.2 H                                                                          Et        H        OCF.sub.2 H                                                                          Me      n-Pr                                    OCF.sub.2 H                                                                          Et        Me       OCF.sub.2 H                                                                          Me      COMe                                    OCF.sub.2 H                                                                          Et        Et       OCF.sub.2 H                                                                          Me      COEt                                    OCF.sub.2 H                                                                          Et        n-Pr     OCF.sub.2 H                                                                          Me      CO.sub.2 Me                             OCF.sub.2 H                                                                          Et        COMe     OCF.sub.2 H                                                                          Me      CO.sub.2 Et                             OCF.sub.2 H                                                                          Et        COEt     OCF.sub.2 H                                                                          Me      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Et        CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Et        CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Et        CH.sub.2 OMe                                                                            OCF.sub.3                                                                            n-Pr    COEt                                    OCF.sub.2 H                                                                          Et        CH.sub.2 CHCH.sub.2                                                                     Cl    n-Pr    CO.sub.2 Me                             Cl    n-Pr      H        Br    n-Pr    CO.sub.2 Me                             Br    n-Pr      H        CF.sub.3                                                                             n-Pr    CO.sub.2 Me                             CF.sub.3                                                                             n-Pr      H        OCF.sub.3                                                                            n-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            n-Pr      H        Cl    n-Pr    CO.sub.2 Et                             Cl    n-Pr      Me       Br    n-Pr    CO.sub.2 Et                             Br    n-Pr      Me       CF.sub.3                                                                             n-Pr    CO.sub.2 Et                             CF.sub.3                                                                             n-Pr      Me       OCF.sub.3                                                                            n-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            n-Pr      Me       Cl    n-Pr    CH.sub.2 OMe                            Cl    n-Pr      Et       Br    n-Pr    CH.sub.2 OMe                            Br    n-Pr      Et       CF.sub.3                                                                             n-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             n-Pr      Et       OCF.sub.3                                                                            n-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            n-Pr      Et       Cl    n-Pr    CH.sub.2 CHCH.sub.2                     Cl    n-Pr      n-Pr     Br    n-Pr    CH.sub.2 CHCH.sub.2                     Br    n-Pr      n-Pr     CF.sub.3                                                                             n-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             n-Pr      n-Pr     OCF.sub.3                                                                            n-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            n-Pr      n-Pr     Cl    n-Pr    CH.sub.2 SCH.sub.3                      Cl    n-Pr      COMe     Br    n-Pr    CH.sub.2 SCH.sub.3                      Br    n-Pr      COMe     CF.sub.3                                                                             n-Pr    CH.sub.2 SCM.sub.3                      CF.sub.3                                                                             n-Pr      COMe     OCF.sub.3                                                                            n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            n-Pr      COMe     OCF.sub.2 H                                                                          n-Pr    COEt                                    Cl    n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Me                             Br    n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Et                             CF.sub.3                                                                             n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          n-Pr      H        OCF.sub.2 H                                                                          n-Pr    CH.sub.2 CHC.sub.2                      OCF.sub.2 H                                                                          n-Pr      Me       OCF.sub.2 H                                                                          n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          n-Pr      Et                                                             OCF.sub.2 H                                                                          n-Pr      n-Pr                                                           OCF.sub.2 H                                                                          n-Pr      COMe                                                           Cl    i-Pr      H        OCF.sub.3                                                                            i-Pr    COEt                                    Br    i-Pr      H        Cl    i-Pr    CO.sub.2 Me                             CF.sub.3                                                                             i-Pr      H        Br    i-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            i-Pr      H        CF.sub.3                                                                             i-Pr    CO.sub.2 Me                             Cl    i-Pr      Me       OCF.sub.3                                                                            i-Pr    CO.sub.2 Me                             Br    i-Pr      Me       Cl    i-Pr    CO.sub.2 Et                             CF.sub.3                                                                             i-Pr      Me       Br    i-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            i-Pr      Me       CF.sub.3                                                                             i-Pr    CO.sub.2 Et                             Cl    i-Pr      Et       OCF.sub.3                                                                            i-Pr    CO.sub.2 Et                             Br    i-Pr      Et       Cl    i-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             i-Pr      Et       Br    i-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Pr      Et       CF.sub.3                                                                             i-Pr    CH.sub.2 OMe                            Cl    i-Pr      n-Pr     OCF.sub.3                                                                            i-Pr    CH.sub.2 OMe                            Br    i-Pr      n-Pr     Cl    i-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Pr      n-Pr     Br    i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Pr      n-Pr     CF.sub.3                                                                             i-Pr    CH.sub.2 CHCH.sub.2                     Cl    i-Pr      COMe     OCF.sub.3                                                                            i-Pr    CH.sub.2 CHCH.sub.2                     Br    i-Pr      COMe     Cl    i-Pr    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             i-Pr      COMe     Br    i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Pr      COMe     CF.sub.3                                                                             i-Pr    CH.sub.2 SCH.sub.3                      Cl    i-Pr      COEt     OCF.sub.3                                                                            i-Pr    CH.sub.2 SCH.sub.3                      Br    i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    COEt                                    CF.sub.3                                                                             i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Pr      H        OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Pr      Me       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Pr      Et       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Pr      n-Pr     OCF.sub.2 H                                                                          i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Pr      COMe                                                           Cl    i-Bu      H        OCF.sub.3                                                                            i-Bu    COEt                                    Br    i-Bu      H        Cl    i-Bu    CO.sub.2 Me                             CF.sub.3                                                                             i-Bu      H        Br    i-Bu    CO.sub.2 Me                             OCF.sub.3                                                                            i-Bu      H        CF.sub.3                                                                             i-Bu    CO.sub.2 Me                             Cl    i-Bu      Me       OCF.sub.3                                                                            i-Bu    CO.sub.2 Me                             Br    i-Bu      Me       Cl    i-Bu    CO.sub.2 Et                             CF.sub.3                                                                             i-Bu      Me       Br    i-Bu    CO.sub.2 Et                             OCF.sub.3                                                                            i-Bu      Me       CF.sub.3                                                                             i-Bu    CO.sub.2 Et                             Cl    i-Bu      Et       OCF.sub.3                                                                            i-Bu    CO.sub.2 Et                             Br    i-Bu      Et       Cl    i-Bu    CH.sub.2 OMe                            CF.sub.3                                                                             i-Bu      Et       Br    i-Bu    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Bu      Et       CF.sub.3                                                                             i-Bu    CH.sub.2 OMe                            Cl    i-Bu      n-Pr     OCF.sub.3                                                                            i-Bu    CH.sub.2 OMe                            Br    i-Bu      n-Pr     Cl    i-Bu    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Bu      n-Pr     Br    i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Bu      n-Pr     CF.sub.3                                                                             i-Bu    CH.sub.2 CHCH.sub.2                     Cl    i-Bu      COMe     OCF.sub.3                                                                            i-Bu    CH.sub.2 CHCH.sub.2                     Br    i-Bu      COMe     Cl    i-Bu    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             i-Bu      COMe     Br    i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Bu      COMe     CF.sub.3                                                                             i-Bu    CH.sub.2 SCH.sub.3                      Cl    i-Bu      COEt     OCF.sub.3                                                                            i-Bu    CH.sub.2 SCH.sub.3                      Br    i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    COEt                                    CF.sub.3                                                                             i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Bu      H        OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Bu      Me       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Bu      Et       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Bu      n-Pr     OCF.sub.2 H                                                                          i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Bu      COMe                                                           Cl    CO.sub.2 Me                                                                              H        OCF.sub.3                                                                            CO.sub.2 Me                                                                            COEt                                    Br    CO.sub.2 Me                                                                              H        Cl    CO.sub.2 Me                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                              H        Br    CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              H        CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Me                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                             Br    CO.sub.2 Me                                                                              Me       Cl    CO.sub.2 Me                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                              Me       Br    CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              Me       CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Me                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                             Br    CO.sub.2 Me                                                                              Et       Cl    CO.sub.2 Me                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Me                                                                              Et       Br    CO.sub.2 Me                                                                            CH.sub.2 CMe                            OCF.sub.3                                                                            CO.sub.2 Me                                                                              Et       CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Me                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Me                                                                              n-Pr     Cl    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Me                                                                              n-Pr     Br    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Me                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Me                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Me                                                                              COMe     Cl    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Me                                                                              COMe     Br    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Me                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Me                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              COMe                                                           Cl    CO.sub.2 Et                                                                              H        OCF.sub.3                                                                            CO.sub.2 Et                                                                            COEt                                    Br    CO.sub.2 Et                                                                              H        Cl    CO.sub.2 Et                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Et                                                                              H        Br    CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              H        CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Et                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Me                             Br    CO.sub.2 Et                                                                              Me       Cl    CO.sub.2 Et                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Et                                                                              Me       Br    CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              Me       CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Et                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Et                             Br    CO.sub.2 Et                                                                              Et       Cl    CO.sub.2 Et                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Et                                                                              Et       Br    CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.3                                                                            CO.sub.2 Et                                                                              Et       CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Et                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Et                                                                              n-Pr     Cl    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Et                                                                              n-Pr     Br    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Et                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Et                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Et                                                                              COMe     Cl    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Et                                                                              COMe     Br    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Et                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Et                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              COMe                                                           Cl    Ph        H        OCF.sub.3                                                                            Ph      COEt                                    Br    Ph        H        Cl    Ph      CO.sub.2 Me                             CF.sub.3                                                                             Ph        H        Br    Ph      CO.sub.2 Me                             OCF.sub.3                                                                            Ph        H        CF.sub.3                                                                             Ph      CO.sub.2 Me                             Cl    Ph        Me       OCF.sub.3                                                                            Ph      CO.sub.2 Me                             Br    Ph        Me       Cl    Ph      CO.sub.2 Et                             CF.sub.3                                                                             Ph        Me       Br    Ph      CO.sub.2 Et                             OCF.sub.3                                                                            Ph        Me       CF.sub.3                                                                             Ph      CO.sub.2 Et                             Cl    Ph        Et       OCF.sub.3                                                                            Ph      CO.sub.2 Et                             Br    Ph        Et       Cl    Ph      CH.sub.2 OMe                            CF.sub.3                                                                             Ph        Et       Br    Ph      CH.sub.2 OMe                            OCF.sub.3                                                                            Ph        Et       CF.sub.3                                                                             Ph      CH.sub.2 OMe                            Cl    Ph        n-Pr     OCF.sub.3                                                                            Ph      CH.sub.2 OMe                            Br    Ph        n-Pr     Cl    Ph      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Ph        n-Pr     Br    Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Ph        n-Pr     CF.sub.3                                                                             Ph      CH.sub.2 CHCH.sub.2                     Cl    Ph        COMe     OCF.sub.3                                                                            Ph      CH.sub.2 CHCH.sub.2                     Br    Ph        COMe     Cl    Ph      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Ph        COMe     Br    Ph      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Ph        COMe     CF.sub.3                                                                             Ph      CH.sub.2 SCH.sub.3                      Cl    Ph        COEt     OCF.sub.3                                                                            Ph      CH.sub.2 SCH.sub.3                      Br    Ph        COEt     OCF.sub.2 H                                                                          Ph      COEt                                    CF.sub.3                                                                             Ph        COEt     OCF.sub.2 H                                                                          Ph      CO.sub.2 Me                             OCF.sub.2 H                                                                          Ph        H        OCF.sub.2 H                                                                          Ph      CO.sub.2 Et                             OCF.sub.2 H                                                                          Ph        Me       OCF.sub.2 H                                                                          Ph      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Ph        Et       OCF.sub.2 H                                                                          Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Ph        n-Pr     OCF.sub.2 H                                                                          Ph      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Ph        COMe                                                           Cl    4-ClPh    H        OCF.sub.3                                                                            4-ClPh  COEt                                    Br    4-ClPh    H        Cl    4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             4-ClPh    H        Br    4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            4-ClPh    H        CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             Cl    4-ClPh    Me       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             Br    4-ClPh    Me       Cl    4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             4-ClPh    Me       Br    4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            4-ClPh    Me       CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             Cl    4-ClPh    Et       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             Br    4-ClPh    Et       Cl    4-ClPh  CH.sub.2 OMe                            CF.sub.3                                                                             4-ClPh    Et       Br    4-ClPh  CH.sub.2 OMe                            OCF.sub.3                                                                            4-ClPh    Et       CF.sub.3                                                                             4-ClPh  CH.sub.2 OMe                            Cl    4-ClPh    n-Pr     OCF.sub.3                                                                            4-ClPh  CH.sub.2 OMe                            Br    4-ClPh    n-Pr     Cl    4-ClPh  CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-ClPh    n-Pr     Br    4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-ClPh    n-Pr     CF.sub.3                                                                             4-ClPh  CH.sub.2 CHCH.sub.2                     Cl    4-ClPh    COMe     OCF.sub.3                                                                            4-ClPh  CH.sub.2 CHCH.sub.2                     Br    4-ClPh    COMe     Cl    4-ClPh  CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-ClPh    COMe     Br    4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-ClPh    COMe     CF.sub.3                                                                             4-ClPh  CH.sub.2 SCH.sub.3                      Cl    4-ClPh    COEt     OCF.sub.3                                                                            4-ClPh  CH.sub.2 SCH.sub.3                      Br    4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  COEt                                    CF.sub.3                                                                             4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Me                             OCF.sub.2 H                                                                          4-ClPh    H        OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Et                             OCF.sub.2 H                                                                          4-ClPh    Me       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-ClPh    Et       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-ClPh    n-Pr     OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-ClPh    COMe                                                           Cl    4-FPh     H        OCF.sub.3                                                                            4-FPh   COEt                                    Br    4-FPh     H        Cl    4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             4-FPh     H        Br    4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            4-FPh     H        CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             Cl    4-FPh     Me       OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             Br    4-FPh     Me       Cl    4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             4-FPh     Me       Br    4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            4-FPh     Me       CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             Cl    4-FPh     Et       OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             Br    4-FPh     Et       Cl    4-FPh   CH.sub.2 OMe                            CF.sub.3                                                                             4-FPh     Et       Br    4-FPh   CH.sub.2 OMe                            OCF.sub.3                                                                            4-FPh     Et       CF.sub.3                                                                             4-FPh   CH.sub.2 OMe                            Cl    4-FPh     n-Pr     OCF.sub.3                                                                            4-FPh   CH.sub.2 OMe                            Br    4-FPh     n-Pr     Cl    4-FPh   CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-FPh     n-Pr     Br    4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-FPh     n-Pr     CF.sub.3                                                                             4-FPh   CH.sub.2 CHCH.sub.2                     Cl    4-FPh     COMe     OCF.sub.3                                                                            4-FPh   CH.sub.2 CHCH.sub.2                     Br    4-FPh     COMe     Cl    4-FPh   CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-FPh     COMe     Br    4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-FPh     COMe     CF.sub.3                                                                             4-FPh   CH.sub.2 SCH.sub.3                      Cl    4-FPh     COEt     OCF.sub.3                                                                            4-FPh   CH.sub.2 SCH.sub.3                      Br    4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   COEt                                    CF.sub.3                                                                             4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Me                             OCF.sub.2 H                                                                          4-FPh     H        OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Et                             OCF.sub.2 H                                                                          4-FPh     Me       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-FPh     Et       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-FPh     n-Pr     OCF.sub.2 H                                                                          4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-FPh     COMe                                                           Cl    CHCH.sub.2                                                                               H        OCF.sub.3                                                                            CHCH.sub.2                                                                             COEt                                    Br    CHCH.sub.2                                                                               H        Cl    CHCH.sub.2                                                                             CO.sub.2 Me                             CF.sub.3                                                                             CHCH.sub.2                                                                               H        Br    CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.3                                                                            CHCH.sub.2                                                                               H        CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                             Cl    CHCH.sub.2                                                                               Me       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Me                             Br    CHCH.sub.2                                                                               Me       Cl    CHCH.sub.2                                                                             CO.sub.2 Et                             CF.sub.3                                                                             CHCH.sub.2                                                                               Me       Br    CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.3                                                                            CHCH.sub.2                                                                               Me       CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Et                             Cl    CHCH.sub.2                                                                               Et       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Et                             Br    CHCH.sub.2                                                                               Et       Cl    CHCH.sub.2                                                                             CH.sub.2 OMe                            CF.sub.3                                                                             CHCH.sub.2                                                                               Et       Br    CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.3                                                                            CHCH.sub.2                                                                               Et       CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 OMe                            Cl    CHCH.sub.2                                                                               n-Pr     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 OMe                            Br    CHCH.sub.2                                                                               n-Pr     Cl    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CHCH.sub.2                                                                               n-Pr     Br    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CHCH.sub.2                                                                               n-Pr     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Cl    CHCH.sub.2                                                                               COMe     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Br    CHCH.sub.2                                                                               COMe     Cl    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CHCH.sub.2                                                                               COMe     Br    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CHCH.sub.2                                                                               COMe     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Cl    CHCH.sub.2                                                                               COEt     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Br    CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             COEt                                    CF.sub.3                                                                             CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               H        OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Me       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Et       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CHCH.sub.2                                                                               n-Pr     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CHCH.sub.2                                                                               COMe                                                           Cl    C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    COEt                                    Br    C(CH.sub.3)CH.sub.2                                                                      H        Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      H        Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      H        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Cl    C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Br    C(CH.sub.3)CH.sub.2                                                                      Me       Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Me       Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Me       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Cl    C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Br    C(CH.sub.3)CH.sub.2                                                                      Et       Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Et       Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Et       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Cl    C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Br    C(CH.sub.3)CH.sub.2                                                                      n-Pr     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      n-Pr     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      n-Pr     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Cl    C(CH.sub.3)CH.sub.2                                                                      COMe     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Br    C(CH.sub.3)CH.sub.2                                                                      COMe     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COMe     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      COMe     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Cl    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Br    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    COEt                                    CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      COMe                                                           CF.sub.3                                                                             Me        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Me        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Me        CO(n-Pr) CF.sub.3                                                                             n-Pr    CO(n-Pr)                                CF.sub.3                                                                             Me        CO(i-Pr) CF.sub.3                                                                             n-Pr    CO(i-Pr)                                CF.sub.3                                                                             Me        CO(t-u)  CF.sub.3                                                                             n-Pr    CO(t-Bu)                                CF.sub.3                                                                             Me        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Me        CO(n-Pr) OCF.sub.3                                                                            n-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Me        CO(i-Pr) OCF.sub.3                                                                            n-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Me        CO(t-Bu) OCF.sub.3                                                                            n-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Et        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Et        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Et        CO(n-Pr) CF.sub.3                                                                             i-Pr    CO(n-Pr)                                CF.sub.3                                                                             Et        CO(i-Pr) CF.sub.3                                                                             i-Pr    CO(i-Pr)                                CF.sub.3                                                                             Et        CO(t-Bu) CF.sub.3                                                                             i-Pr    CO(t-Bu)                                CF.sub.3                                                                             Et        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Et        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Et        CO(n-Pr) OCF.sub.3                                                                            i-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Et        CO(i-Pr) OCF.sub.3                                                                            i-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Et        CO(t-Bu) OCF.sub.3                                                                            i-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Et        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(n-Pr) OCF.sub.2 H                                                                          Et      CO(i-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          Me        CO(i-Pr) OCF.sub.2 H                                                                          Et      CO(t-Bu)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(t-Bu) OCF.sub.2 H                                                                          n-Pr    CO(n-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          Et        CO(n-Pr) OCF.sub.2 H                                                                          n-Pr    CO(i-Pr)                                OCF.sub.2 H                                                                          Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO(n-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(n-Pr)                                CF.sub.3                                                                             i-Bu      CO(i-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(i-Pr)                                CF.sub.3                                                                             i-Bu      CO(t-Bu) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(t-Bu)                                CF.sub.3                                                                             i-Bu      CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            i-Bu      CO(n-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.3                                                                            i-Bu      CO(i-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(i-Pr)                                OCF.sub.3                                                                            i-Bu      CO(t-Bu) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(t-Bu)                                OCF.sub.3                                                                            i-Bu      CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (n-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (i-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(n-Pr) CF.sub.3                                                                             Ph      CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(i-Pr) CF.sub.3                                                                             Ph      CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(t-Bu) CF.sub.3                                                                             Ph      CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(n-Pr) OCF.sub.3                                                                            Ph      CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(i-Pr) OCF.sub.3                                                                            Ph      CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(t-Bu) OCF.sub.3                                                                            Ph      CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          n-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(i-Pr)                                OCF.sub.2 H                                                                          n-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(i-Pr) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(t-Bu)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          i-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(n-Pr) OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-ClPh    CO(n-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(n-Pr)                                CF.sub.3                                                                             4-ClPh    CO(i-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(i-Pr)                                CF.sub.3                                                                             4-ClPh    CO(t-Bu) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(t-Bu)                                CF.sub.3                                                                             4-ClPh    CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-ClPh    CO(n-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(n-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(i-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(i-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(t-Bu) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(t-Bu)                                OCF.sub.3                                                                            4-ClPh    CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-FPh     CO(n-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                CF.sub.3                                                                             4-FPh     CO(i-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                CF.sub.3                                                                             4-FPh     CO(t-Bu) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                CF.sub.3                                                                             4-FPh     CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-FPh     CO(n-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                OCF.sub.3                                                                            4-FPh     CO(i-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                OCF.sub.3                                                                            4-FPh     CO(t-Bu) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                OCF.sub.3                                                                            4-FPh     CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(i-Pr) OCF.sub.2 H                                                                          4-ClPh  CO(t-Bu)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(t-Bu) OCF.sub.2 H                                                                          4-FPh   CO(n-Pr)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(n-Pr) OCF.sub.2 H                                                                          4-FPh   CO(i-Pr)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(i-Pr) OCF.sub.2 H                                                                          4-FPh   CO(t-Bu)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (t-Bu)                         ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                          ##STR45##                                                                     R.sup.1                                                                              R.sup.3   Y        R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         Cl    Me        H        OCF.sub.3                                                                            Me      COEt                                    Br    Me        H        Cl    Me      CO.sub.2 Me                             CF.sub.3                                                                             Me        H        Br    Me      CO.sub.2 Me                             OCF.sub.3                                                                            Me        H        CF.sub.3                                                                             Me      CO.sub.2 Me                             Cl    Me        Me       OCF.sub.3                                                                            Me      CO.sub.2 Me                             Br    Me        Me       Cl    Me      CO.sub.2 Et                             CF.sub.3                                                                             Me        Me       Br    Me      CO.sub.2 Et                             OCF.sub.3                                                                            Me        Me       CF.sub.3                                                                             Me      CO.sub.2 Et                             Cl    Me        Et       OCF.sub.3                                                                            Me      CO.sub.2 Et                             Br    Me        Et       Cl    Me      CH.sub.2 OMe                            CF.sub.3                                                                             Me        Et       Br    Me      CH.sub.2 OMe                            OCF.sub.3                                                                            Me        Et       CF.sub.3                                                                             Me      CH.sub.2 OMe                            Cl    Me        n-Pr     OCF.sub.3                                                                            Me      CH.sub.2 OMe                            Br    Me        n-Pr     Cl    Me      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Me        n-Pr     Br    Me      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Me        n-Pr     CF.sub.3                                                                             Me      CH.sub.2 CHCH.sub.2                     Cl    Me        COMe     OCF.sub.3                                                                            Me      CH.sub.2 CHCH.sub.2                     Br    Me        COMe     Cl    Me      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Me        COMe     Br    Me      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Me        COMe     CF.sub.3                                                                             Me      CH.sub.2 SCH.sub.3                      Cl    Me        COEt     OCF.sub.3                                                                            Me      CH.sub.2 SCH.sub.3                      Br    Me        COEt     OCF.sub.2 H                                                                          Me      H                                       CF.sub.3                                                                             Me        COEt     OCF.sub.2 H                                                                          Me      Me                                      Cl    Et        H        OCF.sub.3                                                                            Et      COEt                                    Br    Et        H        Cl    Et      CO.sub.2 Me                             CF.sub.3                                                                             Et        H        Br    Et      CO.sub.2 Me                             OCF.sub.3                                                                            Et        H        CF.sub.3                                                                             Et      CO.sub.2 Me                             Cl    Et        Me       OCF.sub.3                                                                            Et      CO.sub.2 Me                             Br    Et        Me       Cl    Et      CO.sub.2 Et                             CF.sub.3                                                                             Et        Me       Br    Et      CO.sub.2 Et                             OCF.sub.3                                                                            Et        Me       CF.sub.3                                                                             Et      CO.sub.2 Et                             Cl    Et        Et       OCF.sub.3                                                                            Et      CO.sub.2 Et                             Br    Et        Et       Cl    Et      CH.sub.2 OMe                            CF.sub.3                                                                             Et        Et       Br    Et      CH.sub.2 OMe                            OCF.sub.3                                                                            Et        Et       CF.sub.3                                                                             Et      CH.sub.2 OMe                            Cl    Et        n-Pr     OCF.sub.3                                                                            Et      CH.sub.2 OMe                            Br    Et        n-Pr     Cl    Et      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Et        n-Pr     Br    Et      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Et        n-Pr     CF.sub.3                                                                             Et      CH.sub.2 CHCH.sub.2                     Cl    Et        COMe     OCF.sub.3                                                                            Et      CH.sub.2 CHCH.sub.2                     Br    Et        COMe     Cl    Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COMe     Br    Et      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Et        COMe     CF.sub.3                                                                             Et      CH.sub.2 SCH.sub.3                      Cl    Et        COEt     OCF.sub.3                                                                            Et      CH.sub.2 SCH.sub.3                      Br    Et        COEt     OCF.sub.2 H                                                                          Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COEt     OCF.sub.2 H                                                                          Me      Et                                      OCF.sub.2 H                                                                          Et        H        OCF.sub.2 H                                                                          Me      n-Pr                                    OCF.sub.2 H                                                                          Et        Me       OCF.sub.2 H                                                                          Me      COMe                                    OCF.sub.2 H                                                                          Et        Et       OCF.sub.2 H                                                                          Me      COEt                                    OCF.sub.2 H                                                                          Et        n-Pr     OCF.sub.2 H                                                                          Me      CO.sub.2 Me                             OCF.sub.2 H                                                                          Et        COMe     OCF.sub.2 H                                                                          Me      CO.sub.2 Et                             OCF.sub.2 H                                                                          Et        COEt     OCF.sub.2 H                                                                          Me      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Et        CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Et        CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Et        CH.sub.2 OMe                                                                            OCF.sub.3                                                                            n-Pr    COEt                                    OCF.sub.2 H                                                                          Et        CH.sub.2 CHCH.sub.2                                                                     Cl    n-Pr    CO.sub.2 Me                             Cl    n-Pr      H        Br    n-Pr    CO.sub.2 Me                             Br    n-Pr      H        CF.sub.3                                                                             n-Pr    CO.sub.2 Me                             CF.sub.3                                                                             n-Pr      H        OCF.sub.3                                                                            n-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            n-Pr      H        Cl    n-Pr    CO.sub.2 Et                             Cl    n-Pr      Me       Br    n-Pr    CO.sub.2 Et                             Br    n-Pr      Me       CF.sub.3                                                                             n-Pr    CO.sub.2 Et                             CF.sub.3                                                                             n-Pr      Me       OCF.sub.3                                                                            n-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            n-Pr      Me       Cl    n-Pr    CH.sub.2 OMe                            Cl    n-Pr      Et       Br    n-Pr    CH.sub.2 OMe                            Br    n-Pr      Et       CF.sub.3                                                                             n-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             n-Pr      Et       OCF.sub.3                                                                            n-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            n-Pr      Et       Cl    n-Pr    CH.sub.2 CHCH.sub.2                     Cl    n-Pr      n-Pr     Br    n-Pr    CH.sub.2 CHCH.sub.2                     Br    n-Pr      n-Pr     CF.sub.3                                                                             n-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             n-Pr      n-Pr     OCF.sub.3                                                                            n-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            n-Pr      n-Pr     Cl    n-Pr    CH.sub.2 SCH.sub.3                      Cl    n-Pr      COMe     Br    n-Pr    CH.sub.2 SCH.sub.3                      Br    n-Pr      COMe     CF.sub.3                                                                             n-Pr    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             n-Pr      COMe     OCF.sub.3                                                                            n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            n-Pr      COMe     OCF.sub.2 H                                                                          n-Pr    COEt                                    Cl    n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Me                             Br    n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Et                             CF.sub.3                                                                             n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          n-Pr      H        OCF.sub.2 H                                                                          n-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          n-Pr      Me       OCF.sub.2 H                                                                          n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          n-Pr      Et                                                             OCF.sub.2 H                                                                          n-Pr      n-Pr                                                           OCF.sub.2 H                                                                          n-Pr      COMe                                                           Cl    i-Pr      H        OCF.sub.3                                                                            i-Pr    COEt                                    Br    i-Pr      H        Cl    i-Pr    CO.sub.2 Me                             CF.sub.3                                                                             i-Pr      H        Br    i-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            i-Pr      H        CF.sub.3                                                                             i-Pr    CO.sub.2 Me                             Cl    i-Pr      Me       OCF.sub.3                                                                            i-Pr    CO.sub.2 Me                             Br    i-Pr      Me       Cl    i-Pr    CO.sub.2 Et                             CF.sub.3                                                                             i-Pr      Me       Br    i-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            i-Pr      Me       CF.sub.3                                                                             i-Pr    CO.sub.2 Et                             Cl    i-Pr      Et       OCF.sub.3                                                                            i-Pr    CO.sub.2 Et                             Br    i-Pr      Et       Cl    i-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             i-Pr      Et       Br    i-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Pr      Et       CF.sub.3                                                                             i-Pr    CH.sub.2 OMe                            Cl    i-Pr      n-Pr     OCF.sub.3                                                                            i-Pr    CH.sub.2 OMe                            Br    i-Pr      n-Pr     Cl    i-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Pr      n-Pr     Br    i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Pr      n-Pr     CF.sub.3                                                                             i-Pr    CH.sub.2 CHCH.sub.2                     Cl    i-Pr      COMe     OCF.sub.3                                                                            i-Pr    CH.sub.2 CHCH.sub.2                     Br    i-Pr      COMe     Cl    i-Pr    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             i-Pr      COMe     Br    i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Pr      COMe     CF.sub.3                                                                             i-Pr    CH.sub.2 SCH.sub.3                      Cl    i-Pr      COEt     OCF.sub.3                                                                            i-Pr    CH.sub.2 SCH.sub.3                      Br    i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    COEt                                    CF.sub.3                                                                             i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Pr      H        OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Pr      Me       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Pr      Et       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Pr      n-Pr     OCF.sub.2 H                                                                          i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Pr      COMe                                                           Cl    i-Bu      H        OCF.sub.3                                                                            i-Bu    COEt                                    Br    i-Bu      H        Cl    i-Bu    CO.sub.2 Me                             CF.sub.3                                                                             i-Bu      H        Br    i-Bu    CO.sub.2 Me                             OCF.sub.3                                                                            i-Bu      H        CF.sub.3                                                                             i-Bu    CO.sub.2 Me                             Cl    i-Bu      Me       OCF.sub.3                                                                            i-Bu    CO.sub.2 Me                             Br    i-Bu      Me       Cl    i-Bu    CO.sub.2 Et                             CF.sub.3                                                                             i-Bu      Me       Br    i-Bu    CO.sub.2 Et                             OCF.sub.3                                                                            i-Bu      Me       CF.sub.3                                                                             i-Bu    CO.sub.2 Et                             Cl    i-Bu      Et       OCF.sub.3                                                                            i-Bu    CO.sub.2 Et                             Br    i-Bu      Et       Cl    i-Bu    CH.sub.2 OMe                            CF.sub.3                                                                             i-Bu      Et       Br    i-Bu    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Bu      Et       CF.sub.3                                                                             i-Bu    CH.sub.2 OMe                            Cl    i-Bu      n-Pr     OCF.sub.3                                                                            i-Bu    CH.sub.2 OMe                            Br    i-Bu      n-Pr     Cl    i-Bu    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Bu      n-Pr     Br    i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Bu      n-Pr     CF.sub.3                                                                             i-Bu    CH.sub.2 CHCH.sub.2                     Cl    i-Bu      COMe     OCF.sub.3                                                                            i-Bu    CH.sub.2 CHCH.sub.2                     Br    i-Bu      COMe     Cl    i-Bu    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             i-Bu      COMe     Br    i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Bu      COMe     CF.sub.3                                                                             i-Bu    CH.sub.2 SCH.sub.3                      Cl    i-Bu      COEt     OCF.sub.3                                                                            i-Bu    CH.sub.2 SCH.sub.3                      Br    i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    COEt                                    CF.sub.3                                                                             i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Bu      H        OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Bu      Me       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Bu      Et       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Bu      n-Pr     OCF.sub.2 H                                                                          i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Bu      COMe                                                           Cl    CO.sub.2 Me                                                                              H        OCF.sub.3                                                                            CO.sub.2 Me                                                                            COEt                                    Br    CO.sub.2 Me                                                                              H        Cl    CO.sub.2 Me                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                              H        Br    CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              H        CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Me                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                             Br    CO.sub.2 Me                                                                              Me       Cl    CO.sub.2 Me                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                              Me       Br    CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              Me       CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Me                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                             Br    CO.sub.2 Me                                                                              Et       Cl    CO.sub.2 Me                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Me                                                                              Et       Br    CO.sub.2 Me                                                                            CH.sub.2 OMe                            OCF.sub.3                                                                            CO.sub.2 Me                                                                              Et       CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Me                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Me                                                                              n-Pr     Cl    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Me                                                                              n-Pr     Br    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Me                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Me                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Me                                                                              COMe     Cl    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Me                                                                              COMe     Br    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Me                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Me                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              COMe                                                           Cl    CO.sub.2 Et                                                                              H        OCF.sub.3                                                                            CO.sub.2 Et                                                                            COEt                                    Br    CO.sub.2 Et                                                                              H        Cl    CO.sub.2 Et                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Et                                                                              H        Br    CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              H        CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Et                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Me                             Br    CO.sub.2 Et                                                                              Me       Cl    CO.sub.2 Et                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Et                                                                              Me       Br    CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              Me       CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Et                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Et                             Br    CO.sub.2 Et                                                                              Et       Cl    CO.sub.2 Et                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Et                                                                              Et       Br    CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.3                                                                            CO.sub.2 Et                                                                              Et       CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Et                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Et                                                                              n-Pr     Cl    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Et                                                                              n-Pr     Br    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Et                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Et                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Et                                                                              COMe     Cl    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Et                                                                              COMe     Br    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Et                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Et                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              COMe                                                           Cl    Ph        H        OCF.sub.3                                                                            Ph      COEt                                    Br    Ph        H        Cl    Ph      CO.sub.2 Me                             CF.sub.3                                                                             Ph        H        Br    Ph      CO.sub.2 Me                             OCF.sub.3                                                                            Ph        H        CF.sub.3                                                                             Ph      CO.sub.2 Me                             Cl    Ph        Me       OCF.sub.3                                                                            Ph      CO.sub.2 Me                             Br    Ph        Me       Cl    Ph      CO.sub.2 Et                             CF.sub.3                                                                             Ph        Me       Br    Ph      CO.sub.2 Et                             OCF.sub.3                                                                            Ph        Me       CF.sub.3                                                                             Ph      CO.sub.2 Et                             Cl    Ph        Et       OCF.sub.3                                                                            Ph      CO.sub.2 Et                             Br    Ph        Et       Cl    Ph      CH.sub.2 OMe                            CF.sub.3                                                                             Ph        Et       Br    Ph      CH.sub.2 OMe                            OCF.sub.3                                                                            Ph        Et       CF.sub.3                                                                             Ph      CH.sub.2 OMe                            Cl    Ph        n-Pr     OCF.sub.3                                                                            Ph      CH.sub.2 OMe                            Br    Ph        n-Pr     Cl    Ph      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Ph        n-Pr     Br    Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Ph        n-Pr     CF.sub.3                                                                             Ph      CH.sub.2 CHCH.sub.2                     Cl    Ph        COMe     OCF.sub.3                                                                            Ph      CH.sub.2 CHCH.sub.2                     Br    Ph        COMe     Cl    Ph      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Ph        COMe     Br    Ph      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Ph        COMe     CF.sub.3                                                                             Ph      CH.sub.2 SCH.sub.3                      Cl    Ph        COEt     OCF.sub.3                                                                            Ph      CH.sub.2 SCH.sub.3                      Br    Ph        COEt     OCF.sub.2 H                                                                          Ph      COEt                                    CF.sub.3                                                                             Ph        COEt     OCF.sub.2 H                                                                          Ph      CO.sub.2 Me                             OCF.sub.2 H                                                                          Ph        H        OCF.sub.2 H                                                                          Ph      CO.sub.2 Et                             OCF.sub.2 H                                                                          Ph        Me       OCF.sub.2 H                                                                          Ph      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Ph        Et       OCF.sub.2 H                                                                          Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Ph        n-Pr     OCF.sub.2 H                                                                          Ph      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Ph        COMe                                                           Cl    4-ClPh    H        OCF.sub.3                                                                            4-ClPh  COEt                                    Br    4-ClPh    H        Cl    4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             4-ClPh    H        Br    4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            4-ClPh    H        CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             Cl    4-ClPh    Me       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             Br    4-ClPh    Me       Cl    4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             4-ClPh    Me       Br    4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            4-ClPh    Me       CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             Cl    4-ClPh    Et       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             Br    4-ClPh    Et       Cl    4-ClPh  CH.sub.2 OMe                            CF.sub.3                                                                             4-ClPh    Et       Br    4-ClPh  CH.sub.2 OMe                            OCF.sub.3                                                                            4-ClPh    Et       CF.sub.3                                                                             4-ClPh  CH.sub.2 OMe                            Cl    4-ClPh    n-Pr     OCF.sub.3                                                                            4-ClPh  CH.sub.2 OMe                            Br    4-ClPh    n-Pr     Cl    4-ClPh  CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-ClPh    n-Pr     Br    4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-ClPh    n-Pr     CF.sub.3                                                                             4-ClPh  CH.sub.2 CHCH.sub.2                     Cl    4-ClPh    COMe     OCF.sub.3                                                                            4-ClPh  CH.sub.2 CHCH.sub.2                     Br    4-ClPh    COMe     Cl    4-ClPh  CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-ClPh    COMe     Br    4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-ClPh    COMe     CF.sub.3                                                                             4-ClPh  CH.sub.2 SCH.sub.3                      Cl    4-ClPh    COEt     OCF.sub.3                                                                            4-ClPh  CH.sub.2 SCH.sub.3                      Br    4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  COEt                                    CF.sub.3                                                                             4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Me                             OCF.sub.2 H                                                                          4-ClPh    H        OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Et                             OCF.sub.2 H                                                                          4-ClPh    Me       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-ClPh    Et       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-ClPh    n-Pr     OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-ClPh    COMe                                                           Cl    4-FPh     H        OCF.sub.3                                                                            4-FPh   COEt                                    Br    4-FPh     H        Cl    4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             4-FPh     H        Br    4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            4-FPh     H        CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             Cl    4-FPh     Me       OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             Br    4-FPh     Me       Cl    4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             4-FPh     Me       Br    4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            4-FPh     Me       CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             Cl    4-FPh     Et       OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             Br    4-FPh     Et       Cl    4-FPh   CH.sub.2 OMe                            CF.sub.3                                                                             4-FPh     Et       Br    4-FPh   CH.sub.2 OMe                            OCF.sub.3                                                                            4-FPh     Et       CF.sub.3                                                                             4-FPh   CH.sub.2 OMe                            Cl    4-FPh     n-Pr     OCF.sub.3                                                                            4-FPh   CH.sub.2 OMe                            Br    4-FPh     n-Pr     Cl    4-FPh   CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-FPh     n-Pr     Br    4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-FPh     n-Pr     CF.sub.3                                                                             4-FPh   CH.sub.2 CHCH.sub.2                     Cl    4-FPh     COMe     OCF.sub.3                                                                            4-FPh   CH.sub.2 CHCH.sub.2                     Br    4-FPh     COMe     Cl    4-FPh   CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-FPh     COMe     Br    4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-FPh     COMe     CF.sub.3                                                                             4-FPh   CH.sub.2 SCH.sub.3                      Cl    4-FPh     COEt     OCF.sub.3                                                                            4-FPh   CH.sub.2 SCH.sub.3                      Br    4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   COEt                                    CF.sub.3                                                                             4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Me                             OCF.sub.2 H                                                                          4-FPh     H        OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Et                             OCF.sub.2 H                                                                          4-FPh     Me       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-FPh     Et       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-FPh     n-Pr     OCF.sub.2 H                                                                          4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-FPh     COMe                                                           Cl    CHCH.sub.2                                                                               H        OCF.sub.3                                                                            CHCH.sub.2                                                                             COEt                                    Br    CHCH.sub.2                                                                               H        Cl    CHCH.sub.2                                                                             CO.sub.2 Me                             CF.sub.3                                                                             CHCH.sub.2                                                                               H        Br    CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.3                                                                            CHCH.sub.2                                                                               H        CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                             Cl    CHCH.sub.2                                                                               Me       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Me                             Br    CHCH.sub.2                                                                               Me       Cl    CHCH.sub.2                                                                             CO.sub.2 Et                             CF.sub.3                                                                             CHCH.sub.2                                                                               Me       Br    CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.3                                                                            CHCH.sub.2                                                                               Me       CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Et                             Cl    CHCH.sub.2                                                                               Et       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Et                             Br    CHCH.sub.2                                                                               Et       Cl    CHCH.sub.2                                                                             CH.sub.2 OMe                            CF.sub.3                                                                             CHCH.sub.2                                                                               Et       Br    CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.3                                                                            CHCH.sub.2                                                                               Et       CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 OMe                            Cl    CHCH.sub.2                                                                               n-Pr     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 OMe                            Br    CHCH.sub.2                                                                               n-Pr     Cl    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CHCH.sub.2                                                                               n-Pr     Br    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CHCH.sub.2                                                                               n-Pr     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Cl    CHCH.sub.2                                                                               COMe     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Br    CHCH.sub.2                                                                               COMe     Cl    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CHCH.sub.2                                                                               COMe     Br    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CHCH.sub.2                                                                               COMe     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Cl    CHCH.sub.2                                                                               COEt     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Br    CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             COEt                                    CF.sub.3                                                                             CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               H        OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Me       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Et       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CHCH.sub.2                                                                               n-Pr     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CHCH.sub.2                                                                               COMe                                                           Cl    C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    COEt                                    Br    C(CH.sub.3)CH.sub.2                                                                      H        Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      H        Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      H        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Cl    C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Br    C(CH.sub.3)CH.sub.2                                                                      Me       Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Me       Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Me       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Cl    C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Br    C(CH.sub.3)CH.sub.2                                                                      Et       Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Et       Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Et       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Cl    C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Br    C(CH.sub.3)CH.sub.2                                                                      n-Pr     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      n-Pr     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      n-Pr     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Cl    C(CH.sub.3)CH.sub.2                                                                      COMe     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Br    C(CH.sub.3)CH.sub.2                                                                      COMe     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COMe     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      COMe     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Cl    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Br    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    COEt                                    CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      COMe                                                           CF.sub.3                                                                             Me        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Me        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Me        CO(n-Pr) CF.sub.3                                                                             n-Pr    CO(n-Pr)                                CF.sub.3                                                                             Me        CO(i-Pr) CF.sub.3                                                                             n-Pr    CO(i-Pr)                                CF.sub.3                                                                             Me        CO(t-Bu) CF.sub.3                                                                             n-Pr    CO(t-Bu)                                CF.sub.3                                                                             Me        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Me        CO(n-Pr) OCF.sub.3                                                                            n-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Me        CO(i-Pr) OCF.sub.3                                                                            n-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Me        CO(t-Bu) OCF.sub.3                                                                            n-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Et        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Et        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Et        CO(n-Pr) CF.sub.3                                                                             i-Pr    CO(n-Pr)                                CF.sub.3                                                                             Et        CO(i-Pr) CF.sub.3                                                                             i-Pr    CO(i-Pr)                                CF.sub.3                                                                             Et        CO(t-Bu) CF.sub.3                                                                             i-Pr    CO(t-Bu)                                CF.sub.3                                                                             Et        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Et        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Et        CO(n-Pr) OCF.sub.3                                                                            i-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Et        CO(i-Pr) OCF.sub.3                                                                            i-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Et        CO(t-Bu) OCF.sub.3                                                                            i-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Et        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(n-Pr) OCF.sub.2 H                                                                          Et      CO(i-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          Me        CO(i-Pr) OCF.sub.2 H                                                                          Et      CO(t-Bu)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(t-Bu) OCF.sub.2 H                                                                          n-Pr    CO(n-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          Et        CO(n-Pr) OCF.sub.2 H                                                                          n-Pr    CO(i-Pr)                                OCF.sub.2 H                                                                          Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO(n-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(n-Pr)                                CF.sub.3                                                                             i-Bu      CO(i-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(i-Pr)                                CF.sub.3                                                                             i-Bu      CO(t-Bu) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(t-Bu)                                CF.sub.3                                                                             i-Bu      CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            i-Bu      CO(n-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.3                                                                            i-Bu      CO(i-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(i-Pr)                                OCF.sub.3                                                                            i-Bu      CO(t-Bu) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(t-Bu)                                OCF.sub.3                                                                            i-Bu      CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (n-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (i-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(n-Pr) CF.sub.3                                                                             Ph      CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(i-Pr) CF.sub.3                                                                             Ph      CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(t-Bu) CF.sub.3                                                                             Ph      CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(n-Pr) OCF.sub.3                                                                            Ph      CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(i-Pr) OCF.sub.3                                                                            Ph      CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(t-Bu) OCF.sub.3                                                                            Ph      CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          n-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(i-Pr)                                OCF.sub.2 H                                                                          n-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(i-Pr) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(t-Bu)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          i-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(n-Pr) OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-ClPh    CO(n-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(n-Pr)                                CF.sub.3                                                                             4-ClPh    CO(i-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(i-Pr)                                CF.sub.3                                                                             4-ClPh    CO(t-Bu) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(t-Bu)                                CF.sub.3                                                                             4-ClPh    CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-ClPh    CO(n-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(n-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(i-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(i-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(t-Bu) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(t-Bu)                                OCF.sub.3                                                                            4-ClPh    CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-FPh     CO(n-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                CF.sub.3                                                                             4-FPh     CO(i-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                CF.sub.3                                                                             4-FPh     CO(t-Bu) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                CF.sub.3                                                                             4-FPh     CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-FPh     CO(n-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                OCF.sub.3                                                                            4-FPh     CO(i-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                OCF.sub.3                                                                            4-FPh     CO(t-Bu) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                OCF.sub.3                                                                            4-FPh     CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(i-Pr) OCF.sub.2 H                                                                          4-ClPh  CO(t-Bu)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(t-Bu) OCF.sub.2 H                                                                          4-FPh   CO(n-Pr)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(n-Pr) OCF.sub.2 H                                                                          4-FPh   CO(i-Pr)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(i-Pr) OCF.sub.2 H                                                                          4-FPh   CO(t-Bu)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (t-Bu)                         ______________________________________                                    

                  TABLE 8                                                          ______________________________________                                          ##STR46##                                                                     R.sup.1                                                                              R.sup.3   Y        R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         Cl    Me        H        OCF.sub.3                                                                            Me      COEt                                    Br    Me        H        Cl    Me      CO.sub.2 Me                             CF.sub.3                                                                             Me        H        Br    Me      CO.sub.2 Me                             OCF.sub.3                                                                            Me        H        CF.sub.3                                                                             Me      CO.sub.2 Me                             Cl    Me        Me       OCF.sub.3                                                                            Me      CO.sub.2 Me                             Br    Me        Me       Cl    Me      CO.sub.2 Et                             CF.sub.3                                                                             Me        Me       Br    Me      CO.sub.2 Et                             OCF.sub.3                                                                            Me        Me       CF.sub.3                                                                             Me      CO.sub.2 Et                             Cl    Me        Et       OCF.sub.3                                                                            Me      CO.sub.2 Et                             Br    Me        Et       Cl    Me      CH.sub.2 OMe                            CF.sub.3                                                                             Me        Et       Br    Me      CH.sub.2 OMe                            OCF.sub.3                                                                            Me        Et       CF.sub.3                                                                             Me      CH.sub.2 OMe                            Cl    Me        n-Pr     OCF.sub.3                                                                            Me      CH.sub.2 OMe                            Br    Me        n-Pr     Cl    Me      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Me        n-Pr     Br    Me      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Me        n-Pr     CF.sub.3                                                                             Me      CH.sub.2 CHCH.sub.2                     Cl    Me        COMe     OCF.sub.3                                                                            Me      CH.sub.2 CHCH.sub.2                     Br    Me        COMe     Cl    Me      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Me        COMe     Br    Me      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Me        COMe     CF.sub.3                                                                             Me      CH.sub.2 SCH.sub.3                      Cl    Me        COEt     OCF.sub.3                                                                            Me      CH.sub.2 SCH.sub.3                      Br    Me        COEt     OCF.sub.2 H                                                                          Me      H                                       CF.sub.3                                                                             Me        COEt     OCF.sub.2 H                                                                          Me      Me                                      Cl    Et        H        OCF.sub.3                                                                            Et      COEt                                    Br    Et        H        Cl    Et      CO.sub.2 Me                             CF.sub.3                                                                             Et        H        Br    Et      CO.sub.2 Me                             OCF.sub.3                                                                            Et        H        CF.sub.3                                                                             Et      CO.sub.2 Me                             Cl    Et        Me       OCF.sub.3                                                                            Et      CO.sub.2 Me                             Br    Et        Me       Cl    Et      CO.sub.2 Et                             CF.sub.3                                                                             Et        Me       Br    Et      CO.sub.2 Et                             OCF.sub.3                                                                            Et        Me       CF.sub.3                                                                             Et      CO.sub.2 Et                             Cl    Et        Et       OCF.sub.3                                                                            Et      CO.sub.2 Et                             Br    Et        Et       Cl    Et      CH.sub.2 OMe                            CF.sub.3                                                                             Et        Et       Br    Et      CH.sub.2 OMe                            OCF.sub.3                                                                            Et        Et       CF.sub.3                                                                             Et      CH.sub.2 OMe                            Cl    Et        n-Pr     OCF.sub.3                                                                            Et      CH.sub.2 OMe                            Br    Et        n-Pr     Cl    Et      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Et        n-Pr     Br    Et      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Et        n-Pr     CF.sub.3                                                                             Et      CH.sub.2 CHCH.sub.2                     Cl    Et        COMe     OCF.sub.3                                                                            Et      CH.sub.2 CHCH.sub.2                     Br    Et        COMe     Cl    Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COMe     Br    Et      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Et        COMe     CF.sub.3                                                                             Et      CH.sub.2 SCH.sub.3                      Cl    Et        COEt     OCF.sub.3                                                                            Et      CH.sub.2 SCH.sub.3                      Br    Et        COEt     OCF.sub.2 H                                                                          Et      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Et        COEt     OCF.sub.2 H                                                                          Me      Et                                      OCF.sub.2 H                                                                          Et        H        OCF.sub.2 H                                                                          Me      n-Pr                                    OCF.sub.2 H                                                                          Et        Me       OCF.sub.2 H                                                                          Me      COMe                                    OCF.sub.2 H                                                                          Et        Et       OCF.sub.2 H                                                                          Me      COEt                                    OCF.sub.2 H                                                                          Et        n-Pr     OCF.sub.2 H                                                                          Me      CO.sub.2 Me                             OCF.sub.2 H                                                                          Et        COMe     OCF.sub.2 H                                                                          Me      CO.sub.2 Et                             OCF.sub.2 H                                                                          Et        COEt     OCF.sub.2 H                                                                          Me      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Et        CO.sub.2 Me                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Et        CO.sub.2 Et                                                                             OCF.sub.2 H                                                                          Me      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Et        CH.sub.2 OMe                                                   OCF.sub.2 H                                                                          Et        CH.sub.2 CHCH.sub.2                                            Cl    n-Pr      H        OCF.sub.3                                                                            n-Pr    COEt                                    Br    n-Pr      H        Cl    n-Pr    CO.sub.2 Me                             CF.sub.3                                                                             n-Pr      H        Br    n-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            n-Pr      H        CF.sub.3                                                                             n-Pr    CO.sub.2 Me                             Cl    n-Pr      Me       OCF.sub.3                                                                            n-Pr    COMe                                    Br    n-Pr      Me       Cl    n-Pr    CO.sub.2 Et                             CF.sub.3                                                                             n-Pr      Me       Br    n-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            n-Pr      Me       CF.sub.3                                                                             n-Pr    CO.sub.2 Et                             Cl    n-Pr      Et       OCF.sub.3                                                                            n-Pr    CO.sub.2 Et                             Br    n-Pr      Et       Cl    n-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             n-Pr      Et       Br    n-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            n-Pr      Et       CF.sub.3                                                                             n-Pr    CH.sub.2 OMe                            Cl    n-Pr      n-Pr     OCF.sub.3                                                                            n-Pr    CH.sub.2 OMe                            Br    n-Pr      n-Pr     Cl    n-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             n-Pr      n-Pr     Br    n-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            n-Pr      n-Pr     CF.sub.3                                                                             n-Pr    CH.sub.2 CHCH.sub.2                     Cl    n-Pr      COMe     OCF.sub.3                                                                            n-Pr    CH.sub.2 CHCH.sub.2                     Br    n-Pr      COMe     Cl    n-Pr    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             n-Pr      COMe     Br    n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            n-Pr      COMe     CF.sub.3                                                                             n-Pr    CH.sub.2 SCH.sub.3                      Cl    n-Pr      COEt     OCF.sub.3                                                                            n-Pr    CH.sub.2 SCH.sub.3                      Br    n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    COEt                                    CF.sub.3                                                                             n-Pr      COEt     OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Me                             OCF.sub.2 H                                                                          n-Pr      H        OCF.sub.2 H                                                                          n-Pr    CO.sub.2 Et                             OCF.sub.2 H                                                                          n-Pr      Me       OCF.sub.2 H                                                                          n-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          n-Pr      Et       OCF.sub.2 H                                                                          n-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          n-Pr      n-Pr     OCF.sub.2 H                                                                          n-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          n-Pr      COMe                                                           Cl    i-Pr      H        OCF.sub.3                                                                            i-Pr    COEt                                    Br    i-Pr      H        Cl    i-Pr    CO.sub.2 Me                             CF.sub.3                                                                             i-Pr      H        Br    i-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            i-Pr      H        CF.sub.3                                                                             i-Pr    CO.sub.2 Me                             Cl    i-Pr      Me       OCF.sub.3                                                                            i-Pr    CO.sub.2 Me                             Br    i-Pr      Me       Cl    i-Pr    CO.sub.2 Et                             CF.sub.3                                                                             i-Pr      Me       Br    i-Pr    CO.sub.2 Et                             OCF.sub.3                                                                            i-Pr      Me       CF.sub.3                                                                             i-Pr    CO.sub.2 Et                             Cl    i-Pr      Et       OCF.sub.3                                                                            i-Pr    CO.sub.2 Et                             Br    i-Pr      Et       Cl    i-Pr    CH.sub.2 OMe                            CF.sub.3                                                                             i-Pr      Et       Br    i-Pr    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Pr      Et       CF.sub.3                                                                             i-Pr    CH.sub.2 OMe                            Cl    i-Pr      n-Pr     OCF.sub.3                                                                            i-Pr    CH.sub.2 OMe                            Br    i-Pr      n-Pr     Cl    i-Pr    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Pr      n-Pr     Br    i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Pr      n-Pr     CF.sub.3                                                                             i-Pr    CH.sub.2 CHCH.sub.2                     Cl    i-Pr      COMe     OCF.sub.3                                                                            i-Pr    CH.sub.2 CHCH.sub.2                     Br    i-Pr      COMe     Cl    i-Pr    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             i-Pr      COMe     Br    i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Pr      COMe     CF.sub.3                                                                             i-Pr    CH.sub.2 SCH.sub.3                      Cl    i-Pr      COEt     OCF.sub.3                                                                            i-Pr    CH.sub.2 SCH.sub.3                      Br    i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    COEt                                    CF.sub.3                                                                             i-Pr      COEt     OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Pr      H        OCF.sub.2 H                                                                          i-Pr    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Pr      Me       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Pr      Et       OCF.sub.2 H                                                                          i-Pr    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Pr      n-Pr     OCF.sub.2 H                                                                          i-Pr    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Pr      COMe                                                           Cl    i-Bu      H        OCF.sub.3                                                                            i-Bu    COEt                                    Br    i-Bu      H        Cl    i-Bu    CO.sub.2 Me                             CF.sub.3                                                                             i-Bu      H        Br    i-Bu    CO.sub.2 Me                             OCF.sub.3                                                                            i-Bu      H        CF.sub.3                                                                             i-Bu    CO.sub.2 Me                             Cl    i-Bu      Me       OCF.sub.3                                                                            i-Bu    CO.sub.2 Me                             Br    i-Bu      Me       Cl    i-Bu    CO.sub.2 Et                             CF.sub.3                                                                             i-Bu      Me       Br    i-Bu    CO.sub.2 Et                             OCF.sub.3                                                                            i-Bu      Me       CF.sub.3                                                                             i-Bu    CO.sub.2 Et                             Cl    i-Bu      Et       OCF.sub.3                                                                            i-Bu    CO.sub.2 Et                             Br    i-Bu      Et       Cl    i-Bu    CH.sub.2 OMe                            CF.sub.3                                                                             i-Bu      Et       Br    i-Bu    CH.sub.2 OMe                            OCF.sub.3                                                                            i-Bu      Et       CF.sub.3                                                                             i-Bu    CH.sub.2 OMe                            Cl    i-Bu      n-Pr     OCF.sub.3                                                                            i-Bu    CH.sub.2 OMe                            Br    i-Bu      n-Pr     Cl    i-Bu    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             i-Bu      n-Pr     Br    i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            i-Bu      n-Pr     CF.sub.3                                                                             i-Bu    CH.sub.2 CHCH.sub.2                     Cl    i-Bu      COMe     OCF.sub.3                                                                            i-Bu    CH.sub.2 CHCH.sub.2                     Br    i-Bu      COMe     Cl    i-Bu    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             i-Bu      COMe     Br    i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            i-Bu      COMe     CF.sub.3                                                                             i-Bu    CH.sub.2 SCH.sub.3                      Cl    i-Bu      COEt     OCF.sub.3                                                                            i-Bu    CH.sub.2 SCH.sub.3                      Br    i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    COEt                                    CF.sub.3                                                                             i-Bu      COEt     OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Me                             OCF.sub.2 H                                                                          i-Bu      H        OCF.sub.2 H                                                                          i-Bu    CO.sub.2 Et                             OCF.sub.2 H                                                                          i-Bu      Me       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 OMe                            OCF.sub.2 H                                                                          i-Bu      Et       OCF.sub.2 H                                                                          i-Bu    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          i-Bu      n-Pr     OCF.sub.2 H                                                                          i-Bu    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          i-Bu      COMe                                                           Cl    CO.sub.2 Me                                                                              H        OCF.sub.3                                                                            CO.sub.2 Me                                                                            COEt                                    Br    CO.sub.2 Me                                                                              H        Cl    CO.sub.2 Me                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                              H        Br    CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              H        CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Me                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                             Br    CO.sub.2 Me                                                                              Me       Cl    CO.sub.2 Me                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                              Me       Br    CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                              Me       CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Me                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Et                             Br    CO.sub.2 Me                                                                              Et       Cl    CO.sub.2 Me                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Me                                                                              Et       Br    CO.sub.2 Me                                                                            CH.sub.2 OMe                            OCF.sub.3                                                                            CO.sub.2 Me                                                                              Et       CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Me                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Me                                                                              n-Pr     Cl    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Me                                                                              n-Pr     Br    CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Me                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Me                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Me                                                                              COMe     Cl    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Me                                                                              COMe     Br    CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Me                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Me                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Me                                                                              COMe                                                           Cl    CO.sub.2 Et                                                                              H        OCF.sub.3                                                                            CO.sub.2 Et                                                                            COEt                                    Br    CO.sub.2 Et                                                                              H        Cl    CO.sub.2 Et                                                                            CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Et                                                                              H        Br    CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              H        CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Me                             Cl    CO.sub.2 Et                                                                              Me       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Me                             Br    CO.sub.2 Et                                                                              Me       Cl    CO.sub.2 Et                                                                            CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Et                                                                              Me       Br    CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Et                                                                              Me       CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 Et                             Cl    CO.sub.2 Et                                                                              Et       OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 Et                             Br    CO.sub.2 Et                                                                              Et       Cl    CO.sub.2 Et                                                                            CH.sub.2 OMe                            CF.sub.3                                                                             CO.sub.2 Et                                                                              Et       Br    CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.3                                                                            CO.sub.2 Et                                                                              Et       CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 OMe                            Cl    CO.sub.2 Et                                                                              n-Pr     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 OMe                            Br    CO.sub.2 Et                                                                              n-Pr     Cl    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CO.sub.2 Et                                                                              n-Pr     Br    CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CO.sub.2 Et                                                                              n-Pr     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Cl    CO.sub.2 Et                                                                              COMe     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     Br    CO.sub.2 Et                                                                              COMe     Cl    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CO.sub.2 Et                                                                              COMe     Br    CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CO.sub.2 Et                                                                              COMe     CF.sub.3                                                                             CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Cl    CO.sub.2 Et                                                                              COEt     OCF.sub.3                                                                            CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      Br    CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            COEt                                    CF.sub.3                                                                             CO.sub.2 Et                                                                              COEt     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Me                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              H        OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 Et                             OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Me       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 OMe                            OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              Et       OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              n-Pr     OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              COMe                                                           Cl    Ph        H        OCF.sub.3                                                                            Ph      COEt                                    Br    Ph        H        Cl    Ph      CO.sub.2 Me                             CF.sub.3                                                                             Ph        H        Br    Ph      CO.sub.2 Me                             OCF.sub.3                                                                            Ph        H        CF.sub.3                                                                             Ph      CO.sub.2 Me                             Cl    Ph        Me       OCF.sub.3                                                                            Ph      CO.sub.2 Me                             Br    Ph        Me       Cl    Ph      CO.sub.2 Et                             CF.sub.3                                                                             Ph        Me       Br    Ph      CO.sub.2 Et                             OCF.sub.3                                                                            Ph        Me       CF.sub.3                                                                             Ph      CO.sub.2 Et                             Cl    Ph        Et       OCF.sub.3                                                                            Ph      CO.sub.2 Et                             Br    Ph        Et       Cl    Ph      CH.sub.2 OMe                            CF.sub.3                                                                             Ph        Et       Br    Ph      CH.sub.2 OMe                            OCF.sub.3                                                                            Ph        Et       CF.sub.3                                                                             Ph      CH.sub.2 OMe                            Cl    Ph        n-Pr     OCF.sub.3                                                                            Ph      CH.sub.2 OMe                            Br    Ph        n-Pr     Cl    Ph      CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             Ph        n-Pr     Br    Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            Ph        n-Pr     CF.sub.3                                                                             Ph      CH.sub.2 CHCH.sub.2                     Cl    Ph        COMe     OCF.sub.3                                                                            Ph      CH.sub.2 CHCH.sub.2                     Br    Ph        COMe     Cl    Ph      CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             Ph        COMe     Br    Ph      CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            Ph        COMe     CF.sub.3                                                                             Ph      CH.sub.2 SCH.sub.3                      Cl    Ph        COEt     OCF.sub.3                                                                            Ph      CH.sub.2 SCH.sub.3                      Br    Ph        COEt     OCF.sub.2 H                                                                          Ph      COEt                                    CF.sub.3                                                                             Ph        COEt     OCF.sub.2 H                                                                          Ph      CO.sub.2 Me                             OCF.sub.2 H                                                                          Ph        H        OCF.sub.2 H                                                                          Ph      CO.sub.2 Et                             OCF.sub.2 H                                                                          Ph        Me       OCF.sub.2 H                                                                          Ph      CH.sub.2 OMe                            OCF.sub.2 H                                                                          Ph        Et       OCF.sub.2 H                                                                          Ph      CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          Ph        n-Pr     OCF.sub.2 H                                                                          Ph      CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          Ph        COMe                                                           Cl    4-ClPh    H        OCF.sub.3                                                                            4-ClPh  COEt                                    Br    4-ClPh    H        Cl    4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             4-ClPh    H        Br    4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            4-ClPh    H        CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             Cl    4-ClPh    Me       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             Br    4-ClPh    Me       Cl    4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             4-ClPh    Me       Br    4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            4-ClPh    Me       CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             Cl    4-ClPh    Et       OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             Br    4-ClPh    Et       Cl    4-ClPh  CH.sub.2 OMe                            CF.sub.3                                                                             4-ClPh    Et       Br    4-ClPh  CH.sub.2 OMe                            OCF.sub.3                                                                            4-ClPh    Et       CF.sub.3                                                                             4-ClPh  CH.sub.2 OMe                            Cl    4-ClPh    n-Pr     OCF.sub.3                                                                            4-ClPh  CH.sub.2 OMe                            Br    4-ClPh    n-Pr     Cl    4-ClPh  CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-ClPh    n-Pr     Br    4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-ClPh    n-Pr     CF.sub.3                                                                             4-ClPh  CH.sub.2 CHCH.sub.2                     Cl    4-ClPh    COMe     OCF.sub.3                                                                            4-ClPh  CH.sub.2 CHCH.sub.2                     Br    4-ClPh    COMe     Cl    4-ClPh  CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-ClPh    COMe     Br    4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-ClPh    COMe     CF.sub.3                                                                             4-ClPh  CH.sub.2 SCH.sub.3                      Cl    4-ClPh    COEt     OCF.sub.3                                                                            4-ClPh  CH.sub.2 SCH.sub.3                      Br    4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  COEt                                    CF.sub.3                                                                             4-ClPh    COEt     OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Me                             OCF.sub.2 H                                                                          4-ClPh    H        OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 Et                             OCF.sub.2 H                                                                          4-ClPh    Me       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-ClPh    Et       OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-ClPh    n-Pr     OCF.sub.2 H                                                                          4-ClPh  CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-ClPh    COMe                                                           Cl    4-FPh     H        OCF.sub.3                                                                            4-FPh   COEt                                    Br    4-FPh     H        Cl    4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             4-FPh     H        Br    4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            4-FPh     H        CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             Cl    4-FPh     Me       OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             Br    4-FPh     Me       Cl    4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             4-FPh     Me       Br    4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            4-FPh     Me       CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             Cl    4-FPh     Et       OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             Br    4-FPh     Et       Cl    4-FPh   CH.sub.2 OMe                            CF.sub.3                                                                             4-FPh     Et       Br    4-FPh   CH.sub.2 OMe                            OCF.sub.3                                                                            4-FPh     Et       CF.sub.3                                                                             4-FPh   CH.sub.2 OMe                            Cl    4-FPh     n-Pr     OCF.sub.3                                                                            4-FPh   CH.sub.2 OMe                            Br    4-FPh     n-Pr     Cl    4-FPh   CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             4-FPh     n-Pr     Br    4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            4-FPh     n-Pr     CF.sub.3                                                                             4-FPh   CH.sub.2 CHCH.sub.2                     Cl    4-FPh     COMe     OCF.sub.3                                                                            4-FPh   CH.sub.2 CHCH.sub.2                     Br    4-FPh     COMe     Cl    4-FPh   CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             4-FPh     COMe     Br    4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            4-FPh     COMe     CF.sub.3                                                                             4-FPh   CH.sub.2 SCH.sub.3                      Cl    4-FPh     COEt     OCF.sub.3                                                                            4-FPh   CH.sub.2 SCH.sub.3                      Br    4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   COEt                                    CF.sub.3                                                                             4-FPh     COEt     OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Me                             OCF.sub.2 H                                                                          4-FPh     H        OCF.sub.2 H                                                                          4-FPh   CO.sub.2 Et                             OCF.sub.2 H                                                                          4-FPh     Me       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 OMe                            OCF.sub.2 H                                                                          4-FPh     Et       OCF.sub.2 H                                                                          4-FPh   CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          4-FPh     n-Pr     OCF.sub.2 H                                                                          4-FPh   CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          4-FPh     COMe                                                           Cl    CHCH.sub.2                                                                               H        OCF.sub.3                                                                            CHCH.sub.2                                                                             COEt                                    Br    CHCH.sub.2                                                                               H        Cl    CHCH.sub.2                                                                             CO.sub.2 Me                             CF.sub.3                                                                             CHCH.sub.2                                                                               H        Br    CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.3                                                                            CHCH.sub.2                                                                               H        CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                             Cl    CHCH.sub.2                                                                               Me       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Me                             Br    CHCH.sub.2                                                                               Me       Cl    CHCH.sub.2                                                                             CO.sub.2 Et                             CF.sub.3                                                                             CHCH.sub.2                                                                               Me       Br    CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.3                                                                            CHCH.sub.2                                                                               Me       CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Et                             Cl    CHCH.sub.2                                                                               Et       OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 Et                             Br    CHCH.sub.2                                                                               Et       Cl    CHCH.sub.2                                                                             CH.sub.2 OMe                            CF.sub.3                                                                             CHCH.sub.2                                                                               Et       Br    CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.3                                                                            CHCH.sub.2                                                                               Et       CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 OMe                            Cl    CHCH.sub.2                                                                               n-Pr     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 OMe                            Br    CHCH.sub.2                                                                               n-Pr     Cl    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             CHCH.sub.2                                                                               n-Pr     Br    CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            CHCH.sub.2                                                                               n-Pr     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Cl    CHCH.sub.2                                                                               COMe     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     Br    CHCH.sub.2                                                                               COMe     Cl    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             CHCH.sub.2                                                                               COMe     Br    CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            CHCH.sub.2                                                                               COMe     CF.sub.3                                                                             CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Cl    CHCH.sub.2                                                                               COEt     OCF.sub.3                                                                            CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      Br    CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             COEt                                    CF.sub.3                                                                             CHCH.sub.2                                                                               COEt     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Me                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               H        OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CO.sub.2 Et                             OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Me       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 OMe                            OCF.sub.2 H                                                                          CHCH.sub.2                                                                               Et       OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          CHCH.sub.2                                                                               n-Pr     OCF.sub.2 H                                                                          CHCH.sub.2                                                                             CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          CHCH.sub.2                                                                               COMe                                                           Cl    C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    COEt                                    Br    C(CH.sub.3)CH.sub.2                                                                      H        Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      H        Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      H        CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Cl    C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             Br    C(CH.sub.3)CH.sub.2                                                                      Me       Cl    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Me       Br    C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Me       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Cl    C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             Br    C(CH.sub.3)CH.sub.2                                                                      Et       Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      Et       Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      Et       CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Cl    C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            Br    C(CH.sub.3)CH.sub.2                                                                      n-Pr     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      n-Pr     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      n-Pr     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Cl    C(CH.sub.3)CH.sub.2                                                                      COMe     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     Br    C(CH.sub.3)CH.sub.2                                                                      COMe     Cl    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COMe     Br    C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                      COMe     CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Cl    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      Br    C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    COEt                                    CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                      COEt     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      H        OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                             OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Me       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 OMe                            OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      Et       OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 CHCH.sub.2                     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      n-Pr     OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                    CH.sub.2 SCH.sub.3                      OCF.sub.2 H                                                                          C(CH.sub.3)CH.sub.2                                                                      COMe                                                           CF.sub.3                                                                             Me        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Me        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Me        CO(n-Pr) CF.sub.3                                                                             n-Pr    CO(n-Pr)                                CF.sub.3                                                                             Me        CO(i-Pr) CF.sub.3                                                                             n-Pr    CO(i-Pr)                                CF.sub.3                                                                             Me        CO(t-Bu) CF.sub.3                                                                             n-Pr    CO(t-Bu)                                CF.sub.3                                                                             Me        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             n-Pr    CO.sub.2 (tBu)                          OCF.sub.3                                                                            Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Me        CO(n-Pr) OCF.sub.3                                                                            n-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Me        CO(i-Pr) OCF.sub.3                                                                            n-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Me        CO(t-Bu) OCF.sub.3                                                                            n-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            n-Pr    CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Et        CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             Et        CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             Et        CO(n-Pr) CF.sub.3                                                                             i-Pr    CO(n-Pr)                                CF.sub.3                                                                             Et        CO(i-Pr) CF.sub.3                                                                             i-Pr    CO(i-Pr)                                CF.sub.3                                                                             Et        CO(t-Bu) CF.sub.3                                                                             i-Pr    CO(t-Bu)                                CF.sub.3                                                                             Et        CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            Et        CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            Et        CO(n-Pr) OCF.sub.3                                                                            i-Pr    CO(n-Pr)                                OCF.sub.3                                                                            Et        CO(i-Pr) OCF.sub.3                                                                            i-Pr    CO(i-Pr)                                OCF.sub.3                                                                            Et        CO(t-Bu) OCF.sub.3                                                                            i-Pr    CO(t-Bu)                                OCF.sub.3                                                                            Et        CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            i-Pr    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(n-Pr) OCF.sub.2 H                                                                          Et      CO(i-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          Me        CO(i-Pr) OCF.sub.2 H                                                                          Et      CO(t-Bu)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          Et      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          Me        CO(t-Bu) OCF.sub.2 H                                                                          n-Pr    CO(n-Pr)                                OCF.sub.2 H                                                                          Me        CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          Et        CO(n-Pr) OCF.sub.2 H                                                                          n-Pr    CO(i-Pr)                                OCF.sub.2 H                                                                          Et        CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          n-Pr    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             i-Bu      CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         CF.sub.3                                                                             i-Bu      CO(n-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(n-Pr)                                CF.sub.3                                                                             i-Bu      CO(i-Pr) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(i-Pr)                                CF.sub.3                                                                             i-Bu      CO(t-Bu) CF.sub.3                                                                             CO.sub.2 Et                                                                            CO(t-Bu)                                CF.sub.3                                                                             i-Bu      CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            i-Bu      CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            i-Bu      CO(n-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.3                                                                            i-Bu      CO(i-Pr) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(i-Pr)                                OCF.sub.3                                                                            i-Bu      CO(t-Bu) OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO(t-Bu)                                OCF.sub.3                                                                            i-Bu      CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CO.sub.2 Et                                                                            CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (n-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (i-Pr)                         CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(n-Pr) CF.sub.3                                                                             Ph      CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(i-Pr) CF.sub.3                                                                             Ph      CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO(t-Bu) CF.sub.3                                                                             Ph      CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             Ph      CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(n-Pr) OCF.sub.3                                                                            Ph      CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(i-Pr) OCF.sub.3                                                                            Ph      CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO(t-Bu) OCF.sub.3                                                                            Ph      CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            Ph      CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          n-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(i-Pr)                                OCF.sub.2 H                                                                          n-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(i-Pr) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(t-Bu)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          i-Pr      CO(t-Bu) OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Me                                                                            CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          i-Pr      CO(n-Pr) OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO(n-Pr)                                OCF.sub.2 H                                                                          i-Pr      CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                            CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-ClPh    CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-ClPh    CO(n-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(n-Pr)                                CF.sub.3                                                                             4-ClPh    CO(i-Pr) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(i-Pr)                                CF.sub.3                                                                             4-ClPh    CO(t-Bu) CF.sub.3                                                                             CHCH.sub.2                                                                             CO(t-Bu)                                CF.sub.3                                                                             4-ClPh    CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-ClPh    CO(n-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(n-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(i-Pr) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(i-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(t-Bu) OCF.sub.3                                                                            CHCH.sub.2                                                                             CO(t-Bu)                                OCF.sub.3                                                                            4-ClPh    CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            CHCH.sub.2                                                                             CO.sub.2 (t-Bu)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         CF.sub.3                                                                             4-FPh     CO.sub.2 (i-Pr)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         CF.sub.3                                                                             4-FPh     CO(n-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                CF.sub.3                                                                             4-FPh     CO(i-Pr) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                CF.sub.3                                                                             4-FPh     CO(t-Bu) CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                CF.sub.3                                                                             4-FPh     CO.sub.2 (t-Bu)                                                                         CF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (n-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (n-Pr)                         OCF.sub.3                                                                            4-FPh     CO.sub.2 (i-Pr)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (i-Pr)                         OCF.sub.3                                                                            4-FPh     CO(n-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                                OCF.sub.3                                                                            4-FPh     CO(i-Pr) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                                OCF.sub.3                                                                            4-FPh     CO(t-Bu) OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                                OCF.sub.3                                                                            4-FPh     CO.sub.2 (t-Bu)                                                                         OCF.sub.3                                                                            C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(i-Pr) OCF.sub.2 H                                                                          4-ClPh  CO(t-Bu)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO(t-Bu) OCF.sub.2 H                                                                          4-FPh   CO(n-Pr)                                OCF.sub.2 H                                                                          CO.sub.2 Et                                                                              CO.sub.2 (t-Bu)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (n-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(n-Pr) OCF.sub.2 H                                                                          4-FPh   CO(i-Pr)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (n-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (i-Pr)                         OCF.sub.2 H                                                                          4-ClPh    CO(i-Pr) OCF.sub.2 H                                                                          4-FPh   CO(t-Bu)                                OCF.sub.2 H                                                                          4-ClPh    CO.sub.2 (i-Pr)                                                                         OCF.sub.2 H                                                                          4-FPh   CO.sub.2 (t-Bu)                         ______________________________________                                    

                  TABLE 9                                                          ______________________________________                                          ##STR47##                                                                     R.sup.1                                                                               R.sup.3  Y        R.sup.1                                                                               R.sup.3 Y                                      ______________________________________                                         Cl     Ph       H        Cl     4-Cl-Ph H                                      Br     Ph       H        Br     4-Cl-Ph H                                      CF.sub.3                                                                              Ph       H        CF.sub.3                                                                              4-Cl-Ph H                                      OCF.sub.3                                                                             Ph       H        OCF.sub.3                                                                             4-Cl-Ph H                                      Cl     Ph       Me       Cl     4-Cl-Ph Me                                     Br     Ph       Me       Br     4-Cl-Ph Me                                     CF.sub.3                                                                              Ph       Me       CF.sub.3                                                                              4-Cl-Ph Me                                     OCF.sub.3                                                                             Ph       Me       OCF.sub.3                                                                             4-CL-Ph Me                                     Cl     Ph       Et       Cl     4-Cl-Ph Et                                     Br     Ph       Et       Br     4-CL-Ph Et                                     CF.sub.3                                                                              Ph       Et       CF.sub.3                                                                              4-Cl-Ph Et                                     OCF.sub.3                                                                             Ph       Et       OCF.sub.3                                                                             4-Cl-Ph Et                                     Cl     Ph       COMe     Cl     4-Cl-Ph COMe                                   Br     Ph       COMe     Br     4-Cl-Ph COMe                                   CF.sub.3                                                                              Ph       COMe     CF.sub.3                                                                              4-Cl-Ph COMe                                   OCF.sub.3                                                                             Ph       COMe     OCF.sub.3                                                                             4-Cl-Ph COMe                                   Cl     Ph       CO.sub.2 Me                                                                             Cl     4-Cl-Ph CO.sub.2 Me                            Br     Ph       CO.sub.2 Me                                                                             Br     4-Cl-Ph CO.sub.2 Me                            CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                              4-Cl-Ph CO.sub.2 Me                            OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                             4-Cl-Ph CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       H        OCF.sub.2 H                                                                           Ph      COMe                                   OCF.sub.2 H                                                                           Ph       Me       OCF.sub.2 H                                                                           Ph      CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       Et       OCF.sub.2 H                                                                           Ph      COEt                                   OCF.sub.2 H                                                                           Ph       n-Pr     OCF.sub.2 H                                                                           Ph      CO.sub.2 Et                            Cl     4-F-Ph   H        OCF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                     Br     4-F-Ph   H        Cl     CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              4-F-Ph   H        Br     CO.sub.2 Me                                                                            Et                                     OCF.sub.3                                                                             4-F-Ph   H        CF.sub.3                                                                              CO.sub.2 Me                                                                            Et                                     Cl     4-F-Ph   Me       OCF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                     Br     4-F-Ph   Me       Cl     CO.sub.2 Me                                                                            COMe                                   CF.sub.3                                                                              4-F-Ph   Me       Br     CO.sub.2 Me                                                                            COMe                                   OCF.sub.3                                                                             4-F-Ph   Me       CF.sub.3                                                                              CO.sub.2 Me                                                                            COMe                                   Cl     4-F-Ph   Et       OCF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                   Br     4-F-Ph   Et       Cl     CO.sub.2 Me                                                                            CO.sub.2 Me                            CF.sub.3                                                                              4-F-Ph   Et       Br     CO.sub.2 Me                                                                            CO.sub.2 Me                            OCF.sub.3                                                                             4-F-Ph   Et       CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                            Cl     4-F-Ph   COMe     OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                            Br     4-F-Ph   COMe     Cl     n-Pr    H                                      CF.sub.3                                                                              4-F-Ph   COMe     Br     n-Pr    H                                      OCF.sub.3                                                                             4-F-Ph   COMe     CF.sub.3                                                                              n-Pr    H                                      Cl     4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.3                                                                             n-Pr    H                                      Br     4-F-Ph   CO.sub.2 Me                                                                             Cl     n-Pr    Me                                     CF.sub.3                                                                              4-F-Ph   CO.sub.2 Me                                                                             Br     n-Pr    Me                                     OCF.sub.3                                                                             4-F-Ph   CO.sub.2 Me                                                                             CF.sub.3                                                                              n-Pr    Me                                     Cl     CO.sub.2 Me                                                                             H        OCF.sub.3                                                                             n-Pr    Me                                     Br     CO.sub.2 Me                                                                             H        Cl     n-Pr    Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H        Br     n-Pr    Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             H        CF.sub.3                                                                              n-Pr    Et                                     Cl     CO.sub.2 Me                                                                             Me       OCF.sub.3                                                                             n-Pr    Et                                     Br     CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-Cl-Ph Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-Cl-Ph n-Pr                                   OCF.sub.2 H                                                                           Ph       CO(n-Pr) OCF.sub.2 H                                                                           4-Cl-Ph COMe                                   OCF.sub.2 H                                                                           Ph       CO(i-Pr) OCF.sub.2 H                                                                           4-Cl-Ph CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       CO(t-Bu) OCF.sub.2 H                                                                           4-Cl-Ph COEt                                   OCF.sub.2 H                                                                           4-Cl-Ph  H        OCF.sub.2 H                                                                           4-Cl-Ph CO.sub.2 Et                            OCF.sub.2 H                                                                           4-Cl-Ph  Me       OCF.sub.2 H                                                                           4-Cl-Ph CO(n-Pr)                               Cl     n-Pr     COMe     Cl     CHCH.sub.2                                                                             CO.sub.2 Me                            Br     n-Pr     COMe     Br     CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     COMe     CF.sub.3                                                                              CHCH.sub.2                                                                             CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     COMe     OCF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                            Cl     n-Pr     CO.sub.2 Me                                                                             Cl     C(CH.sub.3)CH.sub.2                                                                    H                                      Br     n-Pr     CO.sub.2 Me                                                                             Br     C(CH.sub.3)CH.sub.2                                                                    H                                      CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    H                                      Cl     CHCH.sub.2                                                                              H        Cl     C(CH.sub.3)CH.sub.2                                                                    Me                                     Br     CHCH.sub.2                                                                              H        Br     C(CH.sub.3)CH.sub.2                                                                    Me                                     CF.sub.3                                                                              CHCH.sub.2                                                                              H        CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              H        OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Me                                     Cl     CHCH.sub.2                                                                              Me       Cl     C(CH.sub.3)CH.sub.2                                                                    Et                                     Br     CHCH.sub.2                                                                              Me       Br     C(CH.sub.3)CH.sub.2                                                                    Et                                     CF.sub.3                                                                              CHCH.sub.2                                                                              Me       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              Me       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Et                                     Cl     CHCH.sub.2                                                                              Et       Cl     C(CH.sub.3)CH.sub.2                                                                    COMe                                   Br     CHCH.sub.2                                                                              Et       Br     C(CH.sub.3)CH.sub.2                                                                    COMe                                   CF.sub.3                                                                              CHCH.sub.2                                                                              Et       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              Et       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COMe                                   Cl     CHCH.sub.2                                                                              COMe     Cl     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            Br     CHCH.sub.2                                                                              COMe     Br     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              COMe     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.3                                                                             CHCH.sub.2                                                                              COMe     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           4-Cl-Ph  CO(i-Pr) OCF.sub.2 H                                                                           4-F-Ph  COEt                                   OCF.sub.2 H                                                                           4-Cl-Ph  CO(t-Bu) OCF.sub.2 H                                                                           4-F-Ph  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-F-Ph   H        OCF.sub.2 H                                                                           4-F-Ph  CO(n-Pr)                               OCF.sub.2 H                                                                           4-F-Ph   Me       OCF.sub.2 H                                                                           4-F-Ph  CO(i-Pr)                               OCF.sub.2 H                                                                           4-F-Ph   Et       OCF.sub.2 H                                                                           4-F-Ph  CO(t-Bu)                               OCF.sub.2 H                                                                           4-F-Ph   n-Pr     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            H                                      OCF.sub.2 H                                                                           4-F-Ph   COMe     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Me                                     OCF.sub.2 H                                                                           4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              Ph       COEt     CF.sub.3                                                                              4-F-Ph  COEt                                   CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                              4-F-Ph  CO.sub.2 Et                            CF.sub.3                                                                              Ph       CO(n-Pr) CF.sub.3                                                                              4-F-Ph  Co(n-Pr)                               CF.sub.3                                                                              Ph       CO(i-Pr) CF.sub.3                                                                              4-F-Ph  CO(i-Pr)                               CF.sub.3                                                                              Ph       CO(t-Bu) CF.sub.3                                                                              4-F-Ph  CO(t-Bu)                               CF.sub.3                                                                              Ph       n-Pr     CF.sub.3                                                                              4-F-Ph  n-Pr                                   OCF.sub.3                                                                             Ph       COEt     OCF.sub.3                                                                             4-F-Ph  COEt                                   OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                             4-F-Ph  CO.sub.2 Et                            OCF.sub.3                                                                             Ph       CO(n-Pr) OCF.sub.3                                                                             4-F-Ph  CO(n-Pr)                               OCF.sub.3                                                                             Ph       CO(i-Pr) OCF.sub.3                                                                             4-F-Ph  CO(i-Pr)                               OCF.sub.3                                                                             Ph       CO(t-BU) OCF.sub.3                                                                             4-F-Ph  CO(t-Bu)                               OCF.sub.3                                                                             Ph       n-Pr     OCF.sub.3                                                                             4-F-Ph  n-Pr                                   CF.sub.3                                                                              4-Cl-Ph  COEt     CF.sub.3                                                                              CO.sub.2 Me                                                                            COEt                                   CF.sub.3                                                                              4-Cl-Ph  CO.sub.2 Et                                                                             CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                            CF.sub.3                                                                              4-Cl-Ph  CO(n-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)                               CF.sub.3                                                                              4-Cl-Ph  CO(i-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)                               CF.sub.3                                                                              4-Cl-Ph  CO(t-Bu) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)                               CF.sub.3                                                                              4-Cl-Ph  n-Pr     CF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.3                                                                             4-Cl-Ph  COEt     OCF.sub.3                                                                             CO.sub.2 Me                                                                            COEt                                   OCF.sub.3                                                                             4-Cl-Ph  CO.sub.2 Et                                                                             OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                            OCF.sub.3                                                                             4-Cl-Ph  CO(n-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)                               OCF.sub.3                                                                             4-Cl-Ph  CO(i-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(i-Pr)                               OCF.sub.3                                                                             4-Cl-Ph  CO(t-Bu) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(t-Bu)                               OCF.sub.3                                                                             4-Cl-Ph  n-Pr     OCF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr     OCF.sub.2 H                                                                           n-Pr    H                                      OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe     OCF.sub.2 H                                                                           n-Pr    Me                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           n-Pr    Et                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt     OCF.sub.2 H                                                                           n-Pr    n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           n-Pr    COMe                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Me                            OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr) OCF.sub.2 H                                                                           n-Pr    COEt                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(t-Bu) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     COEt     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             n-Pr     COEt     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Eu) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   CF.sub.3                                                                              CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                             COEt                                   CF.sub.3                                                                              CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Et                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(n-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(i-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(t-Bu)                               OCF.sub.3                                                                             CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           n-Pr     CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.2 H                                                                           n-Pr     CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              H        OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Me       OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Et                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                              n-Pr                                                           OCF.sub.2 H                                                                           CHCH.sub.2                                                                              COMe                                                           ______________________________________                                    

                  TABLE 10                                                         ______________________________________                                          ##STR48##                                                                     R.sup.1                                                                               R.sup.3  Y        R.sup.1                                                                               R.sup.3 Y                                      ______________________________________                                         Cl     Ph       H        Cl     4-Cl-Ph H                                      Br     Ph       H        Br     4-Cl-Ph H                                      CF.sub.3                                                                              Ph       H        CF.sub.3                                                                              4-Cl-Ph H                                      OCF.sub.3                                                                             Ph       H        OCF.sub.3                                                                             4-Cl-Ph H                                      Cl     Ph       Me       Cl     4-Cl-Ph Me                                     Br     Ph       Me       Br     4-Cl-Ph Me                                     CF.sub.3                                                                              Ph       Me       CF.sub.3                                                                              4-Cl-Ph Me                                     OCF.sub.3                                                                             Ph       Me       OCF.sub.3                                                                             4-Cl-Ph Me                                     Cl     Ph       Et       Cl     4-Cl-Ph Et                                     Br     Ph       Et       Br     4-Cl-Ph Et                                     CF.sub.3                                                                              Ph       Et       CF.sub.3                                                                              4-Cl-Ph Et                                     OCF.sub.3                                                                             Ph       Et       OCF.sub.3                                                                             4-Cl-Ph Et                                     Cl     Ph       COMe     Cl     4-Cl-Ph COMe                                   Br     Ph       COMe     Br     4-Cl-Ph COMe                                   CF.sub.3                                                                              Ph       COMe     CF.sub.3                                                                              4-Cl-Ph COMe                                   OCF.sub.3                                                                             Ph       COMe     OCF.sub.3                                                                             4-Cl-Ph COMe                                   Cl     Ph       CO.sub.2 Me                                                                             Cl     4-Cl-Ph CO.sub.2 Me                            Br     Ph       CO.sub.2 Me                                                                             Br     4-Cl-Ph CO.sub.2 Me                            CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                              4-Cl-Ph CO.sub.2 Me                            OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                             4-Cl-Ph CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       H        OCF.sub.2 H                                                                           Ph      COMe                                   OCF.sub.2 H                                                                           Ph       Me       OCF.sub.2 H                                                                           Ph      CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       Et       OCF.sub.2 H                                                                           Ph      COEt                                   OCF.sub.2 H                                                                           Ph       n-Pr     OCF.sub.2 H                                                                           Ph      CO.sub.2 Et                            Cl     4-F-Ph   H        OCF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                     Br     4-F-Ph   H        Cl     CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              4-F-Ph   H        Br     CO.sub.2 Me                                                                            Et                                     OCF.sub.3                                                                             4-F-Ph   H        CF.sub.3                                                                              CO.sub.2 Me                                                                            Et                                     Cl     4-F-Ph   Me       OCF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                     Br     4-F-Ph   Me       Cl     CO.sub.2 Me                                                                            COMe                                   CF.sub.3                                                                              4-F-Ph   Me       Br     CO.sub.2 Me                                                                            COMe                                   OCF.sub.3                                                                             4-F-Ph   Me       CF.sub.3                                                                              CO.sub.2 Me                                                                            COMe                                   Cl     4-F-Ph   Et       OCF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                   Br     4-F-Ph   Et       Cl     CO.sub.2 Me                                                                            CO.sub.2 Me                            CF.sub.3                                                                              4-F-Ph   Et       Br     CO.sub.2 Me                                                                            CO.sub.2 Me                            OCF.sub.3                                                                             4-F-Ph   Et       CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                            Cl     4-F-Ph   COMe     OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                            Br     4-F-Ph   COMe     Cl     n-Pr    H                                      CF.sub.3                                                                              4-F-Ph   COMe     Br     n-Pr    H                                      OCF.sub.3                                                                             4-F-Ph   COMe     CF.sub.3                                                                              n-Pr    H                                      Cl     4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.3                                                                             n-Pr    H                                      Br     4-F-Ph   CO.sub.2 Me                                                                             Cl     n-Pr    Me                                     CF.sub.3                                                                              4-F-Ph   CO.sub.2 Me                                                                             Br     n-Pr    Me                                     OCF.sub.3                                                                             4-F-Ph   CO.sub.2 Me                                                                             CF.sub.3                                                                              n-Pr    Me                                     Cl     CO.sub.2 Me                                                                             H        OCF.sub.3                                                                             n-Pr    Me                                     Br     CO.sub.2 Me                                                                             H        Cl     n-Pr    Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H        Br     n-Pr    Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             H        CF.sub.3                                                                              n-Pr    Et                                     Cl     CO.sub.2 Me                                                                             Me       OCF.sub.3                                                                             n-Pr    Et                                     Br     CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-Cl-Ph Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-Cl-Ph n-Pr                                   OCF.sub.2 H                                                                           Ph       CO(n-Pr) OCF.sub.2 H                                                                           4-Cl-Ph COMe                                   OCF.sub.2 H                                                                           Ph       CO(i-Pr) OCF.sub.2 H                                                                           4-Cl-Ph CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       CO(t-Bu) OCF.sub.2 H                                                                           4-Cl-Ph COEt                                   OCF.sub.2 H                                                                           4-Cl-Ph  H        OCF.sub.2 H                                                                           4-Cl-Ph CO.sub.2 Et                            OCF.sub.2 H                                                                           4-Cl-Ph  Me       OCF.sub.2 H                                                                           4-Cl-Ph CO(n-Pr)                               Cl     n-Pr     COMe     Cl     CHCH.sub.2                                                                             CO.sub.2 Me                            Br     n-Pr     COMe     Br     CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     COMe     CF.sub.3                                                                              CHCH.sub.2                                                                             CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     COMe     OCF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                            Cl     n-Pr     CO.sub.2 Me                                                                             Cl     C(CH.sub.3)CH.sub.2                                                                    H                                      Br     n-Pr     CO.sub.2 Me                                                                             Br     C(CH.sub.3)CH.sub.2                                                                    H                                      CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    H                                      Cl     CHCH.sub.2                                                                              H        Cl     C(CH.sub.3)CH.sub.2                                                                    Me                                     Br     CHCH.sub.2                                                                              H        Br     C(CH.sub.3)CH.sub.2                                                                    Me                                     CF.sub.3                                                                              CHCH.sub.2                                                                              H        CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              H        OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Me                                     Cl     CHCH.sub.2                                                                              Me       Cl     C(CH.sub.3)CH.sub.2                                                                    Et                                     Br     CHCH.sub.2                                                                              Me       Br     C(CH.sub.3)CH.sub.2                                                                    Et                                     CF.sub.3                                                                              CHCH.sub.2                                                                              Me       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              Me       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Et                                     Cl     CHCH.sub.2                                                                              Et       Cl     C(CH.sub.3)CH.sub.2                                                                    COMe                                   Br     CHCH.sub.2                                                                              Et       Br     C(CH.sub.3)CH.sub.2                                                                    COMe                                   CF.sub.3                                                                              CHCH.sub.2                                                                              Et       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              Et       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COMe                                   Cl     CHCH.sub.2                                                                              COMe     Cl     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            Br     CHCH.sub.2                                                                              COMe     Br     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              COMe     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.3                                                                             CHCH.sub.2                                                                              COMe     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           4-Cl-Ph  CO(i-Pr) OCF.sub.2 H                                                                           4-F-Ph  COEt                                   OCF.sub.2 H                                                                           4-Cl-Ph  CO(t-Eu) OCF.sub.2 H                                                                           4-F-Ph  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-F-Ph   H        OCF.sub.2 H                                                                           4-F-Ph  CO(n-Pr)                               OCF.sub.2 H                                                                           4-F-Ph   Me       OCF.sub.2 H                                                                           4-F-Ph  CO(i-Pr)                               OCF.sub.2 H                                                                           4-F-Ph   Et       OCF.sub.2 H                                                                           4-F-Ph  CO(t-Eu)                               OCF.sub.2 H                                                                           4-F-Ph   n-Pr     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            H                                      OCF.sub.2 H                                                                           4-F-Ph   COMe     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Me                                     OCF.sub.2 H                                                                           4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              Ph       COEt     CF.sub.3                                                                              4-F-Ph  COEt                                   CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                              4-F-Ph  CO.sub.2 Et                            CF.sub.3                                                                              Ph       CO.sub.2 (n-Pr)                                                                         CF.sub.3                                                                              4-F-Ph  CO(n-Pr)                               CF.sub.3                                                                              Ph       CO(i-Pr) CF.sub.3                                                                              4-F-Ph  CO(i-Pr)                               CF.sub.3                                                                              Ph       CO(t-Bu) CF.sub.3                                                                              4-F-Ph  CO(t-Bu)                               CF.sub.3                                                                              Ph       n-Pr     CF.sub.3                                                                              4-F-Ph  n-Pr                                   OCF.sub.3                                                                             Ph       COEt     OCF.sub.3                                                                             4-F-Ph  COEt                                   OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                             4-F-Ph  CO.sub.2 Et                            OCF.sub.3                                                                             Ph       CO(n-Pr) OCF.sub.3                                                                             4-F-Ph  CO(n-Pr)                               OCF.sub.3                                                                             Ph       CO(i-Pr) OCF.sub.3                                                                             4-F-Ph  CO(i-Pr)                               OCF.sub.3                                                                             Ph       CO(t-Bu) OCF.sub.3                                                                             4-F-Ph  CO(t-Bu)                               OCF.sub.3                                                                             Ph       n-Pr     OCF.sub.3                                                                             4-F-Ph  n-Pr                                   CF.sub.3                                                                              4-Cl-Ph  COEt     CF.sub.3                                                                              CO.sub.2 Me                                                                            COEt                                   CF.sub.3                                                                              4-Cl-Ph  CO.sub.2 Et                                                                             CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                            CF.sub.3                                                                              4-Cl-Ph  CO(n-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)                               CF.sub.3                                                                              4-Cl-Ph  CO(i-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)                               CF.sub.3                                                                              4-Cl-Ph  CO(t-Bu) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)                               CF.sub.3                                                                              4-Cl-Ph  n-Pr     CF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.3                                                                             4-Cl-Ph  COEt     OCF.sub.3                                                                             CO.sub.2 Me                                                                            COEt                                   OCF.sub.3                                                                             4-Cl-Ph  CO.sub.2 Et                                                                             OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                            OCF.sub.3                                                                             4-Cl-Ph  CO(n-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)                               OCF.sub.3                                                                             4-Cl-Ph  CO(i-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(i-Pr)                               OCF.sub.3                                                                             Me       CO.sub.2 Et                                                                             OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(t-Bu)                               OCF.sub.3                                                                             Me       CO(n-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.3                                                                             Me       CO(i-Pr) OCF.sub.2 H                                                                           n-Pr    H                                      OCF.sub.3                                                                             Me       CO(t-Bu) OCF.sub.2 H                                                                           Me      n-Pr                                   OCF.sub.3                                                                             Me       n-Pr     OCF.sub.2 H                                                                           n-Pr    Et                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             Et       OCF.sub.2 H                                                                           n-Pr    n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr     OCF.sub.2 H                                                                           n-Pr    COMe                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe     OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Me                            OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           n-Pr    COEt                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt     OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Et                            OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr)                                                       OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr)                                                       CF.sub.3                                                                              n-Pr     COEt     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             n-Pr     COEt     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Bu) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   CF.sub.3                                                                              CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                             COEt                                   CF.sub.3                                                                              CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Et                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(n-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(i-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(t-Bu)                               OCF.sub.3                                                                             CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           n-Pr     CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.2 H                                                                           n-Pr     CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              H        OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Me       OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Et                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                              n-Pr                                                           OCF.sub.2 H                                                                           CHCH.sub.2                                                                              COMe                                                           ______________________________________                                    

                  TABLE 11                                                         ______________________________________                                          ##STR49##                                                                     R.sup.1                                                                               R.sup.3  Y        R.sup.1                                                                               R.sup.3 Y                                      ______________________________________                                         Cl     Ph       H        Cl     4-Cl-Ph H                                      Br     Ph       H        Br     4-Cl-Ph H                                      CF.sub.3                                                                              Ph       H        CF.sub.3                                                                              4-Cl-Ph H                                      OCF.sub.3                                                                             Ph       H        OCF.sub.3                                                                             4-Cl-Ph H                                      Cl     Ph       Me       Cl     4-Cl-Ph Me                                     Br     Ph       Me       Br     4-Cl-Ph Me                                     CF.sub.3                                                                              Ph       Me       CF.sub.3                                                                              4-Cl-Ph Me                                     OCF.sub.3                                                                             Ph       Me       OCF.sub.3                                                                             4-Cl-Ph Me                                     Cl     Ph       Et       Cl     4-Cl-Ph Et                                     Br     Ph       Et       Br     4-Cl-Ph Et                                     CF.sub.3                                                                              Ph       Et       CF.sub.3                                                                              4-Cl-Ph Et                                     OCF.sub.3                                                                             Ph       Et       OCF.sub.3                                                                             4-Cl-Ph Et                                     Cl     Ph       COMe     Cl     4-Cl-Ph COMe                                   Br     Ph       COMe     Br     4-Cl-Ph COMe                                   CF.sub.3                                                                              Ph       COMe     CF.sub.3                                                                              4-Cl-Ph COMe                                   OCF.sub.3                                                                             Ph       COMe     OCF.sub.3                                                                             4-Cl-Ph COMe                                   Cl     Ph       CO.sub.2 Me                                                                             Cl     4-Cl-Ph CO.sub.2 Me                            Br     Ph       CO.sub.2 Me                                                                             Br     4-Cl-Ph Co Me                                  CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                              4-Cl-Ph CO.sub.2 Me                            OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                             4-Cl-Ph CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       H        OCF.sub.2 H                                                                           Ph      CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       Me       OCF.sub.2 H                                                                           Ph      CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       Et       OCF.sub.2 H                                                                           Ph      COEt                                   OCF.sub.2 H                                                                           Ph       n-Pr     OCF.sub.2 H                                                                           Ph      CO.sub.2 Et                            Cl     4-F-Ph   H        OCF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                     Br     4-F-Ph   H        Cl     CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              4-F-Ph   H        Br     CO.sub.2 Me                                                                            Et                                     OCF.sub.3                                                                             4-F-Ph   H        CF.sub.3                                                                              CO.sub.2 Me                                                                            Et                                     Cl     4-F-Ph   Me       OCF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                     Br     4-F-Ph   Me       Cl     CO.sub.2 Me                                                                            COMe                                   CF.sub.3                                                                              4-F-Ph   Me       Br     CO.sub.2 Me                                                                            COMe                                   OCF.sub.3                                                                             4-F-Ph   Me       CF.sub.3                                                                              CO.sub.2 Me                                                                            COMe                                   Cl     4-F-Ph   Et       OCF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                   Br     A-F-Ph   Et       Cl     CO.sub.2 Me                                                                            CO.sub.2 Me                            CF.sub.3                                                                              4-F-Ph   Et       Br     CO.sub.2 Me                                                                            CO.sub.2 Me                            OCF.sub.3                                                                             4-F-Ph   Et       CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                            Cl     4-F-Ph   COMe     OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                            Br     4-F-Ph   COMe     Cl     n-Pr    H                                      CF.sub.3                                                                              4-F-Ph   COMe     Br     n-Pr    H                                      OCF.sub.3                                                                             4-F-Ph   COMe     CF.sub.3                                                                              n-Pr    H                                      Cl     4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.3                                                                             n-Pr    H                                      Br     4-F-Ph   CO.sub.2 Me                                                                             Cl     n-Pr    Me                                     CF.sub.3                                                                              4-F-Ph   CO.sub.2 Me                                                                             Br     n-Pr    Me                                     OCF.sub.3                                                                             4-F-Ph   CO.sub.2 Me                                                                             CF.sub.3                                                                              n-Pr    Me                                     Cl     CO.sub.2 Me                                                                             H        OCF.sub.3                                                                             n-Pr    Me                                     Br     CO.sub.2 Me                                                                             H        Cl     n-Pr    Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H        Br     n-Pr    Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             H        CF.sub.3                                                                              n-Pr    Et                                     Cl     CO.sub.2 Me                                                                             Me       OCF.sub.3                                                                             n-Pr    Et                                     Br     CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-Cl-Ph Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-Cl-Ph n-Pr                                   OCF.sub.2 H                                                                           Ph       CO(n-Pr) OCF.sub.2 H                                                                           4-Cl-Ph COMe                                   OCF.sub.2 H                                                                           Ph       CO(i-Pr) OCF.sub.2 H                                                                           4-Cl-Ph CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       CO(t-Bu) OCF.sub.2 H                                                                           4-Cl-Ph COEt                                   OCF.sub.2 H                                                                           4-Cl-Ph  H        OCF.sub.2 H                                                                           4-Cl-Ph CO.sub.2 Et                            OCF.sub.2 H                                                                           4-Cl-Ph  Me       OCF.sub.2 H                                                                           4-Cl-Ph CO(n-Pr)                               Cl     n-Pr     COMe     Cl     CHCH.sub.2                                                                             CO.sub.2 Me                            Br     n-Pr     COMe     Br     CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     COMe     CF.sub.3                                                                              CHCH.sub.2                                                                             CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     COMe     OCF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                            Cl     n-Pr     CO.sub.2 Me                                                                             Cl     C(CH.sub.3)CH.sub.2                                                                    H                                      Br     n-Pr     CO.sub.2 Me                                                                             Br     C(CH.sub.3)CH.sub.2                            CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    H                                      Cl     CHCH.sub.2                                                                              H        Cl     C(CH.sub.3)CH.sub.2                                                                    Me                                     Br     CHCH.sub.2                                                                              H        Br     C(CH.sub.3)CH.sub.2                                                                    Me                                     CF.sub.3                                                                              CHCH.sub.2                                                                              H        CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              H        OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Me                                     Cl     CHCH.sub.2                                                                              Me       Cl     C(CH.sub.3)CH.sub.2                                                                    Et                                     Br     CHCH.sub.2                                                                              Me       Br     C(CH.sub.3)CH.sub.2                                                                    Et                                     CF.sub.3                                                                              CHCH.sub.2                                                                              Me       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              Me       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Et                                     Cl     CHCH.sub.2                                                                              Et       Cl     C(CH.sub.3)CH.sub.2                                                                    COMe                                   Br     CHCH.sub.2                                                                              Et       Br     C(CH.sub.3)CH.sub.2                                                                    COMe                                   CF.sub.3                                                                              CHCH.sub.2                                                                              Et       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              Et       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COMe                                   Cl     CHCH.sub.2                                                                              COMe     Cl     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            Br     CHCH.sub.2                                                                              COMe     Br     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO.sub.2 Me                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.3                                                                             CHCH.sub.2                                                                              COMe     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           4-Cl-Ph  CO(i-Pr) OCF.sub.2 H                                                                           4-F-Ph  COEt                                   OCF.sub.2 H                                                                           4-Cl-Ph  CO(t-BU) OCF.sub.2 H                                                                           4-F-Ph  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-F-Ph   H        OCF.sub.2 H                                                                           4-F-Ph  CO(n-Pr)                               OCF.sub.2 H                                                                           4-F-Ph   Me       OCF.sub.2 H                                                                           4-F-Ph  CO(i-Pr)                               OCF.sub.2 H                                                                           4-F-Ph   Et       OCF.sub.2 H                                                                           4-F-Ph  CO (t-Bu)                              OCF.sub.2 H                                                                           4-F-Ph   n-Pr     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            H                                      OCF.sub.2 H                                                                           4-F-Ph   COMe     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Me                                     OCF.sub.2 H                                                                           4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              Ph       COEt     CF.sub.3                                                                              4-F-Ph  COEt                                   CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                              4-F-Ph  CO.sub.2 Et                            CF.sub.3                                                                              Ph       CO(n-Pr) CF.sub.3                                                                              4-F-Ph  CO.sub.(n-Pr)                          CF.sub.3                                                                              Ph       CO(i-Pr) CF.sub.3                                                                              4-F-Ph  CO(i-Pr)                               CF.sub.3                                                                              Ph       CO(t-Bu) CF.sub.3                                                                              4-F-Ph  CO(t-Bu)                               CF.sub.3                                                                              Ph       n-Pr     CF.sub.3                                                                              4-F-Ph                                         OCF.sub.3                                                                             Ph       COEt     OCF.sub.3                                                                             4-F-Ph  COEt                                   OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                             4-F-Ph  CO.sub.2 Et                            OCF.sub.3                                                                             Ph       CO(n-Pr) OCF.sub.3                                                                             4-F-Ph  CO(n-Pr)                               OCF.sub.3                                                                             Ph       CO(i-Pr) OCF.sub.3                                                                             4-F-Ph  CO(i-Pr)                               OCF.sub.3                                                                             Ph       CO(t-Bu) OCF.sub.3                                                                             4-F-Ph  CO(t-Bu)                               OCF.sub.3                                                                             Ph       n-Pr     OCF.sub.3                                                                             4-F-Ph  n-Pr                                   CF.sub.3                                                                              4-Cl-Ph  COEt     CF.sub.3                                                                              CO.sub.2 Me                                                                            COEt                                   CF.sub.3                                                                              4-Cl-Ph  CO.sub.2 Et                                                                             CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                            CF.sub.3                                                                              4-Cl-Ph  CO(n-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)                               CF.sub.3                                                                              4-Cl-Ph  CO(i-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)                               CF.sub.3                                                                              4-Cl-Ph  CO(t-Bu) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)                               CF.sub.3                                                                              4-Cl-Ph  n-Pr     CF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.3                                                                             4-Cl-Ph  COEt     OCF.sub.3                                                                             CO.sub.2 Me                                                                            COEt                                   OCF.sub.3                                                                             4-Cl-Ph  CO.sub.2 Et                                                                             OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                            OCF.sub.3                                                                             4-Cl-Ph  CO(n-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)                               OCF.sub.3                                                                             4-Cl-Ph  CO(i-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(i-Pr)                               OCF.sub.3                                                                             4-Cl-Ph  CO(t-Bu) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(t-Bu)                               OCF.sub.3                                                                             4-Cl-Ph  n-Pr     OCF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr     OCF.sub.2 H                                                                           n-Pr    H                                      OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe     OCF.sub.2 H                                                                           n-Pr    Me                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           n-Pr    Et                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt     OCF.sub.2 H                                                                           n-Pr    n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           n-Pr    COMe                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Me                            OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr) OCF.sub.2 H                                                                           n-Pr    COEt                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(t-Bu) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     COEt     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             n-Pr     COEt     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Bu) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   CF.sub.3                                                                              CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                             COEt                                   CF.sub.3                                                                              CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Et                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(n-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(i-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(t-Bu)                               OCF.sub.3                                                                             CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           n-Pr     CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.2 H                                                                           n-Pr     CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              H        OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Me       OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Et                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                              n-Pr                                                           OCF.sub.2 H                                                                           CHCH.sub.2                                                                              COMe                                                           ______________________________________                                    

                  TABLE 12                                                         ______________________________________                                          ##STR50##                                                                     R.sup.1                                                                               R.sup.3  Y        R.sup.1                                                                               R.sup.3 Y                                      ______________________________________                                         Cl     Ph       H        Cl     4-ClPh  H                                      Br     Ph       H        Br     4-ClPh  H                                      CF.sub.3                                                                              Ph       H        CF.sub.3                                                                              4-ClPh  H                                      OCF.sub.3                                                                             Ph       H        OCF.sub.3                                                                             4-ClPh  H                                      Cl     Ph       Me       Cl     4-ClPh  Me                                     Br     Ph       Me       Br     4-ClPh  Me                                     CF.sub.3                                                                              Ph       Me       CF.sub.3                                                                              4-ClPh  Me                                     OCF.sub.3                                                                             Ph       Me       OCF.sub.3                                                                             4-ClPh  Me                                     Cl     Ph       Et       Cl     4-ClPh  Et                                     Br     Ph       Et       Br     4-ClPh  Et                                     CF.sub.3                                                                              Ph       Et       CF.sub.3                                                                              4-ClPh  Et                                     OCF.sub.3                                                                             Ph       Et       OCF.sub.3                                                                             4-ClPh  Et                                     Cl     Ph       COMe     Cl     4-ClPh  COMe                                   Br     Ph       COMe     Br     4-ClPh  COMe                                   CF.sub.3                                                                              Ph       COMe     CF.sub.3                                                                              4-ClPh  COMe                                   OCF.sub.3                                                                             Ph       COMe     OCF.sub.3                                                                             4-ClPh  COMe                                   Cl     Ph       CO.sub.2 Me                                                                             Cl     4-ClPh  CO.sub.2 Me                            Br     Ph       CO.sub.2 Me                                                                             Br     4-ClPh  CO.sub.2 Me                            CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                              4-ClPh  CO.sub.2 Me                            OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                             4-ClPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       H        OCF.sub.2 H                                                                           Ph      COMe                                   OCF.sub.2 H                                                                           Ph       Me       OCF.sub.2 H                                                                           Ph      CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       Et       OCF.sub.2 H                                                                           Ph      COEt                                   OCF.sub.2 H                                                                           Ph       n-Pr     OCF.sub.2 H                                                                           Ph      CO.sub.2 Et                            Cl     4-FPh    H        OCF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                     Br     4-FPh    H        Cl     CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              4-FPh    H        Br     CO.sub.2 Me                                                                            Et                                     OCF.sub.3                                                                             4-FPh    H        CF.sub.3                                                                              CO.sub.2 Me                                                                            Et                                     Cl     4-FPh    Me       OCF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                     Br     4-FPh    Me       Cl     CO.sub.2 Me                                                                            COMe                                   CF.sub.3                                                                              4-FPh    Me       Br     CO.sub.2 Me                                                                            COMe                                   OCF.sub.3                                                                             4-FPh    Me       CF.sub.3                                                                              CO.sub.2 Me                                                                            COMe                                   Cl     4-FPh    Et       OCF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                   Br     4-FPh    Et       Cl     CO.sub.2 Me                                                                            CO.sub.2 Me                            CF.sub.3                                                                              4-FPh    Et       Br     CO.sub.2 Me                                                                            CO.sub.2 Me                            OCF.sub.3                                                                             4-FPh    Et       CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                            Cl     4-FPh    COMe     OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                            Br     4-FPh    COMe     Cl     n-Pr    H                                      CF.sub.3                                                                              4-FPh    COMe     Br     n-Pr    H                                      OCF.sub.3                                                                             4-FPh    COMe     CF.sub.3                                                                              n-Pr    H                                      Cl     4-FPh    CO.sub.2 Me                                                                             OCF.sub.3                                                                             n-Pr    H                                      Br     4-FPh    CO.sub.2 Me                                                                             Cl     n-Pr    Me                                     CF.sub.3                                                                              4-FPh    CO.sub.2 Me                                                                             Br     n-Pr    Me                                     OCF.sub.3                                                                             4-FPh    CO.sub.2 Me                                                                             CF.sub.3                                                                              n-Pr    Me                                     Cl     CO.sub.2 Me                                                                             H        OCF.sub.3                                                                             n-Pr    Me                                     Br     CO.sub.2 Me                                                                             H        Cl     n-Pr    Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H        Br     n-Pr    Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             H        CF.sub.3                                                                              n-Pr    Et                                     Cl     CO.sub.2 Me                                                                             Me       OCF.sub.3                                                                             n-Pr    Et                                     Br     CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-ClPh  Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-ClPh  n-Pr                                   OCF.sub.2 H                                                                           Ph       CO(n-Pr) OCF.sub.2 H                                                                           4-ClPh  COMe                                   OCF.sub.2 H                                                                           Ph       CO(i-Pr) OCF.sub.2 H                                                                           4-ClPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       CO(t-Bu) OCF.sub.2 H                                                                           4-ClPh  COEt                                   OCF.sub.2 H                                                                           4-ClPh   H        OCF.sub.2 H                                                                           4-ClPh  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-ClPh   Me       OCF.sub.2 H                                                                           4-ClPh  CO(n-Pr)                               Cl     n-Pr     COMe     Cl     CHCH.sub.2                                                                             CO.sub.2 Me                            Br     n-Pr     COMe     Br     CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     COMe     CF.sub.3                                                                              CHCH.sub.2                                                                             CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     COMe     OCF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                            Cl     n-Pr     CO.sub.2 Me                                                                             Cl     C(CH.sub.3)CH.sub.2                                                                    H                                      Br     n-Pr     CO.sub.2 Me                                                                             Br     C(CH.sub.3)CH.sub.2                                                                    H                                      CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    H                                      Cl     CHCH.sub.2                                                                              H        Cl     C(CH.sub.3)CH.sub.2                                                                    Me                                     Br     CHCH.sub.2                                                                              H        Br     C(CH.sub.3)CH.sub.2                                                                    Me                                     CF.sub.3                                                                              CHCH.sub.2                                                                              H        CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              H        OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Me                                     Cl     CHCH.sub.2                                                                              Me       Cl     C(CH.sub.3)CH.sub.2                                                                    Et                                     Br     CHCH.sub.2                                                                              Me       Br     C(CH.sub.3)CH.sub.2                                                                    Et                                     CF.sub.3                                                                              CHCH.sub.2                                                                              Me       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              Me       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Et                                     Cl     CHCH.sub.2                                                                              Et       Cl     C(CH.sub.3)CH.sub.2                                                                    COMe                                   Br     CHCH.sub.2                                                                              Et       Br     C(CH.sub.3)CH.sub.2                                                                    COMe                                   CF.sub.3                                                                              CHCH.sub.2                                                                              Et       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              Et       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COMe                                   Cl     CHCH.sub.2                                                                              COMe     Cl     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            Br     CHCH.sub.2                                                                              COMe     Br     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              COMe     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.3                                                                             CHCH.sub.2                                                                              COMe     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   CO(i-Pr) OCF.sub.2 H                                                                           4-FPh   COEt                                   OCF.sub.2 H                                                                           4-ClPh   CO(t-Bu) OCF.sub.2 H                                                                           4-FPh   CO.sub.2 Et                            OCF.sub.2 H                                                                           4-FPh    H        OCF.sub.2 H                                                                           4-FPh   CO(n-Pr)                               OCF.sub.2 H                                                                           4-FPh    Me       OCF.sub.2 H                                                                           4-FPh   CO(i-Pr)                               OCF.sub.2 H                                                                           4-FPh    Et       OCF.sub.2 H                                                                           4-FPh   CO(t-Bu)                               OCF.sub.2 H                                                                           4-FPh    n-Pr     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            H                                      OCF.sub.2 H                                                                           4-FPh    COMe     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Me                                     OCF.sub.2 H                                                                           4-FPh    CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              Ph       COEt     CF.sub.3                                                                              4-FPh   COEt                                   CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                              4-FPh   CO.sub.2 Et                            CF.sub.3                                                                              Ph       CO(n-Pr) CF.sub.3                                                                              4-FPh   CO(n-Pr)                               CF.sub.3                                                                              Ph       CO(i-Pr) CF.sub.3                                                                              4-FPh   CO(i-Pr)                               CF.sub.3                                                                              Ph       CO(t-Bu) CF.sub.3                                                                              4-FPh   CO(t-Bu)                               CF.sub.3                                                                              Ph       n-Pr     CF.sub.3                                                                              4-FPh   n-Pr                                   OCF.sub.3                                                                             Ph       COEt     OCF.sub.3                                                                             4-FPh   COEt                                   OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                             4-FPh   CO.sub.2 Et                            OCF.sub.3                                                                             Ph       CO(n-Pr) OCF.sub.3                                                                             4-FPh   CO(n-Pr)                               OCF.sub.3                                                                             Ph       CO(i-Pr) OCF.sub.3                                                                             4-FPh   CO(i-Pr)                               OCF.sub.3                                                                             Ph       CO(t-Bu) OCF.sub.3                                                                             4-FPh   CO(t-Bu)                               OCF.sub.3                                                                             Ph       n-Pr     OCF.sub.3                                                                             4-FPh   n-Pr                                   CF.sub.3                                                                              4-ClPh   COEt     CF.sub.3                                                                              CO.sub.2 Me                                                                            COEt                                   CF.sub.3                                                                              4-ClPh   CO.sub.2 Et                                                                             CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                            CF.sub.3                                                                              4-ClPh   CO(n-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)                               CF.sub.3                                                                              4-ClPh   CO(i-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)                               CF.sub.3                                                                              4-ClPh   CO(t-Bu) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)                               CF.sub.3                                                                              4-ClPh   n-Pr     CF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.3                                                                             4-ClPh   COEt     OCF.sub.3                                                                             CO.sub.2 Me                                                                            COEt                                   OCF.sub.3                                                                             4-ClPh   CO.sub.2 Et                                                                             OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                            OCF.sub.3                                                                             4-ClPh   CO(n-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)                               OCF.sub.3                                                                             4-ClPh   CO(i-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(i-Pr)                               OCF.sub.3                                                                             4-ClPh   CO(t-Bu) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(t-Bu)                               OCF.sub.3                                                                             4-ClPh   n-Pr     OCF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr     OCF.sub.2 H                                                                           n-Pr    H                                      OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe     OCF.sub.2 H                                                                           n-Pr    Me                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           n-Pr    Et                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt     OCF.sub.2 H                                                                           n-Pr    n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           n-Pr    COMe                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Me                            OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr) OCF.sub.2 H                                                                           n-Pr    COEt                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(t-Bu) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     COEt     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             n-Pr     COEt     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Bu) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   CF.sub.3                                                                              CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                             COEt                                   CF.sub.3                                                                              CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Et                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(n-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(i-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(t-Bu)                               OCF.sub.3                                                                             CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           n-Pr     CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.2 H                                                                           n-Pr     CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              H        OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Me       OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Et                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                              n-Pr                                                           OCF.sub.2 H                                                                           CHCH.sub.2                                                                              COMe                                                           ______________________________________                                    

                  TABLE 13                                                         ______________________________________                                          ##STR51##                                                                     R.sup.1                                                                               R.sup.3  Y        R.sup.1                                                                               R.sup.3 Y                                      ______________________________________                                         Cl     Ph       H        Cl     4-ClPh  H                                      Br     Ph       H        Br     4-ClPh  H                                      CF.sub.3                                                                              Ph       H        CF.sub.3                                                                              4-ClPh  H                                      OCF.sub.3                                                                             Ph       H        OCF.sub.3                                                                             4-ClPh  H                                      Cl     Ph       Me       Cl     4-ClPh  Me                                     Br     Ph       Me       Br     4-ClPh  Me                                     CF.sub.3                                                                              Ph       Me       CF.sub.3                                                                              4-ClPh  Me                                     OCF.sub.3                                                                             Ph       Me       OCF.sub.3                                                                             4-ClPh  Me                                     Cl     Ph       Et       Cl     4-ClPh  Et                                     Br     Ph       Et       Br     4-ClPh  Et                                     CF.sub.3                                                                              Ph       Et       CF.sub.3                                                                              4-ClPh  Et                                     OCF.sub.3                                                                             Ph       Et       OCF.sub.3                                                                             4-ClPh  Et                                     Cl     Ph       COMe     Cl     4-ClPh  COMe                                   Br     Ph       COMe     Br     4-ClPh  COMe                                   CF.sub.3                                                                              Ph       COMe     CF.sub.3                                                                              4-ClPh  COMe                                   OCF.sub.3                                                                             Ph       COMe     OCF.sub.3                                                                             4-ClPh  COMe                                   Cl     Ph       CO.sub.2 Me                                                                             Cl     4-ClPh  CO.sub.2 Me                            Br     Ph       CO.sub.2 Me                                                                             Br     4-ClPh  CO.sub.2 Me                            CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                             CF.sub.3                                                                              4-ClPh  CO.sub.2 Me                            OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                             OCF.sub.3                                                                             4-ClPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       H        OCF.sub.2 H                                                                           Ph      COMe                                   OCF.sub.2 H                                                                           Ph       Me       OCF.sub.2 H                                                                           Ph      CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       Et       OCF.sub.2 H                                                                           Ph      COEt                                   OCF.sub.2 H                                                                           Ph       n-Pr     OCF.sub.2 H                                                                           Ph      CO.sub.2 Et                            Cl     4-FPh    H        OCF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                     Br     4-FPh    H        Cl     CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              4-FPh    H        Br     CO.sub.2 Me                                                                            Et                                     OCF.sub.3                                                                             4-FPh    H        CF.sub.3                                                                              CO.sub.2 Me                                                                            Et                                     Cl     4-FPh    Me       OCF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                     Br     4-FPh    Me       Cl     CO.sub.2 Me                                                                            COMe                                   CF.sub.3                                                                              4-FPh    Me       Br     CO.sub.2 Me                                                                            COMe                                   OCF.sub.3                                                                             4-FPh    Me       CF.sub.3                                                                              CO.sub.2 Me                                                                            COMe                                   Cl     4-FPh    Et       OCF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                   Br     4-FPh    Et       Cl     CO.sub.2 Me                                                                            CO.sub.2 Me                            CF.sub.3                                                                              4-FPh    Et       Br     CO.sub.2 Me                                                                            CO.sub.2 Me                            OCF.sub.3                                                                             4-FPh    Et       CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                            Cl     4-FPh    COMe     OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                            Br     4-FPh    COMe     Cl     n-Pr    H                                      CF.sub.3                                                                              4-FPh    COMe     Br     n-Pr    H                                      OCF.sub.3                                                                             4-FPh    COMe     CF.sub.3                                                                              n-Pr    H                                      Cl     4-FPh    CO.sub.2 Me                                                                             OCF.sub.3                                                                             n-Pr    H                                      Br     4-FPh    CO.sub.2 Me                                                                             Cl     n-Pr    Me                                     CF.sub.3                                                                              4-FPh    CO.sub.2 Me                                                                             Br     n-Pr    Me                                     OCF.sub.3                                                                             4-FPh    CO.sub.2 Me                                                                             CF.sub.3                                                                              n-Pr    Me                                     Cl     CO.sub.2 Me                                                                             H        OCF.sub.3                                                                             n-Pr    Me                                     Br     CO.sub.2 Me                                                                             H        Cl     n-Pr    Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H        Br     n-Pr    Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             H        CF.sub.3                                                                              n-Pr    Et                                     Cl     CO.sub.2 Me                                                                             Me       OCF.sub.3                                                                             n-Pr    Et                                     Br     CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-ClPh  Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Me       OCF.sub.2 H                                                                           4-ClPh  n-Pr                                   OCF.sub.2 H                                                                           Ph       CO(n-Pr) OCF.sub.2 H                                                                           4-ClPh  COMe                                   OCF.sub.2 H                                                                           Ph       CO(i-Pr) OCF.sub.2 H                                                                           4-ClPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           Ph       CO(t-Bu) OCF.sub.2 H                                                                           4-ClPh  COEt                                   OCF.sub.2 H                                                                           4-ClPh   H        OCF.sub.2 H                                                                           4-ClPh  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-ClPh   Me       OCF.sub.2 H                                                                           4-ClPh  CO(n-Pr)                               Cl     n-Pr     COMe     Cl     CHCH.sub.2                                                                             CO.sub.2 Me                            Br     n-Pr     COMe     Br     CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     COMe     CF.sub.3                                                                              CHCH.sub.2                                                                             CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     COMe     OCF.sub.3                                                                             CHCH.sub.2                                                                             CO.sub.2 Me                            Cl     n-Pr     CO.sub.2 Me                                                                             Cl     C(CH.sub.3)CH.sub.2                                                                    H                                      Br     n-Pr     CO.sub.2 Me                                                                             Br     C(CH.sub.3)CH.sub.2                                                                    H                                      CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    H                                      Cl     CHCH.sub.2                                                                              H        Cl     C(CH.sub.3)CH.sub.2                                                                    Me                                     Br     CHCH.sub.2                                                                              H        Br     C(CH.sub.3)CH.sub.2                                                                    Me                                     CF.sub.3                                                                              CHCH.sub.2                                                                              H        CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              H        OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Me                                     Cl     CHCH.sub.2                                                                              Me       Cl     C(CH.sub.3)CH.sub.2                                                                    Et                                     Br     CHCH.sub.2                                                                              Me       Br     C(CH.sub.3)CH.sub.2                                                                    Et                                     CF.sub.3                                                                              CHCH.sub.2                                                                              Me       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              Me       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    Et                                     Cl     CHCH.sub.2                                                                              Et       Cl     C(CH.sub.3)CH.sub.2                                                                    COMe                                   Br     CHCH.sub.2                                                                              Et       Br     C(CH.sub.3)CH.sub.2                                                                    COMe                                   CF.sub.3                                                                              CHCH.sub.2                                                                              Et       CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              Et       OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COMe                                   Cl     CHCH.sub.2                                                                              COMe     Cl     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            Br     CHCH.sub.2                                                                              COMe     Br     C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              COMe     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.3                                                                             CHCH.sub.2                                                                              COMe     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   CO(i-Pr) OCF.sub.2 H                                                                           4-FPh   COEt                                   OCF.sub.2 H                                                                           4-ClPh   CO(t-Bu) OCF.sub.2 H                                                                           4-FPh   CO.sub.2 Et                            OCF.sub.2 H                                                                           4-FPh    H        OCF.sub.2 H                                                                           4-FPh   CO(n-Pr)                               OCF.sub.2 H                                                                           4-FPh    Me       OCF.sub.2 H                                                                           4-FPh   CO(i-Pr)                               OCF.sub.2 H                                                                           4-FPh    Et       OCF.sub.2 H                                                                           4-FPh   CO(t-Bu)                               OCF.sub.2 H                                                                           4-FPh    n-Pr     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            H                                      OCF.sub.2 H                                                                           4-FPh    COMe     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Me                                     OCF.sub.2 H                                                                           4-FPh    CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           CO.sub.2 Me                                                                            Et                                     CF.sub.3                                                                              Ph       COEt     CF.sub.3                                                                              4-FPh   COEt                                   CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                             CF.sub.3                                                                              4-FPh   CO.sub.2 Et                            CF.sub.3                                                                              Ph       CO(n-Pr) CF.sub.3                                                                              4-FPh   CO(n-Pr)                               CF.sub.3                                                                              Ph       CO(i-Pr) CF.sub.3                                                                              4-FPh   CO(i-Pr)                               CF.sub.3                                                                              Ph       CO(t-Bu) CF.sub.3                                                                              4-FPh   CO(t-Bu)                               CF.sub.3                                                                              Ph       n-Pr     CF.sub.3                                                                              4-FPh   n-Pr                                   OCF.sub.3                                                                             Ph       COEt     OCF.sub.3                                                                             4-FPh   COEt                                   OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                             OCF.sub.3                                                                             4-FPh   CO.sub.2 Et                            OCF.sub.3                                                                             Ph       CO(n-Pr) OCF.sub.3                                                                             4-FPh   CO(n-Pr)                               OCF.sub.3                                                                             Ph       CO(i-Pr) OCF.sub.3                                                                             4-FPh   CO(i-Pr)                               OCF.sub.3                                                                             Ph       CO(t-Bu) OCF.sub.3                                                                             4-FPh   CO(t-Bu)                               OCF.sub.3                                                                             Ph       n-Pr     OCF.sub.3                                                                             4-FPh   n-Pr                                   CF.sub.3                                                                              4-ClPh   COEt     CF.sub.3                                                                              CO.sub.2 Me                                                                            COEt                                   CF.sub.3                                                                              4-ClPh   CO.sub.2 Et                                                                             CF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                            CF.sub.3                                                                              4-ClPh   CO(n-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)                               CF.sub.3                                                                              4-ClPh   CO(i-Pr) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)                               CF.sub.3                                                                              4-ClPh   CO(t-Bu) CF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)                               CF.sub.3                                                                              4-ClPh   n-Pr     CF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.3                                                                             4-ClPh   COEt     OCF.sub.3                                                                             CO.sub.2 Me                                                                            COEt                                   OCF.sub.3                                                                             4-ClPh   CO.sub.2 Et                                                                             OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Et                            OCF.sub.3                                                                             4-ClPh   CO(n-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(n-Pr)                               OCF.sub.3                                                                             4-ClPh   CO(i-Pr) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(i-Pr)                               OCF.sub.3                                                                             4-ClPh   CO(t-Bu) OCF.sub.3                                                                             CO.sub.2 Me                                                                            CO(t-Bu)                               OCF.sub.3                                                                             4-ClPh   n-Pr     OCF.sub.3                                                                             CO.sub.2 Me                                                                            n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr     OCF.sub.2 H                                                                           n-Pr    H                                      OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe     OCF.sub.2 H                                                                           n-Pr    Me                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             OCF.sub.2 H                                                                           n-Pr    Et                                     OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt     OCF.sub.2 H                                                                           n-Pr    n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           n-Pr    COMe                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Me                            OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr) OCF.sub.2 H                                                                           n-Pr    COEt                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(t-Bu) OCF.sub.2 H                                                                           n-Pr    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     COEt     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                             CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu) CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr     CF.sub.3                                                                              C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             n-Pr     COEt     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                             OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Bu) OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr     OCF.sub.3                                                                             C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   CF.sub.3                                                                              CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Me                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                             COEt                                   CF.sub.3                                                                              CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO.sub.2 Et                            CF.sub.3                                                                              CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(n-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(i-Pr)                               CF.sub.3                                                                              CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           CHCH.sub.2                                                                             CO(t-Bu)                               OCF.sub.3                                                                             CHCH.sub.2                                                                              COEt     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    H                                      OCF.sub.3                                                                             CHCH.sub.2                                                                              CO.sub.2 Et                                                                             OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Me                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    Et                                     OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    n-Pr                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COMe                                   OCF.sub.3                                                                             CHCH.sub.2                                                                              n-Pr     OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Me                            OCF.sub.2 H                                                                           n-Pr     CO(n-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    COEt                                   OCF.sub.2 H                                                                           n-Pr     CO(i-Pr) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     CO(t-Bu) OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(n-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              H        OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(i-Pr)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Me       OCF.sub.2 H                                                                           C(CH.sub.3)CH.sub.2                                                                    CO(t-Bu)                               OCF.sub.2 H                                                                           CHCH.sub.2                                                                              Et                                                             OCF.sub.2 H                                                                           CHCH.sub.2                                                                              n-Pr                                                           OCF.sub.2 H                                                                           CHCH.sub.2                                                                              COMe                                                           ______________________________________                                    

                  TABLE 14                                                         ______________________________________                                          ##STR52##                                                                     R.sup.1                                                                              R.sup.3   Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                             Ph        H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                             Ph        Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                             Ph        Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                             Ph        COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                             Ph        CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                            Ph        H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                            Ph        Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                            Ph        Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                            Ph        COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                            Ph        CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                             4-ClPh    H         CF.sub.3                                                                             n-Pr   H                                       CF.sub.3                                                                             4-ClPh    Me        CF.sub.3                                                                             n-Pr   Me                                      CF.sub.3                                                                             4-ClPh    Et        CF.sub.3                                                                             n-Pr   Et                                      CF.sub.3                                                                             4-ClPh    COMe      CF.sub.3                                                                             n-Pr   COMe                                    CF.sub.3                                                                             4-ClPh    CO.sub.2 Me                                                                              CF.sub.3                                                                             n-Pr   CO.sub.2 Me                             OCF.sub.3                                                                            4-ClPh    H         OCF.sub.3                                                                            n-Pr   H                                       OCF.sub.3                                                                            4-ClPh    Me        OCF.sub.3                                                                            n-Pr   Me                                      OCF.sub.3                                                                            4-ClPh    Et        OCF.sub.3                                                                            n-Pr   Et                                      OCF.sub.3                                                                            4-ClPh    COMe      OCF.sub.3                                                                            n-Pr   COMe                                    OCF.sub.3                                                                            4-ClPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                             CF.sub.3                                                                             Ph        COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                             Ph        CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                             Ph        CO(n-Pr)  CF.sub.3                                                                             4-FPh  (n-Pr)                                  CF.sub.3                                                                             Ph        CO(i-Pr)  CF.sub.3                                                                             4-FPh  (i-Pr)                                  CF.sub.3                                                                             Ph        CO(t-Bu)  CF.sub.3                                                                             4-FPh  (t-Bu)                                  CF.sub.3                                                                             Ph        n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                            Ph        COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                            Ph        CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                            Ph        CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                            Ph        CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                            Ph        CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                            Ph        n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                             4-ClPh    COEt      CF.sub.3                                                                             n-Pr   COEt                                    CF.sub.3                                                                             4-ClPh    CO.sub.2 Et                                                                              CF.sub.3                                                                             n-Pr   CO.sub.2 Et                             CF.sub.3                                                                             4-ClPh    CO(n-Pr)  CF.sub.3                                                                             n-Pr   CO(n-Pr)                                CF.sub.3                                                                             4-ClPh    CO(i-Pr)  CF.sub.3                                                                             n-Pr   CO(i-Pr)                                CF.sub.3                                                                             4-ClPh    CO(t-Bu)  CF.sub.3                                                                             n-Pr   CO(t-Bu)                                CF.sub.3                                                                             4-ClPh    n-Pr      CF.sub.3                                                                             n-Pr   n-Pr                                    OCF.sub.3                                                                            4-ClPh    COEt      OCF.sub.3                                                                            n-Pr   COEt                                    OCF.sub.3                                                                            4-ClPh    CO.sub.2 Et                                                                              OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                             OCF.sub.3                                                                            4-ClPh    CO(n-Pr)  OCF.sub.3                                                                            n-Pr   CO(n-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(i-Pr)  OCF.sub.3                                                                            n-Pr   CO(i-Pr)                                OCF.sub.3                                                                            4-ClPh    CO(t-Bu)  OCF.sub.3                                                                            n-Pr   CO(t-Bu)                                OCF.sub.3                                                                            4-ClPh    n-Pr      OCF.sub.3                                                                            n-Pr   n-Pr                                    ______________________________________                                    

                  TABLE 15                                                         ______________________________________                                          ##STR53##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-F-Ph H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-F-Ph Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-F-Ph Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-F-Ph COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-F-Ph H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-F-Ph Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-F-Ph Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-F-Ph COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                              4-Cl-Ph  H         CF.sub.3                                                                             n-Pr   H                                       CF.sub.3                                                                              4-Cl-Ph  Me        CF.sub.3                                                                             n-Pr   Me                                      CF.sub.3                                                                              4-Cl-Ph  Et        CF.sub.3                                                                             n-Pr   Et                                      CF.sub.3                                                                              4-Cl-Ph  COMe      CF.sub.3                                                                             n-Pr   COMe                                    CF.sub.3                                                                              4-Cl-Ph  CO.sub.2 Me                                                                              CF.sub.3                                                                             n-Pr   CO.sub.2 Me                             OCF.sub.3                                                                             4-Cl-Ph  H         OCF.sub.3                                                                            n-Pr   H                                       OCF.sub.3                                                                             4-Cl-Ph  Me        OCF.sub.3                                                                            n-Pr   Me                                      OCF.sub.3                                                                             4-Cl-Ph  Et        OCF.sub.3                                                                            n-Pr   Et                                      OCF.sub.3                                                                             4-Cl-Ph  COMe      OCF.sub.3                                                                            n-Pr   COMe                                    OCF.sub.3                                                                             4-Cl-Ph  CO.sub.2 Me                                                                              OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                             CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-F-Ph COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-F-Ph CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-F-Ph CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-F-Ph CO(t-Bu)                                CF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-F-Ph n-Pr                                    OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-F-Ph COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                             Ph       n-Pr      OCF.sub.3                                                                            4-F-Ph n-Pr                                    CF.sub.3                                                                              4-Cl-Ph  COEt      CF.sub.3                                                                             n-Pr   COEt                                    CF.sub.3                                                                              4-Cl-Ph  CO.sub.2 Et                                                                              CF.sub.3                                                                             n-Pr   CO.sub.2 Et                             CF.sub.3                                                                              4-Cl-Ph  CO(n-Pr)  CF.sub.3                                                                             n-Pr   CO(n-Pr)                                CF.sub.3                                                                              4-Cl-Ph  CO(i-Pr)  CF.sub.3                                                                             n-Pr   CO(i-Pr)                                CF.sub.3                                                                              4-Cl-Ph  CO(t-Bu)  CF.sub.3                                                                             n-Pr   CO(t-Bu)                                CF.sub.3                                                                              4-Cl-Ph  n-Pr      CF.sub.3                                                                             n-Pr   n-Pr                                    OCF.sub.3                                                                             4-Cl-Ph  COEt      OCF.sub.3                                                                            n-Pr   COEt                                    OCF.sub.3                                                                             4-Cl-Ph  CO.sub.2 Et                                                                              OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                             OCF.sub.3                                                                             4-Cl-Ph  CO(n-Pr)  OCF.sub.3                                                                            n-Pr   CO(n-Pr)                                OCF.sub.3                                                                             4-Cl-Ph  CO(i-Pr)  OCF.sub.3                                                                            n-Pr   CO(i-Pr)                                OCF.sub.3                                                                             4-Cl-Ph  CO(t-Bu)  OCF.sub.3                                                                            n-Pr   CO(t-Bu)                                OCF.sub.3                                                                             4-Cl-Ph  n-Pr      OCF.sub.3                                                                            n-Pr   n-Pr                                    ______________________________________                                    

                  TABLE 16                                                         ______________________________________                                          ##STR54##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-F-Ph H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-F-Ph Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-F-Ph Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-F-Ph COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-F-Ph CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-F-Ph H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-F-Ph Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-F-Ph Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-F-Ph COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-F-Ph CO.sub.2 Me                             CF.sub.3                                                                              4-Cl-Ph  H         CF.sub.3                                                                             n-Pr   H                                       CF.sub.3                                                                              4-Cl-Ph  Me        CF.sub.3                                                                             n-Pr   Me                                      CF.sub.3                                                                              4-Cl-Ph  Et        CF.sub.3                                                                             n-Pr   Et                                      CF.sub.3                                                                              4-Cl-Ph  COMe      CF.sub.3                                                                             n-Pr   COMe                                    CF.sub.3                                                                              4-Cl-Ph  CO.sub.2 Me                                                                              CF.sub.3                                                                             n-Pr   CO.sub.2 Me                             OCF.sub.3                                                                             4-Cl-Ph  H         OCF.sub.3                                                                            n-Pr   H                                       OCF.sub.3                                                                             4-Cl-Ph  Me        OCF.sub.3                                                                            n-Pr   Me                                      OCF.sub.3                                                                             4-Cl-Ph  Et        OCF.sub.3                                                                            n-Pr   Et                                      OCF.sub.3                                                                             4-Cl-Ph  COMe      OCF.sub.3                                                                            n-Pr   COMe                                    OCF.sub.3                                                                             4-Cl-Ph  CO.sub.2 Me                                                                              OCF.sub.3                                                                            n-Pr   CO.sub.2 Me                             CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-F-Ph COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-F-Ph CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-F-Ph CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-F-Ph CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-F-Ph CO(t-Bu)                                CF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-F-Ph n-Pr                                    OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-F-Ph COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-F-Ph CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-F-Ph CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-F-Ph CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-F-Ph CO(t-Bu)                                OCF.sub.3                                                                             Ph       n-Pr      OCF.sub.3                                                                            4-F-Ph n-Pr                                    CF.sub.3                                                                              4-Cl-Ph  COEt      CF.sub.3                                                                             n-Pr   COEt                                    CF.sub.3                                                                              4-Cl-Ph  CO.sub.2 Et                                                                              CF.sub.3                                                                             n-Pr   CO.sub.2 Et                             CF.sub.3                                                                              4-Cl-Ph  CO(n-Pr)  CF.sub.3                                                                             n-Pr   CO(n-Pr)                                CF.sub.3                                                                              4-Cl-Ph  CO(i-Pr)  CF.sub.3                                                                             n-Pr   CO(i-Pr)                                CF.sub.3                                                                              4-Cl-Ph  CO(t-Bu)  CF.sub.3                                                                             n-Pr   CO(t-Bu)                                CF.sub.3                                                                              4-Cl-Ph  n-Pr      CF.sub.3                                                                             n-Pr   n-Pr                                    OCF.sub.3                                                                             4-Cl-Ph  COEt      OCF.sub.3                                                                            n-Pr   COEt                                    OCF.sub.3                                                                             4-Cl-Ph  CO.sub.2 Et                                                                              OCF.sub.3                                                                            n-Pr   CO.sub.2 Et                             OCF.sub.3                                                                             4-Cl-Ph  CO(n-Pr)  OCF.sub.3                                                                            n-Pr   CO(n-Pr)                                OCF.sub.3                                                                             4-Cl-Ph  CO(i-Pr)  OCF.sub.3                                                                            n-Pr   CO(i-Pr)                                OCF.sub.3                                                                             4-Cl-Ph  CO(t-Bu)  OCF.sub.3                                                                            n-Pr   CO(t-Bu)                                OCF.sub.3                                                                             4-Cl-Ph  n-Pr      OCF.sub.3                                                                            n-Pr   n-Pr                                    ______________________________________                                    

                  TABLE 17                                                         ______________________________________                                          ##STR55##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                               R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                              Et       H         CF.sub.3                                                                              4-ClPh H                                      CF.sub.3                                                                              Et       Me        CF.sub.3                                                                              4-ClPh Me                                     CF.sub.3                                                                              Et       Et        CF.sub.3                                                                              4-ClPh Et                                     CF.sub.3                                                                              Et       COMe      CF.sub.3                                                                              4-ClPh COMe                                   CF.sub.3                                                                              Et       CO.sub.2 Me                                                                              CF.sub.3                                                                              4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                             Et       H         OCF.sub.3                                                                             4-ClPh H                                      OCF.sub.3                                                                             Et       Me        OCF.sub.3                                                                             4-ClPh Me                                     OCF.sub.3                                                                             Et       Et        OCF.sub.3                                                                             4-ClPh Et                                     OCF.sub.3                                                                             Et       COMe      OCF.sub.3                                                                             4-ClPh COMe                                   OCF.sub.3                                                                             Et       CO.sub.2 Me                                                                              OCF.sub.3                                                                             4-ClPh CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     H         CF.sub.3                                                                              4-FPh  H                                      CF.sub.3                                                                              n-Pr     Me        CF.sub.3                                                                              4-FPh  Me                                     CF.sub.3                                                                              n-Pr     Et        CF.sub.3                                                                              4-FPh  Et                                     CF.sub.3                                                                              n-Pr     COMe      CF.sub.3                                                                              4-FPh  COMe                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                              4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     H         OCF.sub.3                                                                             4-FPh  H                                      OCF.sub.3                                                                             n-Pr     Me        OCF.sub.3                                                                             4-FPh  Me                                     OCF.sub.3                                                                             n-Pr     Et        OCF.sub.3                                                                             4-FPh  Et                                     OCF.sub.3                                                                             n-Pr     COMe      OCF.sub.3                                                                             4-FPh  COMe                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       H         OCF.sub.2 H                                                                           Et     COMe                                   OCF.sub.2 H                                                                           Et       Me        OCF.sub.2 H                                                                           Et     CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       Et        OCF.sub.2 H                                                                           Et     COEt                                   OCF.sub.2 H                                                                           Et       n-Pr      OCF.sub.2 H                                                                           Et     CO.sub.2 Et                            CF.sub.3                                                                              Et       COEt      CF.sub.3                                                                              4-ClPh COEt                                   CF.sub.3                                                                              Et       CO.sub.2 Et                                                                              CF.sub.3                                                                              4-ClPh CO.sub.2 Et                            CF.sub.3                                                                              Et       CO(n-Pr)  CF.sub.3                                                                              4-ClPh CO(n-Pr)                               CF.sub.3                                                                              Et       CO(i-Pr)  CF.sub.3                                                                              4-ClPh CO(i-Pr)                               CF.sub.3                                                                              Et       CO(t-Bu)  CF.sub.3                                                                              4-ClPh CO(t-Bu)                               CF.sub.3                                                                              Et       n-Pr      CF.sub.3                                                                              4-ClPh n-Pr                                   OCF.sub.3                                                                             Et       COEt      OCF.sub.3                                                                             4-ClPh COEt                                   OCF.sub.3                                                                             Et       CO.sub.2 Et                                                                              OCF.sub.3                                                                             4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                             Et       CO(n-Pr)  OCF.sub.3                                                                             4-ClPh CO(n-Pr)                               OCF.sub.3                                                                             Et       CO(i-Pr)  OCF.sub.3                                                                             4-ClPh CO(i-Pr)                               OCF.sub.3                                                                             Et       CO(t-Bu)  OCF.sub.3                                                                             4-ClPh CO(t-Bu)                               OCF.sub.3                                                                             Et       n-Pr      OCF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                              n-Pr     COEt      CF.sub.3                                                                              4-FPh  COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                              CF.sub.3                                                                              4-FPh  CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr)  CF.sub.3                                                                              4-FPh  CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr)  CF.sub.3                                                                              4-FPh  CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu)  CF.sub.3                                                                              4-FPh  CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr      CF.sub.3                                                                              4-FPh  n-Pr                                   OCF.sub.3                                                                             n-Pr     COEt      OCF.sub.3                                                                             4-FPh  COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                              OCF.sub.3                                                                             4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr)  OCF.sub.3                                                                             4-FPh  CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr)  OCF.sub.3                                                                             4-FPh  CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Bu)  OCF.sub.3                                                                             4-FPh  CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr      OCF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.2 H                                                                           Et       CO(n-Pr)  OCF.sub.2 H                                                                           n-Pr   CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       CO(i-Pr)  OCF.sub.2 H                                                                           n-Pr   COEt                                   OCF.sub.2 H                                                                           Et       CO(t-Bu)  OCF.sub.2 H                                                                           n-Pr   CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     H         OCF.sub.2 H                                                                           n-Pr   CO(n-Pr)                               OCF.sub.2 H                                                                           n-Pr     Me        OCF.sub.2 H                                                                           n-Pr   CO(i-Pr)                               OCF.sub.2 H                                                                           n-Pr     Et        OCF.sub.2 H                                                                           n-Pr   CO(t-Bu)                               OCF.sub.2 H                                                                           n-Pr     n-Pr      OCF.sub.2 H                                                                           4-ClPh H                                      OCF.sub.2 H                                                                           n-Pr     COMe      OCF.sub.2 H                                                                           4-ClPh Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                              Ph     H                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                              Ph     Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                              Ph     Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                              Ph     COMe                                   CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                              Ph     CO.sub.2 Me                            OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                             Ph     H                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                             Ph     Me                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                             Ph     Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                             Ph     COMe                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                             Ph     CO.sub.2 Me                            CF.sub.3                                                                              Me       H         CF.sub.3                                                                              CO.sub.2 Et                                                                           H                                      CF.sub.3                                                                              Me       Me        CF.sub.3                                                                              CO.sub.2 Et                                                                           Me                                     CF.sub.3                                                                              Me       Et        CF.sub.3                                                                              CO.sub.2 Et                                                                           Et                                     CF.sub.3                                                                              Me       COMe      CF.sub.3                                                                              CO.sub.2 Et                                                                           COMe                                   CF.sub.3                                                                              Me       CO.sub.2 Me                                                                              CF.sub.3                                                                              CO.sub.2 Et                                                                           CO.sub.2 Me                            OCF.sub.3                                                                             Me       H         OCF.sub.3                                                                             CO.sub.2 Et                                                                           H                                      OCF.sub.3                                                                             Me       Me        OCF.sub.3                                                                             CO.sub.2 Et                                                                           Me                                     OCF.sub.3                                                                             Me       Et        OCF.sub.3                                                                             CO.sub.2 Et                                                                           Et                                     OCF.sub.3                                                                             Me       COMe      OCF.sub.3                                                                             CO.sub.2 Et                                                                           COMe                                   OCF.sub.3                                                                             Me       CO.sub.2 Me                                                                              OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   Et        OCF.sub.2 H                                                                           4-FPh  Et                                     OCF.sub.2 H                                                                           4-ClPh   n-Pr      OCF.sub.2 H                                                                           4-FPh  n-Pr                                   OCF.sub.2 H                                                                           4-ClPh   COMe      OCF.sub.2 H                                                                           4-FPh  COMe                                   OCF.sub.2 H                                                                           4-ClPh   CO.sub.2 Me                                                                              OCF.sub.2 H                                                                           4-FPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   COEt      OCF.sub.2 H                                                                           4-FPh  COEt                                   OCF.sub.2 H                                                                           4-ClPh   CO.sub.2 Et                                                                              OCF.sub.2 H                                                                           4-FPh  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-ClPh   CO(n-Pr)  OCF.sub.2 H                                                                           4-FPh  CO(n-Pr)                               OCF.sub.2 H                                                                           4-ClPh   CO(i-Pr)  OCF.sub.2 H                                                                           4-FPh  CO(i-Pr)                               OCF.sub.2 H                                                                           4-ClPh   CO(t-Bu)  OCF.sub.2 H                                                                           4-FPh  CO(t-Bu)                               OCF.sub.2 H                                                                           4-FPh    H         OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           H                                      OCF.sub.2 H                                                                           4-FPh    Me        OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                              Ph     COEt                                   CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                              Ph     CO.sub.2 Et                            CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                              Ph     CO(n-Pr)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                              Ph     CO(i-Pr)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                              Ph     CO(t-Bu)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                              Ph     n-Pr                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                             Ph     COEt                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                             Ph     CO.sub.2 Et                            OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                             Ph     CO(n-Pr)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                             Ph     CO(i-Pr)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                             Ph     CO(t-Bu)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                             Ph     n-Pr                                   CF.sub.3                                                                              Me       COEt      CF.sub.3                                                                              CO.sub.2 Et                                                                           COEt                                   CF.sub.3                                                                              Me       CO.sub.2 Et                                                                              CF.sub.3                                                                              CO.sub.2 Et                                                                           CO.sub.2 Et                            CF.sub.3                                                                              Me       CO(n-Pr)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(n-Pr)                               CF.sub.3                                                                              Me       CO(i-Pr)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(i-Pr)                               CF.sub.3                                                                              Me       CO(t-Bu)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(t-Bu)                               CF.sub.3                                                                              Me       n-Pr      CF.sub.3                                                                              CO.sub.2 Et                                                                           n-Pr                                   OCF.sub.3                                                                             Me       COEt      OCF.sub.3                                                                             CO.sub.2 Et                                                                           COEt                                   OCF.sub.3                                                                             Me       CO.sub.2 Et                                                                              OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO.sub.2 Et                            OCF.sub.3                                                                             Me       CO(n-Pr)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(n-Pr)                               OCF.sub.3                                                                             Me       CO(i-Pr)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(i-Pr)                               OCF.sub.3                                                                             Me       CO(t-Bu)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(t-Bu)                               OCF.sub.3                                                                             Me       n-Pr      OCF.sub.3                                                                             CO.sub.2 Et                                                                           n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             Et        OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                               OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr)                                                       OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr)                                                       ______________________________________                                    

                  TABLE 18                                                         ______________________________________                                          ##STR56##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                               R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                              Et       H         CF.sub.3                                                                              4-ClPh H                                      CF.sub.3                                                                              Et       Me        CF.sub.3                                                                              4-ClPh Me                                     CF.sub.3                                                                              Et       Et        CF.sub.3                                                                              4-ClPh Et                                     CF.sub.3                                                                              Et       COMe      CF.sub.3                                                                              4-ClPh COMe                                   CF.sub.3                                                                              Et       CO.sub.2 Me                                                                              CF.sub.3                                                                              4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                             Et       H         OCF.sub.3                                                                             4-ClPh H                                      OCF.sub.3                                                                             Et       Me        OCF.sub.3                                                                             4-ClPh Me                                     OCF.sub.3                                                                             Et       Et        OCF.sub.3                                                                             4-ClPh Et                                     OCF.sub.3                                                                             Et       COMe      OCF.sub.3                                                                             4-ClPh COMe                                   OCF.sub.3                                                                             Et       CO.sub.2 Me                                                                              OCF.sub.3                                                                             4-ClPh CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     H         CF.sub.3                                                                              4-FPh  H                                      CF.sub.3                                                                              n-Pr     Me        CF.sub.3                                                                              4-FPh  Me                                     CF.sub.3                                                                              n-Pr     Et        CF.sub.3                                                                              4-FPh  Et                                     CF.sub.3                                                                              n-Pr     COMe      CF.sub.3                                                                              4-FPh  COMe                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                              4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     H         OCF.sub.3                                                                             4-FPh  H                                      OCF.sub.3                                                                             n-Pr     Me        OCF.sub.3                                                                             4-FPh  Me                                     OCF.sub.3                                                                             n-Pr     Et        OCF.sub.3                                                                             4-FPh  Et                                     OCF.sub.3                                                                             n-Pr     COMe      OCF.sub.3                                                                             4-FPh  COMe                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       H         OCF.sub.2 H                                                                           Et     COMe                                   OCF.sub.2 H                                                                           Et       Me        OCF.sub.2 H                                                                           Et     CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       Et        OCF.sub.2 H                                                                           Et     COEt                                   OCF.sub.2 H                                                                           Et       n-Pr      OCF.sub.2 H                                                                           Et     CO.sub.2 Et                            CF.sub.3                                                                              Et       COEt      CF.sub.3                                                                              4-ClPh COEt                                   CF.sub.3                                                                              Et       CO.sub.2 Et                                                                              CF.sub.3                                                                              4-ClPh CO.sub.2 Et                            CF.sub.3                                                                              Et       CO(n-Pr)  CF.sub.3                                                                              4-ClPh CO(n-Pr)                               CF.sub.3                                                                              Et       CO(i-Pr)  CF.sub.3                                                                              4-ClPh CO(i-Pr)                               CF.sub.3                                                                              Et       CO(t-Bu)  CF.sub.3                                                                              4-ClPh CO(t-Bu)                               CF.sub.3                                                                              Et       n-Pr      CF.sub.3                                                                              4-ClPh n-Pr                                   OCF.sub.3                                                                             Et       COEt      OCF.sub.3                                                                             4-ClPh COEt                                   OCF.sub.3                                                                             Et       CO.sub.2 Et                                                                              OCF.sub.3                                                                             4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                             Et       CO(n-Pr)  OCF.sub.3                                                                             4-ClPh CO(n-Pr)                               OCF.sub.3                                                                             Et       CO(i-Pr)  OCF.sub.3                                                                             4-ClPh CO(i-Pr)                               OCF.sub.3                                                                             Et       CO(t-Bu)  OCF.sub.3                                                                             4-ClPh CO(t-Bu)                               OCF.sub.3                                                                             Et       n-Pr      OCF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                              n-Pr     COEt      CF.sub.3                                                                              4-FPh  COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                              CF.sub.3                                                                              4-FPh  CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr)  CF.sub.3                                                                              4-FPh  CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr)  CF.sub.3                                                                              4-FPh  CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu)  CF.sub.3                                                                              4-FPh  CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr      CF.sub.3                                                                              4-FPh  n-Pr                                   OCF.sub.3                                                                             n-Pr     COEt      OCF.sub.3                                                                             4-FPh  COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                              OCF.sub.3                                                                             4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr)  OCF.sub.3                                                                             4-FPh  CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr)  OCF.sub.3                                                                             4-FPh  CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Bu)  OCF.sub.3                                                                             4-FPh  CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr      OCF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.2 H                                                                           Et       CO(n-Pr)  OCF.sub.2 H                                                                           n-Pr   CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       CO(i-Pr)  OCF.sub.2 H                                                                           n-Pr   COEt                                   OCF.sub.2 H                                                                           Et       CO(t-Bu)  OCF.sub.2 H                                                                           n-Pr   CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     H         OCF.sub.2 H                                                                           n-Pr   CO(n-Pr)                               OCF.sub.2 H                                                                           n-Pr     Me        OCF.sub.2 H                                                                           n-Pr   CO(i-Pr)                               OCF.sub.2 H                                                                           n-Pr     Et        OCF.sub.2 H                                                                           n-Pr   CO(t-Bu)                               OCF.sub.2 H                                                                           n-Pr     n-Pr      OCF.sub.2 H                                                                           4-ClPh H                                      OCF.sub.2 H                                                                           n-Pr     COMe      OCF.sub.2 H                                                                           4-ClPh Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                              Ph     H                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                              Ph     Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                              Ph     Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                              Ph     COMe                                   CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                              Ph     CO.sub.2 Me                            OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                             Ph     H                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                             Ph     Me                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                             Ph     Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                             Ph     COMe                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                             Ph     CO.sub.2 Me                            CF.sub.3                                                                              Me       H         CF.sub.3                                                                              CO.sub.2 Et                                                                           H                                      CF.sub.3                                                                              Me       Me        CF.sub.3                                                                              CO.sub.2 Et                                                                           Me                                     CF.sub.3                                                                              Me       Et        CF.sub.3                                                                              CO.sub.2 Et                                                                           Et                                     CF.sub.3                                                                              Me       COMe      CF.sub.3                                                                              CO.sub.2 Et                                                                           COMe                                   CF.sub.3                                                                              Me       CO.sub.2 Me                                                                              CF.sub.3                                                                              CO.sub.2 Et                                                                           CO.sub.2 Me                            OCF.sub.3                                                                             Me       H         OCF.sub.3                                                                             CO.sub.2 Et                                                                           H                                      OCF.sub.3                                                                             Me       Me        OCF.sub.3                                                                             CO.sub.2 Et                                                                           Me                                     OCF.sub.3                                                                             Me       Et        OCF.sub.3                                                                             CO.sub.2 Et                                                                           Et                                     OCF.sub.3                                                                             Me       COMe      OCF.sub.3                                                                             CO.sub.2 Et                                                                           COMe                                   OCF.sub.3                                                                             Me       CO.sub.2 Me                                                                              OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   Et        OCF.sub.2 H                                                                           4-FPh  Et                                     OCF.sub.2 H                                                                           4-ClPh   n-Pr      OCF.sub.2 H                                                                           4-FPh  n-Pr                                   OCF.sub.2 H                                                                           4-ClPh   COMe      OCF.sub.2 H                                                                           4-FPh  COMe                                   OCF.sub.2 H                                                                           4-ClPh   CO.sub.2 Me                                                                              OCF.sub.2 H                                                                           4-FPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   COEt      OCF.sub.2 H                                                                           4-FPh  COEt                                   OCF.sub.2 H                                                                           4-ClPh   CO.sub.2 Et                                                                              OCF.sub.2 H                                                                           4-FPh  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-ClPh   CO(n-Pr)  OCF.sub.2 H                                                                           4-FPh  CO(n-Pr)                               OCF.sub.2 H                                                                           4-ClPh   CO(i-Pr)  OCF.sub.2 H                                                                           4-FPh  CO(i-Pr)                               OCF.sub.2 H                                                                           4-ClPh   CO(t-Bu)  OCF.sub.2 H                                                                           4-FPh  CO(t-Bu)                               OCF.sub.2 H                                                                           4-FPh    H         OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           H                                      OCF.sub.2 H                                                                           4-FPh    Me        OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                              Ph     COEt                                   CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                              Ph     CO.sub.2 Et                            CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                              Ph     CO(n-Pr)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                              Ph     CO(i-Pr)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                              Ph     CO(t-Bu)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                              Ph     n-Pr                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                             Ph     COEt                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                             Ph     CO.sub.2 Et                            OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                             Ph     CO(n-Pr)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                             Ph     CO(i-Pr)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                             Ph     CO(t-Bu)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                             Ph     n-Pr                                   CF.sub.3                                                                              Me       COEt      CF.sub.3                                                                              CO.sub.2 Et                                                                           COEt                                   CF.sub.3                                                                              Me       CO.sub.2 Et                                                                              CF.sub.3                                                                              CO.sub.2 Et                                                                           CO.sub.2 Et                            CF.sub.3                                                                              Me       CO(n-Pr)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(n-Pr)                               CF.sub.3                                                                              Me       CO(i-Pr)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(i-Pr)                               CF.sub.3                                                                              Me       CO(t-Bu)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(t-Bu)                               CF.sub.3                                                                              Me       n-Pr      CF.sub.3                                                                              CO.sub.2 Et                                                                           n-Pr                                   OCF.sub.3                                                                             Me       COEt      OCF.sub.3                                                                             CO.sub.2 Et                                                                           COEt                                   OCF.sub.3                                                                             Me       CO.sub.2 Et                                                                              OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO.sub.2 Et                            OCF.sub.3                                                                             Me       CO(n-Pr)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(n-Pr)                               OCF.sub.3                                                                             Me       CO(i-Pr)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(i-Pr)                               OCF.sub.3                                                                             Me       CO(t-Bu)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(t-Bu)                               OCF.sub.3                                                                             Me       n-Pr      OCF.sub.3                                                                             CO.sub.2 Et                                                                           n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             Et        OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                               OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr)                                                       OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr)                                                       ______________________________________                                    

                  TABLE 19                                                         ______________________________________                                          ##STR57##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                               R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                              Et       H         CF.sub.3                                                                              4-ClPh H                                      CF.sub.3                                                                              Et       Me        CF.sub.3                                                                              4-ClPh Me                                     CF.sub.3                                                                              Et       Et        CF.sub.3                                                                              4-ClPh Et                                     CF.sub.3                                                                              Et       COMe      CF.sub.3                                                                              4-ClPh COMe                                   CF.sub.3                                                                              Et       CO.sub.2 Me                                                                              CF.sub.3                                                                              4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                             Et       H         OCF.sub.3                                                                             4-ClPh H                                      OCF.sub.3                                                                             Et       Me        OCF.sub.3                                                                             4-ClPh Me                                     OCF.sub.3                                                                             Et       Et        OCF.sub.3                                                                             4-ClPh Et                                     OCF.sub.3                                                                             Et       COMe      OCF.sub.3                                                                             4-ClPh COMe                                   OCF.sub.3                                                                             Et       CO.sub.2 Me                                                                              OCF.sub.3                                                                             4-ClPh CO.sub.2 Me                            CF.sub.3                                                                              n-Pr     H         CF.sub.3                                                                              4-FPh  H                                      CF.sub.3                                                                              n-Pr     Me        CF.sub.3                                                                              4-FPh  Me                                     CF.sub.3                                                                              n-Pr     Et        CF.sub.3                                                                              4-FPh  Et                                     CF.sub.3                                                                              n-Pr     COMe      CF.sub.3                                                                              4-FPh  COMe                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                              4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                             n-Pr     H         OCF.sub.3                                                                             4-FPh  H                                      OCF.sub.3                                                                             n-Pr     Me        OCF.sub.3                                                                             4-FPh  Me                                     OCF.sub.3                                                                             n-Pr     Et        OCF.sub.3                                                                             4-FPh  Et                                     OCF.sub.3                                                                             n-Pr     COMe      OCF.sub.3                                                                             4-FPh  COMe                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       H         OCF.sub.2 H                                                                           Et     COMe                                   OCF.sub.2 H                                                                           Et       Me        OCF.sub.2 H                                                                           Et     CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       Et        OCF.sub.2 H                                                                           Et     COEt                                   OCF.sub.2 H                                                                           Et       n-Pr      OCF.sub.2 H                                                                           Et     CO.sub.2 Et                            CF.sub.3                                                                              Et       COEt      CF.sub.3                                                                              4-ClPh COEt                                   CF.sub.3                                                                              Et       CO.sub.2 Et                                                                              CF.sub.3                                                                              4-ClPh CO.sub.2 Et                            CF.sub.3                                                                              Et       CO(n-Pr)  CF.sub.3                                                                              4-ClPh CO(n-Pr)                               CF.sub.3                                                                              Et       CO(i-Pr)  CF.sub.3                                                                              4-ClPh CO(i-Pr)                               CF.sub.3                                                                              Et       CO(t-Bu)  CF.sub.3                                                                              4-ClPh CO(t-Bu)                               CF.sub.3                                                                              Et       n-Pr      CF.sub.3                                                                              4-ClPh n-Pr                                   OCF.sub.3                                                                             Et       COEt      OCF.sub.3                                                                             4-ClPh COEt                                   OCF.sub.3                                                                             Et       CO.sub.2 Et                                                                              OCF.sub.3                                                                             4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                             Et       CO(n-Pr)  OCF.sub.3                                                                             4-ClPh CO(n-Pr)                               OCF.sub.3                                                                             Et       CO(i-Pr)  OCF.sub.3                                                                             4-ClPh CO(i-Pr)                               OCF.sub.3                                                                             Et       CO(t-Bu)  OCF.sub.3                                                                             4-ClPh CO(t-Bu)                               OCF.sub.3                                                                             Et       n-Pr      OCF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                              n-Pr     COEt      CF.sub.3                                                                              4-FPh  COEt                                   CF.sub.3                                                                              n-Pr     CO.sub.2 Et                                                                              CF.sub.3                                                                              4-FPh  CO.sub.2 Et                            CF.sub.3                                                                              n-Pr     CO(n-Pr)  CF.sub.3                                                                              4-FPh  CO(n-Pr)                               CF.sub.3                                                                              n-Pr     CO(i-Pr)  CF.sub.3                                                                              4-FPh  CO(i-Pr)                               CF.sub.3                                                                              n-Pr     CO(t-Bu)  CF.sub.3                                                                              4-FPh  CO(t-Bu)                               CF.sub.3                                                                              n-Pr     n-Pr      CF.sub.3                                                                              4-FPh  n-Br                                   OCF.sub.3                                                                             n-Pr     COEt      OCF.sub.3                                                                             4-FPh  COEt                                   OCF.sub.3                                                                             n-Pr     CO.sub.2 Et                                                                              OCF.sub.3                                                                             4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                             n-Pr     CO(n-Pr)  OCF.sub.3                                                                             4-FPh  CO(n-Pr)                               OCF.sub.3                                                                             n-Pr     CO(i-Pr)  OCF.sub.3                                                                             4-FPh  CO(i-Pr)                               OCF.sub.3                                                                             n-Pr     CO(t-Bu)  OCF.sub.3                                                                             4-FPh  CO(t-Bu)                               OCF.sub.3                                                                             n-Pr     n-Pr      OCF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.2 H                                                                           Et       CO(n-Pr)  OCF.sub.2 H                                                                           n-Pr   CO.sub.2 Me                            OCF.sub.2 H                                                                           Et       CO(i-Pr)  OCF.sub.2 H                                                                           n-Pr   COEt                                   OCF.sub.2 H                                                                           Et       CO(t-Bu)  OCF.sub.2 H                                                                           n-Pr   CO.sub.2 Et                            OCF.sub.2 H                                                                           n-Pr     H         OCF.sub.2 H                                                                           n-Pr   CO(n-Pr)                               OCF.sub.2 H                                                                           n-Pr     Me        OCF.sub.2 H                                                                           n-Pr   CO(i-Pr)                               OCF.sub.2 H                                                                           n-Pr     Et        OCF.sub.2 H                                                                           n-Pr   CO(t-Bu)                               OCF.sub.2 H                                                                           n-Pr     n-Pr      OCF.sub.2 H                                                                           4-ClPh H                                      OCF.sub.2 H                                                                           n-Pr     COMe      OCF.sub.2 H                                                                           4-ClPh Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                              Ph     H                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                              Ph     Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                              Ph     Et                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                              Ph     COMe                                   CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                              Ph     CO.sub.2 Me                            OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                             Ph     H                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                             Ph     Me                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                             Ph     Et                                     OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                             Ph     COMe                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                             Ph     CO.sub.2 Me                            CF.sub.3                                                                              Me       H         CF.sub.3                                                                              CO.sub.2 Et                                                                           H                                      CF.sub.3                                                                              Me       Me        CF.sub.3                                                                              CO.sub.2 Et                                                                           Me                                     CF.sub.3                                                                              Me       Et        CF.sub.3                                                                              CO.sub.2 Et                                                                           Et                                     CF.sub.3                                                                              Me       COMe      CF.sub.3                                                                              CO.sub.2 Et                                                                           COMe                                   CF.sub.3                                                                              Me       CO.sub.2 Me                                                                              CF.sub.3                                                                              CO.sub.2 Et                                                                           CO.sub.2 Me                            OCF.sub.3                                                                             Me       H         OCF.sub.3                                                                             CO.sub.2 Et                                                                           H                                      OCF.sub.3                                                                             Me       Me        OCF.sub.3                                                                             CO.sub.2 Et                                                                           Me                                     OCF.sub.3                                                                             Me       Et        OCF.sub.3                                                                             CO.sub.2 Et                                                                           Et                                     OCF.sub.3                                                                             Me       COMe      OCF.sub.3                                                                             CO.sub.2 Et                                                                           COMe                                   OCF.sub.3                                                                             Me       CO.sub.2 Me                                                                              OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   Et        OCF.sub.2 H                                                                           4-FPh  Et                                     OCF.sub.2 H                                                                           4-ClPh   n-Pr      OCF.sub.2 H                                                                           4-FPh  n-Pr                                   OCF.sub.2 H                                                                           4-ClPh   COMe      OCF.sub.2 H                                                                           4-FPh  COMe                                   OCF.sub.2 H                                                                           4-ClPh   CO.sub.2 Me                                                                              OCF.sub.2 H                                                                           4-FPh  CO.sub.2 Me                            OCF.sub.2 H                                                                           4-ClPh   COEt      OCF.sub.2 H                                                                           4-FPh  COEt                                   OCF.sub.2 H                                                                           4-ClPh   CO.sub.2 Et                                                                              OCF.sub.2 H                                                                           4-FPh  CO.sub.2 Et                            OCF.sub.2 H                                                                           4-ClPh   CO(n-Pr)  OCF.sub.2 H                                                                           4-FPh  CO(n-Pr)                               OCF.sub.2 H                                                                           4-ClPh   CO(i-Pr)  OCF.sub.2 H                                                                           4-FPh  CO(i-Pr)                               OCF.sub.2 H                                                                           4-ClPh   CO(t-Bu)  OCF.sub.2 H                                                                           4-FPh  CO(t-Bu)                               OCF.sub.2 H                                                                           4-FPh    H         OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           H                                      OCF.sub.2 H                                                                           4-FPh    Me        OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           Me                                     CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                              Ph     COEt                                   CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                              Ph     CO.sub.2 Et                            CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                              Ph     CO(n-Pr)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                              Ph     CO(i-Pr)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                              Ph     CO(t-Bu)                               CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                              Ph     n-Pr                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                             Ph     COEt                                   OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                             Ph     CO.sub.2 Et                            OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                             Ph     CO(n-Pr)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                             Ph     CO(i-Pr)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                             Ph     CO(t-Bu)                               OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                             Ph     n-Pr                                   CF.sub.3                                                                              Me       COEt      CF.sub.3                                                                              CO.sub.2 Et                                                                           COEt                                   CF.sub.3                                                                              Me       CO.sub.2 Et                                                                              CF.sub.3                                                                              CO.sub.2 Et                                                                           CO.sub.2 Et                            CF.sub.3                                                                              Me       CO(n-Pr)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(n-Pr)                               CF.sub.3                                                                              Me       CO(i-Pr)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(i-Pr)                               CF.sub.3                                                                              Me       CO(t-Bu)  CF.sub.3                                                                              CO.sub.2 Et                                                                           CO(t-Bu)                               CF.sub.3                                                                              Me       n-Pr      CF.sub.3                                                                              CO.sub.2 Et                                                                           n-Pr                                   OCF.sub.3                                                                             Me       COEt      OCF.sub.3                                                                             CO.sub.2 Et                                                                           COEt                                   OCF.sub.3                                                                             Me       CO.sub.2 Et                                                                              OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO.sub.2 Et                            OCF.sub.3                                                                             Me       CO(n-Pr)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(n-Pr)                               OCF.sub.3                                                                             Me       CO(i-Pr)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(i-Pr)                               OCF.sub.3                                                                             Me       CO(t-Bu)  OCF.sub.3                                                                             CO.sub.2 Et                                                                           CO(t-Bu)                               OCF.sub.3                                                                             Me       n-Pr      OCF.sub.3                                                                             CO.sub.2 Et                                                                           n-Pr                                   OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             Et        OCF.sub.2 H                                                                           CO.sub.2 Me                                                                           CO(t-Bu)                               OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             n-Pr                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COMe                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Me                                                    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             COEt                                                           OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO.sub.2 Et                                                    OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(n-Pr)                                                       OCF.sub.2 H                                                                           CO.sub.2 Me                                                                             CO(i-Pr)                                                       ______________________________________                                    

                  TABLE 20                                                         ______________________________________                                          ##STR58##                                                                     R.sup.1 R.sup.2 R.sup.3   R.sup.1                                                                              R.sup.2                                                                              R.sup.3                                  ______________________________________                                         CF.sub.3                                                                               6-Cl    Me        CF.sub.3                                                                             7-Cl  Me                                       CF.sub.3                                                                               6-Cl    Et        CF.sub.3                                                                             7-Cl  Et                                       CF.sub.3                                                                               6-Cl    n-Pr      CF.sub.3                                                                             7-Cl  n-Pr                                     CF.sub.3                                                                               6-Cl    CO.sub.2 Me                                                                              CF.sub.3                                                                             7-Cl  CO.sub.2 Me                              CF.sub.3                                                                               6-Cl    4-FPh     CF.sub.3                                                                             7-Cl  4-FPh                                    OCF.sub.3                                                                              6-Cl    Me        OCF.sub.3                                                                            7-Cl  Me                                       OCF.sub.3                                                                              6-Cl    Et        OCF.sub.3                                                                            7-Cl  Et                                       OCF.sub.3                                                                              6-Cl    n-Pr      OCF.sub.3                                                                            7-Cl  n-Pr                                     OCF.sub.3                                                                              6-Cl    CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-Cl  CO.sub.2 Me                              OCF.sub.3                                                                              6-Cl    4-FPh     OCF.sub.3                                                                            7-Cl  4-FPh                                    CF.sub.3                                                                               6-F     Me        CF.sub.3                                                                             7-F   Me                                       CF.sub.3                                                                               6-F     Et        CF.sub.3                                                                             7-F   Et                                       CF.sub.3                                                                               6-F     n-Pr      CF.sub.3                                                                             7-F   n-Pr                                     CF.sub.3                                                                               6-F     CO.sub.2 Me                                                                              CF.sub.3                                                                             7-F   CO.sub.2 Me                              CF.sub.3                                                                               6-F     4-FPh     CF.sub.3                                                                             7-F   4-FPh                                    OCF.sub.3                                                                              6-F     Me        OCF.sub.3                                                                            7-F   Me                                       OCF.sub.3                                                                              6-F     Et        OCF.sub.3                                                                            7-F   Et                                       OCF.sub.3                                                                              6-F     n-Pr      OCF.sub.3                                                                            7-F   n-Pr                                     OCF.sub.3                                                                              6-F     CO.sub.2 Me                                                                              OCF.sub.3                                                                            7-F   CO.sub.2 Me                              OCF.sub.3                                                                              6-F     4-FPh     OCF.sub.3                                                                            7-F   4-FPh                                    ______________________________________                                    

                  TABLE 21                                                         ______________________________________                                          ##STR59##                                                                     R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               6-Cl     Me       CF.sub.3                                                                              7-Cl  Me                                      CF.sub.3                                                                               6-Cl     Et       CF.sub.3                                                                              7-Cl  Et                                      CF.sub.3                                                                               6-Cl     n-Pr     CF.sub.3                                                                              7-Cl  n-Pr                                    CF.sub.3                                                                               6-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              7-Cl  CO.sub.2 Me                             CF.sub.3                                                                               6-Cl     4-FPh    CF.sub.3                                                                              7-Cl  4-FPh                                   OCF.sub.3                                                                              6-Cl     Me       OCF.sub.3                                                                             7-Cl  Me                                      OCF.sub.3                                                                              6-Cl     Et       OCF.sub.3                                                                             7-Cl  Et                                      OCF.sub.3                                                                              6-Cl     n-Pr     OCF.sub.3                                                                             7-Cl  n-Pr                                    OCF.sub.3                                                                              6-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              6-Cl     4-FPh    OCF.sub.3                                                                             7-Cl  4-FPh                                   CF.sub.3                                                                               6-F      Me       CF.sub.3                                                                              7-F   Me                                      CF.sub.3                                                                               6-F      Et       CF.sub.3                                                                              7-F   Et                                      CF.sub.3                                                                               6-F      n-Pr     CF.sub.3                                                                              7-F   n-Pr                                    CF.sub.3                                                                               6-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              7-F   CO.sub.2 Me                             CF.sub.3                                                                               6-F      4-FPh    CF.sub.3                                                                              7-F   4-FPh                                   OCF.sub.3                                                                              6-F      Me       OCF.sub.3                                                                             7-F   Me                                      OCF.sub.3                                                                              6-F      Et       OCF.sub.3                                                                             7-F   Et                                      OCF.sub.3                                                                              6-F      n-Pr     OCF.sub.3                                                                             7-F   n-Pr                                    OCF.sub.3                                                                              6-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-F   CO.sub.2 Me                             OCF.sub.3                                                                              6-F      4-FPh    OCF.sub.3                                                                             7-F   4-FPh                                   ______________________________________                                    

                  TABLE 22                                                         ______________________________________                                          ##STR60##                                                                     R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               6-Cl     Me       CF.sub.3                                                                              7-Cl  Me                                      CF.sub.3                                                                               6-Cl     Et       CF.sub.3                                                                              7-Cl  Et                                      CF.sub.3                                                                               6-Cl     n-Pr     CF.sub.3                                                                              7-Cl  n-Pr                                    CF.sub.3                                                                               6-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              7-Cl  CO.sub.2 Me                             CF.sub.3                                                                               6-Cl     4-FPh    CF.sub.3                                                                              7-Cl  4-FPh                                   OCF.sub.3                                                                              6-Cl     Me       OCF.sub.3                                                                             7-Cl  Me                                      OCF.sub.3                                                                              6-Cl     Et       OCF.sub.3                                                                             7-Cl  Et                                      OCF.sub.3                                                                              6-Cl     n-Pr     OCF.sub.3                                                                             7-Cl  n-Pr                                    OCF.sub.3                                                                              6-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              6-Cl     4-FPh    OCF.sub.3                                                                             7-Cl  4-FPh                                   CF.sub.3                                                                               6-F      Me       CF.sub.3                                                                              7-F   Me                                      CF.sub.3                                                                               6-F      Et       CF.sub.3                                                                              7-F   Et                                      CF.sub.3                                                                               6-F      n-Pr     CF.sub.3                                                                              7-F   n-Pr                                    CF.sub.3                                                                               6-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              7-F   CO.sub.2 Me                             CF.sub.3                                                                               6-F      4-FPh    CF.sub.3                                                                              7-F   4-FPh                                   OCF.sub.3                                                                              6-F      Me       OCF.sub.3                                                                             7-F   Me                                      OCF.sub.3                                                                              6-F      Et       OCF.sub.3                                                                             7-F   Et                                      OCF.sub.3                                                                              6-F      n-Pr     OCF.sub.3                                                                             7-F   n-Pr                                    OCF.sub.3                                                                              6-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-F   CO.sub.2 Me                             OCF.sub.3                                                                              6-F      4-FPh    OCF.sub.3                                                                             7-F   4-FPh                                   ______________________________________                                    

                  TABLE 23                                                         ______________________________________                                          ##STR61##                                                                     R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               6-Cl     Me       CF.sub.3                                                                              7-Cl  Me                                      CF.sub.3                                                                               6-Cl     Et       CF.sub.3                                                                              7-Cl  Et                                      CF.sub.3                                                                               6-Cl     n-Pr     CF.sub.3                                                                              7-Cl  n-Pr                                    CF.sub.3                                                                               6-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              7-Cl  CO.sub.2 Me                             CF.sub.3                                                                               6-Cl     4-FPh    CF.sub.3                                                                              7-Cl  4-FPh                                   OCF.sub.3                                                                              6-Cl     Me       OCF.sub.3                                                                             7-Cl  Me                                      OCF.sub.3                                                                              6-Cl     Et       OCF.sub.3                                                                             7-Cl  Et                                      OCF.sub.3                                                                              6-Cl     n-Pr     OCF.sub.3                                                                             7-Cl  n-Pr                                    OCF.sub.3                                                                              6-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              6-Cl     4-FPh    OCF.sub.3                                                                             7-Cl  4-FPh                                   CF.sub.3                                                                               6-F      Me       CF.sub.3                                                                              7-F   Me                                      CF.sub.3                                                                               6-F      Et       CF.sub.3                                                                              7-F   Et                                      CF.sub.3                                                                               6-F      n-Pr     CF.sub.3                                                                              7-F   n-Pr                                    CF.sub.3                                                                               6-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              7-F   CO.sub.2 Me                             CF.sub.3                                                                               6-F      4-FPh    CF.sub.3                                                                              7-F   4-FPh                                   OCF.sub.3                                                                              6-F      Me       OCF.sub.3                                                                             7-F   Me                                      OCF.sub.3                                                                              6-F      Et       OCF.sub.3                                                                             7-F   Et                                      OCF.sub.3                                                                              6-F      n-Pr     OCF.sub.3                                                                             7-F   n-Pr                                    OCF.sub.3                                                                              6-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-F   CO.sub.2 Me                             OCF.sub.3                                                                              6-F      4-FPh    OCF.sub.3                                                                             7-F   4-FPh                                   ______________________________________                                    

                  TABLE 24                                                         ______________________________________                                          ##STR62##                                                                     R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               6-Cl     Me       CF.sub.3                                                                              7-Cl  Me                                      CF.sub.3                                                                               6-Cl     Et       CF.sub.3                                                                              7-Cl  Et                                      CF.sub.3                                                                               6-Cl     n-Pr     CF.sub.3                                                                              7-Cl  n-Pr                                    CF.sub.3                                                                               6-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              7-Cl  CO.sub.2 Me                             CF.sub.3                                                                               6-Cl     4-FPh    CF.sub.3                                                                              7-Cl  4-FPh                                   OCF.sub.3                                                                              6-Cl     Me       OCF.sub.3                                                                             7-Cl  Me                                      OCF.sub.3                                                                              6-Cl     Et       OCF.sub.3                                                                             7-Cl  Et                                      OCF.sub.3                                                                              6-Cl     n-Pr     OCF.sub.3                                                                             7-Cl  n-Pr                                    OCF.sub.3                                                                              6-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              6-Cl     4-FPh    OCF.sub.3                                                                             7-Cl  4-FPh                                   CF.sub.3                                                                               6-F      Me       CF.sub.3                                                                              7-F   Me                                      CF.sub.3                                                                               6-F      Et       CF.sub.3                                                                              7-F   Et                                      CF.sub.3                                                                               6-F      n-Pr     CF.sub.3                                                                              7-F   n-Pr                                    CF.sub.3                                                                               6-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              7-F   CO.sub.2 Me                             CF.sub.3                                                                               6-F      4-FPh    CF.sub.3                                                                              7-F   4-FPh                                   OCF.sub.3                                                                              6-F      Me       OCF.sub.3                                                                             7-F   Me                                      OCF.sub.3                                                                              6-F      Et       OCF.sub.3                                                                             7-F   Et                                      OCF.sub.3                                                                              6-F      n-Pr     OCF.sub.3                                                                             7-F   n-Pr                                    OCF.sub.3                                                                              6-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-F   CO.sub.2 Me                             OCF.sub.3                                                                              6-F      4-FPh    OCF.sub.3                                                                             7-F   4-FPh                                   ______________________________________                                    

                  TABLE 25                                                         ______________________________________                                          ##STR63##                                                                     R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               6-Cl     Me       CF.sub.3                                                                              7-Cl  Me                                      CF.sub.3                                                                               6-Cl     Et       CF.sub.3                                                                              7-Cl  Et                                      CF.sub.3                                                                               6-Cl     n-Pr     CF.sub.3                                                                              7-Cl  n-Pr                                    CF.sub.3                                                                               6-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              7-Cl  CO.sub.2 Me                             CF.sub.3                                                                               6-Cl     4-FPh    CF.sub.3                                                                              7-Cl  4-FPh                                   OCF.sub.3                                                                              6-Cl     Me       OCF.sub.3                                                                             7-Cl  Me                                      OCF.sub.3                                                                              6-Cl     Et       OCF.sub.3                                                                             7-Cl  Et                                      OCF.sub.3                                                                              6-Cl     n-Pr     OCF.sub.3                                                                             7-Cl  n-Pr                                    OCF.sub.3                                                                              6-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              6-Cl     4-FPh    OCF.sub.3                                                                             7-Cl  4-FPh                                   CF.sub.3                                                                               6-F      Me       CF.sub.3                                                                              7-F   Me                                      CF.sub.3                                                                               6-F      Et       CF.sub.3                                                                              7-F   Et                                      CF.sub.3                                                                               6-F      n-Pr     CF.sub.3                                                                              7-F   n-Pr                                    CF.sub.3                                                                               6-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              7-F   CO.sub.2 Me                             CF.sub.3                                                                               6-F      4-FPh    CF.sub.3                                                                              7-F   4-FPh                                   OCF.sub.3                                                                              6-F      Me       OCF.sub.3                                                                             7-F   Me                                      OCF.sub.3                                                                              6-F      Et       OCF.sub.3                                                                             7-F   Et                                      OCF.sub.3                                                                              6-F      n-Pr     OCF.sub.3                                                                             7-F   n-Pr                                    OCF.sub.3                                                                              6-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-F   CO.sub.2 Me                             OCF.sub.3                                                                              6-F      4-FPh    OCF.sub.3                                                                             7-F   4-FPh                                   ______________________________________                                    

                  TABLE 26                                                         ______________________________________                                          ##STR64##                                                                     R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               6-Cl     Me       CF.sub.3                                                                              7-Cl  Me                                      CF.sub.3                                                                               6-Cl     Et       CF.sub.3                                                                              7-Cl  Et                                      CF.sub.3                                                                               6-Cl     n-Pr     CF.sub.3                                                                              7-Cl  n-Pr                                    CF.sub.3                                                                               6-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              7-Cl  CO.sub.2 Me                             CF.sub.3                                                                               6-Cl     4-FPh    CF.sub.3                                                                              7-Cl  4-FPh                                   OCF.sub.3                                                                              6-Cl     Me       OCF.sub.3                                                                             7-Cl  Me                                      OCF.sub.3                                                                              6-Cl     Et       OCF.sub.3                                                                             7-Cl  Et                                      OCF.sub.3                                                                              6-Cl     n-Pr     OCF.sub.3                                                                             7-Cl  n-Pr                                    OCF.sub.3                                                                              6-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              6-Cl     4-FPh    OCF.sub.3                                                                             7-Cl  4-FPh                                   CF.sub.3                                                                               6-F      Me       CF.sub.3                                                                              7-F   Me                                      CF.sub.3                                                                               6-F      Et       CF.sub.3                                                                              7-F   Et                                      CF.sub.3                                                                               6-F      n-Pr     CF.sub.3                                                                              7-F   n-Pr                                    CF.sub.3                                                                               6-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              7-F   CO.sub.2 Me                             CF.sub.3                                                                               6-F      4-FPh    CF.sub.3                                                                              7-F   4-FPh                                   OCF.sub.3                                                                              6-F      Me       OCF.sub.3                                                                             7-F   Me                                      OCF.sub.3                                                                              6-F      Et       OCF.sub.3                                                                             7-F   Et                                      OCF.sub.3                                                                              6-F      n-Pr     OCF.sub.3                                                                             7-F   n-Pr                                    OCF.sub.3                                                                              6-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-F   CO.sub.2 Me                             OCF.sub.3                                                                              6-F      4-FPh    OCF.sub.3                                                                             7-F   4-FPh                                   ______________________________________                                    

                  TABLE 27                                                         ______________________________________                                          ##STR65##                                                                     R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               6-Cl     Me       CF.sub.3                                                                              7-Cl  Me                                      CF.sub.3                                                                               6-Cl     Et       CF.sub.3                                                                              7-Cl  Et                                      CF.sub.3                                                                               6-Cl     n-Pr     CF.sub.3                                                                              7-Cl  n-Pr                                    CF.sub.3                                                                               6-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              7-Cl  CO.sub.2 Me                             CF.sub.3                                                                               6-Cl     4-FPh    CF.sub.3                                                                              7-Cl  4-FPh                                   OCF.sub.3                                                                              6-Cl     Me       OCF.sub.3                                                                             7-Cl  Me                                      OCF.sub.3                                                                              6-Cl     Et       OCF.sub.3                                                                             7-Cl  Et                                      OCF.sub.3                                                                              6-Cl     n-Pr     OCF.sub.3                                                                             7-Cl  n-Pr                                    OCF.sub.3                                                                              6-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              6-Cl     4-FPh    OCF.sub.3                                                                             7-Cl  4-FPh                                   CF.sub.3                                                                               6-F      Me       CF.sub.3                                                                              7-F   Me                                      CF.sub.3                                                                               6-F      Et       CF.sub.3                                                                              7-F   Et                                      CF.sub.3                                                                               6-F      n-Pr     CF.sub.3                                                                              7-F   n-Pr                                    CF.sub.3                                                                               6-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              7-F   CO.sub.2 Me                             CF.sub.3                                                                               6-F      4-FPh    CF.sub.3                                                                              7-F   4-FPh                                   OCF.sub.3                                                                              6-F      Me       OCF.sub.3                                                                             7-F   Me                                      OCF.sub.3                                                                              6-F      Et       OCF.sub.3                                                                             7-F   Et                                      OCF.sub.3                                                                              6-F      n-Pr     OCF.sub.3                                                                             7-F   n-Pr                                    OCF.sub.3                                                                              6-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             7-F   CO.sub.2 Me                             OCF.sub.3                                                                              6-F      4-FPh    OCF.sub.3                                                                             7-F   4-FPh                                   ______________________________________                                    

                  TABLE 28                                                         ______________________________________                                          ##STR66##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               Et      CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              Et      CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             CF.sub.3                                                                               n-Pr    H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               n-Pr    Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               n-Pr    Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               n-Pr    COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr    H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              n-Pr    Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              n-Pr    Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              n-Pr    COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                           COEt                                    CF.sub.3                                                                               Et      CO.sub.2 Et                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Et                             CF.sub.3                                                                               Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(n-Pr)                                CF.sub.3                                                                               Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(i-Pr)                                CF.sub.3                                                                               Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(t-Bu)                                CF.sub.3                                                                               Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                           n-Pr                                    OCF.sub.3                                                                              Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                    OCF.sub.3                                                                              Et      CO.sub.2 Et                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                             OCF.sub.3                                                                              Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                OCF.sub.3                                                                              Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                OCF.sub.3                                                                              Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                OCF.sub.3                                                                              Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                    CF.sub.3                                                                               n-Pr    COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               n-Pr    n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              n-Pr    COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              n-Pr    n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    ______________________________________                                    

                  TABLE 29                                                         ______________________________________                                          ##STR67##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               Et      CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              Et      CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             CF.sub.3                                                                               n-Pr    H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               n-Pr    Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               n-Pr    Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               n-Pr    COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr    H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              n-Pr    Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              n-Pr    Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              n-Pr    COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                           COEt                                    CF.sub.3                                                                               Et      CO.sub.2 Et                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Et                             CF.sub.3                                                                               Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(n-Pr)                                CF.sub.3                                                                               Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(i-Pr)                                CF.sub.3                                                                               Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(t-Bu)                                CF.sub.3                                                                               Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                           n-Pr                                    OCF.sub.3                                                                              Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                    OCF.sub.3                                                                              Et      CO.sub.2 Et                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                             OCF.sub.3                                                                              Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                OCF.sub.3                                                                              Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                OCF.sub.3                                                                              Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                OCF.sub.3                                                                              Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                    CF.sub.3                                                                               n-Pr    COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               n-Pr    n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              n-Pr    COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              n-Pr    n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    ______________________________________                                    

                  TABLE 30                                                         ______________________________________                                          ##STR68##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               Et      CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              Et      CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             CF.sub.3                                                                               n-Pr    H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               n-Pr    Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               n-Pr    Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               n-Pr    COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr    H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              n-Pr    Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              n-Pr    Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              n-Pr    COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                           COEt                                    CF.sub.3                                                                               Et      CO.sub.2 Et                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Et                             CF.sub.3                                                                               Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(n-Pr)                                CF.sub.3                                                                               Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(i-Pr)                                CF.sub.3                                                                               Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(t-Bu)                                CF.sub.3                                                                               Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                           n-Pr                                    OCF.sub.3                                                                              Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                    OCF.sub.3                                                                              Et      CO.sub.2 Et                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                             OCF.sub.3                                                                              Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                OCF.sub.3                                                                              Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                OCF.sub.3                                                                              Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                OCF.sub.3                                                                              Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                    CF.sub.3                                                                               n-Pr    COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               n-Pr    n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              n-Pr    COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              n-Pr    n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    ______________________________________                                    

                  TABLE 31                                                         ______________________________________                                          ##STR69##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               Et      CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              Et      CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             CF.sub.3                                                                               n-Pr    H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               n-Pr    Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               n-Pr    Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               n-Pr    COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr    H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              n-Pr    Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              n-Pr    Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              n-Pr    COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                           COEt                                    CF.sub.3                                                                               Et      CO.sub.2 Et                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Et                             CF.sub.3                                                                               Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(n-Pr)                                CF.sub.3                                                                               Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(i-Pr)                                CF.sub.3                                                                               Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(t-Bu)                                CF.sub.3                                                                               Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                           n-Pr                                    OCF.sub.3                                                                              Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                    OCF.sub.3                                                                              Et      CO.sub.2 Et                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                             OCF.sub.3                                                                              Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                OCF.sub.3                                                                              Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                OCF.sub.3                                                                              Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                OCF.sub.3                                                                              Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                    CF.sub.3                                                                               n-Pr    COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               n-Pr    n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              n-Pr    COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              n-Pr    n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    ______________________________________                                    

                  TABLE 32                                                         ______________________________________                                          ##STR70##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               Et      H         CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               Et      Me        CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               Et      Et        CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               Et      COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               Et      CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              Et      H         OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              Et      Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              Et      Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              Et      COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              Et      CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             CF.sub.3                                                                               n-Pr    H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               n-Pr    Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               n-Pr    Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               n-Pr    COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr    H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              n-Pr    Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              n-Pr    Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              n-Pr    COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               Et      COEt      CF.sub.3                                                                             CO.sub.2 Me                                                                           COEt                                    CF.sub.3                                                                               Et      CO.sub.2 Et                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Et                             CF.sub.3                                                                               Et      CO(n-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(n-Pr)                                CF.sub.3                                                                               Et      CO(i-Pr)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(i-Pr)                                CF.sub.3                                                                               Et      CO(t-Bu)  CF.sub.3                                                                             CO.sub.2 Me                                                                           CO(t-Bu)                                CF.sub.3                                                                               Et      n-Pr      CF.sub.3                                                                             CO.sub.2 Me                                                                           n-Pr                                    OCF.sub.3                                                                              Et      COEt      OCF.sub.3                                                                            CO.sub.2 Me                                                                           COEt                                    OCF.sub.3                                                                              Et      CO.sub.2 Et                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Et                             OCF.sub.3                                                                              Et      CO(n-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(n-Pr)                                OCF.sub.3                                                                              Et      CO(i-Pr)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(i-Pr)                                OCF.sub.3                                                                              Et      CO(t-Bu)  OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO(t-Bu)                                OCF.sub.3                                                                              Et      n-Pr      OCF.sub.3                                                                            CO.sub.2 Me                                                                           n-Pr                                    CF.sub.3                                                                               n-Pr    COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               n-Pr    CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               n-Pr    CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               n-Pr    CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               n-Pr    CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               n-Pr    n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              n-Pr    COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              n-Pr    CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              n-Pr    CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              n-Pr    CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              n-Pr    CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              n-Pr    n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    ______________________________________                                    

                  TABLE 33                                                         ______________________________________                                          ##STR71##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                            H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                               CO.sub.2 Me                                                                            Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                               CO.sub.2 Me                                                                            Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                               CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                              CO.sub.2 Me                                                                            H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                              CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                               Ph      H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               Ph      Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               Ph      Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               Ph      COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               Ph      CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              Ph      H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              Ph      Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              Ph      Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              Ph      COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              Ph      CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                              CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                               Ph      COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               Ph      CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               Ph      CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               Ph      CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               Ph      CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               Ph      CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                              Ph      COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              Ph      CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              Ph      CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              Ph      CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              Ph      CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              Ph      CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                               CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                              Ph      n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              Ph      i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                               Ph      n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                               Ph      i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 34                                                         ______________________________________                                          ##STR72##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                            H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                               CO.sub.2 Me                                                                            Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                               CO.sub.2 Me                                                                            Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                               CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                              CO.sub.2 Me                                                                            H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                              CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                               Ph      H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               Ph      Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               Ph      Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               Ph      COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               Ph      CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              Ph      H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              Ph      Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              Ph      Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              Ph      COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              Ph      CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                              CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                               Ph      COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               Ph      CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               Ph      CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               Ph      CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               Ph      CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               Ph      CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                              Ph      COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              Ph      CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              Ph      CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              Ph      CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              Ph      CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              Ph      CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                               CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                              Ph      n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              Ph      i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                               Ph      n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                               Ph      i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 35                                                         ______________________________________                                          ##STR73##                                                                     R.sup.1 R.sup.3 Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                            H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                               CO.sub.2 Me                                                                            Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                               CO.sub.2 Me                                                                            Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                               CO.sub.2 Me                                                                            COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                              CO.sub.2 Me                                                                            H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                              CO.sub.2 Me                                                                            Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                            Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                            COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                               Ph      H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                               Ph      Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                               Ph      Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                               Ph      COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                               Ph      CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                              Ph      H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                              Ph      Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                              Ph      Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                              Ph      COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                              Ph      CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                               CO.sub.2 Me                                                                            COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                               CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                              CO.sub.2 Me                                                                            COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                              CO.sub.2 Me                                                                            CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                               Ph      COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                               Ph      CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                               Ph      CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                               Ph      CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                               Ph      CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                               Ph      CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                              Ph      COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                              Ph      CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                              Ph      CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                              Ph      CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                              Ph      CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                              Ph      CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                               CO.sub.2 Me                                                                            n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                               CO.sub.2 Me                                                                            i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                              CO.sub.2 Me                                                                            i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                              Ph      n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                              Ph      i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                               Ph      n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                               Ph      i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 36                                                         ______________________________________                                          ##STR74##                                                                     R.sup.1 R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                            CF.sub.3                                                                               Ph       H         CF.sub.3                                                                             4-FPh  H                                      CF.sub.3                                                                               Ph       Me        CF.sub.3                                                                             4-FPh  Me                                     CF.sub.3                                                                               Ph       Et        CF.sub.3                                                                             4-FPh  Et                                     CF.sub.3                                                                               Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                   CF.sub.3                                                                               Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                              Ph       H         OCF.sub.3                                                                            4-FPh  H                                      OCF.sub.3                                                                              Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                     OCF.sub.3                                                                              Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                     OCF.sub.3                                                                              Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                   OCF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                            CF.sub.3                                                                               CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                            CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                               Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                   CF.sub.3                                                                               Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                            CF.sub.3                                                                               Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                               CF.sub.3                                                                               Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                               CF.sub.3                                                                               Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                               CF.sub.3                                                                               Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                   OCF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                              Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                               OCF.sub.3                                                                              Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                               OCF.sub.3                                                                              Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                               OCF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                               CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.3                                                                              Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                   CF.sub.3                                                                               Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                   CF.sub.3                                                                               Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 37                                                         ______________________________________                                          ##STR75##                                                                     R.sup.1 R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                            CF.sub.3                                                                               Ph       H         CF.sub.3                                                                             4-FPh  H                                      CF.sub.3                                                                               Ph       Me        CF.sub.3                                                                             4-FPh  Me                                     CF.sub.3                                                                               Ph       Et        CF.sub.3                                                                             4-FPh  Et                                     CF.sub.3                                                                               Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                   CF.sub.3                                                                               Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                              Ph       H         OCF.sub.3                                                                            4-FPh  H                                      OCF.sub.3                                                                              Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                     OCF.sub.3                                                                              Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                     OCF.sub.3                                                                              Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                   OCF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                            CF.sub.3                                                                               CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                            CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                               Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                   CF.sub.3                                                                               Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                            CF.sub.3                                                                               Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                               CF.sub.3                                                                               Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                               CF.sub.3                                                                               Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                               CF.sub.3                                                                               Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                   OCF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                              Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                               OCF.sub.3                                                                              Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                               OCF.sub.3                                                                              Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                               OCF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                               CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.3                                                                              Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                   CF.sub.3                                                                               Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                   CF.sub.3                                                                               Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 38                                                         ______________________________________                                          ##STR76##                                                                     R.sup.1 R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                            CF.sub.3                                                                               Ph       H         CF.sub.3                                                                             4-FPh  H                                      CF.sub.3                                                                               Ph       Me        CF.sub.3                                                                             4-FPh  Me                                     CF.sub.3                                                                               Ph       Et        CF.sub.3                                                                             4-FPh  Et                                     CF.sub.3                                                                               Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                   CF.sub.3                                                                               Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                              Ph       H         OCF.sub.3                                                                            4-FPh  H                                      OCF.sub.3                                                                              Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                     OCF.sub.3                                                                              Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                     OCF.sub.3                                                                              Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                   OCF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                            CF.sub.3                                                                               CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                            CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                               Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                   CF.sub.3                                                                               Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                            CF.sub.3                                                                               Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                               CF.sub.3                                                                               Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                               CF.sub.3                                                                               Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                               CF.sub.3                                                                               Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                   OCF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                              Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                               OCF.sub.3                                                                              Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                               OCF.sub.3                                                                              Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                               OCF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                               CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.3                                                                              Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                   CF.sub.3                                                                               Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                   CF.sub.3                                                                               Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 39                                                         ______________________________________                                          ##STR77##                                                                     R.sup.1 R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                            CF.sub.3                                                                               Ph       H         CF.sub.3                                                                             4-FPh  H                                      CF.sub.3                                                                               Ph       Me        CF.sub.3                                                                             4-FPh  Me                                     CF.sub.3                                                                               Ph       Et        CF.sub.3                                                                             4-FPh  Et                                     CF.sub.3                                                                               Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                   CF.sub.3                                                                               Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                              Ph       H         OCF.sub.3                                                                            4-FPh  H                                      OCF.sub.3                                                                              Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                     OCF.sub.3                                                                              Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                     OCF.sub.3                                                                              Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                   OCF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                            CF.sub.3                                                                               CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                            CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                               Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                   CF.sub.3                                                                               Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                            CF.sub.3                                                                               Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                               CF.sub.3                                                                               Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                               CF.sub.3                                                                               Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                               CF.sub.3                                                                               Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                   OCF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                              Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                               OCF.sub.3                                                                              Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                               OCF.sub.3                                                                              Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                               OCF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                               CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.3                                                                              Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                   CF.sub.3                                                                               Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                   CF.sub.3                                                                               Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 40                                                         ______________________________________                                          ##STR78##                                                                     R.sup.1 R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                            CF.sub.3                                                                               Ph       H         CF.sub.3                                                                             4-FPh  H                                      CF.sub.3                                                                               Ph       Me        CF.sub.3                                                                             4-FPh  Me                                     CF.sub.3                                                                               Ph       Et        CF.sub.3                                                                             4-FPh  Et                                     CF.sub.3                                                                               Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                   CF.sub.3                                                                               Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                              Ph       H         OCF.sub.3                                                                            4-FPh  H                                      OCF.sub.3                                                                              Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                     OCF.sub.3                                                                              Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                     OCF.sub.3                                                                              Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                   OCF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                            CF.sub.3                                                                               CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                            CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                               Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                   CF.sub.3                                                                               Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                            CF.sub.3                                                                               Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                               CF.sub.3                                                                               Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                               CF.sub.3                                                                               Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                               CF.sub.3                                                                               Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                   OCF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                              Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                               OCF.sub.3                                                                              Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                               OCF.sub.3                                                                              Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                               OCF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                               CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.3                                                                              Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                   CF.sub.3                                                                               Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                   CF.sub.3                                                                               Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 41                                                         ______________________________________                                          ##STR79##                                                                     R.sup.1 R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                            CF.sub.3                                                                               Ph       H         CF.sub.3                                                                             4-FPh  H                                      CF.sub.3                                                                               Ph       Me        CF.sub.3                                                                             4-FPh  Me                                     CF.sub.3                                                                               Ph       Et        CF.sub.3                                                                             4-FPh  Et                                     CF.sub.3                                                                               Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                   CF.sub.3                                                                               Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                              Ph       H         OCF.sub.3                                                                            4-FPh  H                                      OCF.sub.3                                                                              Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                     OCF.sub.3                                                                              Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                     OCF.sub.3                                                                              Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                   OCF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                            CF.sub.3                                                                               CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                            CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CC(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                               Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                   CF.sub.3                                                                               Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                            CF.sub.3                                                                               Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                               CF.sub.3                                                                               Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                               CF.sub.3                                                                               Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                               CF.sub.3                                                                               Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                   OCF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                              Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                               OCF.sub.3                                                                              Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                               OCF.sub.3                                                                              Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                               OCF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                               CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.3                                                                              Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                   CF.sub.3                                                                               Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                   CF.sub.3                                                                               Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 42                                                         ______________________________________                                          ##STR80##                                                                     R.sup.1 R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                      ______________________________________                                         CF.sub.3                                                                               CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                      CF.sub.3                                                                               CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                     CF.sub.3                                                                               CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                      OCF.sub.3                                                                              CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                     OCF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                            CF.sub.3                                                                               Ph       H         CF.sub.3                                                                             4-FPh  H                                      CF.sub.3                                                                               Ph       Me        CF.sub.3                                                                             4-FPh  Me                                     CF.sub.3                                                                               Ph       Et        CF.sub.3                                                                             4-FPh  Et                                     CF.sub.3                                                                               Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                   CF.sub.3                                                                               Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                            OCF.sub.3                                                                              Ph       H         OCF.sub.3                                                                            4-FPh  H                                      OCF.sub.3                                                                              Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                     OCF.sub.3                                                                              Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                     OCF.sub.3                                                                              Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                   OCF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                            CF.sub.3                                                                               CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                            CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                               CF.sub.3                                                                               CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                            OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                               OCF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                        CF.sub.3                                                                               Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                   CF.sub.3                                                                               Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                            CF.sub.3                                                                               Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                               CF.sub.3                                                                               Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                               CF.sub.3                                                                               Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                               CF.sub.3                                                                               Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                        OCF.sub.3                                                                              Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                   OCF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                            OCF.sub.3                                                                              Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                               OCF.sub.3                                                                              Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                               OCF.sub.3                                                                              Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                               OCF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                        CF.sub.3                                                                               CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                   CF.sub.3                                                                               CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                   OCF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                   OCF.sub.3                                                                              Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                   OCF.sub.3                                                                              Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                   CF.sub.3                                                                               Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                   CF.sub.3                                                                               Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                   ______________________________________                                    

                  TABLE 43                                                         ______________________________________                                          ##STR81##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                             Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                              Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                              Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 44                                                         ______________________________________                                          ##STR82##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                             Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                              Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                              Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 45                                                         ______________________________________                                          ##STR83##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                             Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                              Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                              Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 46                                                         ______________________________________                                          ##STR84##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                             Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                              Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                              Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 47                                                         ______________________________________                                          ##STR85##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                             Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                              Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                              Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 48                                                         ______________________________________                                          ##STR86##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                             Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                              Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                              Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 49                                                         ______________________________________                                          ##STR87##                                                                     R.sup.1                                                                               R.sup.3  Y         R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                              CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh H                                       CF.sub.3                                                                              CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh Me                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh Et                                      CF.sub.3                                                                              CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh COMe                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Me                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh H                                       OCF.sub.3                                                                             CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh Me                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh Et                                      OCF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh COMe                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Me                             CF.sub.3                                                                              Ph       H         CF.sub.3                                                                             4-FPh  H                                       CF.sub.3                                                                              Ph       Me        CF.sub.3                                                                             4-FPh  Me                                      CF.sub.3                                                                              Ph       Et        CF.sub.3                                                                             4-FPh  Et                                      CF.sub.3                                                                              Ph       COMe      CF.sub.3                                                                             4-FPh  COMe                                    CF.sub.3                                                                              Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Me                             OCF.sub.3                                                                             Ph       H         OCF.sub.3                                                                            4-FPh  H                                       OCF.sub.3                                                                             Ph       Me        OCF.sub.3                                                                            4-FPh  Me                                      OCF.sub.3                                                                             Ph       Et        OCF.sub.3                                                                            4-FPh  Et                                      OCF.sub.3                                                                             Ph       COMe      OCF.sub.3                                                                            4-FPh  COMe                                    OCF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Me                             CF.sub.3                                                                              CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh COEt                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh CO.sub.2 Et                             CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh CO(n-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh CO(i-Pr)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh CO(t-Bu)                                CF.sub.3                                                                              CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh COEt                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh CO.sub.2 Et                             OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh CO(n-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh CO(i-Pr)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh CO(t-Bu)                                OCF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh CO.sub.2 (t-Bu)                         CF.sub.3                                                                              Ph       COEt      CF.sub.3                                                                             4-FPh  COEt                                    CF.sub.3                                                                              Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh  CO.sub.2 Et                             CF.sub.3                                                                              Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh  CO(n-Pr)                                CF.sub.3                                                                              Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh  CO(i-Pr)                                CF.sub.3                                                                              Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh  CO(t-Bu)                                CF.sub.3                                                                              Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                             Ph       COEt      OCF.sub.3                                                                            4-FPh  COEt                                    OCF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh  CO.sub.2 Et                             OCF.sub.3                                                                             Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh  CO(n-Pr)                                OCF.sub.3                                                                             Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh  CO(i-Pr)                                OCF.sub.3                                                                             Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh  CO(t-Bu)                                OCF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                              CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh n-Pr                                    CF.sub.3                                                                              CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh i-Bu                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh n-Pr                                    OCF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh i-Bu                                    OCF.sub.3                                                                             Ph       n-Pr      CF.sub.3                                                                             4-FPh  n-Pr                                    OCF.sub.3                                                                             Ph       i-Bu      CF.sub.3                                                                             4-FPh  i-Bu                                    CF.sub.3                                                                              Ph       n-Pr      OCF.sub.3                                                                            4-FPh  n-Pr                                    CF.sub.3                                                                              Ph       i-Bu      OCF.sub.3                                                                            4-FPh  i-Bu                                    ______________________________________                                    

                  TABLE 50                                                         ______________________________________                                          ##STR88##                                                                     (R.sup.2 is CN)                                                                R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         CF.sub.3                                                                             CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh  H                                       CF.sub.3                                                                             CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh  Me                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh  Et                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh  COMe                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh  H                                       OCF.sub.3                                                                            CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh  Me                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh  Et                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh  COMe                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             Ph       H         CF.sub.3                                                                             4-FPh   H                                       CF.sub.3                                                                             Ph       Me        CF.sub.3                                                                             4-FPh   Me                                      CF.sub.3                                                                             Ph       Et        CF.sub.3                                                                             4-FPh   Et                                      CF.sub.3                                                                             Ph       COMe      CF.sub.3                                                                             4-FPh   COMe                                    CF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            Ph       H         OCF.sub.3                                                                            4-FPh   H                                       OCF.sub.3                                                                            Ph       Me        OCF.sub.3                                                                            4-FPh   Me                                      OCF.sub.3                                                                            Ph       Et        OCF.sub.3                                                                            4-FPh   Et                                      OCF.sub.3                                                                            Ph       COMe      OCF.sub.3                                                                            4-FPh   COMe                                    OCF.sub.3                                                                            Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh  COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh  CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh  CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh  CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh  COEt                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh  CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh  CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh  CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Ph       COEt      CF.sub.3                                                                             4-FPh   COEt                                    CF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh   CO(n-Pr)                                CF.sub.3                                                                             Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh   CO(i-Pr)                                CF.sub.3                                                                             Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh   CO(t-Bu)                                CF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh   CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Ph       COEt      OCF.sub.3                                                                            4-FPh   COEt                                    OCF.sub.3                                                                            Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh   CO(n-Pr)                                OCF.sub.3                                                                            Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh   CO(i-Pr)                                OCF.sub.3                                                                            Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh   CO(t-Bu)                                OCF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh   CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh  n-Pr                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh  i-Bu                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh  n-Pr                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh  i-Bu                                    OCF.sub.3                                                                            Ph       n-Pr      CF.sub.3                                                                             4-FPh   n-Pr                                    OCF.sub.3                                                                            Ph       i-Bu      CF.sub.3                                                                             4-FPh   i-Bu                                    CF.sub.3                                                                             Ph       n-Pr      OCF.sub.3                                                                            4-FPh   n-Pr                                    CF.sub.3                                                                             Ph       i-Bu      OCF.sub.3                                                                            4-FPh   i-Bu                                    ______________________________________                                    

                  TABLE 51                                                         ______________________________________                                          ##STR89##                                                                     (R.sup.2 is Br)                                                                R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         CF.sub.3                                                                             CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh  H                                       CF.sub.3                                                                             CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh  Me                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh  Et                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh  COMe                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh  H                                       OCF.sub.3                                                                            CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh  Me                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh  Et                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh  COMe                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             Ph       H         CF.sub.3                                                                             4-FPh   H                                       CF.sub.3                                                                             Ph       Me        CF.sub.3                                                                             4-FPh   Me                                      CF.sub.3                                                                             Ph       Et        CF.sub.3                                                                             4-FPh   Et                                      CF.sub.3                                                                             Ph       COMe      CF.sub.3                                                                             4-FPh   COMe                                    CF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            Ph       H         OCF.sub.3                                                                            4-FPh   H                                       OCF.sub.3                                                                            Ph       Me        OCF.sub.3                                                                            4-FPh   Me                                      OCF.sub.3                                                                            Ph       Et        OCF.sub.3                                                                            4-FPh   Et                                      OCF.sub.3                                                                            Ph       COMe      OCF.sub.3                                                                            4-FPh   COMe                                    OCF.sub.3                                                                            Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh  COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh  CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh  CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh  CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh  COEt                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh  CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh  CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh  CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Ph       COEt      CF.sub.3                                                                             4-FPh   COEt                                    CF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh   CO(n-Pr)                                CF.sub.3                                                                             Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh   CO(i-Pr)                                CF.sub.3                                                                             Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh   CO(t-Bu)                                CF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh   CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Ph       COEt      OCF.sub.3                                                                            4-FPh   COEt                                    OCF.sub.3                                                                            Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh   CO(n-Pr)                                OCF.sub.3                                                                            Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh   CO(i-Pr)                                OCF.sub.3                                                                            Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh   CO(t-Bu)                                OCF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh   CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh  n-Pr                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh  i-Bu                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh  n-Pr                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh  i-Bu                                    OCF.sub.3                                                                            Ph       n-Pr      CF.sub.3                                                                             4-FPh   n-Pr                                    OCF.sub.3                                                                            Ph       i-Bu      CF.sub.3                                                                             4-FPh   i-Bu                                    CF.sub.3                                                                             Ph       n-Pr      OCF.sub.3                                                                            4-FPh   n-Pr                                    CF.sub.3                                                                             Ph       i-Bu      OCF.sub.3                                                                            4-FPh   i-Bu                                    ______________________________________                                    

                  TABLE 52                                                         ______________________________________                                          ##STR90##                                                                     (R.sup.2 is CF.sub.3)                                                          R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         CF.sub.3                                                                             CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh  H                                       CF.sub.3                                                                             CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh  Me                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh  Et                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh  COMe                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh  H                                       OCF.sub.3                                                                            CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh  Me                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh  Et                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh  COMe                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             Ph       H         CF.sub.3                                                                             4-FPh   H                                       CF.sub.3                                                                             Ph       Me        CF.sub.3                                                                             4-FPh   Me                                      CF.sub.3                                                                             Ph       Et        CF.sub.3                                                                             4-FPh   Et                                      CF.sub.3                                                                             Ph       COMe      CF.sub.3                                                                             4-FPh   COMe                                    CF.sub.3                                                                             Pb       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            Ph       H         OCF.sub.3                                                                            4-FPh   H                                       OCF.sub.3                                                                            Ph       Me        OCF.sub.3                                                                            4-FPh   Me                                      OCF.sub.3                                                                            Ph       Et        OCF.sub.3                                                                            4-FPh   Et                                      OCF.sub.3                                                                            Ph       COMe      OCF.sub.3                                                                            4-FPh   COMe                                    OCF.sub.3                                                                            Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh  COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh  CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh  CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh  CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh  COEt                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh  CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh  CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh  CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Ph       COEt      CF.sub.3                                                                             4-FPh   COEt                                    CF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh   CO(n-Pr)                                CF.sub.3                                                                             Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh   CO(i-Pr)                                CF.sub.3                                                                             Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh   CO(t-Bu)                                CF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh   CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Ph       COEt      OCF.sub.3                                                                            4-FPh   COEt                                    OCF.sub.3                                                                            Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh   CO(n-Pr)                                OCF.sub.3                                                                            Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh   CO(i-Pr)                                OCF.sub.3                                                                            Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh   CO(t-Bu)                                OCF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh   CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh  n-Pr                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh  i-Bu                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh  n-Pr                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh  i-Bu                                    OCF.sub.3                                                                            Ph       n-Pr      CF.sub.3                                                                             4-FPh   n-Pr                                    OCF.sub.3                                                                            Ph       i-Bu      CF.sub.3                                                                             4-FPh   i-Bu                                    CF.sub.3                                                                             Ph       n-Pr      OCF.sub.3                                                                            4-FPh   n-Pr                                    CF.sub.3                                                                             Ph       i-Bu      OCF.sub.3                                                                            4-FPh   i-Bu                                    ______________________________________                                    

                  TABLE 53                                                         ______________________________________                                          ##STR91##                                                                     (R.sup.2 is OCF.sub.2 H)                                                       R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         CF.sub.3                                                                             CO.sub.2 Me                                                                             H         CF.sub.3                                                                             4-ClPh  H                                       CF.sub.3                                                                             CO.sub.2 Me                                                                             Me        CF.sub.3                                                                             4-ClPh  Me                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             Et        CF.sub.3                                                                             4-ClPh  Et                                      CF.sub.3                                                                             CO.sub.2 Me                                                                             COMe      CF.sub.3                                                                             4-ClPh  COMe                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Me                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             H         OCF.sub.3                                                                            4-ClPh  H                                       OCF.sub.3                                                                            CO.sub.2 Me                                                                             Me        OCF.sub.3                                                                            4-ClPh  Me                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             Et        OCF.sub.3                                                                            4-ClPh  Et                                      OCF.sub.3                                                                            CO.sub.2 Me                                                                             COMe      OCF.sub.3                                                                            4-ClPh  COMe                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Me                             CF.sub.3                                                                             Ph       H         CF.sub.3                                                                             4-FPh   H                                       CF.sub.3                                                                             Ph       Me        CF.sub.3                                                                             4-FPh   Me                                      CF.sub.3                                                                             Ph       Et        CF.sub.3                                                                             4-FPh   Et                                      CF.sub.3                                                                             Ph       COMe      CF.sub.3                                                                             4-FPh   COMe                                    CF.sub.3                                                                             Ph       CO.sub.2 Me                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Me                             OCF.sub.3                                                                            Ph       H         OCF.sub.3                                                                            4-FPh   H                                       OCF.sub.3                                                                            Ph       Me        OCF.sub.3                                                                            4-FPh   Me                                      OCF.sub.3                                                                            Ph       Et        OCF.sub.3                                                                            4-FPh   Et                                      OCF.sub.3                                                                            Ph       COMe      OCF.sub.3                                                                            4-FPh   COMe                                    OCF.sub.3                                                                            Ph       CO.sub.2 Me                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Me                             CF.sub.3                                                                             CO.sub.2 Me                                                                             COEt      CF.sub.3                                                                             4-ClPh  COEt                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              CF.sub.3                                                                             4-ClPh  CO.sub.2 Et                             CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(n-Pr)  CF.sub.3                                                                             4-ClPh  CO(n-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(i-Pr)  CF.sub.3                                                                             4-ClPh  CO(i-Pr)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO(t-Bu)  CF.sub.3                                                                             4-ClPh  CO(t-Bu)                                CF.sub.3                                                                             CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-ClPh  CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            CO.sub.2 Me                                                                             COEt      OCF.sub.3                                                                            4-ClPh  COEt                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-ClPh  CO.sub.2 Et                             OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(n-Pr)  OCF.sub.3                                                                            4-ClPh  CO(n-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(i-Pr)  OCF.sub.3                                                                            4-ClPh  CO(i-Pr)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO(t-Bu)  OCF.sub.3                                                                            4-ClPh  CO(t-Bu)                                OCF.sub.3                                                                            CO.sub.2 Me                                                                             CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-ClPh  CO.sub.2 (t-Bu)                         CF.sub.3                                                                             Ph       COEt      CF.sub.3                                                                             4-FPh   COEt                                    CF.sub.3                                                                             Ph       CO.sub.2 Et                                                                              CF.sub.3                                                                             4-FPh   CO.sub.2 Et                             CF.sub.3                                                                             Ph       CO(n-Pr)  CF.sub.3                                                                             4-FPh   CO(n-Pr)                                CF.sub.3                                                                             Ph       CO(i-Pr)  CF.sub.3                                                                             4-FPh   CO(i-Pr)                                CF.sub.3                                                                             Ph       CO(t-Bu)  CF.sub.3                                                                             4-FPh   CO(t-Bu)                                CF.sub.3                                                                             Ph       CO.sub.2 (t-Bu)                                                                          CF.sub.3                                                                             4-FPh   CO.sub.2 (t-Bu)                         OCF.sub.3                                                                            Ph       COEt      OCF.sub.3                                                                            4-FPh   COEt                                    OCF.sub.3                                                                            Ph       CO.sub.2 Et                                                                              OCF.sub.3                                                                            4-FPh   CO.sub.2 Et                             OCF.sub.3                                                                            Ph       CO(n-Pr)  OCF.sub.3                                                                            4-FPh   CO(n-Pr)                                OCF.sub.3                                                                            Ph       CO(i-Pr)  OCF.sub.3                                                                            4-FPh   CO(i-Pr)                                OCF.sub.3                                                                            Ph       CO(t-Bu)  OCF.sub.3                                                                            4-FPh   CO(t-Bu)                                OCF.sub.3                                                                            Ph       CO.sub.2 (t-Bu)                                                                          OCF.sub.3                                                                            4-FPh   CO.sub.2 (t-Bu)                         CF.sub.3                                                                             CO.sub.2 Me                                                                             n-Pr      CF.sub.3                                                                             4-ClPh  n-Pr                                    CF.sub.3                                                                             CO.sub.2 Me                                                                             i-Bu      CF.sub.3                                                                             4-ClPh  i-Bu                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             n-Pr      OCF.sub.3                                                                            4-ClPh  n-Pr                                    OCF.sub.3                                                                            CO.sub.2 Me                                                                             i-Bu      OCF.sub.3                                                                            4-ClPh  i-Bu                                    OCF.sub.3                                                                            Ph       n-Pr      CF.sub.3                                                                             4-FPh   n-Pr                                    OCF.sub.3                                                                            Ph       i-Bu      CF.sub.3                                                                             4-FPh   i-Bu                                    CF.sub.3                                                                             Ph       n-Pr      OCF.sub.3                                                                            4-FPh   n-Pr                                    CF.sub.3                                                                             Ph       i-Bu      OCF.sub.3                                                                            4-FPh   i-Bu                                    ______________________________________                                    

                  TABLE 54                                                         ______________________________________                                          ##STR92##                                                                     (R.sup.6 is H)                                                                 R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         CF.sub.3                                                                             4-FPh    H         CF.sub.3                                                                             i-Pr    H                                       CF.sub.3                                                                             4-FPh    Me        CF.sub.3                                                                             i-Pr    Me                                      CF.sub.3                                                                             4-FPh    Et        CF.sub.3                                                                             i-Pr    Et                                      CF.sub.3                                                                             4-FPh    COMe      CF.sub.3                                                                             i-Pr    COMe                                    CF.sub.3                                                                             4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                             i-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            4-FPh    H         OCF.sub.3                                                                            i-Pr    H                                       OCF.sub.3                                                                            4-FPh    Me        OCF.sub.3                                                                            i-Pr    Me                                      OCF.sub.3                                                                            4-FPh    Et        OCF.sub.3                                                                            i-Pr    Et                                      OCF.sub.3                                                                            4-FPh    COMe      OCF.sub.3                                                                            i-Pr    COMe                                    OCF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                            i-Pr    CO.sub.2 Me                             CF.sub.3                                                                             n-Pr     H         CF.sub.3                                                                             CO.sub.2 Me                                                                            H                                       CF.sub.3                                                                             n-Pr     Me        CF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                      CF.sub.3                                                                             n-Pr     Et        CF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                      CF.sub.3                                                                             n-Pr     COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                    CF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            n-Pr     H         OCF.sub.3                                                                            CO.sub.2 Me                                                                            H                                       OCF.sub.3                                                                            n-Pr     Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                            Me                                      OCF.sub.3                                                                            n-Pr     Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                            Et                                      OCF.sub.3                                                                            n-Pr     COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                            COMe                                    OCF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                             ______________________________________                                    

                  TABLE 55                                                         ______________________________________                                          ##STR93##                                                                     (R.sup.6 is Me)                                                                R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         CF.sub.3                                                                             4-FPh    H         CF.sub.3                                                                             i-Pr    H                                       CF.sub.3                                                                             4-FPh    Me        CF.sub.3                                                                             i-Pr    Me                                      CF.sub.3                                                                             4-FPh    Et        CF.sub.3                                                                             i-Pr    Et                                      CF.sub.3                                                                             4-FPh    COMe      CF.sub.3                                                                             i-Pr    COMe                                    CF.sub.3                                                                             4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                             i-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            4-FPh    H         OCF.sub.3                                                                            i-Pr    H                                       OCF.sub.3                                                                            4-FPh    Me        OCF.sub.3                                                                            i-Pr    Me                                      OCF.sub.3                                                                            4-FPh    Et        OCF.sub.3                                                                            i-Pr    Et                                      OCF.sub.3                                                                            4-FPh    COMe      OCF.sub.3                                                                            i-Pr    COMe                                    OCF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                            i-Pr    CO.sub.2 Me                             CF.sub.3                                                                             n-Pr     H         CF.sub.3                                                                             CO.sub.2 Me                                                                            H                                       CF.sub.3                                                                             n-Pr     Me        CF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                      CF.sub.3                                                                             n-Pr     Et        CF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                      CF.sub.3                                                                             n-Pr     COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                    CF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            n-Pr     H         OCF.sub.3                                                                            CO.sub.2 Me                                                                            H                                       OCF.sub.3                                                                            n-Pr     Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                            Me                                      OCF.sub.3                                                                            n-Pr     Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                            Et                                      OCF.sub.3                                                                            n-Pr     COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                            COMe                                    OCF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                             ______________________________________                                    

                  TABLE 56                                                         ______________________________________                                          ##STR94##                                                                     (R.sup.6 is COMe)                                                              R.sup.1                                                                              R.sup.3  Y         R.sup.1                                                                              R.sup.3 Y                                       ______________________________________                                         CF.sub.3                                                                             4-FPh    H         CF.sub.3                                                                             i-Pr    H                                       CF.sub.3                                                                             4-FPh    Me        CF.sub.3                                                                             i-Pr    Me                                      CF.sub.3                                                                             4-FPh    Et        CF.sub.3                                                                             i-Pr    Et                                      CF.sub.3                                                                             4-FPh    COMe      CF.sub.3                                                                             i-Pr    COMe                                    CF.sub.3                                                                             4-FPh    CO.sub.2 Me                                                                              CF.sub.3                                                                             i-Pr    CO.sub.2 Me                             OCF.sub.3                                                                            4-FPh    H         OCF.sub.3                                                                            i-Pr    H                                       OCF.sub.3                                                                            4-FPh    Me        OCF.sub.3                                                                            i-Pr    Me                                      OCF.sub.3                                                                            4-FPh    Et        OCF.sub.3                                                                            i-Pr    Et                                      OCF.sub.3                                                                            4-FPh    COMe      OCF.sub.3                                                                            i-Pr    COMe                                    OCF.sub.3                                                                            4-FPh    CO.sub.2 Me                                                                              OCF.sub.3                                                                            i-Pr    CO.sub.2 Me                             CF.sub.3                                                                             n-Pr     H         CF.sub.3                                                                             CO.sub.2 Me                                                                            H                                       CF.sub.3                                                                             n-Pr     Me        CF.sub.3                                                                             CO.sub.2 Me                                                                            Me                                      CF.sub.3                                                                             n-Pr     Et        CF.sub.3                                                                             CO.sub.2 Me                                                                            Et                                      CF.sub.3                                                                             n-Pr     COMe      CF.sub.3                                                                             CO.sub.2 Me                                                                            COMe                                    CF.sub.3                                                                             n-Pr     CO.sub.2 Me                                                                              CF.sub.3                                                                             CO.sub.2 Me                                                                            CO.sub.2 Me                             OCF.sub.3                                                                            n-Pr     H         OCF.sub.3                                                                            CO.sub.2 Me                                                                            H                                       OCF.sub.3                                                                            n-Pr     Me        OCF.sub.3                                                                            CO.sub.2 Me                                                                            Me                                      OCF.sub.3                                                                            n-Pr     Et        OCF.sub.3                                                                            CO.sub.2 Me                                                                            Et                                      OCF.sub.3                                                                            n-Pr     COMe      OCF.sub.3                                                                            CO.sub.2 Me                                                                            COMe                                    OCF.sub.3                                                                            n-Pr     CO.sub.2 Me                                                                              OCF.sub.3                                                                            CO.sub.2 Me                                                                            CO.sub.2 Me                             ______________________________________                                    

                  TABLE 57                                                         ______________________________________                                          ##STR95##                                                                     R.sup.1 R.sup.3  Y        R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               4-F-Ph   H        CF.sub.3                                                                             i-Pr   H                                       CF.sub.3                                                                               4-F-Ph   Me       CF.sub.3                                                                             i-Pr   Me                                      CF.sub.3                                                                               4-F-Ph   Et       CF.sub.3                                                                             i-Pr   Et                                      CF.sub.3                                                                               4-F-Ph   COMe     CF.sub.3                                                                             i-Pr   COMe                                    CF.sub.3                                                                               4-F-Ph   CO.sub.2 Me                                                                             CF.sub.3                                                                             i-Pr   CO.sub.2 Me                             OCF.sub.3                                                                              4-F-Ph   H        OCF.sub.3                                                                            i-Pr   H                                       OCF.sub.3                                                                              4-F-Ph   Me       OCF.sub.3                                                                            i-Pr   Me                                      OCF.sub.3                                                                              4-F-Ph   Et       OCF.sub.3                                                                            i-Pr   Et                                      OCF.sub.3                                                                              4-F-Ph   COMe     OCF.sub.3                                                                            i-Pr   COMe                                    OCF.sub.3                                                                              4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.3                                                                            i-Pr   CO.sub.2 Me                             CF.sub.3                                                                               n-Pr     H        CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               n-Pr     Me       CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               n-Pr     Et       CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               n-Pr     COMe     CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr     H        OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              n-Pr     Me       OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              n-Pr     Et       OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              n-Pr     COMe     OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             ______________________________________                                    

                  TABLE 58                                                         ______________________________________                                          ##STR96##                                                                     R.sup.1 R.sup.3  Y        R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               4-F-Ph   H        CF.sub.3                                                                             i-Pr   H                                       CF.sub.3                                                                               4-F-Ph   Me       CF.sub.3                                                                             i-Pr   Me                                      CF.sub.3                                                                               4-F-Ph   Et       CF.sub.3                                                                             i-Pr   Et                                      CF.sub.3                                                                               4-F-Ph   COMe     CF.sub.3                                                                             i-Pr   COMe                                    CF.sub.3                                                                               4-F-Ph   CO.sub.2 Me                                                                             CF.sub.3                                                                             i-Pr   CO.sub.2 Me                             OCF.sub.3                                                                              4-F-Ph   H        OCF.sub.3                                                                            i-Pr   H                                       OCF.sub.3                                                                              4-F-Ph   Me       OCF.sub.3                                                                            i-Pr   Me                                      OCF.sub.3                                                                              4-F-Ph   Et       OCF.sub.3                                                                            i-Pr   Et                                      OCF.sub.3                                                                              4-F-Ph   COMe     OCF.sub.3                                                                            i-Pr   COMe                                    OCF.sub.3                                                                              4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.3                                                                            i-Pr   CO.sub.2 Me                             CF.sub.3                                                                               n-Pr     H        CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               n-Pr     Me       CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               n-Pr     Et       CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               n-Pr     COMe     CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr     H        OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              n-Pr     Me       OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              n-Pr     Et       OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              n-Pr     COMe     OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             ______________________________________                                    

                  TABLE 59                                                         ______________________________________                                          ##STR97##                                                                     (R.sup.6 is COMe)                                                              R.sup.1 R.sup.3  Y        R.sup.1                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         CF.sub.3                                                                               4-F-Ph   H        CF.sub.3                                                                             i-Pr   H                                       CF.sub.3                                                                               4-F-Ph   Me       CF.sub.3                                                                             i-Pr   Me                                      CF.sub.3                                                                               4-F-Ph   Et       CF.sub.3                                                                             i-Pr   Et                                      CF.sub.3                                                                               4-F-Ph   COMe     CF.sub.3                                                                             i-Pr   COMe                                    CF.sub.3                                                                               4-F-Ph   CO.sub.2 Me                                                                             CF.sub.3                                                                             i-Pr   CO.sub.2 Me                             OCF.sub.3                                                                              4-F-Ph   H        OCF.sub.3                                                                            i-Pr   H                                       OCF.sub.3                                                                              4-F-Ph   Me       OCF.sub.3                                                                            i-Pr   Me                                      OCF.sub.3                                                                              4-F-Ph   Et       OCF.sub.3                                                                            i-Pr   Et                                      OCF.sub.3                                                                              4-F-Ph   COMe     OCF.sub.3                                                                            i-Pr   COMe                                    OCF.sub.3                                                                              4-F-Ph   CO.sub.2 Me                                                                             OCF.sub.3                                                                            i-Pr   CO.sub.2 Me                             CF.sub.3                                                                               n-Pr     H        CF.sub.3                                                                             CO.sub.2 Me                                                                           H                                       CF.sub.3                                                                               n-Pr     Me       CF.sub.3                                                                             CO.sub.2 Me                                                                           Me                                      CF.sub.3                                                                               n-Pr     Et       CF.sub.3                                                                             CO.sub.2 Me                                                                           Et                                      CF.sub.3                                                                               n-Pr     COMe     CF.sub.3                                                                             CO.sub.2 Me                                                                           COMe                                    CF.sub.3                                                                               n-Pr     CO.sub.2 Me                                                                             CF.sub.3                                                                             CO.sub.2 Me                                                                           CO.sub.2 Me                             OCF.sub.3                                                                              n-Pr     H        OCF.sub.3                                                                            CO.sub.2 Me                                                                           H                                       OCF.sub.3                                                                              n-Pr     Me       OCF.sub.3                                                                            CO.sub.2 Me                                                                           Me                                      OCF.sub.3                                                                              n-Pr     Et       OCF.sub.3                                                                            CO.sub.2 Me                                                                           Et                                      OCF.sub.3                                                                              n-Pr     COMe     OCF.sub.3                                                                            CO.sub.2 Me                                                                           COMe                                    OCF.sub.3                                                                              n-Pr     CO.sub.2 Me                                                                             OCF.sub.3                                                                            CO.sub.2 Me                                                                           CO.sub.2 Me                             ______________________________________                                    

                  TABLE 60                                                         ______________________________________                                          ##STR98##                                                                     R.sup.2 R.sup.3  Y        R.sup.2                                                                              R.sup.3                                                                               Y                                       ______________________________________                                         6-Cl    CO.sub.2 Me                                                                             H        7-F   CO.sub.2 Me                                                                           H                                       6-Cl    CO.sub.2 Me                                                                             Me       7-F   CO.sub.2 Me                                                                           Me                                      6-Cl    CO.sub.2 Me                                                                             Et       7-F   CO.sub.2 Me                                                                           Et                                      6-Cl    CO.sub.2 Me                                                                             COMe     7-F   CO.sub.2 Me                                                                           COMe                                    6-Cl    CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             7-F   CO.sub.2 Me                                                                           CO.sub.2 Me                             6-Cl    CO.sub.2 Me                                                                             COEt     7-F   CO.sub.2 Me                                                                           COEt                                    6-Cl    CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             7-F   CO.sub.2 Me                                                                           CO.sub.2 Et                             7-Cl    CO.sub.2 Me                                                                             H        6-Cl  4-Cl-Ph                                                                               H                                       7-Cl    CO.sub.2 Me                                                                             Me       6-Cl  4-CI-Ph                                                                               Me                                      7-Cl    CO.sub.2 Me                                                                             Et       6-Cl  4-Cl-Ph                                                                               Et                                      7-Cl    CO.sub.2 Me                                                                             COMe     6-Cl  4-Cl-Ph                                                                               COMe                                    7-Cl    CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             6-Cl  4-Cl-Ph                                                                               CO.sub.2 Me                             7-Cl    CO.sub.2 Me                                                                             COEt     6-Cl  4-Cl-Ph                                                                               COEt                                    7-Cl    CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             6-Cl  4-Cl-Ph                                                                               CO.sub.2 Et                             6-F     CO.sub.2 Me                                                                             H        7-Cl  4-Cl-Ph                                                                               H                                       6-F     CO.sub.2 Me                                                                             Me       7-Cl  4-Cl-Ph                                                                               Me                                      6-F     CO.sub.2 Me                                                                             Et       7-Cl  4-Cl-Ph                                                                               Et                                      6-F     CO.sub.2 Me                                                                             COMe     7-Cl  4-Cl-Ph                                                                               COMe                                    6-F     CO.sub.2 Me                                                                             CO.sub.2 Me                                                                             7-Cl  4-Cl-Ph                                                                               CO.sub.2 Me                             6-F     CO.sub.2 Me                                                                             COEt     7-Cl  4-Cl-Ph                                                                               COEt                                    6-F     CO.sub.2 Me                                                                             CO.sub.2 Et                                                                             7-Cl  4-Cl-Ph                                                                               CO.sub.2 Et                             6-F     4-Cl-Ph  H        6-F   4-F-Ph H                                       6-F     4-Cl-Ph  Me       6-F   4-F-Ph Me                                      6-F     4-Cl-Ph  Et       6-F   4-F-Ph Et                                      6-F     4-Cl-Ph  COMe     6-F   4-F-Ph COMe                                    6-F     4-Cl-Ph  CO.sub.2 Me                                                                             6-F   4-F-Ph CO.sub.2 Me                             6-F     4-Cl-Ph  COEt     6-F   4-F-Ph COEt                                    6-F     4-Cl-Ph  CO.sub.2 Et                                                                             6-F   4-F-Ph CO.sub.2 Et                             7-F     4-Cl-Ph  H        7-F   4-F-Ph H                                       7-F     4-Cl-Ph  Me       7-F   4-F-Ph Me                                      7-F     4-Cl-Ph  Et       7-F   4-F-Ph Et                                      7-F     4-Cl-Ph  COMe     7-F   4-F-Ph COMe                                    7-F     4-Cl-Ph  CO.sub.2 Me                                                                             7-F   4-F-Ph CO.sub.2 Me                             7-F     4-Cl-Ph  COEt     7-F   4-F-Ph COEt                                    7-F     4-Cl-Ph  CO.sub.2 Et                                                                             7-F   4-F-Ph CO.sub.2 Et                             6-Cl    4-F-Ph   H        7-Cl  4-F-Ph H                                       6-Cl    4-F-Ph   Me       7-Cl  4-F-Ph Me                                      6-Cl    4-F-Ph   Et       7-Cl  4-F-Ph Et                                      6-Cl    4-F-Ph   COMe     7-Cl  4-F-Ph COMe                                    6-Cl    4-F-Ph   CO.sub.2 Me                                                                             7-Cl  4-F-Ph CO.sub.2 Me                             6-Cl    4-F-Ph   COEt     7-Cl  4-F-Ph COEt                                    6-Cl    4-F-Ph   CO.sub.2 Et                                                                             7-Cl  4-F-Ph CO.sub.2 Et                             ______________________________________                                    

                  TABLE 61                                                         ______________________________________                                          ##STR99##                                                                     (R.sup.2 is Cl, R.sup.3 is CO.sub.2 Me)                                        R.sup.1 Y             R.sup.1  Y                                               ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                        CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                 CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3 CO(i-Bu)                                        CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                 CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3 CO(4-Cl-Ph)                                     CF.sub.3                                                                               i-Pr          CF.sub.3 CO.sub.2 Ph                                     CF.sub.3                                                                               Ph            CF.sub.3 CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               4-Cl-Ph       CF.sub.3 CH.sub.2 CH.sub.2 CN                            CF.sub.3                                                                               4-OMe-Ph      CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                   CF.sub.3                                                                               4-F-Ph        CF.sub.3 CH.sub.2 CH.sub.2 Cl                            CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                               CH.sub.2 SiMe.sub.3                             CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                               CH.sub.2 CF.sub.3                               CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                               CH.sub.2 CCH                                    CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                            CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                               CH.sub.2 CN                                     CF.sub.3                                                                               SN(n-Bu).sub.2                                                                               OCF.sub.3                                                                               i-Pr                                            CF.sub.3                                                                               SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                               Ph                                              CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                               4-Cl-Ph                                         CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                               4-OMe-Ph                                        CF.sub.3                                                                               n-Bu          CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                    CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                               n-Bu                                            OCF.sub.3                                                                              4-F-Ph        Br       CH.sub.2 CO.sub.2 Me                            OCF.sub.3                                                                              t-Bu          Br       CH.sub.2 CN                                     OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                            OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br       4-Cl-Ph                                         OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br       4-OMe-Ph                                        OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br       4-F-Ph                                          OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                            OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                      OCF.sub.3                                                                              CO(n-Bu)      Br       SN(i-Pr)CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                               OCF.sub.3                                                                              CO(i-Bu)      Br       SN(n-Bu).sub.2                                  OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                           OCF.sub.3                                                                              CO(4-Cl-Ph)   Br       SN(i-Pr)CO.sub.2 (n-Bu)                         OCF.sub.3                                                                              CO.sub.2 Ph   Br       SN(i-Pr)CO.sub.2 (n-Pr)                         OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                 OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                 OCF.sub.3                                                                              CH.sub.2 Ph   Br       CO(4-Cl-Ph)                                     OCF.sub.3                                                                              COPh          Br       CO.sub.2 Ph                                     CF.sub.3                                                                               CH.sub.2 Ph   Br       CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               COPh          Br       CH.sub.2 CH.sub.2 CN                            Br      CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                   Br      CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                     Br      CH.sub.2 CCH  Br       COPh                                            OCF.sub.3                                                                              i-Bu          Br       n-Bu                                            CF.sub.3                                                                               s-Bu          Br       i-Bu                                            OCF.sub.3                                                                              s-Bu          Br       s-Bu                                            OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                     ______________________________________                                    

                  TABLE 62                                                         ______________________________________                                          ##STR100##                                                                    (R.sup.2 is F, R.sup.3 is CO.sub.2 Me)                                         R.sup.1 Y             R.sup.1  Y                                               ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                        CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                 CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3 CO(i-Bu)                                        CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                 CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3 CO(4-Cl-Ph)                                     CF.sub.3                                                                               i-Pr          CF.sub.3 CO.sub.2 Ph                                     CF.sub.3                                                                               Ph            CF.sub.3 CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               4-Cl-Ph       CF.sub.3 CH.sub.2 CH.sub.2 CN                            CF.sub.3                                                                               4-OMe-Ph      CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                   CF.sub.3                                                                               4-F-Ph        CF.sub.3 CH.sub.2 CH.sub.2 Cl                            CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                               CH.sub.2 SiMe.sub.3                             CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                               CH.sub.2 CF.sub.3                               CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                               CH.sub.2 CCH                                    CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                            CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                               CH.sub.2 CN                                     CF.sub.3                                                                               SN(n-Bu).sub.2                                                                               OCF.sub.3                                                                               i-Pr                                            CF.sub.3                                                                               SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                               Ph                                              CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                               4-Cl-Ph                                         CF.sub.3                                                                               SN (i-Pr)CO.sub.2 (n-Pr)                                                                     OCF.sub.3                                                                               4-OMe-Ph                                        CF.sub.3                                                                               n-Bu          CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                    CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                               n-Bu                                            OCF.sub.3                                                                              4-F-Ph        Br       CH.sub.2 CO.sub.2 Me                            OCF.sub.3                                                                              t-Bu          Br       CH.sub.2 CN                                     OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                            OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br       4-Cl-Ph                                         OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br       4-OMe-Ph                                        OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br       4-F-Ph                                          OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                            OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                      OCF.sub.3                                                                              CO(n-Bu)      Br       SN(i-Pr)CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                               OCF.sub.3                                                                              CO(i-Bu)      Br       SN(n-Bu).sub.2                                  OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                           OCF.sub.3                                                                              CO(4-Cl-Ph)   Br       SN(i-Pr)CO.sub.2 (n-Bu)                         OCF.sub.3                                                                              CO.sub.2 Ph   Br       SN(i-Pr)CO.sub.2 (n-Pr)                         OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                 OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                 OCF.sub.3                                                                              CH.sub.2 Ph   Br       CO(4-Cl-Ph)                                     OCF.sub.3                                                                              COPh          Br       CO.sub.2 Ph                                     CF.sub.3                                                                               CH.sub.2 Ph   Br       CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               COPh          Br       CH.sub.2 CH.sub.2 CN                            Br      CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                   Br      CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                     Br      CH.sub.2 CCH  Br       COPh                                            OCF.sub.3                                                                              i-Bu          Br       n-Bu                                            CF.sub.3                                                                               s-Bu          Br       i-Bu                                            OCF.sub.3                                                                              s-Bu          Br       s-Bu                                            OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                     ______________________________________                                    

                  TABLE 63                                                         ______________________________________                                          ##STR101##                                                                    (R.sup.2 is OCH.sub.2 CF.sub.3, R.sup.3 is CO.sub.2 Me)                        R.sup.1 Y             R.sup.1  Y                                               ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                        CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                 CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3 CO(i-Bu)                                        CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                 CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3 CO(4-Cl-Ph)                                     CF.sub.3                                                                               i-Pr          CF.sub.3 CO.sub.2 Ph                                     CF.sub.3                                                                               Ph            CF.sub.3 CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               4-Cl-Ph       CF.sub.3 CH.sub.2 CH.sub.2 CN                            CF.sub.3                                                                               4-OMe-Ph      CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                   CF.sub.3                                                                               4-F-Ph        CF.sub.3 CH.sub.2 CH.sub.2 Cl                            CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                               CH.sub.2 SiMe.sub.3                             CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                               CH.sub.2 CF.sub.3                               CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                               CH.sub.2 CCH                                    CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                            CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                               CH.sub.2 CN                                     CF.sub.3                                                                               SN(n-Bu).sub.2                                                                               OCF.sub.3                                                                               i-Pr                                            CF.sub.3                                                                               SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                               Ph                                              CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                               4-Cl-Ph                                         CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                               4-OMe-Ph                                        CF.sub.3                                                                               n-Bu          CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                    CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                               n-Bu                                            OCF.sub.3                                                                              4-F-Ph        Br       CH.sub.2 CO.sub.2 Me                            OCF.sub.3                                                                              t-Bu          Br       CH.sub.2 CN                                     OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                            OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br       4-Cl-Ph                                         OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br       4-OMe-Ph                                        OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br       4-F-Ph                                          OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                            OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                      OCF.sub.3                                                                              CO(n-BU)      Br       SN(i-Pr)CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                               OCF.sub.3                                                                              CO(i-Bu)      Br       SN(n-Bu).sub.2                                  OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                           OCF.sub.3                                                                              CO(4-Cl-Ph)   Br       SN(i-Pr)CO.sub.2 (n-Bu)                         OCF.sub.3                                                                              CO.sub.2 Ph   Br       SN(i-Pr)CO.sub.2 (n-Pr)                         OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                 OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                 OCF.sub.3                                                                              CH.sub.2 Ph   Br       CO(4-Cl-Ph)                                     OCF.sub.3                                                                              COPh          Br       CO.sub.2 Ph                                     CF.sub.3                                                                               CH.sub.2 Ph   Br       CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               COPh          Br       CH.sub.2 CH.sub.2 CN                            Br      CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                   Br      CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                     Br      CH.sub.2 CCH  Br       COPh                                            OCF.sub.3                                                                              i-Bu          Br       n-Bu                                            CF.sub.3                                                                               s-Bu          Br       i-Bu                                            OCF.sub.3                                                                              s-Bu          Br       s-Bu                                            OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                     ______________________________________                                    

                  TABLE 63                                                         ______________________________________                                          ##STR102##                                                                    (R.sup.2 is Cl, R.sup.3 is 4-F-Ph)                                             R.sup.1 Y             R.sup.1  Y                                               ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                        CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                 CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3 CO(i-Bu)                                        CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                 CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3 CO(4-Cl-Ph)                                     CF.sub.3                                                                               i-Pr          CF.sub.3 CO.sub.2 Ph                                     CF.sub.3                                                                               Ph            CF.sub.3 CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               4-Cl-Ph       CF.sub.3 CH.sub.2 CH.sub.2 CN                            CF.sub.3                                                                               4-OMe-Ph      CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                   CF.sub.3                                                                               4-F-Ph        CF.sub.3 CH.sub.2 CH.sub.2 Cl                            CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                               CH.sub.2 SiMe.sub.3                             CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                               CH.sub.2 CF.sub.3                               CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                               CH.sub.2 CCH                                    CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                            CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                               CH.sub.2 CN                                     CF.sub.3                                                                               SN(n-Bu).sub.2                                                                               OCF.sub.3                                                                               i-Pr                                            CF.sub.3                                                                               SN(Me)CO.sub.2 (n-BU)                                                                        OCF.sub.3                                                                               Ph                                              CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                               4-Cl-Ph                                         CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                               4-OMe-Ph                                        CF.sub.3                                                                               n-Bu          CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                    CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                               n-Bu                                            OCF.sub.3                                                                              4-F-Ph        Br       CH.sub.2 CO.sub.2 Me                            OCF.sub.3                                                                              t-Bu          Br       CH.sub.2 CN                                     OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                            OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br       4-Cl-Ph                                         OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br       4-OMe-Ph                                        OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br       4-F-Ph                                          OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                            OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Br)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                      OCF.sub.3                                                                              CO(n-Bu)      Br       SN(i-Pr)CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                               OCF.sub.3                                                                              CO(i-Bu)      Br       SN(n-Bu).sub.2                                  OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                           OCF.sub.3                                                                              CO(4-Cl-Ph)   Br       SN(i-Pr)CO.sub.2 (n-Bu)                         OCF.sub.3                                                                              CO.sub.2 Ph   Br       SN(i-Pr)CO.sub.2 (n-Pr)                         OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                 OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                 OCF.sub.3                                                                              CH.sub.2 Ph   Br       CO(4-Cl-Ph)                                     OCF.sub.3                                                                              COPh          Br       CO.sub.2 Ph                                     CF.sub.3                                                                               CH.sub.2 Ph   Br       CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               COPh          Br       CH.sub.2 CH.sub.2 CN                            Br      CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                   Br      CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                     Br      CH.sub.2 CCH  Br       COPh                                            OCF.sub.3                                                                              i-Bu          Br       n-Bu                                            CF.sub.3                                                                               s-Bu          Br       i-Bu                                            OCF.sub.3                                                                              s-Bu          Br       s-Bu                                            OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                     ______________________________________                                    

                  TABLE 65                                                         ______________________________________                                          ##STR103##                                                                    (R.sup.2 is F, R.sup.3 is 4-F-Ph)                                              R.sup.1 Y             R.sup.1  Y                                               ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                        CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                 CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3 CO(i-Bu)                                        CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                 CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3 CO(4-Cl-Ph)                                     CF.sub.3                                                                               i-Pr          CF.sub.3 CO.sub.2 Ph                                     CF.sub.3                                                                               Ph            CF.sub.3 CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               4-Cl-Ph       CF.sub.3 CH.sub.2 CH.sub.2 CN                            CF.sub.3                                                                               4-OMe-Ph      CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                   CF.sub.3                                                                               4-F-Ph        CF.sub.3 CH.sub.2 CH.sub.2 Cl                            CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                               CH.sub.2 SiMe.sub.3                             CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                               CH.sub.2 CF.sub.3                               CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                               CH.sub.2 OCH                                    CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                            CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                               CH.sub.2 CN                                     CF.sub.3                                                                               SN(n-Bu).sub.2                                                                               OCF.sub.3                                                                               i-Pr                                            CF.sub.3                                                                               SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                               Ph                                              CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                               4-Cl-Ph                                         CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                               4-OMe-Ph                                        CF.sub.3                                                                               n-Bu          CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                    CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                               n-Bu                                            OCF.sub.3                                                                              4-F-Ph        Br       CH.sub.2 CO.sub.2 Me                            OCF.sub.3                                                                              t-Bu          Br       CH.sub.2 CN                                     OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                            OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br       4-Cl-Ph                                         OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br       4-OMe-Ph                                        OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br       4-F-Ph                                          OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                            OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                      OCF.sub.3                                                                              CO(n-Bu)      Br       SN(i-Pr)CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                               OCF.sub.3                                                                              CO(i-Bu)      Br       SN(n-Bu).sub.2                                  OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                           OCF.sub.3                                                                              CO(4-Cl-Ph)   Br       SN(i-Pr)CO.sub.2 (n-Bu)                         OCF.sub.3                                                                              CO.sub.2 Ph   Br       SN(i-Pr)CO.sub.2 (n-Pr)                         OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                 OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                 OCF.sub.3                                                                              CH.sub.2 Ph   Br       CO(4-Cl-Ph)                                     OCF.sub.3                                                                              COPh          Br       CO.sub.2 Ph                                     CF.sub.3                                                                               CH.sub.2 Ph   Br       CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               COPh          Br       CH.sub.2 CH.sub.2 CN                            Br      CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                   Br      CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                     Br      CH.sub.2 CCH  Br       COPh                                            OCF.sub.3                                                                              i-Bu          Br       n-Bu                                            CF.sub.3                                                                               s-Bu          Br       i-Bu                                            OCF.sub.3                                                                              s-Bu          Br       s-Bu                                            OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                     ______________________________________                                    

                  TABLE 66                                                         ______________________________________                                          ##STR104##                                                                    (R.sup.2 is OCH.sub.2 CF.sub.3, R.sup.3 is 4-F-Ph)                             R.sup.1 Y             R.sup.1  Y                                               ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3 CO(n-Bu)                                        CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3 CO.sub.2 (n-Bu)                                 CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3 CO(i-Bu)                                        CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3 CO.sub.2 (i-Bu)                                 CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3 CO(4-Cl-Ph)                                     CF.sub.3                                                                               i-Pr          CF.sub.3 CO.sub.2 Ph                                     CF.sub.3                                                                               Ph            CF.sub.3 CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               4-Cl-Ph       CF.sub.3 CH.sub.2 CH.sub.2 CN                            CF.sub.3                                                                               4-OMe-Ph      CF.sub.3 CH.sub.2 CH.sub.2 CO.sub.2 Me                   CF.sub.3                                                                               4-F-Ph        CF.sub.3 CH.sub.2 CH.sub.2 Cl                            CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                               CH.sub.2 SiMe.sub.3                             CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                               CH.sub.2 CF.sub.3                               CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                               CH.sub.2 CCH                                    CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                            CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                               CH.sub.2 CN                                     CF.sub.3                                                                               SN(n-Bu).sub.2                                                                               OCF.sub.3                                                                               i-Pr                                            CF.sub.3                                                                               SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                               Ph                                              CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                               4-Cl-Pb                                         CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                               4-OMe-Ph                                        CF.sub.3                                                                               n-Bu          CF.sub.3 CH.sub.2 C(CH.sub.3)CH.sub.2                    CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                               n-Bu                                            OCF.sub.3                                                                              4-F-Ph        Br       CH.sub.2 CO.sub.2 Me                            OCF.sub.3                                                                              t-Bu          Br       CH.sub.2 CN                                     OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br       i-Pr                                            OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br       Ph                                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br       4-Cl-Ph                                         OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br       4-OMe-Ph                                        OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br       4-F-Ph                                          OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br       t-Bu                                            OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br       CH.sub.2 SOCH.sub.3                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br       CH.sub.2 SO.sub.2 CH.sub.3                      OCF.sub.3                                                                              CO(n-Bu)      Br       SN(i-Pr)CO.sub.2 Et                             OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br       SN(Me)CO.sub.2 Et                               OCF.sub.3                                                                              CO(i-Bu)      Br       SN(n-Bu).sub.2                                  OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br       SN(Me)CO.sub.2 (n-Bu)                           OCF.sub.3                                                                              CO(4-Cl-Ph)   Br       SN(i-Pr)CO.sub.2 (n-Bu)                         OCF.sub.3                                                                              CO.sub.2 Ph   Br       SN(i-Pr)CO.sub.2 (n-Pr)                         OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br       CO(n-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br       CO.sub.2 (n-Bu)                                 OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br       CO(i-Bu)                                        OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br       CO.sub.2 (i-Bu)                                 OCF.sub.3                                                                              CH.sub.2 Ph   Br       CO(4-Cl-Ph)                                     OCF.sub.3                                                                              COPh          Br       CO.sub.2 Ph                                     CF.sub.3                                                                               CH.sub.2 Ph   Br       CH.sub.2 CO.sub.2 Et                            CF.sub.3                                                                               COPh          Br       CH.sub.2 CH.sub.2 CN                            Br      CH.sub.2 SiMe.sub.3                                                                          Br       CH.sub.2 CH.sub.2 CO.sub.2 Me                   Br      CH.sub.2 CF.sub.3                                                                            Br       CH.sub.2 Ph                                     Br      CH.sub.2 CCH  Br       COPh                                            OCF.sub.3                                                                              i-Bu          Br       n-Bu                                            CF.sub.3                                                                               s-Bu          Br       i-Bu                                            OCF.sub.3                                                                              s-Bu          Br       s-Bu                                            OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br       CH.sub.2 (CH.sub.3)CH.sub.2                     ______________________________________                                    

                  TABLE 67                                                         ______________________________________                                          ##STR105##                                                                    R.sup.1 Y             R.sup.1 Y                                                ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3                                                                               CO(n-Bu)                                         CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3                                                                               CO.sub.2 (n-Bu)                                  CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3                                                                               CO(i-Bu)                                         CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3                                                                               CO.sub.2 (i-Bu)                                  CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3                                                                               CO(4-ClPh)                                       CF.sub.3                                                                               i-Pr          CF.sub.3                                                                               CO.sub.2 Ph                                      CF.sub.3                                                                               Ph            CF.sub.3                                                                               CH.sub.2 CO.sub.2 Et                             CF.sub.3                                                                               4-ClPh        CF.sub.3                                                                               CH.sub.2 CH.sub.2 CN                             CF.sub.3                                                                               4-OMePh       CF.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 Me                    CF.sub.3                                                                               4-FPh         CF.sub.3                                                                               CH.sub.2 CH.sub.2 Cl                             CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                              CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                                CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                     CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                             CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                      CF.sub.3                                                                               SN(n-Bu)2     OCF.sub.3                                                                              i-Pr                                             CF.sub.3                                                                               SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                               CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                           CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                          CF.sub.3                                                                               n-Bu          CF.sub.3                                                                               CH.sub.2 C(CH.sub.3)CH.sub.2                     CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                              n-Bu                                             OCF.sub.3                                                                              4-FPh         Br      CH.sub.2 CO.sub.2 Me                             OCF.sub.3                                                                              t-Bu          Br      CH.sub.2 CN                                      OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br      i-Pr                                             OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br      Ph                                               OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br      4-ClPh                                           OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br      4-OMePh                                          OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br      4-FPh                                            OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br      t-Bu                                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br      CH.sub.2 SOCH.sub.3                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br      CH.sub.2 SO.sub.2 CH.sub.3                       OCF.sub.3                                                                              CO(n-Bu)      Br      SN(i-Pr)CO.sub.2 Et                              OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br      SN(Me)CO.sub.2 Et                                OCF.sub.3                                                                              CO(i-Bu)      Br      SN(n-Bu).sub.2                                   OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br      SN(Me)CO.sub.2 (n-Bu)                            OCF.sub.3                                                                              CO(4-ClPh)    Br      SN(i-Pr)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                              CO.sub.2 Ph   Br      SN(i-Pr)CO.sub.2 (n-Pr)                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br      CO(n-Bu)                                         OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br      CO.sub.2 (n-Bu)                                  OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br      CO(i-Bu)                                         OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br      CO.sub.2 (i-Bu)                                  OCF.sub.3                                                                              CH.sub.2 Ph   Br      CO(4-ClPh)                                       OCF.sub.3                                                                              COPh          Br      CO.sub.2 Ph                                      CF.sub.3                                                                               CH.sub.2 Ph   Br      CH.sub.2 CO.sub.2 Et                             CF.sub.3                                                                               COPh          Br      CH.sub.2 CH.sub.2 CN                             Br      CH.sub.2 SiMe.sub.3                                                                          Br      CH.sub.2 CH.sub.2 CO.sub.2 Me                    Br      CH.sub.2 CF.sub.3                                                                            Br      CH.sub.2 Ph                                      Br      CH.sub.2 CCH  Br      COPh                                             OCF.sub.3                                                                              i-Bu          Br      n-Bu                                             CF.sub.3                                                                               s-Bu          Br      i-Bu                                             OCF.sub.3                                                                              s-Bu          Br      s-Bu                                             OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br      CH.sub.2 (CH.sub.3)CH.sub.2                      ______________________________________                                    

                  TABLE 68                                                         ______________________________________                                          ##STR106##                                                                    R.sup.1 Y             R.sup.1 Y                                                ______________________________________                                         CF.sub.3                                                                               CH.sub.2 SiMe.sub.3                                                                          CF.sub.3                                                                               CO(n-Bu)                                         CF.sub.3                                                                               CH.sub.2 CF.sub.3                                                                            CF.sub.3                                                                               CO.sub.2 (i-Bu)                                  CF.sub.3                                                                               CH.sub.2 CCH  CF.sub.3                                                                               CO(i-Bu)                                         CF.sub.3                                                                               CH.sub.2 CO.sub.2 Me                                                                         CF.sub.3                                                                               CO.sub.2 (i-Bu)                                  CF.sub.3                                                                               CH.sub.2 CN   CF.sub.3                                                                               CO(4-ClPh)                                       CF.sub.3                                                                               i-Pr          CF.sub.3                                                                               CO.sub.2 Ph                                      CF.sub.3                                                                               Ph            CF.sub.3                                                                               CH.sub.2 CO.sub.2 Et                             CF.sub.3                                                                               4-ClPh        CF.sub.3                                                                               CH.sub.2 CH.sub.2 CN                             CF.sub.3                                                                               4-OMePh       CF.sub.3                                                                               CH.sub.2 CH.sub.2 CO.sub.2 Me                    CF.sub.3                                                                               4-FPh         CF.sub.3                                                                               CH.sub.2 CH.sub.2 Cl                             CF.sub.3                                                                               t-Bu          OCF.sub.3                                                                              CH.sub.2 SiMe.sub.3                              CF.sub.3                                                                               CH.sub.2 SOCH.sub.3                                                                          OCF.sub.3                                                                              CH.sub.2 CF.sub.3                                CF.sub.3                                                                               CH.sub.2 SO.sub.2 CH.sub.3                                                                   OCF.sub.3                                                                              CH.sub.2 CCH                                     CF.sub.3                                                                               SN(i-Pr)CO.sub.2 Et                                                                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Me                             CF.sub.3                                                                               SN(Me)CO.sub.2 Et                                                                            OCF.sub.3                                                                              CH.sub.2 CN                                      CF.sub.3                                                                               SN(n-Bu).sub.2                                                                               OCF.sub.3                                                                              i-Pr                                             CF.sub.3                                                                               SN(Me)CO.sub.2 (n-Bu)                                                                        OCF.sub.3                                                                              Ph                                               CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Bu)                                                                      OCF.sub.3                                                                              4-ClPh                                           CF.sub.3                                                                               SN(i-Pr)CO.sub.2 (n-Pr)                                                                      OCF.sub.3                                                                              4-OMePh                                          CF.sub.3                                                                               n-Bu          CF.sub.3                                                                               CH.sub.2 C(CH.sub.3)CH.sub.2                     CF.sub.3                                                                               i-Bu          OCF.sub.3                                                                              n-Bu                                             OCF.sub.3                                                                              4-FPh         Br      CH.sub.2 CO.sub.2 Me                             OCF.sub.3                                                                              t-Bu          Br      CH.sub.2 CN                                      OCF.sub.3                                                                              CH.sub.2 SOCH.sub.3                                                                          Br      i-Pr                                             OCF.sub.3                                                                              CH.sub.2 SO.sub.2 CH.sub.3                                                                   Br      Ph                                               OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 Et                                                                          Br      4-ClPh                                           OCF.sub.3                                                                              SN(Me)CO.sub.2 Et                                                                            Br      4-OMePh                                          OCF.sub.3                                                                              SN(n-Bu).sub.2                                                                               Br      4-FPh                                            OCF.sub.3                                                                              SN(Me)CO.sub.2 (n-Bu)                                                                        Br      t-Bu                                             OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Bu)                                                                      Br      CH.sub.2 SOCH.sub.3                              OCF.sub.3                                                                              SN(i-Pr)CO.sub.2 (n-Pr)                                                                      Br      CH.sub.2 SO.sub.2 CH.sub.3                       OCF.sub.3                                                                              CO(n-Bu)      Br      SN(i-Pr)CO.sub.2 Et                              OCF.sub.3                                                                              CO.sub.2 (n-Bu)                                                                              Br      SN(Me)CO.sub.2 Et                                OCF.sub.3                                                                              CO(i-Bu)      Br      SN(n-Bu).sub.2                                   OCF.sub.3                                                                              CO.sub.2 (i-Bu)                                                                              Br      SN(Me)CO.sub.2 (n-Bu)                            OCF.sub.3                                                                              CO(4-ClPh)    Br      SN(i-Pr)CO.sub.2 (n-Bu)                          OCF.sub.3                                                                              CO.sub.2 Ph   Br      SN(i-Pr)CO.sub.2 (n-Pr)                          OCF.sub.3                                                                              CH.sub.2 CO.sub.2 Et                                                                         Br      CO(n-Bu)                                         OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CN                                                                         Br      CO.sub.2 (n-Bu)                                  OCF.sub.3                                                                              CH.sub.2 CH.sub.2 CO.sub.2 Me                                                                Br      CO(i-Bu)                                         OCF.sub.3                                                                              CH.sub.2 CH.sub.2 Cl                                                                         Br      CO.sub.2 (i-Bu)                                  OCF.sub.3                                                                              CH.sub.2 Ph   Br      CO(4-ClPh)                                       OCF.sub.3                                                                              COPh          Br      CO.sub.2 Ph                                      CF.sub.3                                                                               CH.sub.2 Ph   Br      CH.sub.2 CO.sub.2 Et                             CF.sub.3                                                                               COPh          Br      CH.sub.2 CH.sub.2 CN                             Br      CH.sub.2 SiMe.sub.3                                                                          Br      CH.sub.2 CH.sub.2 CO.sub.2 Me                    Br      CH.sub.2 CF.sub.3                                                                            Br      CH.sub.2 Ph                                      Br      CH.sub.2 CCH  Br      COPh                                             OCF.sub.3                                                                              i-Bu          Br      n-Bu                                             CF.sub.3                                                                               s-Bu          Br      i-Bu                                             OCF.sub.3                                                                              s-Bu          Br      s-Bu                                             OCF.sub.3                                                                              CH.sub.2 C(CH.sub.3)CH.sub.2                                                                 Br      CH.sub.2 (CH.sub.3)CH.sub.2                      ______________________________________                                    

                  TABLE 69                                                         ______________________________________                                          ##STR107##                                                                    R.sup.1                                                                              R.sup.2   R.sup.3  R.sup.1                                                                              R.sup.2  R.sup.3                                ______________________________________                                         Cl    7-Cl      Me       Cl    7-CF.sub.3                                                                              Ph                                     Cl    7-Cl      Et       Cl    7-CF.sub.3                                                                              4-ClPh                                 Cl    7-Cl      n-Pr     Cl    7-CF.sub.3                                                                              4-FPh                                  Cl    7-Cl      i-Pr     Cl    7-OCH.sub.2 CF.sub.3                                                                    Me                                     Cl    7-Cl      CO.sub.2 Me                                                                             Cl    7-OCH.sub.2 CF.sub.3                                                                    Et                                     Cl    7-Cl      CO.sub.2 Et                                                                             Cl    7-CCH.sub.2 CF.sub.3                                                                    n-Pr                                   Cl    7-Cl      Ph       Cl    7-OCH.sub.2 CF.sub.3                                                                    CO.sub.2 Me                            Cl    7-Cl      4-ClPh   Cl    7-OCH.sub.2 CF.sub.3                                                                    CO.sub.2 Et                            Cl    7-Cl      4-FPh    Cl    7-OCH.sub.2 CF.sub.3                                                                    Ph                                     Cl    7-F       Me       Cl    7-OCH.sub.2 CF.sub.3                                                                    4-ClPh                                 Cl    7-F       Et       Cl    7-OCH.sub.2 CF.sub.3                                                                    4-FPh                                  Cl    7-F       n-Pr     Cl    6-Cl     Me                                     Cl    7-F       i-Pr     Cl    6-Cl     Et                                     Cl    7-F       CO.sub.2 Me                                                                             Cl    6-Cl     n-Pr                                   Cl    7-F       CO.sub.2 Et                                                                             Cl    6-Cl     CO.sub.2 Me                            Cl    7-F       Ph       Cl    6-Cl     CO.sub.2 Et                            Cl    7-F       4-ClPh   Cl    6-Cl     Ph                                     Cl    7-F       4-FPh    Cl    6-Cl     4-ClPh                                 Cl    7-CF.sub.3                                                                               Me       Cl    6-Cl     4-FPh                                  Cl    7-CF.sub.3                                                                               Et       Br    7-Cl     Me                                     Cl    7-CF.sub.3                                                                               n-Pr     Br    7-Cl     Et                                     Cl    7-CF.sub.3                                                                               i-Pr     Br    7-Cl     n-Pr                                   Cl    7-CF.sub.3                                                                               CO.sub.2 Me                                                                             Br    7-Cl     i-Pr                                   Cl    7-CF.sub.3                                                                               CO.sub.2 Et                                                                             Br    7-Cl     CO.sub.2 Me                            Br    7-Cl      CO.sub.2 Et                                                                             Br    7-OCH.sub.2 CF.sub.3                                                                    Ph                                     Br    7-Cl      Ph       Br    7-OCH.sub.2 CF.sub.3                                                                    4-ClPh                                 Br    7-Cl      4-ClPh   Br    7-OCH.sub.2 CF.sub.3                                                                    4-FPh                                  Br    7-Cl      4-FPh    Br    6-Cl     Me                                     Br    7-F       Me       Br    6-Cl     Et                                     Br    7-F       Et       Br    6-Cl     n-Pr                                   Br    7-F       n-Pr     Br    6-Cl     i-Pr                                   Br    7-F       i-Pr     Br    6-Cl     CO.sub.2 Me                            Br    7-F       CO.sub.2 Me                                                                             Br    6-Cl     CO.sub.2 Et                            Br    7-F       CO.sub.2 Et                                                                             Br    6-Cl     Ph                                     Br    7-F       Ph       Br    6-Cl     4-ClPh                                 Br    7-F       4-ClPh   Br    6-Cl     4-FPh                                  Br    7-F       4-FPh    CF.sub.3                                                                             7-Cl     Me                                     Br    7-CF.sub.3                                                                               Me       CF.sub.3                                                                             7-Cl     Et                                     Br    7-CF.sub.3                                                                               Et       CF.sub.3                                                                             7-Cl     n-Pr                                   Br    7-CF.sub.3                                                                               n-Pr     CF.sub.3                                                                             7-Cl     i-Pr                                   Br    7-CF.sub.3                                                                               i-Pr     CF.sub.3                                                                             7-Cl     CO.sub.2 Me                            Br    7-CF.sub.3                                                                               CO.sub.2 Me                                                                             CF.sub.3                                                                             7-Cl     CO.sub.2 Et                            Br    7-CF.sub.3                                                                               CO.sub.2 Et                                                                             CF.sub.3                                                                             7-Cl     Ph                                     Br    7-CF.sub.3                                                                               Ph       CF.sub.3                                                                             7-Cl     4-ClPh                                 Br    7-CF.sub.3                                                                               4-ClPh   CF.sub.3                                                                             7-Cl     4-FPh                                  Br    7-CF.sub.3                                                                               4-FPh    CF.sub.3                                                                             7-F      Me                                     Br    7-OCH.sub.2 CF.sub.3                                                                     Me       CF.sub.3                                                                             7-F      Et                                     Br    7-OCH.sub.2 CF.sub.3                                                                     Et       CF.sub.3                                                                             7-F      n-Pr                                   Br    7-OCH.sub.2 CF.sub.3                                                                     i-Pr     CF.sub.3                                                                             7-F      i-Pr                                   Br    7-OCH.sub.2 CF.sub.3                                                                     i-Pr     CF.sub.3                                                                             7-F      CO.sub.2 Me                            Br    7-OCH.sub.2 CF.sub.3                                                                     CO Me    CF.sub.3                                                                             7-F      CO.sub.2 Et                            Br    7-CF.sub.3                                                                               CO.sub.2 Et                                                                             CF.sub.3                                                                             7-F      Ph                                     CF.sub.3                                                                             7-F       4-FPh    CF.sub.3                                                                             7-F      4-ClPh                                 CF.sub.3                                                                             7-CF.sub.3                                                                               Me       OCF.sub.3                                                                            7-Cl     Me                                     CF.sub.3                                                                             7-CF.sub.3                                                                               Et       OCF.sub.3                                                                            7-Cl     Et                                     CF.sub.3                                                                             7-CF.sub.3                                                                               n-Pr     OCF.sub.3                                                                            7-Cl     n-Pr                                   CF.sub.3                                                                             7-CF.sub.3                                                                               i-Pr     OCF.sub.3                                                                            7-Cl     i-Pr                                   CF.sub.3                                                                             7-CF.sub.3                                                                               CO.sub.2 Me                                                                             OCF.sub.3                                                                            7-Cl     CO.sub.2 Me                            CF.sub.3                                                                             7-CF.sub.3                                                                               CO.sub.2 Et                                                                             OCF.sub.3                                                                            7-Cl     CO.sub.2 Et                            CF.sub.3                                                                             7-CF.sub.3                                                                               Ph       OCF.sub.3                                                                            7-Cl     Ph                                     CF.sub.3                                                                             7-CF.sub.3                                                                               4-ClPh   OCF.sub.3                                                                            7-Cl     4-ClPh                                 CF.sub.3                                                                             7-CF.sub.3                                                                               4-FPh    OCF.sub.3                                                                            7-Cl     4-FPh                                  CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     Me       OCF.sub.3                                                                            7-F      Me                                     CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     Et       OCF.sub.3                                                                            7-F      Et                                     CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     n-Pr     OCF.sub.3                                                                            7-F      n-Pr                                   CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     i-Pr     OCF.sub.3                                                                            7-F      i-Pr                                   CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     CO.sub.2 Me                                                                             OCF.sub.3                                                                            7-F      CO.sub.2 Me                            CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     CO.sub.2 Et                                                                             OCF.sub.3                                                                            7-F      CO.sub.2 Et                            CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     Ph       OCF.sub.3                                                                            7-F      Ph                                     CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     4-ClPh   OCF.sub.3                                                                            7-F      4-ClPh                                 CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     4-FPh    OCF.sub.3                                                                            7-F      4-FPh                                  CF.sub.3                                                                             6-Cl      Me       OCF.sub.3                                                                            7-CF.sub.3                                                                              Me                                     CF.sub.3                                                                             6-Cl      Et       OCF.sub.3                                                                            7-CF.sub.3                                                                              Et                                     CF.sub.3                                                                             6-Cl      n-Pr     OCF.sub.3                                                                            7-CF.sub.3                                                                              n-Pr                                   CF.sub.3                                                                             6-Cl      i-Pr     OCF.sub.3                                                                            7-CF.sub.3                                                                              i-Pr                                   CF.sub.3                                                                             6-Cl      CO.sub.2 Me                                                                             OCF.sub.3                                                                            7-CF.sub.3                                                                              CO.sub.2 Me                            CF.sub.3                                                                             6-Cl      CO.sub.2 Et                                                                             OCF.sub.3                                                                            7-CF.sub.3                                                                              CO.sub.2 Et                            CF.sub.3                                                                             6-Cl      Ph       OCF.sub.3                                                                            7-CF.sub.3                                                                              Ph                                     CF.sub.3                                                                             6-Cl      4-ClPh   OCF.sub.3                                                                            7-CF.sub.3                                                                              4-ClPh                                 CF.sub.3                                                                             6-Cl      4-FPh    OCF.sub.3                                                                            7-CF.sub.3                                                                              4-FPh                                  OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     Et       OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                    Me                                     OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     n-Pr                                                           OCF.sub.3                                                                            7-OCH.sub.2 CH.sub.3                                                                     i-Pr                                                           OCF.sub.3                                                                            7-OCH.sub.2 CH.sub.3                                                                     CO.sub.2 Me                                                    OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     CO.sub.2 Et                                                    OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     Ph                                                             OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     4-ClPh                                                         OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     4-FPh                                                          OCF.sub.3                                                                            6-Cl      Me                                                             OCF.sub.3                                                                            6-Cl      Et                                                             OCF.sub.3                                                                            6-Cl      n-Pr                                                           OCF.sub.3                                                                            6-Cl      i-Pr                                                           OCF.sub.3                                                                            6-Cl      CO.sub.2 Me                                                    OCF.sub.3                                                                            6-Cl      CO.sub.2 Et                                                    OCF.sub.3                                                                            6-Cl      Ph                                                             OCF.sub.3                                                                            6-Cl      4-ClPh                                                         OCF.sub.3                                                                            6-Cl      4-FPh                                                          Cl    7-OCH.sub.2 CF.sub.3                                                                     i-Pr                                                           Cl    6-Cl      i-Pr                                                           ______________________________________                                    

                  TABLE 70                                                         ______________________________________                                          ##STR108##                                                                    R.sup.1                                                                              R.sup.2   R.sup.3  R.sup.1                                                                              R.sup.2  R.sup.3                                ______________________________________                                         Cl    7-Cl      Me       Cl    7-CF.sub.3                                                                              Ph                                     Cl    7-Cl      Et       Cl    7-CF.sub.3                                                                              4-ClPh                                 Cl    7-Cl      n-Pr     Cl    7-CF.sub.3                                                                              4-FPh                                  Cl    7-Cl      i-Pr     Cl    7-OCH.sub.2 CF.sub.3                                                                    Me                                     Cl    7-Cl      CO.sub.2 Me                                                                             Cl    7-OCH.sub.2 CF.sub.3                                                                    Et                                     Cl    7-Cl      CO.sub.2 Et                                                                             Cl    7-OCH.sub.2 CF.sub.3                                                                    n-Pr                                   Cl    7-Cl      Ph       Cl    7-OCH.sub.2 CF.sub.3                                                                    CO.sub.2 Me                            Cl    7-Cl      4-ClPh   Cl    7-OCH.sub.2 CF.sub.3                                                                    CO.sub.2 Et                            Cl    7-Cl      4-FPh    Cl    7-OCH.sub.2 CF.sub.3                                                                    Ph                                     Cl    7-F       Me       Cl    7-OCH.sub.2 CF.sub.3                                                                    4-ClPh                                 Cl    7-F       Et       Cl    7-OCH.sub.2 CF.sub.3                                                                    4-FPh                                  Cl    7-F       n-Pr     Cl    6-Cl     Me                                     Cl    7-F       i-Pr     Cl    6-Cl     Et                                     Cl    7-F       CO.sub.2 Me                                                                             Cl    6-Cl     n-Pr                                   Cl    7-F       CO.sub.2 Et                                                                             Cl    6-Cl     CO.sub.2 Me                            Cl    7-F       Ph       Cl    6-Cl     CO.sub.2 Et                            Cl    7-F       4-ClPh   Cl    6-Cl     Ph                                     Cl    7-F       4-FPh    Cl    6-Cl     4-ClPh                                 Cl    7-CF.sub.3                                                                               Me       Cl    6-Cl     4-FPh                                  Cl    7-CF.sub.3                                                                               Et       Br    7-Cl     Me                                     Cl    7-CF.sub.3                                                                               n-Pr     Br    7-Cl     Et                                     Cl    7-CF.sub.3                                                                               i-Pr     Br    7-Cl     n-Pr                                   Cl    7-CF.sub.3                                                                               CO.sub.2 Me                                                                             Br    7-Cl     i-Pr                                   Cl    7-CF.sub.3                                                                               CO.sub.2 Et                                                                             Br    7-Cl     CO.sub.2 Me                            Br    7-Cl      CO.sub.2 Et                                                                             Br    7-OCH.sub.2 CF.sub.3                                                                    Ph                                     Br    7-Cl      Ph       Br    7-OCH.sub.2 CF.sub.3                                                                    4-ClPh                                 Br    7-Cl      4-ClPh   Br    7-OCH.sub.2 CF.sub.3                                                                    4-FPh                                  Br    7-Cl      4-FPh    Br    6-Cl     Me                                     Br    7-F       Me       Br    6-Cl     Et                                     Br    7-F       Et       Br    6-Cl     n-Pr                                   Br    7-F       n-Pr     Br    6-Cl     i-Pr                                   Br    7-F       i-Pr     Br    6-Cl     CO.sub.2 Me                            Br    7-F       CO.sub.2 Me                                                                             Br    6-Cl     CO.sub.2 Et                            Br    7-F       CO.sub.2 Et                                                                             Br    6-Cl     Ph                                     Br    7-F       Ph       Br    6-Cl     4-ClPh                                 Br    7-F       4-ClPh   Br    6-Cl     4-FPh                                  Br    7-F       4-FPh    CF.sub.3                                                                             7-Cl     Me                                     Br    7-CF.sub.3                                                                               Me       CF.sub.3                                                                             7-Cl     Et                                     Br    7-CF.sub.3                                                                               Et       CF.sub.3                                                                             7-Cl     n-Pr                                   Br    7-CF.sub.3                                                                               n-Pr     CF.sub.3                                                                             7-Cl     i-Pr                                   Br    7-CF.sub.3                                                                               i-Pr     CF.sub.3                                                                             7-Cl     CO.sub.2 Me                            Br    7-CF.sub.3                                                                               CO.sub.2 Me                                                                             CF.sub.3                                                                             7-Cl     CO.sub.2 Et                            Br    7-CF.sub.3                                                                               CO.sub.2 Et                                                                             CF.sub.3                                                                             7-Cl     Ph                                     Br    7-CF.sub.3                                                                               Ph       CF.sub.3                                                                             7-Cl     4-ClPh                                 Br    7-CF.sub.3                                                                               4-ClPh   CF.sub.3                                                                             7-Cl     4-FPh                                  Br    7-CF.sub.3                                                                               4-FPh    CF.sub.3                                                                             7-F      Me                                     Br    7-OCH.sub.2 CF.sub.3                                                                     Me       CF.sub.3                                                                             7-F      Et                                     Br    7-OCH.sub.2 CF.sub.3                                                                     Et       CF.sub.3                                                                             7-F      n-Pr                                   Br    7-OCH.sub.2 CF.sub.3                                                                     n-Pr     CF.sub.3                                                                             7-F      i-Pr                                   Br    7-OCH.sub.2 CF.sub.3                                                                     i-Pr     CF.sub.3                                                                             7-F      CO.sub.2 Me                            Br    7-OCH.sub.2 CF.sub.3                                                                     CO.sub.2 Me                                                                             CF.sub.3                                                                             7-F      CO.sub.2 Et                            Br    7-CF.sub.3                                                                               CO.sub.2 Et                                                                             CF.sub.3                                                                             7-F      Ph                                     CF.sub.3                                                                             7-F       4-FPh    CF.sub.3                                                                             7-F      4-ClPh                                 CF.sub.3                                                                             7-CF.sub.3                                                                               Me       OCF.sub.3                                                                            7-Cl     Me                                     CF.sub.3                                                                             7-CF.sub.3                                                                               Et       OCF.sub.3                                                                            7-Cl     Et                                     CF.sub.3                                                                             7-CF.sub.3                                                                               n-Pr     OCF.sub.3                                                                            7-Cl     n-Pr                                   CF.sub.3                                                                             7-CF.sub.3                                                                               i-Pr     OCF.sub.3                                                                            7-Cl     i-Pr                                   CF.sub.3                                                                             7-CF.sub.3                                                                               CO.sub.2 Me                                                                             OCF.sub.3                                                                            7-Cl     CO.sub.2 Me                            CF.sub.3                                                                             7-CF.sub.3                                                                               CO.sub.2 Et                                                                             OCF.sub.3                                                                            7-Cl     CO.sub.2 Et                            CF.sub.3                                                                             7-CF.sub.3                                                                               Ph       OCF.sub.3                                                                            7-Cl     Ph                                     CF.sub.3                                                                             7-CF.sub.3                                                                               4-ClPh   OCF.sub.3                                                                            7-Cl     4-ClPh                                 CF.sub.3                                                                             7-CF.sub.3                                                                               4-FPh    OCF.sub.3                                                                            7-Cl     4-FPh                                  CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     Me       OCF.sub.3                                                                            7-F      Me                                     CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     Et       OCF.sub.3                                                                            7-F      Et                                     CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     n-Pr     OCF.sub.3                                                                            7-F      n-Pr                                   CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     i-Pr     OCF.sub.3                                                                            7-F      i-Pr                                   CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     CO.sub.2 Me                                                                             OCF.sub.3                                                                            7-F      CO.sub.2 Me                            CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     CO.sub.2 Et                                                                             OCF.sub.3                                                                            7-F      CO.sub.2 Et                            CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     Ph       OCF.sub.3                                                                            7-F      Ph                                     CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     4-ClPh   OCF.sub.3                                                                            7-F      4-ClPh                                 CF.sub.3                                                                             7-OCH.sub.2 CF.sub.3                                                                     4-FPh    OCF.sub.3                                                                            7-F      4-FPh                                  CF.sub.3                                                                             6-Cl      Me       OCF.sub.3                                                                            7-CF.sub.3                                                                              Me                                     CF.sub.3                                                                             6-Cl      Et       OCF.sub.3                                                                            7-CF.sub.3                                                                              Et                                     CF.sub.3                                                                             6-Cl      n-Pr     OCF.sub.3                                                                            7-CF.sub.3                                                                              n-Pr                                   CF.sub.3                                                                             6-Cl      i-Pr     OCF.sub.3                                                                            7-CF.sub.3                                                                              i-Pr                                   CF.sub.3                                                                             6-Cl      CO.sub.2 Me                                                                             OCF.sub.3                                                                            7-CF.sub.3                                                                              CO.sub.2 Me                            CF.sub.3                                                                             6-Cl      CO.sub.2 Et                                                                             OCF.sub.3                                                                            7-CF.sub.3                                                                              CO.sub.2 Et                            CF.sub.3                                                                             6-Cl      Ph       OCF.sub.3                                                                            7-CF.sub.3                                                                              Ph                                     CF.sub.3                                                                             6-Cl      4-ClPh   OCF.sub.3                                                                            7-CF.sub.3                                                                              4-ClPh                                 CF.sub.3                                                                             6-Cl      4-FPh    OCF.sub.3                                                                            7-CF.sub.3                                                                              4-FPh                                  OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     Et       OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                    Me                                     OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     n-Pr                                                           OCF.sub.3                                                                            7-OCH.sub.2 CH.sub.3                                                                     i-Pr                                                           OCF.sub.3                                                                            7-CCH.sub.2 CH.sub.3                                                                     CO.sub.2 Me                                                    OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     CO.sub.2 Et                                                    OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     Ph                                                             OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     4-ClPh                                                         OCF.sub.3                                                                            7-OCH.sub.2 CF.sub.3                                                                     4-FPh                                                          OCF.sub.3                                                                            6-Cl      Me                                                             OCF.sub.3                                                                            6-Cl      Et                                                             OCF.sub.3                                                                            6-Cl      n-Pr                                                           OCF.sub.3                                                                            6-Cl      i-Pr                                                           OCF.sub.3                                                                            6-Cl      CO.sub.2 Me                                                    OCF.sub.3                                                                            6-Cl      CO.sub.2 Et                                                    OCF.sub.3                                                                            6-Cl      Ph                                                             OCF.sub.3                                                                            6-Cl      4-ClPh                                                         OCF.sub.3                                                                            6-Cl      4-FPh                                                          Cl    7-OCH.sub.2 CF.sub.3                                                                     i-Pr                                                           Cl    6-Cl      i-Pr                                                           ______________________________________                                    

                  TABLE 71                                                         ______________________________________                                          ##STR109##                                                                    R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.3                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               7-Cl     Me       CF.sub.3                                                                              8-Cl  Me                                      CF.sub.3                                                                               7-Cl     Et       CF.sub.3                                                                              8-Cl  Et                                      CF.sub.3                                                                               7-Cl     n-Pr     CF.sub.3                                                                              8-Cl  n-Pr                                    CF.sub.3                                                                               7-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              8-Cl  CO.sub.2 Me                             CF.sub.3                                                                               7-Cl     4-FPh    CF.sub.3                                                                              8-Cl  4-FPh                                   OCF.sub.3                                                                              7-Cl     Me       OCF.sub.3                                                                             8-Cl  Me                                      OCF.sub.3                                                                              7-Cl     Et       OCF.sub.3                                                                             8-Cl  Et                                      OCF.sub.3                                                                              7-Cl     n-Pr     OCF.sub.3                                                                             8-Cl  n-Pr                                    OCF.sub.3                                                                              7-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             8-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              7-Cl     4-FPh    OCF.sub.3                                                                             8-Cl  4-FPh                                   CF.sub.3                                                                               7-F      Me       CF.sub.3                                                                              8-F   Me                                      CF.sub.3                                                                               7-F      Et       CF.sub.3                                                                              8-F   Et                                      CF.sub.3                                                                               7-F      n-Pr     CF.sub.3                                                                              8-F   n-Pr                                    CF.sub.3                                                                               7-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              8-F   CO.sub.2 Me                             CF.sub.3                                                                               7-F      4-FPh    CF.sub.3                                                                              8-F   4-FPh                                   OCF.sub.3                                                                              7-F      Me       OCF.sub.3                                                                             8-F   Me                                      OCF.sub.3                                                                              7-F      Et       OCF.sub.3                                                                             8-F   Et                                      OCF.sub.3                                                                              7-F      n-Pr     OCF.sub.3                                                                             8-F   n-Pr                                    OCF.sub.3                                                                              7-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             8-F   CO.sub.2 Me                             OCF.sub.3                                                                              7-F      4-FPh    OCF.sub.3                                                                             8-F   4-FPh                                   ______________________________________                                    

                  TABLE 72                                                         ______________________________________                                          ##STR110##                                                                    R.sup.1 R.sup.2  R.sup.3  R.sup.1                                                                               R.sup.2                                                                              R.sup.3                                 ______________________________________                                         CF.sub.3                                                                               7-Cl     Me       CF.sub.3                                                                              8-Cl  Me                                      CF.sub.3                                                                               7-Cl     Et       CF.sub.3                                                                              8-Cl  Et                                      CF.sub.3                                                                               7-Cl     n-Pr     CF.sub.3                                                                              8-Cl  n-Pr                                    CF.sub.3                                                                               7-Cl     CO.sub.2 Me                                                                             CF.sub.3                                                                              8-Cl  CO.sub.2 Me                             CF.sub.3                                                                               7-Cl     4-FPh    CF.sub.3                                                                              8-Cl  4-FPh                                   OCF.sub.3                                                                              7-Cl     Me       OCF.sub.3                                                                             8-Cl  Me                                      OCF.sub.3                                                                              7-Cl     Et       OCF.sub.3                                                                             8-Cl  Et                                      OCF.sub.3                                                                              7-Cl     n-Pr     OCF.sub.3                                                                             8-Cl  n-Pr                                    OCF.sub.3                                                                              7-Cl     CO.sub.2 Me                                                                             OCF.sub.3                                                                             8-Cl  CO.sub.2 Me                             OCF.sub.3                                                                              7-Cl     4-FPh    OCF.sub.3                                                                             8-Cl  4-FPh                                   CF.sub.3                                                                               7-F      Me       CF.sub.3                                                                              8-F   Me                                      CF.sub.3                                                                               7-F      Et       CF.sub.3                                                                              8-F   Et                                      CF.sub.3                                                                               7-F      n-Pr     CF.sub.3                                                                              8-F   n-Pr                                    CF.sub.3                                                                               7-F      CO.sub.2 Me                                                                             CF.sub.3                                                                              8-F   CO.sub.2 Me                             CF.sub.3                                                                               7-F      4-FPh    CF.sub.3                                                                              8-F   4-FPh                                   OCF.sub.3                                                                              7-F      Me       OCF.sub.3                                                                             8-F   Me                                      OCF.sub.3                                                                              7-F      Et       OCF.sub.3                                                                             8-F   Et                                      OCF.sub.3                                                                              7-F      n-Pr     OCF.sub.3                                                                             8-F   n-Pr                                    OCF.sub.3                                                                              7-F      CO.sub.2 Me                                                                             OCF.sub.3                                                                             8-F   CO.sub.2 Me                             OCF.sub.3                                                                              7-F      4-FPh    OCF.sub.3                                                                             8-F   4-FPh                                   ______________________________________                                    

Formulation and Use

The compounds of this invention will generally be used in formulation with an agriculturally suitable carrier comprising a liquid or solid diluent or an organic solvent. Useful formulations of the compounds of Formulas I and II can be prepared in conventional ways. They include dusts, granules, baits, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates, dry flowables and the like. Many of these can be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from about one to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain from less than about 1% to 99% by weight of active ingredient(s) and at least one of a) about 0.1% to 20% surfactant(s) and b) about 5% to 99% solid or liquid diluent(s). More specifically, they will contain effective amounts of these ingredients in the following approximate proportions:

    ______________________________________                                                     Percent By Weight                                                              Active                                                                         Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             25-90     0-74      1-10                                         Oil Suspensions,                                                                              5-50     40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Dusts          1-25     70-99     0-5                                          Granules, Baits and                                                                          0.01-95   5-99      0-15                                         Pellets                                                                        High Strength 90-99     0-10      0-2                                          Compositions                                                                   ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed , Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", Allured Publ. Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publ Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth, etc. Preferably, ingredients should be approved by the U.S. Environmental Protection Agency for the use intended.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, U.S. Pat. No. 3,060,084). Granules and pellets can be made by spraying the active material upon preformed granular carriers or by agglomeration techniques See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pages 147 and following, and "Perry's Chemical Engineer's Handbook", 4th Ed., McGraw-Hill, New York, 1963, pages 8 to 59 and following.

EXAMPLE A

Emulsifiable Concentrate

    ______________________________________                                         7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             20%                                                    N-(4-(trifluoromethyl)phenyl!indeno-                                            1,2-e! 1,3,4!-oxadiazine-2(3H)-carboxamide                                    blend of oil soluble sulfonates                                                                        10%                                                    and polyoxyethylene ethers                                                     isophorone              70%                                                    ______________________________________                                    

The ingredients are combined and stirred with gentle warming to speed solution. A fine screen filter is included in packaging operation to insure the absence of any extraneous undissolved material in the product.

EXAMPLE B

Wettable Powder

    ______________________________________                                         7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             30%                                                    N- 4-(trifluoromethyl)phenyl!indeno-                                            1,2-e! 1,3,4!-oxadiazine-2(3H)-carboxamide                                    sodium alkylnaphthalenesulfonate                                                                       2%                                                     sodium ligninsulfonate  2%                                                     synthetic amorphous silica                                                                             3%                                                     kaolinite               63%                                                    ______________________________________                                    

The active ingredient is mixed with the inert materials in a blender. After grinding in a hammer-mill, the material is re-blended and sifted through a 50 mesh screen.

EXAMPLE C

Dust

    ______________________________________                                         Wettable powder of Example B                                                                        10%                                                       pyrophyllite (powder)                                                                               90%                                                       ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blended and then packaged. The product is suitable for use as a dust.

EXAMPLE D

Granule

    ______________________________________                                         7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             10%                                                    N- 4-(trifluoromethyl)phenyl!indeno-                                            1,2-e! 1,3,4!-oxadiazine-2(3H)-                                               carboxamide                                                                    attapulgite granules (low volative                                                                     90%                                                    matter, 0.71/0.30 mm; U.S.S. No.                                               25-50 sieves)                                                                  ______________________________________                                    

The active ingredient is dissolved in a volatile solvent such as acetone and sprayed upon dedusted and pre-warmed attapulgite granules in a double cone blender. The acetone is then driven off by heating. The granules are then allowed to cool and are packaged.

EXAMPLE E

Granule

    ______________________________________                                         Wettable powder of Example B                                                                        15%                                                       gypsum               69%                                                       potassium sulfate    16%                                                       ______________________________________                                    

The ingredients are blended in a rotating mixer and water sprayed on to accomplish granulation. When most of the material has reached the desired range of 0.1 to 0.42 mm (U.S.S. No. 18 to 40 sieves), the granules are removed, dried, and screened. Oversize material is crushed to produce additional material in the desired range. These granules contain 4.5% active ingredient.

EXAMPLE F

Solution

    ______________________________________                                         7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             25%                                                    N- 4-(trifluoromethyl)phenyl!indeno-                                            1,2-e! 1,3,4!-oxadiazine-2(3H)-                                               carboxamide                                                                    N-methyl-pyrrolidone    75%                                                    ______________________________________                                    

The ingredients are combined and stirred to produce a solution suitable for direct, low volume application.

EXAMPLE G

Aqueous Suspension

    ______________________________________                                         7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                              40%                                                   N- 4-(trifluoromethyl)phenyl!indeno-                                            1,2-e! 1,3,4!-oxadiazine-2(3H)-                                               carboxamide                                                                    polyacrylic acid thickener                                                                             0.3%                                                   dodecyclophenol polyethylene glycol ether                                                              0.5%                                                   disodium phosphate      1.0%                                                   monosodium phosphate    0.5%                                                   polyvinyl alcohol       1.0%                                                   water                   56.7%                                                  ______________________________________                                    

The ingredients are blended and ground together in a sand mill to produce particles substantially all under 5 microns in size.

EXAMPLE H

Oil Suspension

    ______________________________________                                         7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             35.0%                                                  N- 4-(trifluoromethyl)phenyl!indeno-                                            1,2-e! 1,3,4!-oxadiazine-2(3H)-carboxamide                                    blend of polyalcohol carboxylic esters                                                                  6.0%                                                  and oil soluble petroleum sulfonates                                           xylene range solvent    59.0%                                                  ______________________________________                                    

The ingredients are combined and ground together in a sand mill to produce particles substantially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE I

Bait Granules

    ______________________________________                                         7-chloro-4a-(4-chlorophenyl)-4a,5-dihydro-                                                             3.0%                                                   N- 4-(trifluoromethyl)phenyl!indeno-                                            1,2-e! 1,3,4!-oxadiazine-2(3H)-carboxamide                                    blend of polyethoxylated nonyl-phenols                                                                 9.0%                                                   and sodium dodecyl-benzene sulfonates                                          ground up corn cobs     88.0%                                                  ______________________________________                                    

The active ingredient and surfactant blend are dissolved in a suitable solvent such as acetone and sprayed onto the ground corn cobs. The granules are then dried and packaged.

Compounds of Formulas I and II can also be mixed with one or more other insecticides, fungicides, nematocides, bactericides, acaricides, or other biologically active compounds to form a multi-component pesticide giving an even broader spectrum of effective agricultural protection. Examples of other agricultural protectants with which compounds of this invention can be formulated are:

Insecticides:

3-hydroxy-N-methylcrotonamide(dimethylphosphate)ester (monocrotophos)

methylcarbamic acid, ester with 2,3-dihydro-2,2-dimethyl-7-benzofuranol (carbofuran)

O- 2,4,5-trichloro-α-(chloromethyl)benzyl!phosphoric acid, O',O'-dimethyl ester (tetrachlorvinphos)

2-mercaptosuccinic acid, diethyl ester, S-ester with thionophosphoric acid, dimethyl ester (malathion)

phosphorothioic acid, O,O-dimethyl, O-p-nitrophenyl ester (methyl parathion)

methylcarbamic acid, ester with a-naphthol (carbaryl)

methyl O-(methylcarbamoyl)thiolacetohydroxamate (methomyl)

N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine (chlordimeform)

O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidylphosphorothioate (diazinon)

octachlorocamphene (toxaphene)

O-ethyl-O-p-nitrophenyl phenylphosphonothioate (EPN)

(S)-α-cyano-m-phenoxybenzyl(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate (deltamethrin)

Methyl-N',N'-dimethyl-N- (methylcarbamoyl)oxy!-1-thioox amimidate (oxamyl)

cyano(3-phenoxyphenyl)-methyl-4-chloro-a-(1-methylethyl)benzeneacetate (fenvalerate)

(3-phenoxyphenyl)methyl(+)-cis,trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate (permethrin)

a-cyano-3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate (cypermethrin)

O-ethyl-S-(p-chlorophenyl)ethylphosphonodithioate (profenofos)

phosphorothiolothionic acid,

O-ethyl-O- 4-(methylthio)-phenyl!-S-n-propyl ester (sulprofos).

Additional insecticides are listed hereafter by their common names: triflumuron, diflubenzuron, methoprene, buprofezin, thiodicarb, acephate, azinphosmethyl, chlorpyrifos, dimethoate, fonophos, isofenphos, methidathion, methamidiphos, monocrotphos, phosmet, phosphamidon, phosalone, pirimicarb, phorate, terbufos, trichlorfon, methoxychlor, bifenthrin, biphenate, cyfluthrin, fenpropathrin, fluvalinate, flucythrinate, tralomethrin, metaldehyde and rotenone.

Fungicides:

methyl 2-benzimidazolecarbamate (carbendazim)

tetramethylthiuram disulfide (thiuram)

n-dodecylguanidine acetate (dodine)

manganese ethylenebisdithiocarbamate (maneb)

1,4-dichloro-2,5-dimethoxybenzene (chloroneb)

methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl)

1- 2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl!-1H-1,2,4-triazole (propiconazole)

2-cyano-N-ethylcarbamoyl-2-methoxyiminoacetamide (cymoxanil)

1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone (triadimefon)

N-(trichloromethylthio)tetrahydrophthalimide (captan)

N-(trichloromethylthio)phthalimide (folpet)

1- bis(4-fluorophenyl)! methyl!silyl!methyl!-1H-1,2,4-triazole

Nematicides:

S-methyl 1-(dimethylcarbamoyl)-N-(methylcarbamoyloxy)thioformimidate

S-methyl 1-carbamoyl-N-(methylcarbamoyloxy)thioformimidate

N-isopropylphosphoramidic acid O-ethyl O'- 4-(methylthio)-m-tolyl!diester (fenamiphos)

Bactericides:

tribasic copper sulfate

streptomycin sulfate

Acaricides:

senecioic acid, ester with 2-sec-butyl-4,6-dinitrophenol (binapacryl)

6-methyl-1,3-cithiolo 4,5-β!quinoxalin-2-one (oxythioquinox)

ethyl 4,4'-dichlorobenzilate (chlorobenzilate)

1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol (dicofol)

bis(pentachloro-2,4-cyclopentadien-1-yl) (dienochlor)

tricyclohexyltin hydroxide (cyhexatin)

trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-thiazolidine-3-carboxamide (hexythiazox)

amitraz

propargite

fenbutatin-oxide

Biological

Bacillus thuringiensis

Avermectin B.

Utility

Some of the compounds of this invention are characterized by favorable metabolic and/or soil residual patterns and exhibit activity against a wide spectrum of foliar and soil inhabiting arthropods which are pests of growing and stored agronomic crops, forestry, greenhouse crops, ornamentals, nursery crops, stored food and fiber products, livestock, household, and public and animal health. Those skilled in the art will recognize that not all compounds are equally effective against all pests. For example, some of the compounds where Y is alkyl have enhanced field efficacy. The compounds of this invention display activity against economically important agronomic, forestry, greenhouse, ornamental food and fiber product, stored product, domestic structure, and nursery pests, such as:

larvae of the order Lepidoptera including fall and beet amyworm and other Spodoptera spp., tobacco budworm, corn earworm and other Heliothis spp., European corn borer, navel orangeworm, stalk/stem borers and other pyralids, cabbage and soybean loopers and other loopers, codling moth, grape berry moth and other tortricids, black cutworm, spotted cutworm, other cutworms and other noctuids, diamondback moth, green cloverworm, velvetbean caterpillar, green cloverworm, pink bollworm, gypsy moth, and spruce budworm;

foliar feeding larvae and adults of the order Coleoptera including Colorado potato beetle, Mexican bean beetle, flea beetle, Japanese beetles, and other leaf beetles, boll weevil, rice water weevil, granary weevil, rice weevil and other weevil pests, and soil inhabiting insects such as Western corn rootworm and other Diabrotica spp., Japanese beetle, European chafer and other coleopteran grubs, and wireworms;

adults and larvae of the orders Hemiptera and Homoptera including tarnished plant bug and other plant bugs (miridae), aster leafhopper and other leafhoppers (cicadellidae), rice planthopper, brown planthopper, and other planthoppers (fulgoroidea), psylids, whiteflies (aleurodidae), aphids (aphidae), scales (coccidae and diaspididae), lace bugs (tingidae), stink bugs (pentatomidae), cinch bugs and other seed bugs (lygaeidae), cicadas (cicadidae), spittlebugs (cercopids), squash bugs (coreidae), red bugs and cotton stainers (pyrrhocoridae);

adults and larvae of the order acari (mites) including European red mite, two spotted spider mite, rust mites, McDaniel mite, and foliar feeding mites;

adults and immatures of the order Orthoptera including grasshoppers;

adults and immatures of the order Diptera including leafminers, midges, fruit flies (tephritidae), and soil maggots;

adults and immatures of the order Thysanoptera including onion thrips and other foliar feeding thrips.

The compounds are also active against economically important livestock, household, public and animal health pests such as:

insect pests of the order Hymenoptera including carpenter ants, bees, hornets, and wasps;

insect pests of the order Diptera including house flies, stable flies, face flies, horn flies, blow flies, and other muscoid fly pests, horse flies, deer flies and other Brachycera, mosquitoes, black flies, biting midges, sand flies, sciarids, and other Nematocera;

insect pests of the order Orthoptera including cockroaches and crickets;

insect pests of the order Isoptera including the Eastern subterranean termite and other termites;

insect pests of the order Mallophaga and Anoplura including the head louse, body louse, chicken head louse and other sucking and chewing parasitic lice that attack man and animals;

insect pests of the order Siphonoptera including the cat flea, dog flea and other fleas.

The specific species for which control is exemplified are: fall armyworm, Spodoptera fruigiperda; tobacco budworm, Heliothis virescens; boll weevil, Anthonomus grandis; aster leafhopper, Macrosteles fascifrons; black bean aphid, (Aphis Fabae); southern corn rootworm, Diabrotica undecimpunctata. The pest control protection afforded by the compounds of the present invention is not limited, however, to these species. The compounds of this invention may also be utilized as rodenticides.

Application

Arthropod pests are controlled and protection of agronomic crops, animal and human health is achieved by applying one or more of the Formula I or II compounds of this invention, in an effective amount, to the environment of the pests including the agronomic and/or nonagronomic locus of infestation, to the area to be protected, or directly on the pests to be controlled. Because of the diversity of habitat and behavior of these arthropod pest species, many different methods of application are employed. A preferred method of application is by spraying with equipment that distributes the compound in the environment of the pests, on the foliage, animal, person, or premise, in the soil or animal, to the plant part that is infested or needs to be protected. Alternatively, granular formulations of these toxicant compounds can be applied to or incorporated into the soil. Other methods of application can also be employed including direct and residual sprays, aerial sprays, baits, eartags, boluses, foggers, aerosols, and many others. The compounds can be incorporated into baits that are consumed by the arthropods or in devices such as traps and the like which entice them to ingest or otherwise contact the compounds.

The compounds of this invention can be applied in their pure state, but most often application will be of a formulation comprising one or more compounds with suitable carriers, diluents, and surfactants and possibly in combination with a food depending on the contemplated end use. A preferred method of application involves spraying a water dispersion or refined oil solution of the compounds. Combinations with spray oils, spray oil concentrations, and synergists such as piperonyl butoxide often enhance the efficacy of the compounds of Formulae I and II.

The rate of application of the Formula I and II compounds required for effective control will depend on such factors as the species of arthropod to be controlled, the pest's life cycle, life stage, its size, location, time of year, host crop or animal, feeding behavior, mating behavior, ambient moisture, temperature, etc. In general, application rates of 0.01 to 2 kg of active ingredient per hectare are sufficient to provide large-scale effective control of pests in agronomic ecosystems under normal circumstances, but as little as 0.001 kg/hectare or as much as 8 kg hectare may be required. For nonagronomic applications, effective use rates will range from about 1.0 to 50 mg/square meter but as little as about 0.1 mg/square meter or as much as 150 mg/square meter may be required.

The following Tests demonstrate the control efficacy of compounds of Formulae I and II on specific pests; see Index Tables A, B, C, D, E and F for compound descriptions.

                  INDEX TABLE A                                                    ______________________________________                                          ##STR111##                                                                    Cmpd      R.sup.1  R.sup.2  R.sup.3                                                                               mp (°C.)                             ______________________________________                                          1        CF.sub.3 Cl       4-ClPh 213-214                                      2        OCF.sub.3                                                                               Cl       CO.sub.2 Me                                                                           126.5-128                                    3        CF.sub.3 Cl       CO.sub.2 Me                                                                           153-155                                      4        Br       Cl       CO.sub.2 Me                                                                           168-170                                      5        Cl       Cl       CO.sub.2 Me                                                                           159-162                                      6        OCF.sub.3                                                                               F        4-FPh  158-160                                      7        Cl       F        4-FPh  189-190                                      8        Br       F        4-FPh  208-209                                      9        OCF.sub.3                                                                               Cl       Me     foam*                                       10        Br       Cl       Me     88-90                                       11        OCF.sub.3                                                                               Cl       n-Pr   oil*                                        12        Br       Cl       n-Pr   oil*                                        13        Cl       Cl       n-Pr   oil*                                        14        OCF.sub.3                                                                               CF.sub.3 CO.sub.2 Me                                                                           oil*                                        15        Cl       CF.sub.3 CO.sub.2 Me                                                                           176-181                                     16        CF.sub.3 F        CO.sub.2 Me                                                                           216-218                                     17        Br       F        CO.sub.2 Me                                                                           186-188                                     18        Cl       F        CO.sub.2 Me                                                                           179-180                                     19        OCF.sub.3                                                                               F        CO.sub.2 Me                                                                           174-176                                     20        Br       F        Ph     180-182                                     21        OCF.sub.3                                                                               F        Ph     154-156                                     51        CF.sub.3 F        4-FPh  182-190                                     52        OCF.sub.3                                                                               F        Et     44-48                                       53        CF.sub.3 F        Et     58-60                                       54        OCF.sub.3                                                                               F        Me     60-61                                       55        CF.sub.3 F        Me     61-62                                       63        OCF.sub.3                                                                               Cl       CO.sub.2 Et                                                                           122-124                                     64        CF.sub.3 CF.sub.3 CO.sub.2 Me                                                                           154-156                                     81        Cl       F        Me     oil*                                        ______________________________________                                    

                  INDEX TABLE B                                                    ______________________________________                                          ##STR112##                                                                    Cmpd  R.sup.1 R.sup.2                                                                               R.sup.3                                                                               R.sup.4                                                                              Y      mp (°C.)                       ______________________________________                                         22    OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           H     Me     130-131                               23    OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           Me    H      162-166                               24    OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           H     CO.sub.2 Me                                                                           oil*                                  25    OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           H     COMe   oil*                                  26    Br      F      4-FPh  H     Me     161-163                               27    Br      F      4-FPh  H     CO.sub.2 Me                                                                           187-169                               28    Br      F      4-FPh  H     COMe   91-93                                 29    Br      F      4-FPh  Me    H      198 (dec)                             30    Br      F      4-FPh  Et    H      219-221                               31    OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           Et    H      151-152                               32    CF.sub.3                                                                               F      CO.sub.2 Me                                                                           Me    H      168-171                               33    OCF.sub.3                                                                              F      CO.sub.2 Me                                                                           Me    H      155-157                               34    OCF.sub.3                                                                              F      4-FPh  Et    H      150-152                               35    OCF.sub.3                                                                              F      4-FPh  Me    H      149-151                               36    Br      Cl     CO.sub.2 Me                                                                           H     Me     114-116                               37    CF.sub.3                                                                               Cl     CO.sub.2 Me                                                                           H     Me     133-135                               38    CF.sub.3                                                                               F      CO.sub.2 Me                                                                           Et    H      168-170                               39    CF.sub.3                                                                               Cl     CO.sub.2 Me                                                                           H     COMe   gum*                                  40    Br      Cl     CO.sub.2 Me                                                                           H     CO.sub.2 Me                                                                           oil*                                  41    OCF.sub.3                                                                              F      CO.sub.2 Me                                                                           H     Me     143-145                               42    CF.sub.3                                                                               F      CO.sub.2 Me                                                                           H     Me     198-200                               43    OCF.sub.3                                                                              Cl     CO.sub.2 Et                                                                           H     Et     oil*                                  44    OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           H     Et     120.5-122                             45    CF.sub.3                                                                               Cl     CO.sub.2 Et                                                                           H     Et     oil*                                  46    CF.sub.3                                                                               Cl     CO.sub.2 Me                                                                           H     Et     oil*                                  47    OCF.sub.3                                                                              Cl     CO.sub.2 Me                                                                           H     CO.sub.2 Et                                                                           oil*                                  48    Br      F      4-FPh  H     CO.sub.2 Et                                                                           oil*                                  49    Br      F      4-FPh  H     Et     177-178                               50    Br      F      4-FPh  H     COMe   oil*                                  65    OCF.sub.3                                                                              Cl     CO.sub.2 Et                                                                           H     Me     oil*                                  66    OCF.sub.3                                                                              F      4-FPh  H     CO.sub.2 Et                                                                           170-173                               67    OCF.sub.3                                                                              F      4-FPh  H     Et     164-166                               68    Br      F      4-FPh  H     CH.sub.2 SMe                                                                          158-160                               ______________________________________                                    

                  INDEX TABLE C                                                    ______________________________________                                          ##STR113##                                                                    Cmpd    R.sup.1    R.sup.2 R.sup.3                                                                               mp(°C.)                               ______________________________________                                         56      OCF.sub.3  F       4-FPh  180-184                                      57      OCF.sub.3  Cl      4-FPh  129-133                                      69      OCF.sub.3  F       Me     125-127                                      ______________________________________                                    

                  INDEX TABLE D                                                    ______________________________________                                          ##STR114##                                                                    Cmpd     R.sup.1  R.sup.2                                                                               R.sup.3 Y   mp (°C.)                           ______________________________________                                         58       OCF.sub.3                                                                               Cl     Me      H   115-117                                   59       CF.sub.3 Cl     Me      H   162-163                                   60       CF.sub.3 Cl     Et      H   132-133                                   61       CF.sub.3 F      Et      H   123-124                                   62       OCF.sub.3                                                                               F      Et      H   100-101                                   70       OCF.sub.3                                                                               Cl     CO.sub.2 Me                                                                            H   160-161                                   71       CF.sub.3 Cl     CO.sub.2 Me                                                                            H   199-200                                   72       Br       Cl     CO.sub.2 Me                                                                            H   230 (dec)                                 73       Cl       Cl     CO.sub.2 Me                                                                            H   221-223                                   74       OCF.sub.3                                                                               F      CO.sub.2 Me                                                                            H   163-164                                   75       CF.sub.3 F      CO.sub.2 Me                                                                            H   199-200                                   76       Br       F      CO.sub.2 Me                                                                            H   205-207                                   77       Cl       F      CO.sub.2 Me                                                                            H   194-196                                   78       OCF.sub.3                                                                               Cl     CO.sub.2 Me                                                                            Me  147-148                                   79       CF.sub.3 Cl     CO.sub.2 Me                                                                            Me  148-149                                   80       Br       Cl     CO.sub.2 Me                                                                            Me  178-179                                   ______________________________________                                    

                  INDEX TABLE E                                                    ______________________________________                                          ##STR115##                                                                    Cmpd     R.sup.1  R.sup.2 R.sup.3                                                                               mp (°C.)                               ______________________________________                                         82       OCF.sub.3                                                                               Cl      CO.sub.2 CH.sub.3                                                                     135-140(d)                                    ______________________________________                                    

                  INDEX TABLE F                                                    ______________________________________                                          ##STR116##                                                                    Cmpd      R.sup.1 R.sup.2 R.sup.3                                                                              E   mp (°C.)                            ______________________________________                                         83        H       H       Ph    H   oil*                                       ______________________________________                                          *See Table G for additional data on selected compounds of Tables A-F.    

                  TABLE G                                                          ______________________________________                                         CMPD       .sup.1 H NMR Data(200 MHz, CDCl.sub.3 solution)                     ______________________________________                                          9         δ1.51(s, 3H), 3.14(abq, 2H), 5.20(d, 1H),                                5.73(d, 1H), 7.18(d, 2H), 7.35(d, 2H),                                         7.51-7.61(m, 3H), 8.40(s, 1H).                                      11         δ0.92(t, 3H), 1.22-1.62(m, 3H), 1.8-2.0(m,                               1H), 3.13(abq, 2H), 5.19(d, 1H), 5.56(d,                                       1H), 7.18(d, 2H), 7.33(d, 2H), 7.51-7.62                                       (m, 3H), 8.39(s, 1H).                                               12         δ0.92(t, 3H), 1.3-1.6(m, 3H), 1.8-2.0(m,                                 1H), 3.12(abq, 2H), 5.19(d, 1H), 5.55(d,                                       1H), 7.31(apparent d, 2H), 7.43(apparent                                       s, 4H), 7.57(d, 1H), 8.36(s, 1H).                                   13         δ0.92(t, 3H), 1.2-1.6(m, 3H), 1.8-2.0(m,                                 1H), 3.15(abq, 2H), 5.18(d, 1H), 5.55(d,                                       1H), 7.24-7.38(m, 4H), 7.50(d, 2H), 7.57                                       (d, 1H) , 8.36(s, 1H).                                              14         δ3.43(abq, 2H), 3.74(s, 3H), 5.07(d, 1H),                                5.97(d, 1H), 7.21(d, 2H), 7.5-7.7(m, 4H),                                      7.81(d, 1H), 8.38(br s, 1H).                                        24         δ3.25(d, 1H), 3.51(d, 1H), 3.72(s, 3H),                                  3.73(s, 3H), 5.22(d, 1H), 5.72(d, 1H),                                         7.20-7.42(m, 6H), 7.53(d, 1H).                                      25         δ2.23(s, 3H), 3.21(d, 1H), 3.47(d, 1H),                                  3.66(s, 3H), 5.22(d, 1H), 5.65(d, 1H),                                         7.18-7.45(m, 7H).                                                   39         δ2.27(s, 3H), 3.20(d, 1H), 3.44(d, 1H),                                  3.65(s, 3H), 5.24(d, 1H), 5.66(d, 1H),                                         7.23-7.45(m, 5H), 7.64(d, 2H).                                      40         δ3.39(abq, 2H), 3.71(s, 3H), 3.72(s, 3H),                                5.21(d, 1H), 5.69(d, 1H), 7.18-7.38(m,                                         4H), 7.43-7.57(m, 3H).                                              43         δ1.05-1.20(m, 5H), 3.23(abq, 2H), 3.65-3.95                              (m, 2H), 4.02-4.2(m, 2H), 5.17(d, 1H),                                         5.44(d, 1H), 6.93(d, 1H), 7.14(apparent                                        s, 5H), 7.19(apparent s, 1H).                                       45         δ1.08-1.30(m, 5H), 3.10(d, 1H), 3.37(d,                                  1H), 3.70-3.95(m, 2H), 4.0-4.2(m, 2H),                                         5.17(d, 1H), 5.47(d, 1H), 6.72(d, 1H),                                         7.19(distorted t, 4H), 7.54(d, 2H).                                 46         δ1.22(t, 3H), 3.09(d, 1H), 3.38(d, 1H),                                  3.67(s, 3H), 3.72-3.98(m, 2H), 5.20(d,                                         1H), 5.42(d, 1H), 6.75(d, 1H), 7.19                                            (distorted t, 4H), 7.54(d, 2H).                                     47         δ1.16(t, 3H), 3.38(abq, 2H), 3.72(s, 3H),                                4.05-4.25(m, 2H), 5.20(d, 1H), 5.76(d,                                         1H), 7.10-7.26(m, 2H), 7.36(distorted t,                                       4H), 7.54(d, 1H).                                                   48         δ1.22(t, 3H), 3.47(abq, 2H), 4.23(q, 2H),                                4.60(d, 1H), 5.61(d, 1H), 6.92-7.10(m,                                         4H), 7.12-7.25(m, 4H), 7.49(distorted d,                                       2H), 7.63(dd, 1H).                                                  50         δ2.19(s, 3H), 3.34(abq, 2H), 3.66(s, 3H),                                5.22(d, 1H), 5.64(d, 1H), 7.18-7.37(m,                                         4H), 7.42-7.51(m, 3H).                                              65         δ1.15(t, 3H), 3.13(d, 1H), 3.35(d, 1H),                                  3.38(s, 3H), 4.0-4.2(m, 2H), 5.19(d, 1H),                                      5.44(d, 1H), 6.83(d, 1H), 7.15(apparent                                        s, 5H), 7.19(br s, 1H).                                             81         δ1.51(s, 3H), 3.17(abq, 2H), 5.20(d, 1H),                                5.72(d, 1H), 7.02-7.17(m, 2H), 7.43(s,                                         4H), 7.62(dd, 1H), 8.38(br s, 1.H).                                 83         δ6.50(s, 1H), 7.4-7.8(m, 14H), 10.6(bs,                                  1H).                                                                ______________________________________                                    

TEST A

Fall Armyworm

Test units, each consisting of an 8-ounce (230 mL) plastic cup containing a layer of wheat germ diet, approximately 0.5 cm thick, were prepared. Ten third-instar larvae of fall armyworm (Spodoptera frugiperda) were placed into each cup. Solutions of each of the test compounds (acetone/distilled water 75/25 solvent) were sprayed into the cups, a single solution per set of three cups. Spraying was accomplished by passing the cups, on a conveyer belt, directly beneath a flat fan hydraulic nozzle which discharged the spray at a rate of 0.5 pounds of active ingredient per acre (about 0.55 kg/ha) at 30 p.s.i. (207 kPa). The cups were then covered and held at 27° C. and 50% relative humidity for 72 hours, after which time readings were taken. Of the compounds tested, the following resulted in greater than or equal to 80% mortality: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 19, 20, 21, 22, 23, 25, 26, 27, 28, 29, 31, 34, 35, 36, 37, 39, 40, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 58, 61, 62, 63, 65, 70, 74, 78, 79, 80.

TEST B

Tobacco Budworm

The test procedure of Test 1 was repeated for efficacy against third-instar larvae of the tobacco budworm (Heliothis virescens) except that mortality was assessed at 48 hours. Of the compounds tested, the following resulted in greater than or equal to 80% mortality: 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 28, 29, 32, 33, 34, 35, 37, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 61, 62, 63, 65, 70, 71, 74, 79.

TEST C

Southern Corn Rootworm

Test units, each consisting of an 8-ounce (230 mL) plastic cup containing 1 sprouted corn seed, were prepared. Sets of three test units were sprayed as described in Test A with individual solutions of the test compounds. After the spray on the cups had dried, five third-instar larvae of the southern corn rootworm (Diabrotica undecimpunctata howardi) were placed into each cup. A moistened dental wick was inserted into each cup to prevent drying and the cups were then covered. The cups were then held at 27° C. and 50% relative humidity for 48 hours, after which time mortality readings were taken. Of the compounds tested, the following resulted in greater than or equal to 80% mortality: 1, 2, 3, 6, 7, 8, 9, 10, 11, 12, 15, 16, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 28, 32, 35, 36, 37, 39, 41, 42, 43, 44, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 59, 61, 62, 63, 65, 70, 71, 74, 75, 76, 77, 78, 79, 80.

TEST D

Aster Leafhopper

Test units were prepared from a series of 12-ounce (350 mL) cups, each containing oat (Avena sativa) seedlings in a 1-inch (2.54 cm) layer of sterilized soil. The test units were sprayed as described in Test A with individual solutions of the below-listed compounds. After the oats had dried from the spraying, between 10 and 15 adult aster leafhoppers (Mascrosteles fascifrons) were aspirated into each of the covered cups. The cups were held at 27° C. and 50% relative humidity for 48 hours, after which time mortality readings were taken. Of the compounds tested, the following resulted in greater than or equal to 80% mortality: 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 17, 18, 19, 21, 22, 25, 26, 27, 28, 35, 36, 37, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 63, 65, 70, 71, 74, 76, 77, 78, 79.

TEST E

Boll Weevil

Five adult boll weevils (Anthonomus grandis grandis) were placed into each of a series of 9 ounce (260 mL) cups. The test procedure employed was then otherwise the same as in Test A with three cups per treatment. Mortality readings were taken 48 hours after treatment. Of the compounds tested, the following resulted in greater than or equal to 80% mortality: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 18, 19, 20, 21, 22, 23, 25, 26, 27, 28, 32, 33, 35, 37, 39, 41, 42, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 61, 62, 63, 65, 70, 71, 74, 75, 76, 77, 78, 79, 80. 

What is claimed is:
 1. A compound of Formula I or II: ##STR117## wherein: Q is selected from the group ##STR118## A is H; E is selected from the group H and C₁ -C₃ alkyl; orA and E can be taken together to form --CH₂ --, --CH₂ CH₂ --, --O--, --S--, --S(O)--, --S(O)₂ --, --NR⁷ --, --OCH₂ --, --SCH₂ --, --N(R⁷)CH₂ --, substituted --CH₂ --, and substituted --CH₂ CH₂ -- the substituents independently selected from 1-2 halogen and 1-2 methyl; G is selected from the group ##STR119## X is selected from the group O, S and N-X² ; X¹ is selected from the group Cl, Br, OR⁸, SR⁸ and NR⁸ R⁹ ; X² is selected from the group R⁸, OH, OR⁸, CN, SO₂ R⁸, SO₂ Ph, OC(O)NR⁹ R¹⁰, OC(O)OR⁸, NR⁹ R¹⁰ and phenyl optionally substituted with R¹¹ ; Y is selected from the group H; C₁ -C₆ alkyl; benzyl; C₂ -C₆ alkoxyalkyl; C₂ -C₆ alkenyl; C₂ -C₆ alkynyl; C₁ -C₆ alkyl optionally substituted with halogen, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, CN, NO₂, S(O)_(r) R³², COR³², CO₂ R³², phenyl optionally substituted with halogen, CN, C₁ -C₂ haloalkyl and C₁ -C₂ haloalkoxy; C₃ -C₆ cycloalkyl; C₃ -C₆ cyclohaloalkyl; C₃ -C₆ cycloalkylalkyl; CHO; C₂ -C₆ alkylcarbonyl; C₂ -C₆ alkoxycarbonyl; C₂ -C₆ haloalkylcarbonyl; COR³⁶ ; CO₂ R³⁶ ; C₁ -C₆ alkylthio; C₁ -C₆ haloalkylthio; phenylthio; R¹² OC(O)N(R¹³)S-- and R¹⁴ (R¹⁵)NS--; A¹ is H; A¹ and Y can be taken together to form --(CH₂)_(t) --; Z is C or N; Z¹ is NR³¹ ; R¹ and R² are independently selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, N₃, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, NR¹⁸ C(O)R¹⁷, OC(O)NHR¹⁷, NR¹⁸ C(O)NHR¹⁷, NR¹⁸ SO₂ R¹⁷, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; or when m or n is 2, (R¹)₂ can be taken together, or (R²)₂ can be taken together as --OCH₂ O--, --OCF₂ O--, --OCH₂ CH₂ O--, --CH₂ C(CH₃)₂ O--, --CF₂ CF₂ O or --OCF₂ CF₂ O-- to form a cyclic bridge; provided that when R¹ or R² is S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷ or OS(O)₂ R¹⁷ then R¹⁷ is other than H; R³ is selected from the group H, J, N₃, NO₂, halogen, N(R²²)R²³, C(R³⁴)═N--O--R³⁵, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₂ -C₆ alkoxylalkyl, C₃ -C₈ alkoxycarbonylalkyl, CO₂ R¹⁷, OR¹⁹, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, C(S)NR¹⁷ R¹⁸, C(S)R¹⁷, C(S)SR¹⁷, CN, Si(R²⁸) (R²⁹)R²⁷, SR²⁷, S(O)R²⁷, SO₂ R²⁷, --P(O) (OR²⁷)₂, phenyl, phenyl substituted with (R¹⁶)_(p), benzyl and benzyl substituted with 1 to 3 substituents independently selected from W; or R³ is C₂ -C₆ epoxyalkyl optionally substituted with a group selected from C₁ -C₃ alkyl, CN, C(O)R²⁴, CO₂ R²⁴ and phenyl optionally substituted with W; or R³ is C₁ -C₆ alkyl substituted with a group selected from C(O)N(R²⁵)R²⁶, C(O)R²⁵, SR²⁷, S(O)R²⁷, SO₂ R²⁷, SCN, CN, C₁ -C₂ haloalkoxy, Si(R²⁸) (R²⁹)R³⁰, N(R²²)R²³, NO₂, OC(O)R²⁵, --P(O) (OR²⁷)₂ and J; J is selected from the group saturated, partially unsaturated or aromatic 5- or 6-membered heterocyclic ring, bonded through carbon or nitrogen, containing 1-4 heteroatoms independently selected from the group consisting of 0-2 oxygen, 0-3 sulfur and 0-4 nitrogen, this substituents optionally containing one carbonyl and optionally substituted with one or more members selected from W; R⁴ and R⁵ are independently selected from the group H, C₁ -C₄ alkyl, COR²⁰ and C₂ -C₄ alkoxycarbonyl; or R⁴ and R⁵ can be taken together to form ═O or ═S; R⁶ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkylcarbonyl, C₂ -C₄ haloalkoxycarbonyl, C₂ -C₄ alkoxycarbonyl C₂ -C₄ haloalkoxycarbonyl, COR³⁶, CO₂ R³⁶, C₂ -C₅ alkylaminocarbonyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, C₄ -C₇ alkylcycloalkyl, C₄ -C₇ haloalkylcycloalkyl, C₁ -C₄ alkylsulfonyl, C₁ -C₄ haloalkylsulfonyl and SO₂ Ph optionally substituted with Cl, Br or CH₃ ; R⁷ is selected from the group H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkenyl, C₂ -C₄ haloalkenyl, SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, R¹⁷, CO₂ R¹⁷, C(O)NR¹⁷ R²¹, C(S)NR¹⁷ R²¹, C(S)R¹⁷, C(S)OR¹⁷, --P(O)(OR¹⁷)₂, --P(S)(OR¹⁷)₂, P(O)(R¹⁷)OR¹⁷, P(O)(R¹⁷)SR²¹, and optionally substituted phenyl and benzyl wherein the substituent(s) are selected from F, Cl, Br, CH₃, CF₃ or OCF₃ ; provided that when R⁷ is other than C(O)R¹⁷, C(O)NR¹⁷ R²¹ or C(S)NR¹⁷ R²¹ then R¹⁷ is other than H; R⁸ is selected from the group C₁ -C₃ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, C₁ -C₃ haloalkyl, C₂ -C₄ haloalkenyl, C₃ -C₆ cycloalkyl; C₁ -C₃ alkyl substituted with OCH₃, OCH₂ CH₃, NO₂, CN, CO₂ CH₃, CO₂ CH₂ CH₃, SCH₃ or SCH₂ CH₃ and benzyl optionally substituted with R¹¹ ; R⁹ is selected from the group H, C₁ -C₄ alkyl C₁ -C₄ haloalkyl, C₂ -C₄ alkoxycarbonyl, and optionally substituted phenyl and pyridine wherein the substituent(s) are selected from R¹⁵ ; or R⁸ and R⁹ can be taken together to form --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ -- each of which is optionally and independently substituted with 1 or 2 CH₃ groups; R¹⁰ is selected from the group H and C₁ -C₄ alkyl; or R⁹ and R¹⁰ can be taken together to form --(CH₂)₄ --, --(CH₂)₅ -- or --CH₂ CH₂ OCH₂ CH₂ -- each of which is optionally and independently substituted with 1 or 2 CH₃ groups; R¹¹ is selected from halogen, CN, C₁ -C₃ haloalkyl and C₁ -C₃ haloalkoxy; R¹² is C₁ -C₆ alkyl; R¹³ is C₁ -C₄ alkyl; R¹⁴ and R¹⁵ are independently C₁ -C₄ alkyl; or R¹⁴ and R¹⁵ can be taken together as --CH₂ CH₂ CH₂ CH₂ CH₂ -- or --CH₂ CH₂ OCH₂ CH₂ --; R¹⁶ is selected from the group C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, N₃, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, NR¹⁸ C(O)R¹⁷, OC(O)NHR¹⁷, NR¹⁸ C(O)NHR¹⁷, NR¹⁸ SO₂ R¹⁷, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; or when p is 2, (R¹⁶)₂ can be taken together as --OCH₂ O--, --OCF₂ O--, --OCH₂ CH₂ O--, --CH₂ C(CH₃)₂ O--, --CF₂ CF₂ O or --OCF₂ CF₂ O-- to form a cyclic bridge; provided that when R¹⁶ is S(O)R¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷ or OS(O)₂ R¹⁷ then R¹⁷ is other than H; R¹⁷ is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, and optionally substituted phenyl and benzyl wherein the substituents are 1 to 3 substituents independently selected from W; R¹⁸ is selected from the group H and C₁ -C₄ alkyl; or R¹⁷ and R¹⁸, when attached to the same atom, can be taken together as --(CH₂)₄ --, --(CH₂)₅ --, or --CH₂ CH₂ OCH₂ CH₂ --; R¹⁹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, C₂ -C₄ alkylcarbonyl, C₂ -C₄ alkoxycarbonyl and C₁ -C₄ alkylsulfonyl; R²⁰ is C₁ -C₃ alkyl; R²¹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl and C₂ -C₄ alkynyl; R²² is selected from the group H, C₂ -C₇ alkylcarbonyl, C₂ -C₇ alkoxycarbonyl, optionally substituted C₁ -C₄ alkyl, optionally substituted C₂ -C₄ alkenyl, and optionally substituted C₂ -C₄ alkynyl, the substituents selected from C₁ -C₂ alkoxy, CN, C(O)R³⁰ and C(O)₂ R²⁷ ; R²³ is selected from the group H, C₁ -C₃ alkyl, phenyl, phenyl substituted with W, benzyl and benzyl substituted with W; R²⁴ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkenyl and C₂ -C₄ alkynyl; R²⁵ and R²⁶ are independently selected from the group H and C₁ -C₂ alkyl; R²⁷ is selected from the group C₁ -C₃ alkyl, phenyl and phenyl substituted with W; R²⁸ is C₁ -C₃ alkyl; R²⁹ is C₁ -C₃ alkyl; R³⁰ is selected from the group H, C₁ -C₃ alkyl, phenyl and phenyl substituted with W; R³¹ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₄ alkylcarbonyl or C₂ -C₄ alkoxycarbonyl; R³² is selected from the group C₁ -C₃ alkyl; R³⁴ is selected from the group H, Cl, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₂ thioalkyl and CN; R³⁵ is selected from the group H, C₁ -C₄ alkyl, C₂ -C₃ alkylcarbonyl and C₂ -C₃ alkoxycarbonyl; R³⁶ is selected from the group phenyl and phenyl substituted with W; W is selected from the group halogen, CN, NO₂, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy, C₁ -C₂ alkylthio, C₁ -C₂ haloalkylthio, C₁ -C₂ alkylsulfonyl and C₁ -C₂ haloalkylsulfonyl; m is 1 to 3; n is 1 to 3; p is 1 to 3; r is 0, 1 or 2; t is 2 or 3; and u is 1 or
 2. 2. A compound according to claim 1 wherein Q is selected from Q-5 and Q-6.
 3. A compound according to claim 1 wherein Q is selected from Q-1, Q-2, Q-3, and Q-4.
 4. A compound according to claim 1 wherein Q=Q₁.
 5. A compound according to claim 2, 3 or 4 wherein J is selected from the group: ##STR120##
 6. A compound according to claim 2, 3 or 4 wherein:R¹ is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, SO₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; with one R¹ substituent in the 4-position, or when m is 2 then (R¹)₂ can be taken together as --CH₂ C(CH₃)₂ O--, --OCH₂ CH₂ O--, --OCF₂ CF₂ O--, or --CF₂ CF₂ O-- to form a 5- or 6-membered fused ring; R² is selected from the group H, C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl, C₃ -C₆ halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; R³ is selected from the group H, C₁ -C₄ alkyl, C₃ -C₄ alkoxycarbonylalkyl, CO₂ R¹⁷, C(O)R¹⁷, phenyl and phenyl substituted by (R¹⁶)_(p) ; R¹⁶ is selected from the group C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ haloalkynyl, C₂ -C₆ alkoxyalkyl, C₂ -C₆ alkylthioalkyl, C₁ -C₆ nitroalkyl, C₂ -C₆ cyanoalkyl, C₃ -C₈ alkoxycarbonylalkyl, C₃ -C₆ cycloalkyl,, C₃ -C₆ halocycloalkyl, halogen, CN, SCN, NO₂, OR¹⁷, SR¹⁷, S(O)₂ R¹⁷, OC(O)R¹⁷, OS(O)₂ R¹⁷, CO₂ R¹⁷, C(O)R¹⁷, C(O)NR¹⁷ R¹⁸, SO₂ NR¹⁷ R¹⁸, NR¹⁷ R¹⁸, phenyl optionally substituted with 1 to 3 substituents independently selected from W, and benzyl optionally substituted with 1 to 3 substituents independently selected from W; R¹⁷ is selected from the group C₁ -C₄ alkyl, C₁ -C₂ haloalkyl, C₃ -C₄ alkenyl and propargyl; R¹⁸ is selected from the group H and CH₃ ; X¹ is selected from the group Cl, OR⁸, SR⁸ and N(CH₃)₂ ; X² is selected from the group R⁸, OR⁸ and N(CH₃)₂ ; m is 1 or 2; n is 1 or 2; and p is 1 or
 2. 7. A compound according to claim 4 wherein G is selected from the group G-2, G-1, G-6 and G-9.
 8. A compound according to claim 4 wherein A and E are taken together to form --O--, --CH₂ --, --CH₂ CH₂ --, --OCH₂ --, --S--, --SCH₂ -- or NR⁷ ; R⁷ is selected from the group H, Me, SO₂ R¹⁷, CO₂ R¹⁷ and CON(R¹⁷)R²¹.
 9. An arthropodicidal composition comprising a compound according to any one of claims 1, 7, 8, 2, 3 or 4 and a carrier therefor.
 10. A method for controlling arthropods comprising contacting them or their environment with an arthropodicidally effective amount of a compound according to any one of claims 1, 7, 8, 2, 3 or
 4. 